Entry Name mTOR signaling pathway - Ornithorhynchus anatinus (platypus)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Organism Ornithorhynchus anatinus (platypus) [GN:
oaa ]
Gene 100077778 SLC7A5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780 ]
100083164 SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995 ]
100073907 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
103168165 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
100073474 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
100092319 LAMTOR3; ragulator complex protein LAMTOR3 isoform X3 [KO:K04370 ]
100088085 RRAGD; LOW QUALITY PROTEIN: ras-related GTP-binding protein D [KO:K16186 ]
100087206 CASTOR1; LOW QUALITY PROTEIN: cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080 ]
100087258 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
100084914 DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402 ]
100084442 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
100091651 TELO2; LOW QUALITY PROTEIN: telomere length regulation protein TEL2 homolog [KO:K11137 ]
100075022 CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
100074527 GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064 ]
100084037 EIF4EBP1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
100082898 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
100090683 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259 ]
100090195 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
103167235 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
100077194 LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
100091980 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
100089867 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
100681615 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
100085735 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
100080187 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
100082075 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
103167126 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100086270 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100073788 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100074273 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100074806 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
100076178 RICTOR; rapamycin-insensitive companion of mTOR isoform X2 [KO:K08267 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related oaa04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
