KEGG   Homo sapiens (human): 5290
Entry
5290              CDS       T01001                                 
Symbol
PIK3CA, CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06182  Shigella
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06325  Hormone/cytokine signaling
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06530  PI3K signaling
nt06533  Chemokine signaling
nt06537  TCR/BCR signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00266  EBV LMP2A to PI3K signaling pathway
N00267  HBV HBx to PI3K signaling pathway
N00272  HCV NS5A to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00485  EBV LMP1 to PI3K signaling pathway
N00501  HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00684  MV F/H to CD28-PI3K signaling pathway
N00736  IAV NS1 to PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
Disease
H00014  Non-small cell lung cancer
H00018  Gastric cancer
H00020  Colorectal cancer
H00027  Ovarian cancer
H00031  Breast cancer
H00048  Hepatocellular carcinoma
H00534  Cerebral cavernous malformation
H01222  Cowden syndrome
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01985  Desmoplastic small round cell tumor
H02153  Megalencephaly-capillary malformation syndrome
H02297  CLAPO syndrome
H02627  Epidermal nevus
H02647  Macrodactyly
Drug target
Alpelisib: D11011<US>
Apitolisib: D10543
Bimiralisib: D11440
Buparlisib (DG01823): D10584 D10609
Copanlisib (DG01926): D10797 D10798<US> D10867
Dactolisib (DG01826): D10552 D10616
Gedatolisib: D10635
Inavolisib: D11942
Leniolisib (DG02927): D11158
Omipalisib: D10718
Paxalisib: D11869
Pictilisib: D10189
Risovalisib (DG03302): D12836 D12837
Samotolisib: D11501
Taselisib: D11774
Voxtalisib: D11727
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5290 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    5290 (PIK3CA)
   04014 Ras signaling pathway
    5290 (PIK3CA)
   04015 Rap1 signaling pathway
    5290 (PIK3CA)
   04370 VEGF signaling pathway
    5290 (PIK3CA)
   04630 JAK-STAT signaling pathway
    5290 (PIK3CA)
   04668 TNF signaling pathway
    5290 (PIK3CA)
   04066 HIF-1 signaling pathway
    5290 (PIK3CA)
   04068 FoxO signaling pathway
    5290 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    5290 (PIK3CA)
   04072 Phospholipase D signaling pathway
    5290 (PIK3CA)
   04071 Sphingolipid signaling pathway
    5290 (PIK3CA)
   04024 cAMP signaling pathway
    5290 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    5290 (PIK3CA)
   04152 AMPK signaling pathway
    5290 (PIK3CA)
   04150 mTOR signaling pathway
    5290 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5290 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    5290 (PIK3CA)
   04218 Cellular senescence
    5290 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5290 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    5290 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5290 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5290 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    5290 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    5290 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    5290 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    5290 (PIK3CA)
   04660 T cell receptor signaling pathway
    5290 (PIK3CA)
   04662 B cell receptor signaling pathway
    5290 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    5290 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    5290 (PIK3CA)
   04670 Leukocyte transendothelial migration
    5290 (PIK3CA)
   04062 Chemokine signaling pathway
    5290 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5290 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    5290 (PIK3CA)
   04929 GnRH secretion
    5290 (PIK3CA)
   04915 Estrogen signaling pathway
    5290 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    5290 (PIK3CA)
   04917 Prolactin signaling pathway
    5290 (PIK3CA)
   04926 Relaxin signaling pathway
    5290 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    5290 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    5290 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5290 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5290 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    5290 (PIK3CA)
   04722 Neurotrophin signaling pathway
    5290 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5290 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    5290 (PIK3CA)
   04380 Osteoclast differentiation
    5290 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    5290 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    5290 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5290 (PIK3CA)
   05206 MicroRNAs in cancer
    5290 (PIK3CA)
   05205 Proteoglycans in cancer
    5290 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    5290 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    5290 (PIK3CA)
   05203 Viral carcinogenesis
    5290 (PIK3CA)
   05230 Central carbon metabolism in cancer
    5290 (PIK3CA)
   05231 Choline metabolism in cancer
    5290 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5290 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5290 (PIK3CA)
   05212 Pancreatic cancer
    5290 (PIK3CA)
   05225 Hepatocellular carcinoma
    5290 (PIK3CA)
   05226 Gastric cancer
    5290 (PIK3CA)
   05214 Glioma
    5290 (PIK3CA)
   05221 Acute myeloid leukemia
    5290 (PIK3CA)
   05220 Chronic myeloid leukemia
    5290 (PIK3CA)
   05218 Melanoma
    5290 (PIK3CA)
   05211 Renal cell carcinoma
    5290 (PIK3CA)
   05215 Prostate cancer
    5290 (PIK3CA)
   05213 Endometrial cancer
    5290 (PIK3CA)
   05224 Breast cancer
    5290 (PIK3CA)
   05222 Small cell lung cancer
    5290 (PIK3CA)
   05223 Non-small cell lung cancer
    5290 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5290 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    5290 (PIK3CA)
   05161 Hepatitis B
    5290 (PIK3CA)
   05160 Hepatitis C
    5290 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    5290 (PIK3CA)
   05164 Influenza A
    5290 (PIK3CA)
   05162 Measles
    5290 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    5290 (PIK3CA)
   05163 Human cytomegalovirus infection
    5290 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5290 (PIK3CA)
