KEGG ORTHOLOGY: K04860

ORTHOLOGY: K04860

Entry

K04860                      KO

Symbol

CACNA2D3

Name

voltage-dependent calcium channel alpha-2/delta-3

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
   04261 Adrenergic signaling in cardiomyocytes
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
   05414 Dilated cardiomyopathy
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3

Other DBs

GO:

0005245

TC:

8.A.18.3

Genes

HSA:	55799(CACNA2D3)

PTR:	460457(CACNA2D3)

PPS:	100972163(CACNA2D3)

GGO:	101147075(CACNA2D3)

PON:	100448999(CACNA2D3)

NLE:	100601674(CACNA2D3)

HMH:	116473364(CACNA2D3)

MCC:	693356(CACNA2D3)

MCF:	102143606(CACNA2D3)

MTHB:

126948780

MNI:	105480634(CACNA2D3)

CSAB:

103227772(CACNA2D3)

CATY:

105585594(CACNA2D3)

PANU:

100999030(CACNA2D3)

TGE:	112619238(CACNA2D3)

MLEU:

105543971(CACNA2D3)

RRO:	104662214(CACNA2D3)

RBB:	108515798(CACNA2D3)

TFN:	117083013(CACNA2D3)

PTEH:

111524372(CACNA2D3)

CANG:

105515471(CACNA2D3)

CJC:	100400467(CACNA2D3)

SBQ:	101040923(CACNA2D3)

CIMI:

108314525

MMUR:

105875382(CACNA2D3)

LCAT:

123623160(CACNA2D3)

PCOQ:

105809503(CACNA2D3)

OGA:	100962617(CACNA2D3)

MMU:	12294(Cacna2d3)

MCAL:

110309146(Cacna2d3)

MPAH:

110325173(Cacna2d3)

RNO:	306243(Cacna2d3)

MCOC:

116084426(Cacna2d3)

ANU:	117706223(Cacna2d3)

MUN:	110546918(Cacna2d3)

CGE:	100753384(Cacna2d3)

MAUA:

101837712(Cacna2d3)

PROB:

127236843

PLEU:

114702139(Cacna2d3)

MORG:

121455299(Cacna2d3)

MFOT:

126511200

AAMP:

119828041(Cacna2d3)

NGI:	103749031(Cacna2d3)

HGL:	101712827(Cacna2d3)

CPOC:

100724165(Cacna2d3)

CCAN:

109678616

DORD:

105996579(Cacna2d3)

DSP:	122108012(Cacna2d3)

PLOP:

125358575(Cacna2d3)

NCAR:

124969140

MMMA:

125616237(Cacna2d3)

OCU:

100351327

OPI:	101524785(CACNA2D3)

TUP:	102489976(CACNA2D3)

GVR:

103603645

CFA:	476585(CACNA2D3)

CLUD:

112665928(CACNA2D3)

VVP:	112909997(CACNA2D3)

VLG:	121495293(CACNA2D3)

NPO:	129521308(CACNA2D3)

AML:	100483814(CACNA2D3)

UMR:	103674731(CACNA2D3)

UAH:	113256988(CACNA2D3)

UAR:	123798769(CACNA2D3)

ELK:

111144138

LLV:

125078684

MPUF:

101675438(CACNA2D3)

MNP:	132011433(CACNA2D3)

MLK:	131824046(CACNA2D3)

NVS:	122909333(CACNA2D3)

ORO:	101369586(CACNA2D3)

EJU:	114225082(CACNA2D3)

ZCA:	113918427(CACNA2D3)

MLX:	118005742(CACNA2D3)

NSU:	110584761(CACNA2D3)

FCA:	101094658(CACNA2D3)

PYU:	121016729(CACNA2D3)

PCOO:

112852483(CACNA2D3)

PBG:	122487338(CACNA2D3)

PVIV:

125161111(CACNA2D3)

LRUF:

124524409

PTG:	102957490(CACNA2D3)

PPAD:

109279120(CACNA2D3)

PUC:

125929488

AJU:

106967034

HHV:	120223632(CACNA2D3)

BTA:	519644(CACNA2D3)

BOM:	102269496(CACNA2D3)

BIU:

109575867

BBUB:

102402860(CACNA2D3)

BBIS:

104997264(CACNA2D3)

CHX:	102172849(CACNA2D3)

OAS:	101105365(CACNA2D3)

