KEGG ORTHOLOGY: K15685

ORTHOLOGY: K15685

Entry

K15685                      KO

Symbol

CBLL1

Name

E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
   04131 Membrane trafficking
    K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
   04121 Ubiquitin system
    K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA processing factors
   3' end processing
    N6-methyltransferase complex
     K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K15685  CBLL1; E3 ubiquitin-protein ligase Hakai
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K15685  CBLL1; E3 ubiquitin-protein ligase Hakai

Genes

HSA:	79872(CBLL1)

PTR:	472482(CBLL1)

PPS:	100994226(CBLL1)

GGO:	101132320(CBLL1)

PON:	100461624(CBLL1)

NLE:	100596656(CBLL1)

HMH:	116814235(CBLL1)

MCC:	699980(CBLL1)

MCF:	101866734(CBLL1)

MTHB:

126951234

MNI:	105475303(CBLL1)

CSAB:

103226720(CBLL1)

CATY:

105583140(CBLL1)

PANU:

101025451(CBLL1)

TGE:	112621146(CBLL1)

MLEU:

105544092(CBLL1)

RRO:	104677413(CBLL1)

RBB:	108540482(CBLL1)

TFN:	117073582(CBLL1)

PTEH:

111520414(CBLL1)

CANG:

105516119(CBLL1)

CJC:	100399104(CBLL1)

SBQ:	101051646(CBLL1)

CIMI:

108316758(CBLL1)

CSYR:

103254411(CBLL1)

MMUR:

105860927(CBLL1)

LCAT:

123647715(CBLL1)

PCOQ:

105815222(CBLL1)

OGA:	100944885(CBLL1)

MMU:	104836(Cbll1)

MCAL:

110307381(Cbll1)

MPAH:

110324527(Cbll1)

RNO:	314028(Cbll1)

MCOC:

116079767(Cbll1)

ANU:	117716965(Cbll1)

MUN:	110558986(Cbll1)

CGE:	100758211(Cbll1)

MAUA:

101825645(Cbll1)

PROB:

127214864(Cbll1)

PLEU:

114708459(Cbll1)

MORG:

121452475(Cbll1)

MFOT:

126488667

AAMP:

119818950(Cbll1)

NGI:	103732171(Cbll1)

HGL:	101701435(Cbll1)

CPOC:

100718115(Cbll1)

CCAN:

109691672(Cbll1)

DORD:

105999672(Cbll1)

DSP:	122111823(Cbll1)

PLOP:

125346883(Cbll1)

NCAR:

124990248

MMMA:

107144540(Cbll1)

OCU:

100358420

OPI:	101532662(CBLL1)

TUP:	102471629(CBLL1) 102497087

GVR:	103586178(CBLL1)

CFA:	483262(CBLL1)

CLUD:

112661507(CBLL1)

VVP:	112908584(CBLL1)

VLG:	121471451(CBLL1)

NPO:	129494124(CBLL1)

AML:	100471827(CBLL1)

UMR:	103674623(CBLL1)

UAH:	113258531(CBLL1)

UAR:	123789406(CBLL1)

ELK:

111155306

LLV:

125080718

MPUF:

101676237(CBLL1)

MNP:	132016042(CBLL1)

MLK:	131822130(CBLL2) 131829239(CBLL1)

NVS:	122904699(CBLL1)

ORO:	101384003(CBLL1)

EJU:	114201699(CBLL1)

ZCA:	113911579(CBLL1)

MLX:	118020614(CBLL1)

NSU:	110574262(CBLL1)

LWW:	102743438(CBLL1)

FCA:	101094835(CBLL1)

PYU:	121028893(CBLL1)

PCOO:

112866737(CBLL1)

PBG:	122487739(CBLL1)

PVIV:

125159546(CBLL1)

LRUF:

124523318

PTG:	102955124(CBLL1)

PPAD:

109268060(CBLL1)

PUC:

125930757

AJU:

106980670

HHV:	120241858(CBLL1)

BTA:	524139(CBLL1)

