KEGG ORTHOLOGY: K11404

ORTHOLOGY: K11404

Entry

K11404                      KO

Symbol

HDAC3

Name

histone deacetylase 3 [EC:3.5.1.98]

Pathway

map04613

Neutrophil extracellular trap formation

map04919

Thyroid hormone signaling pathway

map05034

Alcoholism

map05203

Viral carcinogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K11404  HDAC3; histone deacetylase 3
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K11404  HDAC3; histone deacetylase 3
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K11404  HDAC3; histone deacetylase 3
  09165 Substance dependence
   05034 Alcoholism
    K11404  HDAC3; histone deacetylase 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11404  HDAC3; histone deacetylase 3
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     K11404  HDAC3; histone deacetylase 3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class I HDACs
     K11404  HDAC3; histone deacetylase 3
   HDAC complexes
    SMART complex
     K11404  HDAC3; histone deacetylase 3

Other DBs

GO:

0004407

Genes

HSA:	8841(HDAC3)

PTR:	738624(HDAC3)

PPS:	100978769(HDAC3)

GGO:	101129415(HDAC3)

PON:	100172482(HDAC3)

NLE:	100596866(HDAC3)

HMH:	116471640(HDAC3)

MCC:	704467(HDAC3)

MCF:	102119873(HDAC3)

MTHB:

126957249

MNI:	105466979(HDAC3)

CSAB:

103244700(HDAC3)

CATY:

105599934(HDAC3)

PANU:

101024566(HDAC3)

TGE:	112626417(HDAC3)

MLEU:

105534882(HDAC3)

RRO:	104681822(HDAC3)

RBB:	108530206(HDAC3) 108532627

TFN:	117065699(HDAC3)

PTEH:

111526964(HDAC3)

CANG:

105510108(HDAC3)

CJC:	100386715(HDAC3)

SBQ:	101030664(HDAC3)

CIMI:

108298753 108307076(HDAC3)

CSYR:

103269881(HDAC3)

MMUR:

105862597(HDAC3)

LCAT:

123637903(HDAC3)

PCOQ:

105811560(HDAC3)

OGA:	100943283(HDAC3)

MMU:	15183(Hdac3)

MCAL:

110285017(Hdac3)

MPAH:

110333513(Hdac3)

RNO:	84578(Hdac3)

MCOC:

116087069(Hdac3)

ANU:	117719791(Hdac3)

MUN:	110557100(Hdac3)

CGE:	100752639(Hdac3)

MAUA:

101828093(Hdac3)

PROB:

127234039(Hdac3)

MORG:

121453657(Hdac3)

MFOT:

126491941

AAMP:

119814481(Hdac3)

NGI:	103736071(Hdac3)

HGL:	101708680(Hdac3)

CPOC:

100718985(Hdac3)

CCAN:

109681334(Hdac3)

DORD:

105988738(Hdac3)

DSP:	122118211(Hdac3)

PLOP:

125339784(Hdac3)

NCAR:

124986785 124992800

MMMA:

107142117(Hdac3)

OCU:

100354595

OPI:	101526567(HDAC3)

TUP:	102472062(HDAC3)

GVR:	103587895(HDAC3)

CFA:	478040(HDAC3)

CLUD:

112658953(HDAC3)

VVP:	112934596(HDAC3)

VLG:	121497237(HDAC3)

NPO:	129505328 129514015(HDAC3)

AML:	100466134(HDAC3)

UMR:	103663723(HDAC3)

UAH:	113255378(HDAC3)

UAR:	123790221(HDAC3)

ELK:

111156912

LLV:

125099678

MPUF:

101671294(HDAC3)

MNP:	132028610(HDAC3)

MLK:	131832185(HDAC3)

NVS:	122890048(HDAC3)

ORO:	101367531(HDAC3) 101379690

EJU:	114200673(HDAC3)

ZCA:	113929449(HDAC3)

MLX:	118016741(HDAC3)

NSU:	110591309(HDAC3)

LWW:	102725884(HDAC3)

FCA:	101100941(HDAC3)

PYU:	121016693(HDAC3)

PCOO:

112860215(HDAC3)

PBG:	122484040(HDAC3)

PVIV:

125170195(HDAC3)

LRUF:

124516851

PTG:	102961741(HDAC3)

PPAD:

109252210(HDAC3)

PUC:

125934890

AJU:

106967267

HHV:	120234378(HDAC3)

BTA:	404125(HDAC3)

BOM:	102265865(HDAC3)

BIU:	109562142(HDAC3)

BBUB:

102411856(HDAC3)

BBIS:

104996236(HDAC3)

