KEGG ORTHOLOGY: K15362

ORTHOLOGY: K15362

Entry

K15362                      KO

Symbol

BRIP1, BACH1, FANCJ

Name

fanconi anemia group J protein [EC:5.6.2.3]

Pathway

map03440

Homologous recombination

map03460

Fanconi anemia pathway

Disease

H00031

Breast cancer

H00238

Fanconi anemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein
   03460 Fanconi anemia pathway
    K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-B complex
     K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K15362  BRIP1, BACH1, FANCJ; fanconi anemia group J protein

Other DBs

GO:

0043139

Genes

HSA:	83990(BRIP1)

PTR:	454796(BRIP1)

PPS:	100970763(BRIP1)

GGO:	101142622(BRIP1)

PON:	100460525(BRIP1)

NLE:	100591938(BRIP1)

HMH:	116474316(BRIP1)

MCC:	712408(BRIP1)

MCF:	102121694(BRIP1)

MTHB:

126939367

MNI:	105476851(BRIP1)

CSAB:

103242813(BRIP1)

CATY:

105583344(BRIP1)

PANU:

100998699(BRIP1)

TGE:	112609550(BRIP1)

MLEU:

105539060(BRIP1)

RRO:	104662937(BRIP1)

RBB:	108528833(BRIP1)

TFN:	117067333(BRIP1)

PTEH:

111537663(BRIP1)

CANG:

105520076(BRIP1)

CJC:	100386750(BRIP1)

SBQ:	101037588(BRIP1)

CIMI:

108312036(BRIP1)

CSYR:

103273419(BRIP1)

MMUR:

105875738(BRIP1)

LCAT:

123620396(BRIP1)

PCOQ:

105813634(BRIP1)

OGA:	100965851(BRIP1)

MMU:	237911(Brip1)

MCAL:

110305476(Brip1)

MPAH:

110331928(Brip1)

RNO:	360588(Brip1)

MCOC:

116077032(Brip1)

ANU:	117711738(Brip1)

MUN:	110553746(Brip1)

CGE:	100774617(Brip1)

MAUA:

101824275(Brip1)

PROB:

127218745(Brip1)

PLEU:

114699285(Brip1)

MORG:

121456975(Brip1)

MFOT:

126486968

AAMP:

119811428(Brip1)

NGI:	103741754(Brip1)

HGL:	101716733(Brip1)

CPOC:

100729812(Brip1)

CCAN:

109683199(Brip1)

DORD:

105983241(Brip1)

DSP:	122120373(Brip1)

PLOP:

125366026(Brip1)

MMMA:

107150648(Brip1)

OCU:

100359326

OPI:	101517918(BRIP1)

TUP:	102492421(BRIP1)

GVR:	103593174(BRIP1)

CFA:	491122(BRIP1)

CLUD:

112655507(BRIP1)

VVP:	112917947(BRIP1)

VLG:	121473643(BRIP1)

NPO:	129509573(BRIP1)

AML:	100465678(BRIP1)

UMR:	103667455(BRIP1)

UAH:	113268903(BRIP1)

UAR:	123777000(BRIP1)

ELK:

111151585

LLV:

125087185

MPUF:

101676269(BRIP1)

MNP:	132004541(BRIP1)

MLK:	131816346(BRIP1)

NVS:	122906501(BRIP1)

ORO:	101374959(BRIP1)

EJU:	114213729(BRIP1)

ZCA:	113908297(BRIP1)

MLX:	118024669(BRIP1)

NSU:	110592922(BRIP1)

LWW:	102747605(BRIP1)

FCA:	101091321(BRIP1)

PYU:	121044685(BRIP1)

PCOO:

112855443(BRIP1)

PBG:	122485291(BRIP1)

PVIV:

125151866(BRIP1)

LRUF:

124513160

PTG:	102963020(BRIP1)

PPAD:

109256119(BRIP1)

PUC:

125926767

AJU:

106972708

HHV:	120241928(BRIP1)

BTA:	783256(BRIP1)

BOM:	102269436(BRIP1)

BIU:	109574494(BRIP1)

BBUB:

102407055(BRIP1)

BBIS:

105004072(BRIP1)

CHX:	102171813(BRIP1)

OAS:	101107879(BRIP1)

BTAX:

128065253(BRIP1)

ODA:	120866680(BRIP1)

CCAD:

122450118(BRIP1)

MBEZ:

129539423(BRIP1)

SSC:	100525359(BRIP1)

CFR:	102505597(BRIP1)

CBAI:

105065839(BRIP1)

CDK:	105097835(BRIP1)

VPC:	102542999(BRIP1)

BACU:

103018168(BRIP1)

BMUS:

118887483(BRIP1)

LVE:	103076132(BRIP1)

OOR:	101284749(BRIP1)

DLE:	111163684(BRIP1)

PCAD:

102982599(BRIP1)

PSIU:

116745973(BRIP1)

NASI:

112408117(BRIP1)

ECB:	100071185(BRIP1)

EPZ:	103565220(BRIP1)

EAI:	106841130(BRIP1)

MYB:	102239255(BRIP1)

MYD:	102765897(BRIP1)

MMYO:

118671649(BRIP1)

MLF:	102418884(BRIP1)

PKL:	118726391(BRIP1)

EFUS:

103293260(BRIP1)

MNA:	107530045(BRIP1)

DRO:	112316544(BRIP1)

SHON:

119003666(BRIP1)

AJM:	119062677(BRIP1)

PDIC:

114503537(BRIP1)

PHAS:

123817246(BRIP1)

MMF:	118634709(BRIP1)

PPAM:

129071518(BRIP1)

HAI:	109379742(BRIP1)

RFQ:	117014044(BRIP1)

PALE:

102890464(BRIP1)

PGIG:

120620834(BRIP1)

PVP:	105302095(BRIP1)

RAY:	107510134(BRIP1)

MJV:	108387959(BRIP1)

TOD:	119230767(BRIP1)

SARA:

101551829(BRIP1)

SETR:

125995053(BRIP1)

LAV:	100659441(BRIP1)

TMU:

101348355

ETF:	101652726(BRIP1)

DNM:	101431967(BRIP1)

MDO:	100010194(BRIP1)

GAS:	123243611(BRIP1)

SHR:	111720469(BRIP1)

AFZ:

127559949

PCW:	110212039(BRIP1)

OAA:	100080178(BRIP1)

GGA:	417642(BRIP1)

PCOC:

116227958(BRIP1)

MGP:	100540611(BRIP1)

CJO:	107322509(BRIP1)

TPAI:

128083433(BRIP1)

LMUT:

125702866(BRIP1)

NMEL:

110407916(BRIP1)

APLA:

101791710(BRIP1)

ACYG:

106046856(BRIP1)

CATA:

118255033(BRIP1)

AFUL:

116497321(BRIP1)

TGU:	100217494(BRIP1)

LSR:	110467647(BRIP1)

SCAN:

103820335(BRIP1)

PMOA:

120507840(BRIP1)

OTC:	121347056(BRIP1)

PRUF:

121361837(BRIP1)

FAB:	101816978(BRIP1)

OMA:	130261016(BRIP1)

PHI:	102106120(BRIP1)

PMAJ:

107212860(BRIP1)

CCAE:

111937838(BRIP1)

CCW:	104690999(BRIP1)

CBRC:

103613324(BRIP1)

ETL:	114068830(BRIP1)

ZAB:	102066270(BRIP1)

ACHL:

103805948(BRIP1)

SVG:	106856076(BRIP1)

MMEA:

130580962(BRIP1)

HRT:	120761472(BRIP1)

FPG:	101911383(BRIP1)

FCH:	102057474(BRIP1)

CLV:	102095052(BRIP1)

EGZ:	104121836(BRIP1)

