KEGG ORTHOLOGY: K04861

ORTHOLOGY: K04861

Entry

K04861                      KO

Symbol

CACNA2D4

Name

voltage-dependent calcium channel alpha-2/delta-4

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00481

Cone-rod dystrophy and cone dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
   04261 Adrenergic signaling in cardiomyocytes
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
   05414 Dilated cardiomyopathy
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4

Other DBs

GO:

0005245

TC:

8.A.18.4

Genes

HSA:	93589(CACNA2D4)

PTR:	466912(CACNA2D4)

PPS:	100973190(CACNA2D4)

GGO:	101153550(CACNA2D4)

PON:	100441103(CACNA2D4)

NLE:	100598790(CACNA2D4)

HMH:	116472522(CACNA2D4)

MCC:	721703(CACNA2D4)

MCF:	102131855(CACNA2D4)

MTHB:

126930228

MNI:	105484118(CACNA2D4)

CSAB:

103218378(CACNA2D4)

CATY:

105582965(CACNA2D4)

PANU:

101021906(CACNA2D4)

TGE:	112634396(CACNA2D4)

MLEU:

105529885(CACNA2D4)

RRO:	104662537(CACNA2D4)

RBB:	108522308(CACNA2D4)

TFN:	117090711(CACNA2D4)

PTEH:

111520325(CACNA2D4)

CANG:

105503909(CACNA2D4)

CJC:	100409999(CACNA2D4)

SBQ:	101038775(CACNA2D4)

CIMI:

108315845(CACNA2D4)

MMUR:

105861600(CACNA2D4)

LCAT:

123640621(CACNA2D4)

PCOQ:

105812907(CACNA2D4)

OGA:	100964583(CACNA2D4)

MMU:	319734(Cacna2d4)

MCAL:

110295757(Cacna2d4)

MPAH:

110316341(Cacna2d4)

RNO:	312668(Cacna2d4)

MCOC:

116099984(Cacna2d4)

ANU:	117715240(Cacna2d4)

MUN:	110556683(Cacna2d4)

MAUA:

101834159(Cacna2d4)

PROB:

127236193(Cacna2d4)

PLEU:

114700759(Cacna2d4)

MORG:

121465155(Cacna2d4)

MFOT:

126505517

AAMP:

119807657(Cacna2d4)

NGI:	103739384(Cacna2d4)

HGL:	101705589(Cacna2d4)

CPOC:

100716046(Cacna2d4)

CCAN:

109702845

DORD:

105991062(Cacna2d4)

DSP:

122102546

NCAR:

124982731

MMMA:

125611895(Cacna2d4)

OCU:

100354108

OPI:	101520882(CACNA2D4)

TUP:	102472656(CACNA2D4)

GVR:	103590239(CACNA2D4)

CFA:	477733(CACNA2D4)

CLUD:

112669087(CACNA2D4)

VVP:	112917422(CACNA2D4)

VLG:	121480394(CACNA2D4)

NPO:	129503363(CACNA2D4)

AML:	100480223(CACNA2D4)

UMR:	103675758(CACNA2D4)

UAH:	113258103(CACNA2D4)

UAR:	123778232(CACNA2D4)

ELK:

111159692

LLV:

125107606

MPUF:

101678949(CACNA2D4)

MNP:	132020402(CACNA2D4)

MLK:	131839695(CACNA2D4)

NVS:	122892018(CACNA2D4)

ORO:	101374807(CACNA2D4)

EJU:	114222504(CACNA2D4)

ZCA:	113922256(CACNA2D4)

MLX:	118025806(CACNA2D4)

NSU:	110580741(CACNA2D4)

LWW:	102738417(CACNA2D4)

FCA:	101095834(CACNA2D4)

PYU:	121022070(CACNA2D4)

PCOO:

112867179(CACNA2D4)

PBG:	122473885(CACNA2D4)

PVIV:

125170305(CACNA2D4)

LRUF:

124502050

PTG:	102951140(CACNA2D4)

PPAD:

109276252(CACNA2D4)

PUC:

125918702

AJU:

106965471

HHV:	120234476(CACNA2D4)

BTA:	784075(CACNA2D4)

BOM:	102277012(CACNA2D4)

BIU:	109558613(CACNA2D4)

BBUB:

102403799(CACNA2D4)

BBIS:

104992356(CACNA2D4)

CHX:	102176592(CACNA2D4)

OAS:	101116306(CACNA2D4)

BTAX:

128048256(CACNA2D4)

ODA:	120857775(CACNA2D4)

CCAD:

122423115(CACNA2D4)

MBEZ:

129536148(CACNA2D4)

SSC:	100620898(CACNA2D4)

CFR:	102517334(CACNA2D4)

