KEGG ORTHOLOGY: K10412

ORTHOLOGY: K10412

Entry

K10412                      KO

Symbol

DNAL4

Name

dynein axonemal light chain 4

Pathway

map04814

Motor proteins

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H01287

Congenital mirror movements

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    K10412  DNAL4; dynein axonemal light chain 4
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K10412  DNAL4; dynein axonemal light chain 4
   05016 Huntington disease
    K10412  DNAL4; dynein axonemal light chain 4
   05022 Pathways of neurodegeneration - multiple diseases
    K10412  DNAL4; dynein axonemal light chain 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K10412  DNAL4; dynein axonemal light chain 4
   04812 Cytoskeleton proteins
    K10412  DNAL4; dynein axonemal light chain 4
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Dynein arm
   K10412  DNAL4; dynein axonemal light chain 4
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     K10412  DNAL4; dynein axonemal light chain 4

Genes

HSA:	10126(DNAL4)

PTR:	100611328(DNAL4)

PPS:	100981111(DNAL4)

GGO:	101132070(DNAL4)

PON:	100454413(DNAL4)

NLE:	100583936(DNAL4)

HMH:	116459401(DNAL4)

MCC:	702019(DNAL4)

MCF:	102132365(DNAL4)

MTHB:

126963780

MNI:	105464436(DNAL4)

CSAB:

103223328(DNAL4)

CATY:

105573064(DNAL4)

PANU:

101006108(DNAL4)

TGE:	112632520(DNAL4)

MLEU:

105538866(DNAL4)

RRO:	104682548(DNAL4)

RBB:	108521444(DNAL4)

TFN:	117070532(DNAL4)

PTEH:

111549004(DNAL4)

CANG:

105527775(DNAL4)

CJC:	100411241(DNAL4)

SBQ:	101044741(DNAL4)

CIMI:

108289522(DNAL4)

CSYR:

103271264(DNAL4)

MMUR:

105858621(DNAL4)

LCAT:

123639242(DNAL4)

PCOQ:

105805182(DNAL4)

OGA:	100944575(DNAL4)

MMU:	54152(Dnal4)

MCAL:

110310497(Dnal4)

MPAH:

110334885(Dnal4)

RNO:	300078(Dnal4)

MCOC:

116076010(Dnal4)

ANU:	117719406(Dnal4)

MUN:	110557809(Dnal4)

CGE:	100772767(Dnal4)

MAUA:

101831996(Dnal4)

PROB:

127225806(Dnal4)

PLEU:

114694272(Dnal4)

MFOT:

126515740

AAMP:

119822860(Dnal4)

NGI:	103748577(Dnal4)

HGL:	101701945(Dnal4)

CPOC:

100730733(Dnal4)

CCAN:

109692637(Dnal4)

DORD:

105992031(Dnal4)

DSP:	122119189(Dnal4)

PLOP:

125358288(Dnal4)

NCAR:

124983212

MMMA:

107139854(Dnal4)

OCU:

100359030

OPI:	101523133(DNAL4)

TUP:	102498653(DNAL4)

GVR:	103585797(DNAL4) 103585816

CFA:	474505(DNAL4)

CLUD:

112667707(DNAL4)

VVP:	112908703(DNAL4)

VLG:	121492177(DNAL4)

NPO:	129512076(DNAL4)

AML:	100474865(DNAL4)

UMR:	103676378(DNAL4)

UAH:	113241767(DNAL4)

UAR:	123780783(DNAL4)

ELK:

111157606

LLV:

125107603

MPUF:

101672760(DNAL4)

MNP:	132019217(DNAL4)

MLK:	131839491(DNAL4)

NVS:	122891101(DNAL4)

ORO:	101374043(DNAL4)

EJU:	114218535(DNAL4)

ZCA:	113923083(DNAL4)

MLX:	117998668(DNAL4)

NSU:	110578158(DNAL4)

LWW:	102735024(DNAL4)

FCA:	101082167(DNAL4)

PYU:	121040334(DNAL4)

PCOO:

112863842(DNAL4)