NNI:	104016494(BRIP1)

PCRI:

104028195(BRIP1)

PLET:

104619663(BRIP1)

EHS:	104502531(BRIP1)

PCAO:

104051424(BRIP1)

ACUN:

113487235(BRIP1)

TALA:

104368323(BRIP1)

PADL:

103916893(BRIP1)

AFOR:

103898034(BRIP1)

ACHC:

115347582(BRIP1)

HALD:

104318099(BRIP1)

HLE:	104835664(BRIP1)

AGEN:

126040021

GCL:

127024392

CCRI:

104165118(BRIP1)

CSTI:

104564017(BRIP1)

CMAC:

104482409(BRIP1)

MUI:	104542539(BRIP1)

BREG:

104642094(BRIP1)

FGA:	104083670(BRIP1)

GSTE:

104250296(BRIP1)

LDI:	104342470(BRIP1)

MNB:	103769722(BRIP1)

OHA:	104339634(BRIP1)

NNT:	104406752(BRIP1)

SHAB:

115601973(BRIP1)

DPUB:

104302489(BRIP1)

PGUU:

104468734(BRIP1)

ACAR:

104530279(BRIP1)

CPEA:

104398900(BRIP1)

AVIT:

104271457(BRIP1)

CVF:	104284355(BRIP1)

RTD:	128912662(BRIP1)

CUCA:

104064959(BRIP1)

TEO:	104378612(BRIP1)

BRHI:

104487843(BRIP1)

AAM:	106500343(BRIP1)

AROW:

112968789(BRIP1)

NPD:	112954735(BRIP1)

TGT:	104575241(BRIP1)

DNE:	112991963(BRIP1)

SCAM:

104142768(BRIP1)

ASN:	102368243(BRIP1)

AMJ:	102571940(BRIP1)

CPOO:

109317161(BRIP1)

GGN:	109293283(BRIP1)

PSS:	102454780(BRIP1)

CMY:	102930925(BRIP1)

CCAY:

125624143(BRIP1)

DCC:	119844729(BRIP1)

CPIC:

101931213(BRIP1)

TST:	117867523(BRIP1)

CABI:

116824210(BRIP1)

MRV:	120387305(BRIP1)

ACS:	103281603(brip1)

ASAO:

132763817(BRIP1)

PVT:	110075493(BRIP1)

SUND:

121916789(BRIP1)

PBI:	103063956(BRIP1)

PMUR:

107297891(BRIP1)

CTIG:

120297798(BRIP1)

PGUT:

117656850

APRI:

131188674(BRIP1)

PTEX:

113442541(BRIP1)

NSS:	113422034(BRIP1)

VKO:	123023423(BRIP1)

PMUA:

114585453(BRIP1)

PRAF:

128403064(BRIP1)

ZVI:	118097353(BRIP1)

HCG:	128335815(BRIP1)

GJA:	107123103(BRIP1)

STOW:

125445932(BRIP1)

EMC:	129344944(BRIP1)

XLA:	398837(brip1.L)

XTR:	100489959(brip1)

NPR:	108787174(BRIP1)

RTEM:

120926754(BRIP1)

BBUF:

120995453(BRIP1)

BGAR:

122931193(BRIP1)

MUO:	115456541(BRIP1)

GSH:	117349379(BRIP1)

DRE:	794038(brip1)

SRX:	107743644 107757032

SANH:

107664950 107685073

SGH:	107548546 107589699(brip1)

CCAR:

109070277 109110583

CAUA:

113114902(brip1)

CGIB:

127972924

PTET:

122358391(brip1)

LROH:

127177582(brip1)

OMC:	131554130(brip1)

PPRM:

120478884(brip1)

RKG:	130104555(brip1)

MAMB:

125248518(brip1)

CIDE:

127495886

MASI:

127422042

TROS:

130564884(brip1)

TDW:	130429227(brip1)

MANU:

129438100(brip1)

IPU:

108278344

IFU:	128621111(brip1)

PHYP:

113533024(brip1)

SMEO:

124394605(brip1)

TFD:	113643762(brip1)

TVC:	132857955(brip1)

AMEX:

103037555(brip1)

CMAO:

118801877(brip1)

EEE:	113569717(brip1)

CHAR:

105897148(brip1)

TRU:	101076617(brip1)

TFS:	130534972(brip1)

TNG:	GSTEN00010454G001 GSTEN00026870G001

LCO:	104930587(brip1)

NCC:	104966431 104966493

TBEN:

117468976(brip1)

CGOB:

115017855(brip1)

PGEO:

117457754(brip1)

GACU:

117556319(brip1)

EMAC:

134880821(brip1)

ELY:	117259301(brip1)

EFO:	125889074(brip1)

PLEP:

121943759(brip1)

SLUC:

116040199(brip1)

ECRA:

117942023(brip1)

ESP:	116678258(brip1)

PFLV:

114552466(brip1)

GAT:	120821589(brip1)

PPUG:

119218783(brip1)

AFB:	129092966(brip1)

CLUM:

117728291(brip1)

PSWI:

130210377(brip1)

MSAM:

119883109(brip1)

SCHU:

122878691(brip1)

CUD:	121515173(brip1)

ALAT:

119005968(brip1)

MZE:	101480812(brip1)

ONL:	100696387(brip1)

OAU:	116311449(brip1)

OLA:	101173242(brip1)

OML:	112136435(brip1)

CSAI:

133441417(brip1)

XMA:	102233000(brip1)

XCO:	114133435(brip1)

XHE:	116707746(brip1)

PRET:

103474333(brip1)

PFOR:

103147298(brip1)

PLAI:

106956999(brip1)

PMEI:

106912054 106927771(brip1)

GAF:	122832688(brip1)

PPRL:

129369978(brip1)

CVG:

107091205

CTUL:

119796194(brip1)

GMU:	124884754(brip1)

NFU:	107380728(brip1)

KMR:	108239338(brip1)

ALIM:

106536121(brip1)

NWH:	119410829(brip1)

AOCE:

111581228(brip1)

MCEP:

125013593(brip1)

CSEM:

103377753(brip1)

POV:	109640113(brip1)

SSEN:

122773951(brip1)

HHIP:

117773397(brip1)

HSP:	118106305(brip1)

SMAU:

118299103(brip1)

LCF:

108900170

SDU:	111226296(brip1)

SLAL:

111665473(brip1)

XGL:	120791865(brip1)

HCQ:	109523864(brip1)

SSCV:

125972195

SBIA:

133504479(brip1)

PEE:	133405020(brip1)

PTAO:

133482200(brip1)

BPEC:

110164196(brip1)

MALB:

109969729(brip1)

BSPL:

114868376(brip1)

SJO:	128360471(brip1)

SASA:

106580998(brip1)

STRU:

115163321(brip1)

OTW:	112234731(brip1)

OMY:	110507673(brip1)

OGO:

123992813

ONE:	115136832(brip1)

OKI:	109905644(brip1)

OKE:

118397386

SALP:

111949483(brip1)

SNH:	120018573(brip1)

CCLU:

121566706(brip1)

ELS:	105009514(brip1)

SFM:	108932148(brip1)

PKI:	111849998(brip1)

AANG:

118208922(brip1)

LOC:	102684622(brip1)

PSPA:

121308803(brip1)

ARUT:

117429702 117964243

PSEX:

120531373(brip1)

LCM:	102358812(BRIP1)

CMK:	103180691(brip1)

CPLA:

122563895(brip1)

HOC:	132830303(brip1)

LERI:

129710585(brip1)

PMRN:

116950089(BRIP1)

LRJ:	133348990(BRIP1) 133362877

BFO:	118408298 118425595

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206925

BANY:

MJU:

VCD:

PMAC:

PPOT:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

HVI:

MQU:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110843548 110847580

DPX:	DAPPUDRAFT_311920 DAPPUDRAFT_48831

DMK:

116931252

DPZ:

124348852

PVM:	113819227 113819229

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

SDM:

LPOL:

CEL:	CELE_F33H2.1(dog-1)

CBR:	CBG_19723(Cbr-dog-1)

CRQ:	GCK72_001434

BMY:	BM_BM3807(Bma-dog-1)

LOA:	LOAG_17811

TSP:	Tsp_00165 Tsp_11487 Tsp_12342

HRO:	HELRODRAFT_189813

LGI:	LOTGIDRAFT_144987

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:	106150963 106168985

SMM:	Smp_173440

OVI:	T265_15689

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_30066

AQU:

100635447

ATH:	AT1G20720 AT1G20750

ALY:	9326467 9326469

CRB:

17897868

CSAT:

104743419 104756426 104759314 104776193

EUS:	EUTSA_v10006615mg EUTSA_v10009302mg

BRP:	103838057 103872859

BNA:	106368833 106421240 106449238 111198597

BOE:	106296181 106316568

RSZ:	108813429 108825146 108825148

THJ:

104811474

CPAP:

110818216

CIT:

102620438

CIC:	CICLE_v100000451m

PVY:	116112672 116128506

MINC:

123229735

TCC:

18591724

GRA:

105768773

GHI:	107905720 107905758

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_001G000600g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:	101488528 101497364

PSAT:

127092709

VVO:

131596715

LJA:	Lj5g3v0279130.2(Lj5g3v0279130.2) Lj5g3v0279130.3(Lj5g3v0279130.3)

ADU:

AIP:

AHF:

LANG:

PCIN:

QSA:	O6P43_018779

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:	101217839 101218075

CMO:	103493823 103493825

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107767657 107816608

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:	110866004 110945115

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110685509 110711110

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os09t0551800-00(Os09g0551800)

OBR:

OGL:

BDI:

ATS:

TDC:	119302829 119311518

TAES:

123104739 123113021 123122537

TUA:

125510367

LPER:

127302881

LRD:	124653429 124657509

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121971371 121976294

DCT:

110101508

PEQ:	110019715 110022112

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_408754

PPP:

112287422

CRE:	CHLRE_09g397350v5

VCN:	VOLCADRAFT_96085

MNG:

MNEG_3590

CSL:	COCSUDRAFT_58290

CVR:	CHLNCDRAFT_57565

APRO:

F751_0413

OLU:	OSTLU_32894 OSTLU_37445

OTA:	OT_ostta04g00700 OT_ostta08g00240

BPG:	Bathy18g00670

MIS:	MICPUN_59626

CME:	CYME_CMD129C

GSL:	Gasu_32920

CCP:	CHC_T00002363001

MBR:	MONBRDRAFT_26081

SRE:	PTSG_09876

DDI:	DDB_G0286621(BRIP1)

DPP:	DICPUDRAFT_5561

DFA:	DFA_06937(BRIP1)

FCY:	FRACYDRAFT_236571

TPS:	THAPSDRAFT_5916

PIF:	PITG_15820 PITG_17950

PSOJ:

PHYSODRAFT_330481 PHYSODRAFT_554000

SPAR:

SPRG_08149

GTT:	GUITHDRAFT_111516

TVA:	TVAG_2v0079290

» show all

Reference

PMID:14983014

Authors

Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM

Title

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.

Journal

Proc Natl Acad Sci U S A 101:2357-62 (2004)
DOI:10.1073/pnas.0308717101

Sequence

[hsa:83990]

Reference

PMID:16116421

Authors

Bridge WL, Vandenberg CJ, Franklin RJ, Hiom K

Title

The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.

Journal

Nat Genet 37:953-7 (2005)
DOI:10.1038/ng1627

Sequence

[hsa:83990] [gga:417642]

LinkDB

DBGET integrated database retrieval system