KEGG   PATHWAY: amex00310
Entry
amex00310                   Pathway                                
Name
Lysine degradation - Astyanax mexicanus (Mexican tetra)
Class
Metabolism; Amino acid metabolism
Pathway map
amex00310  Lysine degradation
amex00310

Module
amex_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:amex00310]
Other DBs
GO: 0006554
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103040216  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X2 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
103034062  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103040807  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
103041509  dhtkd1; 2-oxoadipate dehydrogenase complex component E1 [KO:K15791] [EC:1.2.4.-]
103029866  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
103031703  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
103031580  gcdhb; glutaryl-CoA dehydrogenase b [KO:K00252] [EC:1.3.8.6]
103046024  hadhaa; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a [KO:K07515] [EC:4.2.1.17 1.1.1.211]
103035446  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
103032907  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
103039905  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
103033308  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
103040735  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
103038320  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
103024473  hykk.2; hydroxylysine kinase isoform X2 [KO:K18201] [EC:2.7.1.81]
103047782  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
103026319  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
103032177  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
103035686  kmt2a; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
103042576  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
103033881  kmt2ca; histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
103041268  kmt2cb; histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
103022217  kmt2bb; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
103038810  kmt2e; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
103026160  setd1bb; histone-lysine N-methyltransferase SETD1B-A [KO:K11422] [EC:2.1.1.354]
103040137  setd1a; histone-lysine N-methyltransferase SETD1A [KO:K11422] [EC:2.1.1.354]
103032383  setd1ba; histone-lysine N-methyltransferase SETD1B-A isoform X1 [KO:K11422] [EC:2.1.1.354]
103021629  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
103033426  prdm9; histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
103042434  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
103022779  ash1l; histone-lysine N-methyltransferase ASH1L [KO:K06101] [EC:2.1.1.354]
103036607  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
103027211  smyd2b; N-lysine methyltransferase SMYD2-B isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
103044252  smyd1b; histone-lysine N-methyltransferase SMYD1b isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
103040106  smyd2a; N-lysine methyltransferase SMYD2-A [KO:K11426] [EC:2.1.1.354 2.1.1.357]
103034071  smyd1a; histone-lysine N-methyltransferase SMYD1a [KO:K11426] [EC:2.1.1.354 2.1.1.357]
103040252  suv39h1a; histone-lysine N-methyltransferase SUV39H1-A [KO:K11419] [EC:2.1.1.355]
103041908  suv39h1b; histone-lysine N-methyltransferase SUV39H1b [KO:K11419] [EC:2.1.1.355]
103023298  ehmt1a; histone-lysine N-methyltransferase EHMT1a [KO:K11420] [EC:2.1.1.355]
103025689  ehmt1b; histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
103023021  histone-lysine N-methyltransferase EHMT2-like [KO:K11420] [EC:2.1.1.355]
125790042  histone-lysine N-methyltransferase EHMT2-like [KO:K11420] [EC:2.1.1.355]
103028156  setdb1a; histone-lysine N-methyltransferase SETDB1-A isoform X1 [KO:K11421] [EC:2.1.1.366]
103045481  setdb2; histone-lysine N-methyltransferase SETDB2 [KO:K18494] [EC:2.1.1.355]
103034196  prdm2a; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
103025355  prdm2b; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
103044086  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
103027230  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
103031955  setmar; histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
103039586  nsd1b; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
103025117  nsd1a; histone-lysine N-methyltransferase, H3 lysine-36 specific [KO:K15588] [EC:2.1.1.357]
103021320  nsd2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
103039344  setd2; histone-lysine N-methyltransferase SETD2 [KO:K11423] [EC:2.1.1.359]
103023208  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
103046457  kmt5aa; N-lysine methyltransferase KMT5A-A [KO:K11428] [EC:2.1.1.361]
111197404  kmt5ab; lysine methyltransferase 5Ab isoform X1 [KO:K11428] [EC:2.1.1.361]
103024833  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
125781346  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
125782436  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
125785953  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
125787564  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
125806109  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
103046528  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
103035158  kmt5b; histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
103025343  histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
103042447  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X13 [KO:K04462] [EC:2.1.1.367]
103028334  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X6 [KO:K22410] [EC:2.1.1.367]
103033955  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
103026903  aldh3a2a; aldehyde dehydrogenase family 3 member A2a [KO:K00128] [EC:1.2.1.3]
103027191  aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
103043579  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
103029711  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
103036383  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
103023076  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
125806057  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
103030022  bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
103030558  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X2 [KO:K00473] [EC:1.14.11.4]
103032474  plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
103037645  plod3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
103033940  colgalt1a; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
103038801  cercam; procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
103025748  colgalt1b; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
103024967  colgalt2a; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
103042875  colgalt2b; procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
amex00020  Citrate cycle (TCA cycle)
amex00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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