CHX:	102184143(HDAC3)

OAS:	101107092(HDAC3)

BTAX:

128050619(HDAC3)

ODA:	120863536(HDAC3)

CCAD:

122439788(HDAC3)

MBEZ:

129558519(HDAC3)

SSC:	100511372(HDAC3)

CFR:	102511155(HDAC3)

CBAI:

105065467(HDAC3)

CDK:	105090801(HDAC3)

VPC:	102539664(HDAC3)

BACU:

103013037(HDAC3)

BMUS:

118892099(HDAC3)

LVE:	103082097(HDAC3)

OOR:	101280938(HDAC3)

DLE:	111183021(HDAC3)

PCAD:

102980522(HDAC3)

PSIU:

116751986(HDAC3)

NASI:

112404428(HDAC3)

ECB:	100061405(HDAC3)

EPZ:	103550705(HDAC3)

EAI:	106836963(HDAC3)

MYB:	102251571(HDAC3)

MYD:	102760511(HDAC3)

MMYO:

118657910(HDAC3)

MLF:	102436951(HDAC3)

PKL:	118711861(HDAC3)

EFUS:

103285668(HDAC3)

MNA:	107531511(HDAC3)

DRO:	112318147(HDAC3)

SHON:

118998487(HDAC3)

AJM:	119051055(HDAC3)

PDIC:

114509630(HDAC3)

PHAS:

123811396(HDAC3)

MMF:	118615784(HDAC3)

PPAM:

129066593(HDAC3)

HAI:	109393589(HDAC3)

RFQ:	117016952(HDAC3)

PALE:

102898225(HDAC3)

PGIG:

120581463(HDAC3)

PVP:	105297029(HDAC3)

RAY:	107499696(HDAC3)

MJV:	108405534(HDAC3)

TOD:	119243344(HDAC3)

SARA:

101550243(HDAC3)

SETR:

126027887(HDAC3)

LAV:	100662346(HDAC3)

TMU:

101356648

ETF:	101652123(HDAC3)

DNM:	101413155(HDAC3)

MDO:	100022921(HDAC3)

GAS:	123236266(HDAC3)

SHR:	100914869(HDAC3)

AFZ:

127550037

PCW:	110220842(HDAC3)

OAA:	100089433(HDAC3)

GGA:	395506(HDAC3)

PCOC:

116231945(HDAC3)

MGP:	100541774(HDAC3)

CJO:	107320289(HDAC3)

TPAI:

128081411(HDAC3)

LMUT:

125700282(HDAC3)

NMEL:

110405234(HDAC3)

APLA:

101795547

ACYG:

106034394(HDAC3)

CATA:

118256128(HDAC3)

AFUL:

116494820(HDAC3)

TGU:	100222558(HDAC3)

LSR:	110481539(HDAC3)

SCAN:

103817212(HDAC3)

PMOA:

120499185(HDAC3)

OTC:	121343403(HDAC3)

PRUF:

121354901(HDAC3)

GFR:	102045100(HDAC3)

FAB:	101806964(HDAC3)

OMA:	130258538(HDAC3)

PHI:	102105332(HDAC3)

PMAJ:

107210574(HDAC3)

CCAE:

111935705(HDAC3)

CCW:	104696060(HDAC3)

CBRC:

103614977(HDAC3)

ETL:	114066130(HDAC3)

ZAB:	102067220(HDAC3)

ACHL:

103803933(HDAC3)

SVG:	106861320(HDAC3)

MMEA:

130585202(HDAC3)

HRT:	120759069(HDAC3)

FPG:	101911907(HDAC3)

FCH:	102053046(HDAC3)

CLV:	102092101(HDAC3)

EGZ:	104121829(HDAC3)

NNI:	104016574(HDAC3)

PCRI:

104024252(HDAC3)

PLET:

104620948(HDAC3)

EHS:	104503069(HDAC3)

PCAO:

104053145(HDAC3)

ACUN:

113485215(HDAC3)

TALA:

104366591(HDAC3)

PADL:

103921945(HDAC3)

AFOR:

103898948(HDAC3)

ACHC:

115334434(HDAC3)

HALD:

104311478(HDAC3)

HLE:	104839062(HDAC3)

AGEN:

126051179

GCL:

127021882

CCRI:

104161102(HDAC3)

CSTI:

104553816(HDAC3)

CMAC:

104484695(HDAC3)

MUI:	104539687(HDAC3)

BREG:

104629256(HDAC3)

FGA:	104069812(HDAC3)

GSTE:

104251246(HDAC3)

LDI:	104349193(HDAC3)

