KEGG ORTHOLOGY: K01587

ORTHOLOGY: K01587

Entry

K01587                      KO

Symbol

PAICS

Name

phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00048

De novo purine biosynthesis, PRPP + glutamine => IMP

Reaction

R04209

1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase

R04591

1-(5-phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.21  phosphoribosylaminoimidazole carboxylase
     K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase
     K01587  PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase

Other DBs

GO:	0004638 0004639

Genes

HSA:	10606(PAICS)

PTR:	471236(PAICS)

PPS:	100993147(PAICS)

GGO:	101132763(PAICS)

PON:	100190835(PAICS)

NLE:

100580950

HMH:	116467849(PAICS) 116483296

MCC:

694743

MCF:	101864855(PAICS)

MTHB:

126955444

MNI:

105463551

CSAB:

103235649 103237366

CATY:

105591967 105591969(PAICS)

PANU:

101011883(PAICS) 103884449

TGE:	112625131(PAICS)

MLEU:

105552705(PAICS)

RRO:	104655715(PAICS)

RBB:	108513484(PAICS)

TFN:	117085582(PAICS) 117090262

PTEH:

111526496(PAICS)

CANG:

105507807 105525579(PAICS)

CJC:	100390231(PAICS)

SBQ:	101031274(PAICS) 104651700

CIMI:

108296113(PAICS) 108296114

CSYR:

103249285(PAICS)

MMUR:

105867854 105867855(PAICS)

LCAT:

123624098(PAICS) 123637056

PCOQ:

105807688(PAICS)

OGA:	100950463(PAICS)

MMU:	67054(Paics)

MCAL:

110293933

MPAH:

110330578(Paics)

RNO:	140946(Paics)

MCOC:

116071305(Paics)

ANU:	117712646(Paics)

MUN:	110565016(Paics)

CGE:	100753190 100758991(Paics)

MAUA:

101829734(Paics) 121142783

PROB:

127232266(Paics)

PLEU:

114681836(Paics)

MORG:

121432328 121460627(Paics)

MFOT:

126506556 126515426

AAMP:

119808557(Paics) 119810165

NGI:	103734378(Paics)

HGL:	101721606(Paics)

CPOC:

100727779(Paics)

CCAN:

109697886(Paics)

DORD:

105980289(Paics)

DSP:	122106650(Paics)

PLOP:

125364939(Paics)

NCAR:

124985584 124994669

MMMA:

107139249(Paics)

OCU:	100343740 127489901

OPI:	101534729(PAICS)

TUP:	102484181(PAICS)

GVR:	103606004(PAICS)

CFA:	100855769(PAICS)

CLUD:

112652356

VVP:

112923709

VLG:	121473255(PAICS)

NPO:	129519591(PAICS)

AML:	100482672(PAICS)

UMR:	103672750(PAICS)

UAH:	113262521(PAICS)

UAR:	123803985(PAICS)

ELK:

111149362

LLV:

125093749

MPUF:

101670430(PAICS) 106004002

MNP:	132006541(PAICS)

MLK:	131823800(PAICS)

NVS:	122889803(PAICS)

ORO:	101383279(PAICS)

EJU:	114206674(PAICS) 114206809

ZCA:	113924518 113924521(PAICS)

MLX:	118010506(PAICS)

NSU:	110588151 110590760(PAICS)

LWW:	102746659(PAICS)

FCA:	101084705(PAICS)

PYU:

121035341

PCOO:

112858402(PAICS)

PBG:	122497369(PAICS)

PVIV:

125163377(PAICS)

LRUF:

124520511

PTG:	102951236(PAICS)

PPAD:

109278673

PUC:

125922747

AJU:

106971666

HHV:	120243038(PAICS)

BTA:	404170(PAICS)

BOM:	102281546(PAICS)

BIU:

109560492

BBUB:

102392736(PAICS)

BBIS:

105002829 105002831

CHX:

102182773

OAS:	101115345 101117419(PAICS)

BTAX:

128050024(PAICS) 128054482

ODA:	120853000 120862146 120881137

CCAD:

122428484(PAICS)

MBEZ:

129554833 129561729(PAICS)

SSC:	100521281(PAICS)

CFR:

102522524

CBAI:

105077682(PAICS)

CDK:

105091550

VPC:	102531568(PAICS)

BACU:

103009147(PAICS)

BMUS:

118895967(PAICS)

LVE:	103076533(PAICS)

OOR:	101287712(PAICS)

DLE:

111169417

PCAD:

102994548(PAICS)

PSIU:

116754769(PAICS)

NASI:

112400791(PAICS)

ECB:	100058501(PAICS)

EPZ:	103556488(PAICS)

EAI:	106841680(PAICS)

MYB:	102239537(PAICS)

MYD:	102757395(PAICS)

MMYO:

118669110(PAICS)

MLF:	102437295(PAICS)

PKL:	118706364(PAICS)

EFUS:

103284981(PAICS)

MNA:	107532951(PAICS)

DRO:	112320919(PAICS) 112322805

SHON:

118978572(PAICS)

AJM:	119061634(PAICS)

PDIC:

114492579(PAICS)