   05169 Epstein-Barr virus infection
    5290 (PIK3CA)
   05165 Human papillomavirus infection
    5290 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5290 (PIK3CA)
   05131 Shigellosis
    5290 (PIK3CA)
   05135 Yersinia infection
    5290 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    5290 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5290 (PIK3CA)
   05142 Chagas disease
    5290 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5290 (PIK3CA)
   05017 Spinocerebellar ataxia
    5290 (PIK3CA)
   05020 Prion disease
    5290 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5290 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    5290 (PIK3CA)
   05415 Diabetic cardiomyopathy
    5290 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5290 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    5290 (PIK3CA)
   04931 Insulin resistance
    5290 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5290 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5290 (PIK3CA)
   01524 Platinum drug resistance
    5290 (PIK3CA)
   01522 Endocrine resistance
    5290 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5290 (PIK3CA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5290 (PIK3CA)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5290 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 5290
NCBI-ProteinID: NP_006209
OMIM: 171834
HGNC: 8975
Ensembl: ENSG00000121879
UniProt: P42336 Q4LE51
Structure
LinkDB
Position
3:179148126..179240093
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagtcacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

KEGG   Homo sapiens (human): 207
Entry
207               CDS       T01001                                 
Symbol
AKT1, AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Name
(RefSeq) AKT serine/threonine kinase 1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220  PTEN-PIP3-AKT signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00342  MAGI-PTEN signaling pathway
N00355  PP2A-AKT signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01409  Metals to PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01657  GPCR-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
Disease
H00027  Ovarian cancer
H01222  Cowden syndrome
H01556  Meningioma
H01649  Schizophrenia
H02119  Proteus syndrome
Drug target
Afuresertib (DG01408): D10381 D10382
Capivasertib: D11371<JP/US>
Ipatasertib (DG02851): D10641 D11074
Miransertib (DG03026): D11409 D11508
Triciribine phosphate: D06221
Uprosertib: D10674
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    207 (AKT1)
   04012 ErbB signaling pathway
    207 (AKT1)
   04014 Ras signaling pathway
    207 (AKT1)
   04015 Rap1 signaling pathway
    207 (AKT1)
   04370 VEGF signaling pathway
    207 (AKT1)
   04371 Apelin signaling pathway
    207 (AKT1)
   04630 JAK-STAT signaling pathway
    207 (AKT1)
   04668 TNF signaling pathway
    207 (AKT1)
   04066 HIF-1 signaling pathway
    207 (AKT1)
   04068 FoxO signaling pathway
    207 (AKT1)
   04072 Phospholipase D signaling pathway
    207 (AKT1)
   04071 Sphingolipid signaling pathway
    207 (AKT1)
   04024 cAMP signaling pathway
    207 (AKT1)
   04022 cGMP-PKG signaling pathway
    207 (AKT1)
   04151 PI3K-Akt signaling pathway
    207 (AKT1)
   04152 AMPK signaling pathway
    207 (AKT1)
   04150 mTOR signaling pathway
    207 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    207 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    207 (AKT1)
   04218 Cellular senescence
    207 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    207 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    207 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    207 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    207 (AKT1)
   04613 Neutrophil extracellular trap formation
    207 (AKT1)
   04620 Toll-like receptor signaling pathway
    207 (AKT1)
   04625 C-type lectin receptor signaling pathway
    207 (AKT1)
   04660 T cell receptor signaling pathway
    207 (AKT1)
   04662 B cell receptor signaling pathway
    207 (AKT1)
   04664 Fc epsilon RI signaling pathway
    207 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    207 (AKT1)
   04062 Chemokine signaling pathway
    207 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    207 (AKT1)
   04922 Glucagon signaling pathway
    207 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    207 (AKT1)
   04920 Adipocytokine signaling pathway
    207 (AKT1)
   04929 GnRH secretion
    207 (AKT1)
   04915 Estrogen signaling pathway
    207 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    207 (AKT1)
   04917 Prolactin signaling pathway
    207 (AKT1)
   04926 Relaxin signaling pathway
    207 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    207 (AKT1)
   04919 Thyroid hormone signaling pathway
    207 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    207 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    207 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    207 (AKT1)
   04728 Dopaminergic synapse
    207 (AKT1)
   04722 Neurotrophin signaling pathway
    207 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    207 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    207 (AKT1)
   04213 Longevity regulating pathway - multiple species
    207 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    207 (AKT1)
   05205 Proteoglycans in cancer
    207 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    207 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    207 (AKT1)
   05230 Central carbon metabolism in cancer
    207 (AKT1)
   05231 Choline metabolism in cancer
    207 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    207 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    207 (AKT1)
   05212 Pancreatic cancer
    207 (AKT1)
   05225 Hepatocellular carcinoma
    207 (AKT1)
   05226 Gastric cancer
    207 (AKT1)
   05214 Glioma
    207 (AKT1)
   05221 Acute myeloid leukemia
    207 (AKT1)
   05220 Chronic myeloid leukemia
    207 (AKT1)
   05218 Melanoma
    207 (AKT1)
   05211 Renal cell carcinoma
    207 (AKT1)
   05215 Prostate cancer
    207 (AKT1)
   05213 Endometrial cancer
    207 (AKT1)
   05224 Breast cancer