CBAI:

105076657(CACNA2D4)

CDK:	105102927(CACNA2D4)

VPC:	102539361(CACNA2D4)

BACU:

103019660(CACNA2D4)

BMUS:

118901973(CACNA2D4)

LVE:	103076342(CACNA2D4)

OOR:	101279491(CACNA2D4)

DLE:	111176547(CACNA2D4)

PCAD:

102989228(CACNA2D4)

PSIU:

116761251(CACNA2D4)

ECB:	100630648(CACNA2D4)

EPZ:	103560835(CACNA2D4)

EAI:	106839431(CACNA2D4)

MYB:	102254288(CACNA2D4)

MYD:	102752991(CACNA2D4)

MMYO:

118650566(CACNA2D4)

MLF:	102435532(CACNA2D4)

PKL:	118730012(CACNA2D4)

EFUS:

103296758(CACNA2D4)

MNA:	107546422(CACNA2D4)

DRO:	112300270(CACNA2D4)

SHON:

118999988(CACNA2D4)

PDIC:

114514017(CACNA2D4)

PHAS:

123813532(CACNA2D4)

MMF:	118623396(CACNA2D4)

PPAM:

129073524(CACNA2D4)

HAI:	109388949(CACNA2D4)

RFQ:	117028875(CACNA2D4)

PALE:

102885883(CACNA2D4)

PGIG:

120607171(CACNA2D4)

PVP:	105297299(CACNA2D4)

RAY:	107500543(CACNA2D4)

MJV:	108395652(CACNA2D4)

TOD:	119247057(CACNA2D4)

SARA:

101544856(CACNA2D4)

SETR:

126022195(CACNA2D4)

LAV:	100663604(CACNA2D4)

TMU:

101355114

ETF:	101662048(CACNA2D4)

DNM:	101412034(CACNA2D4)

MDO:	100021296(CACNA2D4)

GAS:	123248588(CACNA2D4)

SHR:

100925979

AFZ:

127538669

PCW:	110218752(CACNA2D4)

OAA:	100092094(CACNA2D4)

GGA:	100858946(CACNA2D4)

PCOC:

116226765(CACNA2D4)

MGP:

100544274

CJO:	107314869(CACNA2D4)

TPAI:

128073241(CACNA2D4)

LMUT:

125694751(CACNA2D4)

NMEL:

110395441(CACNA2D4)

APLA:

101792163(CACNA2D4)

ACYG:

106030937(CACNA2D4)

CATA:

118250073(CACNA2D4)

AFUL:

116487287(CACNA2D4)

TGU:	100224985(CACNA2D4)

LSR:	110472972(CACNA2D4)

SCAN:

103820520(CACNA2D4)

PMOA:

120501667(CACNA2D4)

OTC:	121332806(CACNA2D4)

PRUF:

121362745(CACNA2D4)

GFR:	102035174(CACNA2D4)

FAB:	101816433(CACNA2D4)

OMA:	130248555(CACNA2D4)

PHI:	102110049(CACNA2D4)

PMAJ:

107204208(CACNA2D4)

CCAE:

111928463(CACNA2D4)

CCW:	104692243(CACNA2D4)

CBRC:

103624723(CACNA2D4)

ETL:	114068753(CACNA2D4)

ZAB:	102068681(CACNA2D4)

ACHL:

103797268

SVG:	106849424(CACNA2D4)

MMEA:

130588986(CACNA2D4)

HRT:	120751737(CACNA2D4)

FPG:	101919673(CACNA2D4)

FCH:	102054748(CACNA2D4)

CLV:	102089727(CACNA2D4)

EGZ:	104134401(CACNA2D4)

NNI:	104020248(CACNA2D4)

PLET:

104618422

EHS:

104508892

PCAO:

104048054

ACUN:

113491451(CACNA2D4)

TALA:

104359284(CACNA2D4)

PADL:

103924497(CACNA2D4)

AFOR:

103898722(CACNA2D4)

ACHC:

115352274(CACNA2D4)

HALD:

104314891

HLE:	104831024(CACNA2D4)

AGEN:

126047929

GCL:

127020501

CCRI:

104166601(CACNA2D4)

CSTI:

104557739(CACNA2D4)

CMAC:

104487643(CACNA2D4)

MUI:	104544427(CACNA2D4)

FGA:

104077810

GSTE:

104264375

MNB:

103776857

OHA:	104330272(CACNA2D4)

NNT:	104406140(CACNA2D4)

SHAB:

115605596(CACNA2D4)

DPUB:

104310231(CACNA2D4)

PGUU:

104468437

CPEA:

104386598(CACNA2D4)

AVIT:

104278457(CACNA2D4)