PHAS:

123815730(PAICS)

MMF:	118632016(PAICS)

PPAM:

129065527(PAICS)

HAI:	109373280 109394361(PAICS)

RFQ:	117019647 117022388(PAICS)

PALE:

102899036(PAICS)

PGIG:

120588101 120588103(PAICS)

PVP:	105293760(PAICS) 111741353

RAY:	107517721(PAICS)

MJV:	108395834(PAICS) 118969144

SARA:

101547712(PAICS)

SETR:

126028746 126032284(PAICS)

LAV:

100658417

TMU:

101346245

ETF:	101641703 101659036

DNM:	101418600(PAICS)

MDO:	100012535(PAICS)

GAS:	123231909 123250015 123250979(PAICS)

SHR:	100923019(PAICS)

AFZ:

127541800

PCW:	110200170(PAICS)

OAA:

100086365

GGA:	396534(PAICS)

PCOC:

116225927(PAICS)

MGP:	100539860(PAICS)

CJO:	107313717(PAICS) 116653347

TPAI:

128080320

NMEL:

110398445

APLA:

101797218

ACYG:

106048610(PAICS)

CATA:

118248082(PAICS)

TGU:	100225152(PAICS)

LSR:

110471777

SCAN:

103825290(PAICS) 103826194

PMOA:

120497414

OTC:	121335133(PAICS)

GFR:	102043382 102043552(PAICS)

FAB:	101807763 101808142(PAICS)

OMA:	130252536 130252539

PHI:	102111686(PAICS) 106628861

PMAJ:

107202963 107203210(PAICS)

CCAE:

111928008 111928009(PAICS)

CCW:	104690617(PAICS) 104690618

CBRC:

103622559(PAICS) 108449136

ETL:	114058312 114058315(PAICS)

ACHL:

103810554(PAICS)

SVG:	106851478(PAICS)

MMEA:

130579388 130579389

HRT:	120752708(PAICS)

FPG:	101919014(PAICS)

FCH:	102045839 102046009(PAICS)

CLV:	102085431 102094220(PAICS)

EGZ:

104129452

NNI:

104020782

PCRI:

104024908

PLET:

104614437(PAICS)

EHS:	104505978(PAICS)

PCAO:

104050423(PAICS) 104051816

ACUN:

113479039 113479040(PAICS)

PADL:

103926281 103926342

AFOR:

103897396 103897432(PAICS)

ACHC:

115348362 121232396

HALD:

104313976(PAICS)

HLE:	104836135(PAICS)

AGEN:

126035542 126035563

GCL:

127015555

CCRI:

104163262(PAICS)

CSTI:

104556851(PAICS) 104561187

CMAC:

104473864(PAICS)

MUI:

104534205

BREG:

104641570(PAICS)

FGA:	104070300(PAICS)

GSTE:

104251707(PAICS)

LDI:	104348101(PAICS)

MNB:	103772148(PAICS)

OHA:

104334899

NNT:

104400497

SHAB:

115610194

DPUB:

104302244(PAICS)

PGUU:

104463756(PAICS)

ACAR:

104532390(PAICS)

CPEA:

104393033

AVIT:

104280921

CVF:	104286445 104286446

TEO:	104370341(PAICS)

BRHI:

104494915(PAICS) 104498823

AAM:	106490207(PAICS)

AROW:

112976747(PAICS)

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102565809(PAICS)

PSS:	102446966(PAICS) 102447225

CMY:	102937687(PAICS)

CCAY:

125635887(PAICS)

DCC:	119854539(PAICS)

CPIC:

101942651(PAICS)

TST:	117877973(PAICS) 117878023

CABI:

116834617(PAICS)

ACS:	100566555(paics)

ASAO:

132776662(PAICS)

PVT:	110077009 110077010(PAICS)

SUND:

121931240

PBI:	103060841(PAICS)

PMUR:

107297224(PAICS)

TSR:	106554316(PAICS) 106554752

PGUT:

117662104(PAICS)

APRI:

131203468 131203474

VKO:	123016987(PAICS)

PMUA:

114603707

PRAF:

128420983(PAICS)

ZVI:	118083784(PAICS)

GJA:	107123142(PAICS)

EMC:	129336478(PAICS)

XLA:	379855(paics.1.L) 431975(paics.2.L) 444677(paics.1.S)

XTR:	100036662(paics.2) 100488155(paics.1)

NPR:	108794756(PAICS)

BBUF:

120990191(PAICS) 120990192

BGAR:

122939229 122941977

DRE:	321193(paics)

SRX:	107721365 107737306

SANH:

107665310 107683924

SGH:	107555752 107556158

CCAR:

109113011

CAUA:

113062925 113120971

CGIB:

127938623 127984087

PTET:

122325378(paics)

LROH:

127182968(paics)

OMC:	131527253(paics)

PPRM:

120493429(paics)

RKG:	130091798(paics)

MAMB:

125277864(paics)

CIDE:

127502654

MASI:

127410005 127415945

TROS:

130565424(paics)

TDW:	130434255(paics)

MANU:

129429251(paics)

IPU:	108257759(paics)