BOM:	102274390(CBLL1)

BIU:	109557391(CBLL1)

BBUB:

102390915(CBLL1)

BBIS:

104989708(CBLL1)

CHX:	102175647(CBLL1)

OAS:	101104902(CBLL1)

BTAX:

128046652(CBLL1)

ODA:	120878190(CBLL1)

CCAD:

122438316(CBLL1)

MBEZ:

129552402(CBLL1)

SSC:	100623482(CBLL1)

CFR:	102523002(CBLL1)

CBAI:

105063031(CBLL1)

CDK:	105093040(CBLL1)

VPC:	102540113(CBLL1) 102542255

BACU:

103008346(CBLL1)

BMUS:

118888960(CBLL2) 118900966(CBLL1)

LVE:	103083312(CBLL1)

OOR:	101279605(CBLL1)

DLE:	111167530(CBLL2) 111184470(CBLL1)

PCAD:

102985032(CBLL1) 102987573(CBLL2)

PSIU:

116747804(CBLL2) 116759576(CBLL1)

NASI:

112397929(CBLL1)

ECB:	100050845(CBLL1) 100059563(ZNF645)

EPZ:	103558972(CBLL1)

EAI:	106825200(CBLL2) 106825227(CBLL1)

MYB:	102249676(CBLL1) 106726866(ZNF645)

MYD:	102775486(CBLL1)

MMYO:

118665988(CBLL1)

MLF:	102436220(CBLL1) 111825286(CBLL2)

PKL:	118714435(CBLL1)

EFUS:

103293720(CBLL1) 114227398(CBLL2)

MNA:	107526617(CBLL1)

DRO:	112302976(CBLL1)

SHON:

118987267(CBLL2) 119000737(CBLL1)

AJM:	119053042(CBLL1)

PDIC:

114507501(CBLL1)

PHAS:

123811368(CBLL1)

MMF:	118620025(CBLL1)

PPAM:

129063539(CBLL1)

HAI:	109372676(CBLL1)

RFQ:	117012259(CBLL1)

PALE:

102882366(CBLL1)

PGIG:

120591816(CBLL1)

PVP:	105300323(CBLL1)

RAY:	107501117(CBLL1)

MJV:	108398224(CBLL1)

TOD:	119245513(CBLL1)

SARA:

101537790(CBLL1)

SETR:

126022433(CBLL1)

LAV:	100657847(ZNF645) 100674991(CBLL1)

TMU:

101352555

ETF:	101648033(CBLL1)

DNM:	101417360(ZNF645)

MDO:	100010322(CBLL1) 103093274

GAS:	123249078(CBLL1) 123253497

SHR:	100926768(CBLL1)

AFZ:

127564817

PCW:	110207014(CBLL1)

OAA:	100078402(CBLL1)

GGA:	417701(CBLL1)

PCOC:

116232926(CBLL1)

MGP:	100548470(CBLL1)

CJO:	107307957(CBLL1)

TPAI:

128079681(CBLL1)

LMUT:

125693567(CBLL1)

NMEL:

110392385(CBLL1)

APLA:

101798354(CBLL1)

ACYG:

106042037(CBLL1)

CATA:

118249480(CBLL1)

AFUL:

116502184(CBLL1)

TGU:	100228392(CBLL1)

LSR:	110475189(CBLL1)

SCAN:

103813512(CBLL1)

PMOA:

120498138(CBLL1)

OTC:	121336384(CBLL1)

PRUF:

121357400(CBLL1)

GFR:	102036033(CBLL1)

FAB:	101809231(CBLL1)

OMA:	130264920(CBLL1)

PHI:	102104326(CBLL1)

PMAJ:

107205087(CBLL1)

CCAE:

111923006(CBLL1)

CCW:	104686920(CBLL1)

CBRC:

103623468(CBLL1)

ETL:	114060542(CBLL1)

ZAB:	102060790(CBLL1)

SVG:	106848824(CBLL1)

MMEA:

130572686(CBLL1)