CVF:	104281705(CACNA2D4)

RTD:	128914754(CACNA2D4)

CUCA:

104055920(CACNA2D4)

AAM:	106488360(CACNA2D4)

AROW:

112968272(CACNA2D4)

NPD:	112958338(CACNA2D4)

TGT:	104580792(CACNA2D4)

DNE:	112993374(CACNA2D4)

SCAM:

104147383(CACNA2D4)

ASN:	102382465(CACNA2D4)

AMJ:	106736655(CACNA2D4)

CPOO:

109316460(CACNA2D4)

GGN:	109296229(CACNA2D4)

PSS:	102451307(CACNA2D4)

CMY:	102944927(CACNA2D4)

CCAY:

125634188(CACNA2D4)

DCC:	119856304(CACNA2D4)

CPIC:

101946567(CACNA2D4)

TST:	117871167(CACNA2D4)

CABI:

116834558(CACNA2D4)

MRV:	120409009(CACNA2D4)

ACS:	100553057(cacna2d4)

ASAO:

132775774(CACNA2D4)

PVT:	110076680(CACNA2D4)

SUND:

121930893

PBI:	103062231(CACNA2D4)

PMUR:

107294503(CACNA2D4)

CTIG:

120314872(CACNA2D4)

TSR:

106540675

PGUT:

117655633(CACNA2D4)

APRI:

131201975(CACNA2D4)

PTEX:

113437976(CACNA2D4)

VKO:	123016513(CACNA2D4)

PMUA:

114604939(CACNA2D4)

PRAF:

128422469(CACNA2D4)

ZVI:	118091179(CACNA2D4)

HCG:	128326986(CACNA2D4)

GJA:	107120232(CACNA2D4)

STOW:

125434432(CACNA2D4)

EMC:	129335862(CACNA2D4)

XLA:

108704584

XTR:	100488361(cacna2d4)

NPR:	108804593(CACNA2D4)

RTEM:

120932709(CACNA2D4)

BBUF:

121004408(CACNA2D4)

BGAR:

122928490(CACNA2D4)

MUO:	115477756(CACNA2D4)

GSH:	117363538(CACNA2D4)

DRE:	100150428(cacna2d4b) 568225(cacna2d4a)

SRX:	107716619 107738821 107753542

SANH:

107665717 107679611 107694142

SGH:	107574657 107590835 107591101

CCAR:

109051284 109071201 109109500

CAUA:

113062385(cacna2d4) 113066767

CGIB:

127947311 127956880

PTET:

122331122(cacna2d4b) 122342625(cacna2d4a)

LROH:

127156764(cacna2d4b) 127164114(cacna2d4a)

OMC:	131534182(cacna2d4b) 131538522(cacna2d4a)

PPRM:

120459028(cacna2d4b) 120476947(cacna2d4a)

RKG:	130072288(cacna2d4a) 130085347(cacna2d4b)

MAMB:

125245646(cacna2d4a) 125247226(cacna2d4b)

CIDE:

127507589 127511413

MASI:

127434856 127435644 127437594

TROS:

130548108(cacna2d4a) 130551819(cacna2d4b)

TDW:	130413756(cacna2d4b) 130420343(cacna2d4a)

MANU:

129431774(cacna2d4a) 129433887(cacna2d4b)

IPU:	108268693(cacna2d4b)

IFU:	128611598(cacna2d4b)

PHYP:

113546531(cacna2d4)

SMEO:

124386384(cacna2d4b)

TFD:	113635569(cacna2d4b)

TVC:	132856244(cacna2d4b)

AMEX:

103042398 103042404

CMAO:

118806735(cacna2d4b) 118812647(cacna2d4a)

EEE:	113576576 113586434

CHAR:

105891511(cacna2d4b) 105911364(cacna2d4a)

TRU:	101064792(cacna2d4) 101076123

TFS:	130519482(cacna2d4a) 130535774

TNG:	GSTEN00007786G001 GSTEN00014505G001

LCO:	104933373 104940549

TBEN:

117479802 117484878(cacna2d4a)

CGOB:

115009147 115028294(cacna2d4)

PGEO:

117439180(cacna2d4a)

GACU:

117536114(cacna2d4a)

EMAC:

134879276(cacna2d4a) 134880921

ELY:	117249109(cacna2d4a) 117261994

EFO:	125882814(cacna2d4a) 125887861

PLEP:

121956328 121961217(cacna2d4a)

SLUC:

116036315 116060029(cacna2d4a)

ECRA:

117938615(cacna2d4a)

ESP:	116672841 116686864

PFLV:

114550312(cacna2d4) 114559609

GAT:	120809184(cacna2d4b) 120818343(cacna2d4a)