PBG:	122472767(DNAL4)

PVIV:

125171208(DNAL4)

LRUF:

124502361

PTG:	102970981(DNAL4)

PPAD:

109265575(DNAL4)

PUC:

125919619

AJU:

106981085

HHV:	120241140(DNAL4)

BTA:	618379(DNAL4)

BBUB:

102398553(DNAL4)

BBIS:

104992293(DNAL4)

CHX:	102184042(DNAL4)

OAS:	101106580(DNAL4)

BTAX:

128048596(DNAL4)

ODA:	120857658(DNAL4)

CCAD:

122423933(DNAL4)

MBEZ:

129536927(DNAL4)

SSC:	100520304(DNAL4)

CFR:	102509708(DNAL4)

CBAI:

105073112(DNAL4)

CDK:	105091939(DNAL4)

VPC:	102529674(DNAL4)

BACU:

103012834(DNAL4)

BMUS:

118902374(DNAL4)

LVE:	103086633(DNAL4)

OOR:	101280857(DNAL4)

DLE:	111186395(DNAL4)

PCAD:

102981306(DNAL4)

PSIU:

116761104(DNAL4)

NASI:

112410852(DNAL4)

ECB:	100070185(DNAL4)

EPZ:	103559832(DNAL4)

EAI:	106837626(DNAL4)

MYB:	102255053(DNAL4) 102257069

MYD:	102766761(DNAL4)

MMYO:

118650153(DNAL4)

MLF:	102441401(DNAL4)

PKL:	118729862(DNAL4)

EFUS:

103288857(DNAL4)

MNA:	107531257(DNAL4)

DRO:	112321875(DNAL4)

SHON:

119002531(DNAL4)

AJM:	119060580(DNAL4)

PDIC:

114513601(DNAL4)

PHAS:

123816133(DNAL4)

MMF:	118623940(DNAL4)

PPAM:

129077931(DNAL4)

HAI:	109394461(DNAL4)

RFQ:	117027959(DNAL4)

PALE:

102898686(DNAL4)

PGIG:

120614805(DNAL4)

PVP:	105288264(DNAL4)

RAY:	107519300(DNAL4)

MJV:	108399342(DNAL4)

TOD:	119247258(DNAL4)

SARA:

101537560(DNAL4)

SETR:

126006346(DNAL4)

LAV:	100663831(DNAL4)

TMU:

101343327

ETF:	123521767(DNAL4)

DNM:	101419094(DNAL4)

MDO:	100013204(DNAL4)

GAS:	123250314(DNAL4)

SHR:	100914220(DNAL4)

AFZ:

127538298

PCW:	110205792(DNAL4)

OAA:	100090273(DNAL4)

GGA:	418019(DNAL4)

PCOC:

116233353(DNAL4)

MGP:	100542459(DNAL4)

CJO:	107314268(DNAL4)

TPAI:

128073597(DNAL4)

LMUT:

125693034(DNAL4)

NMEL:

110392678(DNAL4)

APLA:

101799919(DNAL4)

ACYG:

106035915(DNAL4)

CATA:

118250474(DNAL4)

AFUL:

116493162(DNAL4)

TGU:	100190499(DNAL4)

LSR:	110483789(DNAL4)

SCAN:

103813268(DNAL4)

PMOA:

120510089(DNAL4)

OTC:	121342443(DNAL4)

PRUF:

121361204(DNAL4)

GFR:	102036028(DNAL4)

FAB:	101815765(DNAL4)

OMA:	130262507(DNAL4)

PHI:	102113880(DNAL4)

PMAJ:

107205115(DNAL4)

CCAE:

111934959(DNAL4)

CCW:	104696328(DNAL4)

CBRC:

103618097(DNAL4)

ETL:	114055370(DNAL4)

ZAB:	102065837(DNAL4)

ACHL:

103810446(DNAL4)

SVG:	106858581(DNAL4)

MMEA:

130587572(DNAL4)

HRT:	120751748(DNAL4)

FPG:	101920519(DNAL4)

FCH:	102048454(DNAL4)

CLV:	102093145(DNAL4)