IFU:	128601397(paics)

PHYP:

113545223(paics)

SMEO:

124376692(paics)

TFD:	113642559(paics)

TVC:	132843443(paics)

AMEX:

103037884

CMAO:

118815403(paics)

EEE:

113586370

TRU:	101073764(paics)

TFS:	130528961 130528965(paics)

TNG:	GSTEN00032745G001

LCO:	104919099(paics)

NCC:	104947087(paics)

TBEN:

117495070(paics)

CGOB:

115007230(paics)

PGEO:

117444932 117444934(paics)

GACU:

117555197 117555199(paics)

EMAC:

134869549(paics)

ELY:	117253892(paics)

EFO:	125895511(paics)

PLEP:

121940268(paics)

SLUC:

116058805(paics)

ECRA:

117950144(paics)

ESP:

116695595

PFLV:

114562112

GAT:	120824171(paics)

PPUG:

119216565(paics)

AFB:	129094579(paics)

CLUM:

117729933 117729935(paics)

PSWI:

130193822(paics)

MSAM:

119901058(paics)

SCHU:

122877194(paics)

CUD:	121511738(paics)

ALAT:

119029246 119029249(paics)

MZE:	101476340(paics) 101482534 106676564 112431584

ONL:	100704318 102077476 102078617 102079785 109194371 109199026 109199183

OAU:	116316740 116331053(paics) 116334329 120434429

OLA:	101171736(paics)

OML:	112136857(paics)

CSAI:

133458279(paics)

XMA:

102236450

XCO:	114151174(paics)

XHE:

116725943

PRET:

103463823

GAF:	122838035(paics)

PPRL:

129369792(paics)

CVG:

107091569

CTUL:

119780629(paics)

NFU:

107393397

KMR:	108243405(paics)

ALIM:

106534470

NWH:	119430855(paics)

AOCE:

111569591(paics)

CSEM:

103376690(paics)

POV:	109646212(paics)

SSEN:

122762456(paics)

HHIP:

117760547(paics)

HSP:	118121417(paics)

PPLT:

128448130(paics)

SMAU:

118318436(paics)

LCF:

108879073

SDU:	111226365(paics)

XGL:	120791276 120791279(paics)

HCQ:	109532211(paics)

SSCV:

125994705

SBIA:

133503459(paics)

PEE:	133405976(paics)

PTAO:

133480896(paics)

BPEC:

110154796(paics)

MALB:

109962065

BSPL:

114853784(paics)

SJO:	128362114(paics)

SASA:

106560280 106584129

STRU:

115158545 115192372

OTW:	112249249(paics) 112251146

OMY:	110521683(paics) 110524564

OGO:	123996807 124037869(paics)

ONE:	115108542 115145144

OKI:	109898037 109902723

OKE:	118359024(paics) 118392653

SALP:

111972328 111975271

SNH:	120052592(paics) 120054934

CCLU:

121533956 121540141(paics)

ELS:

105011850

SFM:

108922797

PKI:	111834756(paics)

AANG:

118225698(paics)

LOC:	102695780(paics) 107077190

PSPA:

121320173 121326752

ARUT:

117409359(paics) 117421369 117962728

PSEX:

120527461(paics)

LCM:	102354332(PAICS)

CMK:	103178180(paics)

RTP:	109915470(paics)

CPLA:

122550019(paics)

HOC:	132819206(paics)

LERI:

129697301(paics)

PMRN:

116943019(PAICS)

LRJ:	133343052(PAICS)

BFO:	118415422 118417541

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

DME:	Dmel_CG3989(Paics)

DER:

6551233

DSE:	6617746 6618591

DSI:	Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)

DYA:	Dyak_GE16201(Dyak_ade5)

DAN:	6503583 6503584

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14693

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108371476 108380553

AOQ:

129238737

TDA:

119669080

MDE:	101893760 131804426

SCAC:

106092606

LCQ:

111687676

LSQ:	119602720 119613245 119615291 119615292

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ009002

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:	122509806 122509809

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:	114335014 126892770

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208829

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119830235 119830386

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105393713 105398682

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM430820

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

PVM:	113816223 113818328

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

ESN:

MNZ:

HAZT:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_B0286.3(paic-1)

CBR:

CBG_03675

CRQ:	GCK72_004561

NAI:	NECAME_06175

TSP:

Tsp_02239

HRO:	HELRODRAFT_186294

LGI:	LOTGIDRAFT_182233

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106173523 106177955

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130654877 130655238

TAD:	TRIADDRAFT_56870

MBR:	MONBRDRAFT_34384

DDI:	DDB_G0283987(purC/E)

DPP:	DICPUDRAFT_147031

DFA:	DFA_08571(purC/E)

ACAN:

ACA1_106300

RHZ:	RHPLAN_45860

BBGW:

UT28_C0001G0672

» show all

Reference

PMID:10757766

Authors

O'Donnell AF, Tiong S, Nash D, Clark DV

Title

The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway.

Journal

Genetics 154:1239-53 (2000)
DOI:10.1093/genetics/154.3.1239

Sequence

[dme:Dmel_CG3989]

LinkDB

DBGET integrated database retrieval system