BTAX:

128047111(CACNA2D3)

ODA:	120867994(CACNA2D3)

CCAD:

122424421(CACNA2D3)

MBEZ:

129547938(CACNA2D3)

SSC:	100153986(CACNA2D3)

CFR:	102505114(CACNA2D3)

CBAI:

105079582(CACNA2D3)

CDK:	105089780(CACNA2D3)

VPC:	102541000(CACNA2D3)

BACU:

103004210(CACNA2D3)

BMUS:

118903895(CACNA2D3)

LVE:	103076318(CACNA2D3)

OOR:	101278227(CACNA2D3)

DLE:	111174274(CACNA2D3)

PCAD:

102981182(CACNA2D3)

PSIU:

116762285(CACNA2D3)

NASI:

112400575(CACNA2D3)

ECB:	100059197(CACNA2D3)

EPZ:	103565858(CACNA2D3)

EAI:	106848683(CACNA2D3)

MYB:

102239827

MYD:	102763556(CACNA2D3)

MMYO:

118667972(CACNA2D3)

MLF:	102433980(CACNA2D3)

PKL:	118715116(CACNA2D3)

EFUS:

103290416(CACNA2D3)

MNA:	107530629(CACNA2D3)

DRO:	112301237(CACNA2D3)

SHON:

118983354(CACNA2D3)

AJM:	119041453(CACNA2D3)

PDIC:

114502043(CACNA2D3)

PHAS:

123814505(CACNA2D3)

MMF:	118633198(CACNA2D3)

PPAM:

129088134(CACNA2D3)

HAI:

109389079

RFQ:	117037026(CACNA2D3)

PALE:

102890987(CACNA2D3)

PGIG:

120606296(CACNA2D3)

PVP:

105304362

RAY:	107516533(CACNA2D3)

TOD:	119261446(CACNA2D3)

SARA:

101545248(CACNA2D3)

SETR:

126014432(CACNA2D3)

LAV:	100659138(CACNA2D3)

TMU:

101358626

ETF:	101649275(CACNA2D3)

DNM:	101416658(CACNA2D3)

MDO:	100013859(CACNA2D3)

GAS:	123246617(CACNA2D3)

SHR:	100918190(CACNA2D3)

AFZ:

127550253

PCW:	110197042(CACNA2D3)

OAA:	100077460(CACNA2D3)

GGA:	415996(CACNA2D3)

PCOC:

116238570(CACNA2D3)

MGP:	100546053(CACNA2D3)

CJO:	107320005(CACNA2D3)

TPAI:

128078545(CACNA2D3)

LMUT:

125698970(CACNA2D3)

NMEL:

110404674(CACNA2D3)

APLA:

101790806(CACNA2D3)

ACYG:

106040528(CACNA2D3)

CATA:

118253745(CACNA2D3)

AFUL:

116492912(CACNA2D3)

TGU:	100222087(CACNA2D3)

LSR:	110471861(CACNA2D3)

SCAN:

103816995(CACNA2D3)

PMOA:

120495709(CACNA2D3)

OTC:	121347256(CACNA2D3)

PRUF:

121351554(CACNA2D3)

GFR:	102037102(CACNA2D3)

FAB:	101821271(CACNA2D3)

OMA:	130258255(CACNA2D3)

PHI:	102102557(CACNA2D3)

PMAJ:

107210399(CACNA2D3)

CCAE:

111935121

CCW:	104683260(CACNA2D3)

CBRC:

103614294(CACNA2D3)

ETL:	114057959(CACNA2D3)

ZAB:	102061718(CACNA2D3)

SVG:	106849161(CACNA2D3)

MMEA:

130577815(CACNA2D3)

HRT:	120758310(CACNA2D3)

FPG:	101916160(CACNA2D3)

FCH:	102054020(CACNA2D3)

CLV:	102089718(CACNA2D3)

EGZ:	104126728(CACNA2D3)

NNI:	104015320(CACNA2D3)

EHS:	104511064(CACNA2D3)

ACUN:

113484883(CACNA2D3)

TALA:

104361785(CACNA2D3)

PADL:

103925487(CACNA2D3)

AFOR:

103903296(CACNA2D3)

ACHC:

115353843(CACNA2D3)

HALD:

104321924(CACNA2D3)

HLE:	104834941(CACNA2D3)

AGEN:

126049785

GCL:

127021634

CSTI:

104554584(CACNA2D3)

CMAC:

104480524

BREG:

104637909(CACNA2D3)

OHA:	104333188(CACNA2D3)

SHAB:

115614872(CACNA2D3)

DPUB:

104308795(CACNA2D3)

CPEA:

104384953(CACNA2D3)

AVIT:

104279527

CVF:	104282800(CACNA2D3)

RTD:	128915514(CACNA2D3)

CUCA:

104068665(CACNA2D3)

TEO:

104376050

AAM:	106495161(CACNA2D3)

AROW:

112971748

NPD:	112953042(CACNA2D3)

TGT:

104565563

DNE:	112981007(CACNA2D3)

SCAM:

104152729(CACNA2D3)

ASN:	102373454(CACNA2D3)

AMJ:	102570532(CACNA2D3)

CPOO:

109311399(CACNA2D3)

GGN:	109288856(CACNA2D3)

PSS:	102448983(CACNA2D3)

CMY:	102933361(CACNA2D3)

CCAY:

125639617(CACNA2D3)

DCC:	119859443(CACNA2D3)

CPIC:

101932053(CACNA2D3)

TST:	117880385(CACNA2D3)

CABI:

116833080(CACNA2D3)

MRV:	120368552(CACNA2D3)

ACS:	100555458(cacna2d3)

ASAO:

132769275(CACNA2D3)

PVT:	110084963(CACNA2D3)

SUND:

121923341(CACNA2D3)

CTIG:

120301001

TSR:	106553921(CACNA2D3)

PGUT:

117677049(CACNA2D3)

APRI:

131191932(CACNA2D3)

PTEX:

113449736(CACNA2D3)

NSS:	113417815(CACNA2D3)

VKO:	123034269(CACNA2D3)

PMUA:

114591690(CACNA2D3)

PRAF:

128408313(CACNA2D3)

ZVI:	118080709(CACNA2D3)

HCG:	128343856(CACNA2D3)

GJA:	107109400(CACNA2D3)

STOW:

125429601(CACNA2D3)

EMC:	129327633(CACNA2D3)

XLA:	108704004(cacna2d3.L) 373777(cacna2d3.S)

XTR:	101732520(cacna2d3)

NPR:	108786049(CACNA2D3)

RTEM:

120945243(CACNA2D3)

BBUF:

120979163(CACNA2D3)

MUO:	115471722(CACNA2D3)

GSH:	117351360(CACNA2D3)

DRE:	100148645(cacna2d3) 100535196(cacna2d3a)

SRX:	107743247 107750816 107751209

SANH:

107659556(cacna2d3) 107686000 107693597

SGH:	107553873 107581790 107582378

CCAR:

109098615 109098785

CAUA:

113055474 113107862(cacna2d3) 113110816

CGIB:

127963142 127968378 128022123

PTET:

122335515(cacna2d3a) 122353967(cacna2d3)

LROH:

127170044(cacna2d3a) 127172721(cacna2d3)

OMC:	131546144(cacna2d3a) 131549743(cacna2d3)

PPRM:

120480808(cacna2d3) 120481297(cacna2d3a)

RKG:	130075707(cacna2d3a) 130083498(cacna2d3)

MAMB:

125256832(cacna2d3) 125280528(cacna2d3a)

CIDE:

127517678 127522375

MASI:

127415221 127426073 127427714

TROS:

130571638(cacna2d3)

TDW:	130407095(cacna2d3a) 130410662(cacna2d3)

MANU:

129414021(cacna2d3a) 129428006(cacna2d3)

IPU:	108254724(cacna2d3) 108265794(cacna2d3a)

IFU:	128607656(cacna2d3a) 128625362(cacna2d3)

PHYP:

113533340(cacna2d3) 113539459

SMEO:

124400039(cacna2d3a) 124402334(cacna2d3)

TFD:	113637036(cacna2d3) 113655882(cacna2d3a)

TVC:	132837953(cacna2d3) 132853795(cacna2d3a)

AMEX:

103032408(cacna2d3) 103035144

CMAO:

118799965(cacna2d3) 118813375(cacna2d3a)

EEE:	113578882 113579151

CHAR:

105898928(cacna2d3a) 105903388 122132928

TRU:	101069779 101075509

TFS:	130521239 130524061 130529982(cacna2d3a)