PPUG:

119196535 119210413(cacna2d4a)

AFB:	129108643 129112372(cacna2d4a)

CLUM:

117726413(cacna2d4a) 117732775

PSWI:

130195260 130200257(cacna2d4a)

MSAM:

119884490 119893321 119917948(cacna2d4a)

SCHU:

122871386(cacna2d4a) 122875593

CUD:	121505451(cacna2d4a) 121515292

ALAT:

119024247 119032666(cacna2d4a)

MZE:	101471517 101471649

ONL:	100700975 100711833

OAU:	116309903(cacna2d4a) 116325242

OLA:	101171407 101173028

OML:	112152695 112155796(cacna2d4a)

CSAI:

133424415(cacna2d4a) 133444415

XMA:	102230819(cacna2d4) 102231641

XCO:	114143095 114160961(cacna2d4)

XHE:	116711210 116736679

PRET:

103459273(cacna2d4) 103465652

PFOR:

103146499(cacna2d4) 103149375

PLAI:

106938116 106943654(cacna2d4)

PMEI:

106922225(cacna2d4) 106925571

GAF:	122826687 122836049

PPRL:

129375540(cacna2d4a)

CVG:	107093595 107095998(cacna2d4)

CTUL:

119780467 119786198(cacna2d4a)

GMU:	124880417 124882654(cacna2d4a)

NFU:	107380887 107385197(cacna2d4)

KMR:	108235065(cacna2d4a) 108248114

ALIM:

106515162(cacna2d4) 106521797 106522094

NWH:	119416071 119428230(cacna2d4a)

AOCE:

111564040 111571445(cacna2d4)

MCEP:

125000014(cacna2d4a) 125015476

CSEM:

103379950 103382790

POV:	109624117(cacna2d4) 109632699

SSEN:

122767003(cacna2d4a) 122776078

HHIP:

117757643(cacna2d4a) 117762555(cacna2d4b)

HSP:	118101855(cacna2d4a) 118109202(cacna2d4b)

SMAU:

118290822(cacna2d4a) 118315864

LCF:	108894951(cacna2d4a) 108902629

SDU:	111224495 111235963

SLAL:

111663642 111671895

XGL:	120793257 120803757(cacna2d4a)

HCQ:	109507929 109520039(cacna2d4)

SSCV:

125970470 125992102

SBIA:

133493431(cacna2d4a) 133511739

PEE:	133397146(cacna2d4a) 133402790

PTAO:

133471942(cacna2d4a) 133478678

BPEC:

110156006 110166781

MALB:

109956360

BSPL:

114857517 114861611(cacna2d4a)

SJO:	128358992 128385257(cacna2d4a)

SASA:

106561009(cacna2d4) 106584529

STRU:

115189934 115189942 115192701 115196999

OTW:	112218193 112260024 121845906

OMY:	110493150 110513258 110522741 118942985(cacna2d4a)

OGO:	124017605 124022289 124037616 124038732

ONE:	115134451(cacna2d4) 115144843

OKI:	109867631 109898656 116360523 116360578

OKE:	118358776 118396491 127925440

SALP:

111962195(cacna2d4) 111971793

SNH:	120051824 120066590

CCLU:

121531704 121540575 121543969 121560280

ELS:	105023094(cacna2d4) 105031141

SFM:	108920806(cacna2d4)

PKI:	111843101(cacna2d4)

AANG:

118231979(cacna2d4a)

LOC:	102684802(cacna2d4)

PSPA:

121317842 121319534

ARUT:

117414667(cacna2d4a) 117420037

PSEX:

120540210

LCM:	102358199(CACNA2D4)

CMK:	103181799(cacna2d4a)

CPLA:

122559589

HOC:

132825070

LERI:

129706539(cacna2d4a)

DME:	Dmel_CG42817(Ca-Ma2d)

DER:

6543385

DSE:

6613670

DSI:	Dsimw501_GD24043(Dsim_GD24043)

DYA:	Dyak_GE21365

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17380

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109400990 115257438 115257543

CQU:	CpipJ_CPIJ001793

CPII:

120423661

CNS:	116338098 116352579

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105143903 105148758

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:	109594880 109608335

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:	110378557(Ca-ma2d)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:	107168932 107173920

AGS:	114119786 114121293

RMD:	113550132 113558909

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM308320

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

GAE:

HSY:

AQU:

Reference

PMID:12181424

Authors

Qin N, Yagel S, Momplaisir ML, Codd EE, D'Andrea MR

Title

Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.

Journal

Mol Pharmacol 62:485-96 (2002)
DOI:10.1124/mol.62.3.485

Sequence

[hsa:93589]

LinkDB

DBGET integrated database retrieval system