KEGG   PATHWAY: aam04142
Entry
aam04142                    Pathway                                
Name
Lysosome - Apteryx mantelli mantelli (North Island brown kiwi)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
aam04142  Lysosome
aam04142

Other DBs
GO: 0005764
Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106487926  TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
106497686  ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
106491100  ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
106488372  ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
106496253  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
106484535  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
106494469  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
106495921  ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
106482361  ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
106484922  ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
106496489  DMXL2; Dmx like 2 [KO:K24155]
106487108  WDR7; WD repeat domain 7 [KO:K24738]
106498006  NCOA7; nuclear receptor coactivator 7 [KO:K25442]
106497597  CTSA; cathepsin A [KO:K13289] [EC:3.4.16.5]
106483924  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
106491260  CTSC; cathepsin C [KO:K01275] [EC:3.4.14.1]
106496991  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
106484553  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
106488475  cathepsin E-A-like [KO:K01382] [EC:3.4.23.34]
106486400  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
106487037  CTSH; cathepsin H [KO:K01366] [EC:3.4.22.16]
106495413  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
106484150  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
106486603  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
106492078  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
106495149  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
106492788  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
106482935  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
106497748  tripeptidyl-peptidase 1-like [KO:K01279] [EC:3.4.14.9]
106484973  uncharacterized LOC106484973 [KO:K01189] [EC:3.2.1.22]
106484974  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
106488991  GLB1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]
106491310  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
106500263  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
106494328  GBA; glucosylceramidase beta [KO:K01201] [EC:3.2.1.45]
106497859  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
106482506  IDUA; iduronidase, alpha-L- [KO:K01217] [EC:3.2.1.76]
106488675  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
106491087  NAGLU; N-acetyl-alpha-glucosaminidase [KO:K01205] [EC:3.2.1.50]
106483066  GALC; galactosylceramidase [KO:K01202] [EC:3.2.1.46]
106495347  GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
106497902  FUCA2; fucosidase, alpha-L- 2, plasma [KO:K01206] [EC:3.2.1.51]
106493293  FUCA1; fucosidase, alpha-L- 1, tissue [KO:K01206] [EC:3.2.1.51]
106486111  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
106496006  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
106491981  MANBA; mannosidase beta [KO:K01192] [EC:3.2.1.25]
106498060  MAN2B1; mannosidase alpha class 2B member 1 [KO:K12311] [EC:3.2.1.24]
106487046  hyaluronidase-like [KO:K01197] [EC:3.2.1.35]
106495897  HYAL4; hyaluronoglucosaminidase 4 [KO:K01197] [EC:3.2.1.35]
106495899  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
106495911  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
106485952  HYAL2; hyaluronoglucosaminidase 2 [KO:K01197] [EC:3.2.1.35]
106485966  HYAL1; hyaluronoglucosaminidase 1 [KO:K01197] [EC:3.2.1.35]
106495129  HYAL3; hyaluronoglucosaminidase 3 [KO:K01197] [EC:3.2.1.35]
106496139  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
106496138  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
106496143  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
106487821  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
106485977  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
106491425  GALNS; galactosamine (N-acetyl)-6-sulfatase [KO:K01132] [EC:3.1.6.4]
106488739  GNS; glucosamine (N-acetyl)-6-sulfatase [KO:K01137] [EC:3.1.6.14]
106487578  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
106484733  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
106485998  SGSH; N-sulfoglucosamine sulfohydrolase [KO:K01565] [EC:3.10.1.1]
106495301  lipase member K-like [KO:K01052] [EC:3.1.1.13]
106487829  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
