KEGG   PATHWAY: oro04666
Entry
oro04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Odobenus rosmarus divergens (Pacific walrus)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
oro04666  Fc gamma R-mediated phagocytosis
oro04666

Other DBs
GO: 0006909
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101370467  uncharacterized protein LOC101370467 [KO:K06856]
101381082  high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101363133  low affinity immunoglobulin gamma Fc region receptor III-like isoform X2 [KO:K06463]
101376134  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
101383723  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
101383639  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101373095  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101381996  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
101365998  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101380728  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101378505  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101385728  PRKCD; protein kinase C delta type isoform X2 [KO:K06068] [EC:2.7.11.13]
101362539  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101377203  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101377493  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101374803  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101362322  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101386671  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101377812  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
101365583  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
101384348  MARCKSL1; MARCKS-related protein [KO:K13536]
101383564  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101369263  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101384673  PPAP2C; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
101378709  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
101370883  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
101376404  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101375807  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
101386060  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101380879  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101363254  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101376795  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101365742  GSN; gelsolin isoform X1 [KO:K05768]
101383540  SCIN; adseverin [KO:K05768]
101363849  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101366888  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101383637  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
101364638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101380859  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
101378347  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101382123  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101367986  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
101366512  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101385551  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
101371053  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101369225  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101364561  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101365594  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
105757069  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
101371741  ARPC5L; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101386265  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
101366585  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101366544  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101385830  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101381480  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
101367711  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101384867  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
101365642  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101373434  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
101365602  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
101378516  CFL1; cofilin-1 isoform X1 [KO:K05765]
101363414  CFL2; cofilin-2 isoform X1 [KO:K05765]
101371074  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101379866  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
101378646  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
101384359  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101369015  CRKL; crk-like protein [KO:K04438]
101384062  CRK; adapter molecule crk isoform X1 [KO:K04438]
101364900  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
101369552  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
101379622  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
101368583  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
101363428  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
101378132  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
101366414  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
101369662  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
101383652  LAT; linker for activation of T-cells family member 1 [KO:K07362]
101381055  DNM2; dynamin-2 isoform X3 [KO:K23484] [EC:3.6.5.5]
101365769  AMPH; amphiphysin isoform X1 [KO:K12562]
101369451  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
101386018  MYO10; unconventional myosin-X [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
oro04020  Calcium signaling pathway
oro04142  Lysosome
oro04144  Endocytosis
oro04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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