EGZ:	104134327(DNAL4)

NNI:	104021617(DNAL4)

PCRI:

104030556(DNAL4)

PLET:

104618253(DNAL4)

EHS:	104516458(DNAL4)

PCAO:

104040663(DNAL4)

ACUN:

113475892(DNAL4)

TALA:

104361933(DNAL4)

PADL:

103914950(DNAL4)

AFOR:

103907757(DNAL4)

ACHC:

115352670(DNAL4)

HALD:

104312738(DNAL4)

HLE:	104830957(DNAL4)

AGEN:

126048062

GCL:

127029761

CCRI:

104168003(DNAL4)

CSTI:

104558550(DNAL4)

CMAC:

104487633(DNAL4)

MUI:	104546569(DNAL4)

BREG:

104639122(DNAL4)

FGA:	104081881(DNAL4)

GSTE:

104264687(DNAL4)

LDI:	104341956(DNAL4)

MNB:	103780553(DNAL4)

OHA:	104329814(DNAL4)

NNT:	104412257(DNAL4)

SHAB:

115604785(DNAL4)

DPUB:

104302016(DNAL4)

PGUU:

104472313(DNAL4)

ACAR:

104532662(DNAL4)

CPEA:

104394716(DNAL4)

AVIT:

104272647(DNAL4)

CVF:	104283623(DNAL4)

RTD:	128904257(DNAL4)

CUCA:

104065894(DNAL4)

TEO:	104379395(DNAL4)

BRHI:

104493797(DNAL4)

AAM:	106488425(DNAL4)

AROW:

112969357(DNAL4)

NPD:	112947729(DNAL4)

TGT:	104572929(DNAL4)

DNE:	112984689(DNAL4)

SCAM:

104137874(DNAL4)

ASN:	102372171(DNAL4)

AMJ:	102562828(DNAL4)

CPOO:

109316686(DNAL4)

GGN:	109295997(DNAL4)

PSS:	102448878(DNAL4)

CMY:	102930235(DNAL4)

CCAY:

125629014(DNAL4)

DCC:	119859248(DNAL4)

CPIC:

101947518(DNAL4)

TST:	117880319(DNAL4)

CABI:

116826246(DNAL4)

MRV:	120371835(DNAL4)

ACS:	100564193(dnal4)

ASAO:

132775949(DNAL4)

PVT:	110075992(DNAL4)

SUND:

121931461(DNAL4)

PBI:	103051356(DNAL4)

PMUR:

107282264(DNAL4)

CTIG:

120305954(DNAL4)

TSR:	106554668(DNAL4)

PGUT:

117677388(DNAL4)

APRI:

131188141(DNAL4)

PTEX:

113435174(DNAL4)

NSS:	113414160(DNAL4)

VKO:	123028855(DNAL4)

PMUA:

114605513(DNAL4)

PRAF:

128422548(DNAL4)

ZVI:	118091422(DNAL4)

HCG:	128326436(DNAL4)

GJA:	107117146(DNAL4)

STOW:

125435627(DNAL4)

EMC:	129335931(DNAL4)

XLA:	108714523(dnal4.L) 447288(dnal4.S)

XTR:	448476(dnal4)

NPR:	108795136(DNAL4)

RTEM:

120945368(DNAL4)

BBUF:

120979198(DNAL4)

BGAR:

122943989(DNAL4)

MUO:	115475107(DNAL4)

GSH:	117353632(DNAL4)

DRE:	100005529(dnal4b) 445209(dnal4a)

SRX:	107710037 107715714 107740666 107741570

SANH:

107655394 107662365 107664997 107690743

SGH:	107570373 107585028

CCAR:

109046679 109093554 109095291 109110705

CAUA:

113039928 113046748 113047889 113064630

CGIB:

127943226 127946160 127953553 127988393

PTET:

122327146(dnal4b) 122341918(dnal4a)

LROH:

127153230(dnal4b) 127162995(dnal4a)

OMC:	131529604(dnal4b) 131534704(dnal4a)

PPRM:

120490007(dnal4a) 120492980(dnal4b)