    207 (AKT1)
   05222 Small cell lung cancer
    207 (AKT1)
   05223 Non-small cell lung cancer
    207 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    207 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    207 (AKT1)
   05161 Hepatitis B
    207 (AKT1)
   05160 Hepatitis C
    207 (AKT1)
   05164 Influenza A
    207 (AKT1)
   05162 Measles
    207 (AKT1)
   05168 Herpes simplex virus 1 infection
    207 (AKT1)
   05163 Human cytomegalovirus infection
    207 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    207 (AKT1)
   05169 Epstein-Barr virus infection
    207 (AKT1)
   05165 Human papillomavirus infection
    207 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    207 (AKT1)
   05131 Shigellosis
    207 (AKT1)
   05135 Yersinia infection
    207 (AKT1)
   05152 Tuberculosis
    207 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    207 (AKT1)
   05142 Chagas disease
    207 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    207 (AKT1)
   05017 Spinocerebellar ataxia
    207 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    207 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    207 (AKT1)
   05415 Diabetic cardiomyopathy
    207 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    207 (AKT1)
   04932 Non-alcoholic fatty liver disease
    207 (AKT1)
   04931 Insulin resistance
    207 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    207 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    207 (AKT1)
   01524 Platinum drug resistance
    207 (AKT1)
   01522 Endocrine resistance
    207 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    207 (AKT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     207 (AKT1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   207 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 PH_20 Seadorna_VP7 ABC1
Other DBs
NCBI-GeneID: 207
NCBI-ProteinID: NP_001014431
OMIM: 164730
HGNC: 391
Ensembl: ENSG00000142208
UniProt: P31749 B0LPE5
Structure
LinkDB
Position
14:complement(104769349..104795748)
AA seq 480 aa
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag
cggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgc
cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca
accgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttc
cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc
ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc
cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt
tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag
gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag
ctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga

KEGG   Homo sapiens (human): 5728
Entry
5728              CDS       T01001                                 
Symbol
PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
Name
(RefSeq) phosphatase and tensin homolog
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04115  p53 signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04510  Focal adhesion
hsa04931  Insulin resistance
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05222  Small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05230  Central carbon metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06166  Human papillomavirus (HPV)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06530  PI3K signaling
  Element
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00220  PTEN-PIP3-AKT signaling pathway
N00342  MAGI-PTEN signaling pathway
N00353  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00354  HPV E6 to PTEN-PIP3-AKT signaling pathway
N00502  HTLV-1 Tax to PTEN-PIP3-AKT signaling pathway
N01409  Metals to PI3K signaling pathway
Disease
H00013  Small cell lung cancer
H00024  Prostate cancer
H00026  Endometrial cancer
H00029  Vulvar cancer
H00031  Breast cancer
H00038  Melanoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H00539  PTEN hamartoma tumor syndrome
H01195  VACTERL/VATER association
H01222  Cowden syndrome
H01463  Mycosis fungoides
H01556  Meningioma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
H02723  Macrocephaly/autism syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5728 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    5728 (PTEN)
   04070 Phosphatidylinositol signaling system
    5728 (PTEN)
   04071 Sphingolipid signaling pathway
    5728 (PTEN)
   04151 PI3K-Akt signaling pathway
    5728 (PTEN)
   04150 mTOR signaling pathway
    5728 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5728 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    5728 (PTEN)
   04218 Cellular senescence
    5728 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5728 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5728 (PTEN)
   05206 MicroRNAs in cancer
    5728 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    5728 (PTEN)
   05230 Central carbon metabolism in cancer
    5728 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5728 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    5728 (PTEN)
   05214 Glioma
    5728 (PTEN)
   05218 Melanoma
    5728 (PTEN)
   05215 Prostate cancer
    5728 (PTEN)
   05213 Endometrial cancer
    5728 (PTEN)
   05224 Breast cancer
    5728 (PTEN)
   05222 Small cell lung cancer
    5728 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5728 (PTEN)
   05165 Human papillomavirus infection
    5728 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5728 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5728 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5728 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5728 (PTEN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5728 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     5728 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     5728 (PTEN)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    5728 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 5728
NCBI-ProteinID: NP_000305
OMIM: 601728
HGNC: 9588
Ensembl: ENSG00000171862
UniProt: P60484 F6KD01
Structure
LinkDB
Position
10:87863625..87971930
AA seq 403 aa
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1212 nt   +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatatgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

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