HRT:	120752015(CBLL1)

FPG:	101924639(CBLL1)

FCH:	102054474(CBLL1)

CLV:	102095736(CBLL1)

EGZ:	104123790(CBLL1)

NNI:	104010801(CBLL1)

PCRI:

104024757(CBLL1)

PLET:

104614402(CBLL1)

EHS:	104513943(CBLL1)

PCAO:

104039853(CBLL1)

ACUN:

113491361(CBLL1)

TALA:

104355908(CBLL1)

PADL:

103920605(CBLL1)

AFOR:

103907003(CBLL1)

ACHC:

115341471(CBLL1)

HALD:

104316319(CBLL1)

HLE:	104840264(CBLL1)

AGEN:

126044482

GCL:

127029586

CCRI:

104168631(CBLL1)

CMAC:

104481963(CBLL1)

MUI:	104541470(CBLL1)

BREG:

104635205(CBLL1)

FGA:	104081935(CBLL1)

GSTE:

104251161(CBLL1)

LDI:	104343950(CBLL1)

MNB:	103779588(ZNF645)

OHA:	104328740(CBLL1)

NNT:	104404431(CBLL1)

SHAB:

115605345(CBLL1)

DPUB:

104308929(CBLL1)

PGUU:

104458551(CBLL1)

ACAR:

104529667(CBLL1)

CPEA:

104387972(CBLL1)

AVIT:

104271948(CBLL1)

CVF:	104291608(CBLL1)

RTD:	128914255(CBLL1)

CUCA:

104056064(CBLL1)

TEO:	104377481(CBLL1)

BRHI:

104488169(CBLL1)

AAM:	106487757(CBLL1)

AROW:

112971033(CBLL1)

NPD:	112953374(CBLL1)

TGT:	104567984(CBLL1)

DNE:	112980491(CBLL1)

SCAM:

104138387(CBLL1)

ASN:	102379440(CBLL1)

AMJ:	102575587(CBLL1)

CPOO:

109315716(CBLL1)

GGN:	109292128(CBLL1)

PSS:	102458193(CBLL1)

CMY:	102930370(CBLL1)

CCAY:

125630413(CBLL1)

DCC:	119857390(CBLL1)

CPIC:

101943753(CBLL1)

TST:	117875432(CBLL1)

CABI:

116838636(CBLL1)

MRV:	120392103(CBLL1)

ACS:	100554749(cbll1)

ASAO:

132776576(CBLL1)

PVT:	110089786(CBLL1)

SUND:

121931016(CBLL1)

PBI:	103059396(CBLL1)

PMUR:

107298717(CBLL1)

CTIG:

120313015(CBLL1)

TSR:	106546141(CBLL1)

PGUT:

117675194(CBLL1)

APRI:

131202635(CBLL1)

PTEX:

113436715(CBLL1)

NSS:	113418355(CBLL1)

VKO:	123020023(CBLL1)

PMUA:

114605682(CBLL1)

PRAF:

128422299(CBLL1)

ZVI:	118090608(CBLL1)

HCG:	128326353(CBLL1)

GJA:	107105978(CBLL1)

STOW:

125435778(CBLL1)

EMC:	129335881(CBLL1)

XLA:	100101300(cbll1.L) 734524(cbll1.S)

XTR:	100170461(cbll1)

NPR:	108789319 108789328

RTEM:

120936479

BBUF:

120982687(CBLL1)

BGAR:

122927888(CBLL1)

MUO:	115478916 115478923

GSH:	117366807(CBLL1)

DRE:	100002706 394041(cbll1)

SRX:	107716693 107725636 107733012 107753561

SANH:

107661492 107664884 107678304 107695901

SGH:	107553882 107574381 107590361 107590816

CCAR:

109067877 109082508

CAUA:

113043312 113048123 113063249 113066890

CGIB:

127946866 127956744 127974451 128014002

PTET:

122330341 122343499(cbll1)

LROH:

127157148 127164372(cbll1)