106487831  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
106487834  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
106483279  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
106499687  DNASE2B; deoxyribonuclease 2 beta [KO:K01158] [EC:3.1.22.1]
106498369  ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
106490075  ASAH1; N-acylsphingosine amidohydrolase 1 [KO:K12348] [EC:3.5.1.23]
106484055  AGA; aspartylglucosaminidase [KO:K01444] [EC:3.5.1.26]
106485380  PSAP; prosaposin [KO:K12382]
106493574  GM2A; GM2 ganglioside activator [KO:K12383]
106493355  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
106487546  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
106493948  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
106482248  lysosome-associated membrane glycoprotein 3-like [KO:K06562]
106482249  lysosome-associated membrane glycoprotein 3-like [KO:K06562]
106482251  lysosome-associated membrane glycoprotein 3-like [KO:K06562]
106492020  SCARB2; scavenger receptor class B member 2 [KO:K12384]
106482292  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
106482864  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
106493766  CTNS; cystinosin, lysosomal cystine transporter [KO:K12386]
106492487  SLC17A5; solute carrier family 17 member 5 [KO:K12301]
106499064  SLC11A1; solute carrier family 11 member 1 [KO:K12347]
106485343  natural resistance-associated macrophage protein 2-like [KO:K21398]
106494753  LAPTM4A; lysosomal protein transmembrane 4 alpha [KO:K12387]
106494810  LAPTM5; lysosomal protein transmembrane 5 [KO:K12387]
106483868  LAPTM4B; lysosomal protein transmembrane 4 beta [KO:K12387]
106494257  ABCA2; ATP binding cassette subfamily A member 2 [KO:K05642]
106497657  ABCB9; ATP binding cassette subfamily B member 9 [KO:K05656]
106489617  CD164; CD164 molecule [KO:K06546]
106485706  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
106495453  SORT1; sortilin 1 [KO:K12388]
106491625  CLN5; ceroid-lipofuscinosis, neuronal 5 [KO:K12390]
106492026  MFSD8; major facilitator superfamily domain containing 8 [KO:K12307]
106484356  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
106489802  SUMF1; sulfatase modifying factor 1 [KO:K13444] [EC:1.8.3.7]
106488838  GNPTAB; N-acetylglucosamine-1-phosphate transferase alpha and beta subunits [KO:K08239] [EC:2.7.8.17]
106486135  GNPTG; N-acetylglucosamine-1-phosphate transferase gamma subunit [KO:K10087]
106499990  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
106486768  IGF2R; insulin like growth factor 2 receptor [KO:K06564]
106495711  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
106487452  CLTA; clathrin light chain A [KO:K04644]
106484328  CLTB; clathrin light chain B [KO:K04645]
106486866  clathrin heavy chain 1-like [KO:K04646]
106500335  CLTC; clathrin heavy chain [KO:K04646]
106498815  AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
106497464  AP-1 complex subunit beta-1 [KO:K12392]
106494270  AP-1 complex subunit mu-1 [KO:K12393]
106491903  AP1S2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394]
106485846  AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
106489530  AP3D1; adaptor related protein complex 3 delta 1 subunit [KO:K12396]
106495613  AP3B2; adaptor related protein complex 3 beta 2 subunit [KO:K12397]
106487784  AP3M2; adaptor related protein complex 3 mu 2 subunit [KO:K12398]
106498943  AP3M1; adaptor related protein complex 3 mu 1 subunit [KO:K12398]
106496837  AP3S2; adaptor related protein complex 3 sigma 2 subunit [KO:K12399]
106498057  AP-3 complex subunit sigma-1 [KO:K12399]
106497707  AP-3 complex subunit sigma-1-like [KO:K12399]
106496561  AP4E1; adaptor related protein complex 4 epsilon 1 subunit [KO:K12400]
106485276  AP4B1; adaptor related protein complex 4 beta 1 subunit [KO:K12401]
106482826  AP4S1; adaptor related protein complex 4 sigma 1 subunit [KO:K12403]
106488849  GGA1; golgi associated, gamma adaptin ear containing, ARF binding protein 1 [KO:K12404]
106486218  GGA2; golgi associated, gamma adaptin ear containing, ARF binding protein 2 [KO:K12404]
106485673  GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3 [KO:K12404]
106487493  mucolipin-1-like [KO:K04992]
106482607  LITAF; lipopolysaccharide induced TNF factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
aam00511  Other glycan degradation
aam00531  Glycosaminoglycan degradation
aam04130  SNARE interactions in vesicular transport
aam04140  Autophagy - animal
aam04144  Endocytosis
KO pathway
ko04142   
LinkDB

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