KEGG   NETWORK: N01592
Entry
N01592                      Network                                
Name
GF-RTK-RAS-ERK signaling pathway
Definition
GF -> RTK -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(1950,7039,2069,374,2246,2247,2248,2249,8822,2251,2252,2253,2254,2255,8823,2250,8817,26281,27006,9965,26291,8074,4803,627,4908,4909,3630,3479,3481,5154,5155,56034,80310,1435,4254,2323,7422,7423,5228,7424,2277,3082,284,285,51378,1942,1943,1944,1945,1946,2668,4902,9048,5623) -> (1956,2064,2065,2066,2260,2263,2261,2264,4804,4914,4915,3643,3480,5156,5159,1436,3815,2322,2321,2324,3791,4233,7010,1969,5979) -> (2260,2263,2261,2264) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06526 MAPK signaling
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
1950  EGF; epidermal growth factor
7039  TGFA; transforming growth factor alpha
2069  EREG; epiregulin
374  AREG; amphiregulin
2246  FGF1; fibroblast growth factor 1
2247  FGF2; fibroblast growth factor 2
2248  FGF3; fibroblast growth factor 3
2249  FGF4; fibroblast growth factor 4
8822  FGF17; fibroblast growth factor 17
2251  FGF6; fibroblast growth factor 6
2252  FGF7; fibroblast growth factor 7
2253  FGF8; fibroblast growth factor 8
2254  FGF9; fibroblast growth factor 9
2255  FGF10; fibroblast growth factor 10
8823  FGF16; fibroblast growth factor 16
2250  FGF5; fibroblast growth factor 5
8817  FGF18; fibroblast growth factor 18
26281  FGF20; fibroblast growth factor 20
27006  FGF22; fibroblast growth factor 22
9965  FGF19; fibroblast growth factor 19
26291  FGF21; fibroblast growth factor 21
8074  FGF23; fibroblast growth factor 23
4803  NGF; nerve growth factor
627  BDNF; brain derived neurotrophic factor
4908  NTF3; neurotrophin 3
4909  NTF4; neurotrophin 4
3630  INS; insulin
3479  IGF1; insulin like growth factor 1
3481  IGF2; insulin like growth factor 2
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
56034  PDGFC; platelet derived growth factor C
80310  PDGFD; platelet derived growth factor D
1435  CSF1; colony stimulating factor 1
4254  KITLG; KIT ligand
2323  FLT3LG; fms related receptor tyrosine kinase 3 ligand
7422  VEGFA; vascular endothelial growth factor A
7423  VEGFB; vascular endothelial growth factor B
5228  PGF; placental growth factor
7424  VEGFC; vascular endothelial growth factor C
2277  VEGFD; vascular endothelial growth factor D
3082  HGF; hepatocyte growth factor
284  ANGPT1; angiopoietin 1
285  ANGPT2; angiopoietin 2
51378  ANGPT4; angiopoietin 4
1942  EFNA1; ephrin A1
1943  EFNA2; ephrin A2
1944  EFNA3; ephrin A3
1945  EFNA4; ephrin A4
1946  EFNA5; ephrin A5
2668  GDNF; glial cell derived neurotrophic factor
4902  NRTN; neurturin
9048  ARTN; artemin
5623  PSPN; persephin
1956  EGFR; epidermal growth factor receptor
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
2065  ERBB3; erb-b2 receptor tyrosine kinase 3
2066  ERBB4; erb-b2 receptor tyrosine kinase 4
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2261  FGFR3; fibroblast growth factor receptor 3
2264  FGFR4; fibroblast growth factor receptor 4
4804  NGFR; nerve growth factor receptor
4914  NTRK1; neurotrophic receptor tyrosine kinase 1
4915  NTRK2; neurotrophic receptor tyrosine kinase 2
3643  INSR; insulin receptor
3480  IGF1R; insulin like growth factor 1 receptor
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
1436  CSF1R; colony stimulating factor 1 receptor
3815  KIT; KIT proto-oncogene, receptor tyrosine kinase
2322  FLT3; fms related receptor tyrosine kinase 3
2321  FLT1; fms related receptor tyrosine kinase 1
2324  FLT4; fms related receptor tyrosine kinase 4
3791  KDR; kinase insert domain receptor
4233  MET; MET proto-oncogene, receptor tyrosine kinase
7010  TEK; TEK receptor tyrosine kinase
1969  EPHA2; EPH receptor A2
5979  RET; ret proto-oncogene
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
PMID:17409820
  Authors
Molina JR, Adjei AA
  Title
The Ras/Raf/MAPK pathway.
  Journal
J Thorac Oncol 1:7-9 (2006)
DOI:10.1016/S1556-0864(15)31506-9
Reference
PMID:31652660
  Authors
Braicu C, Buse M, Busuioc C, Drula R, Gulei D, Raduly L, Rusu A, Irimie A, Atanasov AG, Slaby O, Ionescu C, Berindan-Neagoe I
  Title
A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer.
  Journal
Cancers (Basel) 11:cancers11101618 (2019)
DOI:10.3390/cancers11101618
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