TNG:	GSTEN00027377G001 GSTEN00027968G001

LCO:	104925138 104933195

NCC:	104946165 104946411

TBEN:

117489860 117494408(cacna2d3a)

CGOB:

115008314 115010677(cacna2d3)

PGEO:

117446067 117449500(cacna2d3a)

GACU:

117533998 117559429(cacna2d3)

EMAC:

134865050(cacna2d3a) 134883600

ELY:	117257249 117258390(cacna2d3a)

EFO:	125891347(cacna2d3a) 125895963(cacna2d3)

PLEP:

121947043(cacna2d3a) 121958228

SLUC:

116041545(cacna2d3) 116062064(cacna2d3a)

ECRA:

117943844(cacna2d3) 117948210(cacna2d3a)

ESP:	116688229 116693019

PFLV:

114554801 114558168(cacna2d3)

GAT:	120829159(cacna2d3a) 120835752

PPUG:

119194022(cacna2d3) 119222470(cacna2d3a)

AFB:	129099876(cacna2d3a) 129105810(cacna2d3)

CLUM:

117731006 117734128(cacna2d3a)

PSWI:

130199196(cacna2d3a) 130209021(cacna2d3)

MSAM:

119886958 119906003(cacna2d3a)

SCHU:

122864651(cacna2d3) 122882449(cacna2d3a)

CUD:	121507115(cacna2d3) 121517770(cacna2d3a)

ALAT:

119021561 119023209(cacna2d3a)

MZE:	101467919(cacna2d3) 101486968

ONL:	100694025 100695403

OAU:	116328945(cacna2d3) 116330828(cacna2d3a)

OLA:	101158014 101159822

OML:	112145385(cacna2d3) 112159066(cacna2d3a)

CSAI:

133448539(cacna2d3) 133457126(cacna2d3a)

XMA:	102233586 102233939

XCO:	114134914 114145353

XHE:	116711104 116727826

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122833874(cacna2d3a) 122834295

PPRL:

129358319(cacna2d3) 129370325(cacna2d3a)

CVG:	107087050 107094768

CTUL:

119779992 119784318(cacna2d3a)

GMU:	124856095 124872364(cacna2d3a)

NFU:	107385115 107391001 107395004

KMR:	108235237(cacna2d3a) 108247370

ALIM:

106516185 106523972

NWH:	119412820(cacna2d3) 119417259

AOCE:

111570745 111571956

MCEP:

125006106(cacna2d3) 125013968

CSEM:

103384646 103385813

POV:	109635036 109638461(cacna2d3)

SSEN:

122767676(cacna2d3) 122777272(cacna2d3a)

HHIP:

117761777(cacna2d3) 117764565(cacna2d3a)

HSP:	118105527(cacna2d3) 118110695(cacna2d3a)

SMAU:

118309451(cacna2d3) 118317163(cacna2d3a)

LCF:	108877886(cacna2d3a) 108886529(cacna2d3) 108886596

SDU:	111219056 111222914

SLAL:

111660873 111668970

XGL:	120783417(cacna2d3) 120803818(cacna2d3a)

HCQ:	109522322 109528651(cacna2d3)

SSCV:

125977232 125988870

SBIA:

133496617(cacna2d3a) 133507034(cacna2d3)

PEE:	133408811(cacna2d3) 133413220

PTAO:

133483919(cacna2d3) 133489155

BPEC:

110164934(cacna2d3) 110168660

MALB:

109951927 109971450(cacna2d3)

BSPL:

114856086(cacna2d3) 114858221(cacna2d3a)

SJO:	128355181(cacna2d3) 128357013(cacna2d3a)

SASA:

106565153 106565298 106565323 106583452

STRU:

115150245 115168910 115208209

OTW:	112221471(cacna2d3a) 112244800 112255324

OMY:	110492552(cacna2d3a) 110494954 110529018

OGO:	124002483 124018907 124045580(cacna2d3a)

ONE:	115131688 115143707

OKI:	109869219 109891622

OKE:	118372827 118374132 118380031(cacna2d3a)

SALP:

111962190 111970722

SNH:	120021818 120061676(cacna2d3a) 120064821

CCLU:

121546088(cacna2d3a) 121575425 121578082

ELS:	105006995 105014015

SFM:	108925576(cacna2d3) 108933830

PKI:	111833382(cacna2d3) 111852528

AANG:

118207365(cacna2d3a) 118211658

LOC:	102694678(cacna2d3)