MNB:	103777996(HDAC3)

OHA:	104338333(HDAC3)

NNT:	104404135(HDAC3)

SHAB:

115615669(HDAC3)

DPUB:

104299836(HDAC3)

PGUU:

104464077(HDAC3)

ACAR:

104527073(HDAC3)

CPEA:

104392047(HDAC3)

AVIT:

104267458(HDAC3)

CVF:	104282605(HDAC3)

RTD:	128915979(HDAC3)

CUCA:

104065781(HDAC3)

TEO:	104370120(HDAC3)

AAM:	106488080(HDAC3)

AROW:

112968411(HDAC3)

NPD:	112951735(HDAC3)

TGT:	104578911(HDAC3)

DNE:	112981811(HDAC3)

SCAM:

104154017(HDAC3)

ASN:	102387065(HDAC3)

AMJ:	102563446(HDAC3)

CPOO:

109309917(HDAC3)

GGN:	109290177(HDAC3)

PSS:	102446485(HDAC3)

CMY:	102931754(HDAC3)

CCAY:

125641038(HDAC3)

DCC:	119859998(HDAC3)

CPIC:

101944763(HDAC3)

TST:	117881710(HDAC3)

CABI:

116820214(HDAC3)

MRV:	120370722(HDAC3)

ACS:	100557493(hdac3)

ASAO:

132774277(HDAC3)

PVT:	110082015(HDAC3)

SUND:

121928697(HDAC3)

PBI:	103060965(HDAC3)

PMUR:

107299579(HDAC3)

CTIG:

120300321(HDAC3)

TSR:	106539763 106556188

PGUT:

117660693(HDAC3)

APRI:

131194051(HDAC3)

PTEX:

113448150(HDAC3)

NSS:	113422336(HDAC3)

VKO:	123029702(HDAC3)

PMUA:

114601106(HDAC3)

PRAF:

128418013(HDAC3)

ZVI:	118079352(HDAC3)

HCG:	128323895(HDAC3)

GJA:	107110390(HDAC3)

STOW:

125443552(HDAC3)

EMC:	129333361(HDAC3)

XLA:	432017(hdac3.S)

XTR:	549637(hdac3)

NPR:	108798737(HDAC3)

RTEM:

120932485(HDAC3)

BBUF:

121008770(HDAC3)

BGAR:

122926438(HDAC3)

MUO:	115476436(HDAC3)

GSH:	117351764(HDAC3)

DRE:	393965(hdac3)

SRX:	107724546 107746152

SANH:

107674884 107688598

SGH:	107573547 107577256

CCAR:

109064961(hdac3) 109071718

CAUA:

113113420 113113551

CGIB:

127971670 128026881

PTET:

122357693(hdac3)

LROH:

127176338(hdac3)

OMC:	131553850(hdac3)

PPRM:

120494842(hdac3)

RKG:	130070715(hdac3)

MAMB:

125259418(hdac3)

CIDE:

127494298

MASI:

127418152

TROS:

130551226(hdac3)

TDW:	130438293(hdac3)

MANU:

129422337(hdac3)

IPU:

108268985

IFU:	128611631(hdac3)

PHYP:

113542787(hdac3)

SMEO:

124385995(hdac3)

TFD:	113635858(hdac3)

TVC:	132856036(hdac3)

AMEX:

103021818(hdac3)

CMAO:

118807234(hdac3)

EEE:	113589811(hdac3)

CHAR:

105898498(hdac3)

TRU:	101080240(hdac3)

TFS:	130531794(hdac3)

TNG:	GSTEN00019185G001

LCO:	104932277(hdac3)

NCC:	104955474(hdac3)

TBEN:

117475222(hdac3)

CGOB:

115014363(hdac3)

PGEO:

117454100(hdac3)

GACU:

117546974(hdac3)

EMAC:

134859706(hdac3)

ELY:	117261512(hdac3)

EFO:	125894452(hdac3)

PLEP:

121948267(hdac3)

SLUC:

116036552(hdac3)

ECRA:

117952041(hdac3)

ESP:	116685914(hdac3)

PFLV:

114562488(hdac3)

GAT:	120818106(hdac3)

PPUG:

119211484(hdac3)

AFB:	129089875(hdac3)

CLUM:

117737845(hdac3)

PSWI:

130210019(hdac3)

MSAM:

119888988(hdac3)

SCHU:

122880144(hdac3)

CUD:	121516701(hdac3)

ALAT:

119007335(hdac3)

MZE:	101482849(hdac3)

ONL:	100708372(hdac3)

OAU:	116328143(hdac3)

OLA:	101157788(hdac3)