OMC:	131534974 131539663(cbll1)

PPRM:

120469121 120476987(cbll1)

RKG:	130072279(cbll1) 130085380

MAMB:

125245531(cbll1) 125247505

CIDE:

127507317 127511381

MASI:

127434891 127435965 127436868 127437494

TROS:

130548173(cbll1) 130552317

TDW:	130414424 130420958(cbll1)

MANU:

129432342(cbll1) 129433941

IPU:	108269280 108279897

IFU:	128611814 128623321(cbll1)

PHYP:

113529214 113532353

SMEO:

124386506 124401840(cbll1)

TFD:	113635579 113645746(cbll1)

TVC:	132856258 132858993(cbll1)

AMEX:

103031106 103041099

CMAO:

118806785 118812474(cbll1)

EEE:	113572521 113579742

CHAR:

105913357 122130321(cbll1)

TRU:	101066014(cbll1)

TFS:	130519062(cbll1)

TNG:	GSTEN00038868G001

LCO:	104923753(cbll1)

NCC:	104953214(cbll1)

TBEN:

117483063(cbll1)

CGOB:

115028597(cbll1)

PGEO:

117439045(cbll1)

GACU:

117553139(cbll1)

EMAC:

134879199

ELY:	117249207(cbll1)

EFO:	125883149(cbll1)

PLEP:

121961307(cbll1) 121963498

SLUC:

116054595(cbll1)

ECRA:

117939984

ESP:

116677630

PFLV:

114550575(cbll1)

GAT:

120817495

PPUG:

119211472(cbll1)

AFB:

129112449

CLUM:

117726532(cbll1)

PSWI:

130200490

MSAM:

119917933(cbll1)

SCHU:

122871650

CUD:	121505288(cbll1)

ALAT:

119032808(cbll1)

MZE:	101480688(cbll1)

ONL:

100707368

OAU:	116317364(cbll1)

OLA:	105357056(cbll1)

OML:	112154565(cbll1)

CSAI:

133424114(cbll1)

XMA:	102236932(cbll1)

XCO:	114160896(cbll1)

XHE:	116737047(cbll1)

PRET:

103459706(cbll1)

PFOR:

103151782(cbll1)

PLAI:

106960213(cbll1)

PMEI:

106926619(cbll1)

GAF:	122826506(cbll1)

PPRL:

129376085(cbll1)

CVG:

107080727

CTUL:

119775061

GMU:	124883309(cbll1)

NFU:	107383321(cbll1)

KMR:	108250964(cbll1)

ALIM:

106525782(cbll1)

NWH:	119428166(cbll1)

AOCE:

111579284(cbll1)

MCEP:

125000124(cbll1)

CSEM:

103382988

POV:	109637497(cbll1)

SSEN:

122766011(cbll1)

HHIP:

117757405(cbll1)

HSP:

118101843

SMAU:

118301250(cbll1)

LCF:

108897445

SDU:	111224951(cbll1)

SLAL:

111665419(cbll1)

XGL:	120797293(cbll1)

HCQ:	109513515(cbll1)

SSCV:

125992269

SBIA:

133493698(cbll1)

PEE:

133396950

PTAO:

133472044

BPEC:

110172370(cbll1)

MALB:

109960966

BSPL:

114862791(cbll1)

SJO:	128385284(cbll1)

SASA:

100380279(hakai) 106576238 106609367

STRU:

115180272 115197343 115198898

OTW:	112216965 112218700

OMY:	110490389(cbll1) 110497501 110501036

OGO:

124035352

ONE:	115107035 115133063 115134132

OKI:	109864345 109867543 109896696(cbll1)

OKE:	118366307 118392437

SALP:

111949520 111951533 111962471

SNH:	120031949 120049927 120066744 120066745

CCLU:

121531427 121543543 121548685

ELS:	105020222(cbll1)

SFM:	108931666(cbll1)

PKI:	111838513 111853404

AANG:

118218724 118232437(cbll1)

LOC:	102693893(cbll1)