PSPA:

121298277 121329136

ARUT:

117412410 117971351

LCM:	102354765(CACNA2D3)

CMK:	103176769(cacna2d3a)

RTP:	109932632(cacna2d3a)

CPLA:

122559255(cacna2d3a)

HOC:	132822335(cacna2d3a)

LERI:

129704444(cacna2d3a)

PMRN:

116949350 116952813

LRJ:	133342646 133356632

BFO:

118415148

BBEL:

109476954

SCLV:

120328037

SPU:	100890679 100891463 115918576

LPIC:

129255922

APLC:

110980098 110982123

SKO:

100367067

DME:	Dmel_CG12295(stj)

DER:

6549504

DSE:

6609048

DSI:	Dsimw501_GD10984(Dsim_GD10984)

DYA:	Dyak_GE12562

DAN:

DSR:

DPO:

DPE:

DMN:	108160677 117185938

DWI:

6646109

DGR:

6561308

DMO:	Dmoj_GI18635

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005664

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105557292 105566749

HST:

105181352

DQU:	106744438 106748655

CFO:

105253687

FEX:

115236492

LHU:	105673638 105674568

PGC:	109859364 109859573

OBO:	105276560 105277632

PCF:	106784594 106793303

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109536832 109541160 109542142

SOY:	115881250 115881537

AGRG:

126737908 126738338

ATD:	109600191 109600341

CSET:

123310419 123320406

AGB:	108911988 108914181

LDC:	111503968 111514596

NVL:	108559278 108568021 108568881

APLN:

108740282 108743050

PPYR:

116162567 116168417

OTU:	111415998 111417040

BMOR:

101746672 105842130

BMAN:

114244507 114246246

MSEX:

115442746 115443753

DPL:	KGM_208019 KGM_215762

BANY:

112044251 112052182

MJU:	123869736 123874172

NIQ:

126777119

VCD:	124530538 124534691

MCIX:

123657583 123659269

PMAC:

106709292 106717399

PPOT:

106099347 106105058

PXU:	106119352 106124643

PRAP:

110997797 111003854 111004008

PBX:

123715983

PNAP:

125050417

ZCE:	119829397 119831321 119839779

CCRC:

123693196

LSIN:

126966426 126967513

AAGE:

121730066 121734258

HAW:	110378538(stj) 126055872

HZE:	124632084 124637102

TNL:	113501664 113503367

SLIU:

111353030 111355112

OFU:	114351663 114362088

PXY:

105397600

PGW:	126370763 126376482

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:	124354571 124355236 124355763

MQU:	128996560 128996802 128997174 129005716

PHU:	Phum_PHUM308330

FOC:	113208519 113209075 113209076

TPAL:

117643184 117649585

ZNE:	110826473 110836713 110841320

CSEC:

SGRE:

BROR:

IEL:

FCD:	110853214 110859981

PVM:

PJA:

PCHN:

HAME:

PCLA:

HAZT:

EAF:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107367737 107368794

DPTE:

113795068 113799760

DFR:	124492589 124500015

CSCU:

111637227

PTEP:

107436486 107437533 122271814

ABRU:

129960322 129962384

UDV:	129216644 129219191

SDM:	118181444 118182581

LPOL:

106460714 106473354

PMEO:

129591305 129600197

LOA:	LOAG_18702

PVUL:

PCAN:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MMER:

RPHI:

OBI:	106867600 106868565

OSN:

115209156

LAK:	106156238 106167007 106178538

OVI:	T265_12511

NVE:

5510265

EPA:	110234940 110243421

ATEN:

116306737 116307683

ADF:	107332703 107337421

AMIL:

114959174

PDAM:

113673264 113680062

SPIS:

111336301

DGT:	114524865 114525762 114541959

XEN:

124446033

HSY:	130612059 130622040 130622042 130622043 130622044 130625918 130654646

TAD:	TRIADDRAFT_55341 TRIADDRAFT_56910

» show all

Reference

PMID:24403143

Authors

Pirone A, Kurt S, Zuccotti A, Ruttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rubsamen R, Friauf E, Knipper M, Engel J

Title

alpha2delta3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders.

Journal

J Neurosci 34:434-45 (2014)
DOI:10.1523/JNEUROSCI.3085-13.2014

Sequence

[mmu:12294]

LinkDB

DBGET integrated database retrieval system