OML:	112153145 112153148 112153367 112153368 112153370 112153642

CSAI:

133447272(hdac3)

XMA:	102235096(hdac3)

XCO:	114138991(hdac3)

XHE:	116713927(hdac3)

PFOR:

103149284(hdac3)

PLAI:

106957960(hdac3)

PMEI:

106932986(hdac3)

GAF:	122836576(hdac3)

PPRL:

129362553(hdac3)

CVG:	107093831(hdac3)

CTUL:

119790402(hdac3)

GMU:	124860147(hdac3)

NFU:	107374590(hdac3)

KMR:	108240007(hdac3)

ALIM:

106535107(hdac3)

NWH:	119408585(hdac3)

AOCE:

111574741(hdac3)

MCEP:

125007965(hdac3)

CSEM:

103391257(hdac3)

POV:	109628465(hdac3)

SSEN:

122778453(hdac3)

HHIP:

117768949(hdac3)

HSP:	118112672(hdac3)

SMAU:

118319725(hdac3)

LCF:

108879020

SDU:	111226533(hdac3)

SLAL:

111667607(hdac3)

XGL:	120785032(hdac3)

HCQ:	109524297(hdac3)

SSCV:

125991060

SBIA:

133508588(hdac3)

PEE:	133407909(hdac3)

PTAO:

133484574(hdac3)

BPEC:

110171238(hdac3)

MALB:

109957525(hdac3)

BSPL:

114864410(hdac3)

SJO:	128363100(hdac3)

SASA:

101448005(hdac3) 106604953

STRU:

115174931 115205461

OTW:	112220700 112256037

OMY:	110488554 110504769

OGO:	123993201 124010364

ONE:	115129298 115130485

OKI:	109864512 109905045

OKE:	118363330 118375247

SALP:

111965349 111967335

SNH:	120047511 120062550

CCLU:

121544889 123492853

ELS:	105027296(hdac3)

SFM:	108923163(hdac3)

PKI:	111835050(hdac3)

AANG:

118224384(hdac3)

LOC:	102688652(hdac3)

PSPA:

121297457 121307622

ARUT:

117412944 117431204

PSEX:

120542079(hdac3)

LCM:	102355924(HDAC3)

CMK:	103188219(hdac3)

RTP:	109919895(hdac3)

CPLA:

122556471(hdac3)

HOC:	132823476(hdac3)

LERI:

129701588(hdac3)

PMRN:

116942944(HDAC3)

LRJ:	133342964 133342981

BFO:

BBEL:

CIN:

SCLV:

SPU:	115925190 590047

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG2128(HDAC3)

DER:

6552202

DSE:

6613951

DSI:	Dsimw501_GD19615(Dsim_GD19615)

DYA:	Dyak_GE25277

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24497

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101897559 131805435

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ013384

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212747

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105390065 105396300

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111060155 111062027

HVI:

124355119

MQU:

128991575

PHU:	Phum_PHUM260560

FOC:

113213869

TPAL:

117642238

ZNE:	110830798 110830799

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_128123(HDA3)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:	126987199 126987210

MNZ:

135207494

HAZT:

108675988

EAF:	111696432 111714846

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129226441 129231808

SDM:

118189303

LPOL:

106468721

PMEO:

129581344

NAI:	NECAME_15010

BMY:	BM_BM2064(Bma-hda-2)

LOA:	LOAG_00876

TSP:	Tsp_07527 Tsp_12528

HRO:	HELRODRAFT_65955

LGI:	LOTGIDRAFT_216681

PVUL:

126817575

PCAN:

112573826

BGT:

106058885

GAE:	121366327 121374994

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_093280

SHX:	MS3_00009224(HDAC3)

OVI:	T265_09425

EGL:

NVE:

EPA:

ATEN:

ADF:	107353514 107357281

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_57882

AQU:

100631864

WIC:	J056_003875

EIN:	Eint_090630

EHE:	EHEL_090640

ERO:	EROM_091070

NCE:	NCER_100381

MBR:	MONBRDRAFT_15424

SRE:	PTSG_09405

DDI:	DDB_G0270338

DPP:	DICPUDRAFT_85725

» show all

Reference

PMID:21444723

Authors

Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP

Title

Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.

Journal

Mol Cell Biol 31:2349-63 (2011)
DOI:10.1128/MCB.01205-10

Sequence

[hsa:8841]

Reference

PMID:9464271

Authors

Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR

Title

Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells.

Journal

Biochem Biophys Res Commun 242:648-52 (1998)
DOI:10.1006/bbrc.1997.8033

Sequence

[hsa:8841]

LinkDB

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