PSPA:

121318305 121319805

ARUT:

117415032 117419559

PSEX:

120534562(cbll1)

LCM:	102356792(CBLL1)

CMK:	103189346(cbll1)

RTP:	109921188(cbll1)

CPLA:

122563778(cbll1)

HOC:	132826966(cbll1)

LERI:

129707624

PMRN:

116952685

LRJ:	133356663(CBLL1)

BFO:

118416852

BBEL:

109469322

CIN:	100170062(zf(ring/c2h2)-1)

SCLV:

120339336

APLC:

110974302

SKO:

102801493

DME:	Dmel_CG10263(Hakai)

DER:

6549086

DSE:

6614722

DSI:	Dsimw501_GD21743(Dsim_GD21743)

DYA:	Dyak_GE12638

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17246

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ015415

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:	103576314 106694059

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205847A KGM_205847B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105383393 105386906

PGW:

CFEL:

CCRN:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128994488 128994489

PHU:	Phum_PHUM137340

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135199904 135200007

HAZT:

108678097

LSM:

121122601

TCF:

131888808

PPOI:

119091233 119107484 119107922

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

LAK:

SMM:	Smp_196220

OVI:	T265_10724

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114530603 114544455

XEN:

HMG:

AQU:

ATH:

ALY:

CRB:

CSAT:

104708959 104734191 104768353

EUS:	EUTSA_v10014073mg

BRP:

103847493

BNA:

106435883

BOE:

106313203

RSZ:	108818049 130509835

THJ:

104827038

CPAP:

110825960

CIT:

102607549

CIC:	CICLE_v10011563mg

PVY:	116107590 116134562

MINC:

123202447 123228406

TCC:

18597612

GRA:	105779872 105799918

GHI:	107890984 107899032 107913704 107948863

GAB:	108454322 108459409

HSYR:

120135439 120198584 120199814

DZI:	111294522 111296723 111312015

EGR:

104435456

GMX:	100803063 100817582

GSJ:	114396748 114419019

PVU:	PHAVU_008G108800g

VRA:	106763604 106765858

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:	25498267 25498704

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj3g3v1403950.1(Lj3g3v1403950.1)

ADU:

107484823

AIP:

107639505

AHF:	112743585 112796962

LANG:

109325215 109352625 109359318

PCIN:

129288100

QSA:	O6P43_016664 O6P43_026416

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103423473 103433560

MSYL:

126593947 126617882

PXB:	103949442 103959600

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110643782 110652033

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	119990574 119998767

VVI:

VRI:

SLY:

SPEN:

SOT:	102582158 102601461

SSTN:

SDUL:

CANN:

LBB:

NTA:	107801265 107805152

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:	111365702 111403286

EGT:

105953027

SSPL:

121769378 121770594 121772472 121777594

SMIL:

131001588

SHIS:

125200682 125216084

APAN:

127252217

HAN:	110898821 110901044 110902800

ECAD:

122581690

LSV:

111890640

CCAV:

112525811

DCR:	108205644 108208516

CSIN:

114294682

RVL:

131326763

AEW:	130764166 130794287

BVG:

104894717

SOE:

110784389

CQI:	110733109 110734350

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os10t0494500-01(Os10g0494500)

OBR:

102703342

OGL:

127786310

BDI:

100832672

ATS:	109740954 109770048

TDC:	119270139 119334190

TAES:

123046895 123122346 123181046 123181163

TUA:

LPER:

LRD:

SBI:

ZMA:	100274384 100274553

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:	105042830 105055479

MUS:	103978247 103982979

ZOF:	121971405 121980969 122030015 122038041

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

PPP:	112273492 112275645 112285822

CRE:	CHLRE_05g234658v5

» show all

Reference

PMID:11836526

Authors

Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J, Sommer T, Birchmeier W

Title

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.

Journal

Nat Cell Biol 4:222-31 (2002)
DOI:10.1038/ncb758

Sequence

[mmu:104836]

LinkDB

DBGET integrated database retrieval system