RKG:	130101076(dnal4a) 130103497(dnal4b)

MAMB:

125252531(dnal4b) 125273373(dnal4a)

CIDE:

127508481 127521760

MASI:

127438293 127439184 127450478

TROS:

130548914(dnal4b) 130561892(dnal4a)

TDW:	130426379(dnal4a) 130430303(dnal4b)

MANU:

129436458(dnal4a) 129453847(dnal4b)

IPU:	108259448(dnal4b) 108261343(dnal4a)

IFU:	128600869(dnal4a) 128602678(dnal4b)

PHYP:

113527897 113547414

SMEO:

124379720(dnal4b) 124396338(dnal4a)

TFD:	113638151(dnal4a) 113657075(dnal4b)

TVC:	132838710(dnal4b) 132861434(dnal4a)

AMEX:

103029781(dnal4)

CMAO:

118804660(dnal4b) 118821651(dnal4a)

EEE:	113569900 113581451

CHAR:

105912872

TRU:	101071403(dnal4)

TFS:

130526909

TNG:	GSTEN00034847G001

LCO:	104925450(dnal4)

NCC:	104946141(dnal4)

TBEN:

117484382

CGOB:

115005611(dnal4)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116701064(dnal4)

PFLV:

114571383(dnal4)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

122871800(dnal4b)

CUD:

121507981

ALAT:

119028910

MZE:	101486601(dnal4)

ONL:	100711253(dnal4)

OAU:

116312608

OLA:	101161374(dnal4)

OML:

112137144

CSAI:

133452237

XMA:	102231362(dnal4)

XCO:	114145610(dnal4)

XHE:	116720794(dnal4)

PRET:

103476474(dnal4)

PFOR:

103154838(dnal4)

PLAI:

106936728(dnal4)

PMEI:

106904600(dnal4)

GAF:

122830303

PPRL:

129367153

CVG:	107090072(dnal4)

CTUL:

119796315

GMU:

124868592

NFU:	107375175(dnal4)

KMR:

108238094

ALIM:

106522504(dnal4)

NWH:

119422944

AOCE:

111588205(dnal4)

MCEP:

125003881(dnal4b)

CSEM:

103383215(dnal4)

POV:	109639240(dnal4)

SSEN:

HHIP:

HSP:

SMAU:

LCF:	108887172(dnal4b)

SDU:	111216679(dnal4)

SLAL:

111673424(dnal4)

XGL:

120799696

HCQ:	109511164(dnal4)

SSCV:

125969551

SBIA:

133505028 133505787

PEE:	133403564 133405261

PTAO:

133476821 133482603

BPEC:

110168249(dnal4)

MALB:

109951618(dnal4)

BSPL:

114870619

SJO:

128375190

SASA:

100380497(dnal4) 106564334 106591471 106607436

STRU:

115147471 115170911 115177762 115196233

OTW:	112225809 112230083 112258470

OMY:	110485593 110486118 110538008 118940335

OGO:	123999612 124002812 124015738

ONE:	115103583 115110109 115124922

OKI:	109893189 109898279 116358920 116365183

OKE:	118364717 118378026 118384363

SALP:

111981915 111981980

SNH:	120023903 120034354 120044461

CCLU:

121550562 121570591 121576341

ELS:	105012077(dnal4)

SFM:	108938842(dnal4)

PKI:	111845209(dnal4)

AANG:

PSPA:

ARUT:

PSEX:

LCM:	102360740(DNAL4)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116951350 116952710(DNAL4)

LRJ:	133340996 133347557(DNAL4)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG8407(CG8407)

DER:

6546902

DSE:

6608763

DSI:	Dsimw501_GD15397(Dsim_GD15397)

DYA:	Dyak_GE12408

DAN:

DSR:

DPO:

DPE:

DMN:	108159333 117191930

DWI:

6652487

DGR:

6559953

DMO:	Dmoj_GI20135

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119680148 119684293 119684812

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:	117232503 117237221

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:	122532100 122537516

CCAL:

108630956 108632010 108632011

OBB:

114876006

OLG:	117602776 117610116

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105150049 105150052

ACEP:

105620643 105620644

PBAR:

105426945 105426947

VEM:	105558817 105558818

HST:	105191600 105191601

DQU:	106745493 106745494

CFO:	105251606 105251613

FEX:	115238764 115238765

LHU:	105667415 105667416

PGC:	109856331 109856582

OBO:	105283996 105283999 113563597

PCF:	106785738 106785740

PFUC:

122519302 122519735

VPS:

122630518

VCRB:

124424051 124424191

VVE:	124950539 124950617

NVI:	100120337 100120362

CSOL:

TPRE:

LHT:

MDL:

CGLO:

FAS:	105269076 105269077

DAM:

107039739

AGIF:

122849281 122857357 122857361

CINS:

118073629 118073737

VCAN:

122409665

CCIN:

107269940 107269947

DSM:	124410251 124410532

NPT:	124219859 124219950

NFB:

124183611

NLO:	107227475 107227478

NVG:	124304755 124305669

AROA:

105686506 105686507

TCA:	655564(DLC-B)

DPA:

SOY:

AGRG:

ATD:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212413

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM285760

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:	110860683 110862861

DPX:	DAPPUDRAFT_313094

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128705010 128705011

PTRU:

123508614

ESN:

126983184

HAZT:

108666348

EAF:	111700595 111701036 111706941 111718003

LSM:	121113955 121117332 121122802 121127978

TCF:	131884104 131886776 131886922 131887736

PPOI:

119102601 119102602 119103484

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_156242

LGI:	LOTGIDRAFT_204935

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105343813 117684315

CVN:	111118045 111121252

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:	106867403 106877338

OSN:	115209879 115226740

LAK:

106154108

SMM:	Smp_030910

SHX:	MS3_00008641(DNAL4)

OVI:	T265_07967 T265_15529

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_37233

AQU:

100634774

CRE:	CHLRE_12g527800v5

VCN:	VOLCADRAFT_105940(mot24)

CSL:	COCSUDRAFT_18628

CVR:	CHLNCDRAFT_138129

MIS:	MICPUN_85371

MPP:	MICPUCDRAFT_23001(JGI:MicpuC2_23001)

MBR:	MONBRDRAFT_32058

SRE:	PTSG_04128

PFA:	PF3D7_0204400

PREI:

PRSY57_0203500

PGAB:

PGSY75_0204400

PYO:	PY17X_0302800

PCB:	PCHAS_0304400

PBE:	PBANKA_0302200

PVV:	PVVCY_0300310

PKN:	PKNH_0416500

PVX:	PVX_003650

PCY:	PCYB_042580

PMAL:

PMUG01_04028000

PREL:

PRELSG_0417500

TGO:	TGME49_291160

TET:	TTHERM_00716250

PTM:	GSPATT00000825001 GSPATT00008648001

TPS:	THAPSDRAFT_bd539

PIF:	PITG_09030

PSOJ:

PHYSODRAFT_293265

SPAR:

SPRG_13829

EHX:	EMIHUDRAFT_208296

GTT:	GUITHDRAFT_153648 GUITHDRAFT_68262

TBR:	Tb10.70.2520

TBG:	TbgDal_X5710

TCR:	503891.120 510287.10

LMA:	LMJF_16_0940

LIF:	LINJ_16_0950

LDO:	LDBPK_160950

LMI:	LMXM_16_0940

LBZ:	LBRM_16_0950

LPAN:

LPMP_160900

NGR:	NAEGRDRAFT_32555

TVA:	TVAG_2v0552400

» show all

Reference

PMID:25098561

Authors

Ahmed I, Mittal K, Sheikh TI, Vasli N, Rafiq MA, Mikhailov A, Ohadi M, Mahmood H, Rouleau GA, Bhatti A, Ayub M, Srour M, John P, Vincent JB

Title

Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.

Journal

Hum Genet 133:1419-29 (2014)
DOI:10.1007/s00439-014-1475-8

Sequence

[hsa:10126]

LinkDB

DBGET integrated database retrieval system