KEGG   PATHWAY: aam04142
Entry
aam04142                    Pathway                                
Name
Lysosome - Apteryx mantelli mantelli (North Island brown kiwi)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
aam04142  Lysosome
aam04142

Other DBs
GO: 0005764
Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106482248  [KO:K06562]
106482249  [KO:K06562]
106482251  [KO:K06562]
106482292  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
106482361  ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
106482506  IDUA; iduronidase, alpha-L- [KO:K01217] [EC:3.2.1.76]
106482607  LITAF; lipopolysaccharide induced TNF factor [KO:K19363]
106482826  AP4S1; adaptor related protein complex 4 sigma 1 subunit [KO:K12403]
106482864  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
106482935  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
106483066  GALC; galactosylceramidase [KO:K01202] [EC:3.2.1.46]
106483279  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
106483868  LAPTM4B; lysosomal protein transmembrane 4 beta [KO:K12387]
106483924  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
106484055  AGA; aspartylglucosaminidase [KO:K01444] [EC:3.5.1.26]
106484150  [KO:K01365] [EC:3.4.22.15]
106484328  CLTB; clathrin light chain B [KO:K04645]
106484356  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
106484535  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
106484553  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
106484733  [KO:K01565] [EC:3.10.1.1]
106484922  ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
106484973  [KO:K01189] [EC:3.2.1.22]
106484974  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
106485276  AP4B1; adaptor related protein complex 4 beta 1 subunit [KO:K12401]
106485343  [KO:K21398]
106485380  PSAP; prosaposin [KO:K12382]
106485673  GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3 [KO:K12404]
106485706  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
106485846  AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
106485952  HYAL2; hyaluronoglucosaminidase 2 [KO:K01197] [EC:3.2.1.35]
106485966  HYAL1; hyaluronoglucosaminidase 1 [KO:K01197] [EC:3.2.1.35]
106485977  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
106485998  SGSH; N-sulfoglucosamine sulfohydrolase [KO:K01565] [EC:3.10.1.1]
106486111  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
106486135  GNPTG; N-acetylglucosamine-1-phosphate transferase gamma subunit [KO:K10087]
106486218  GGA2; golgi associated, gamma adaptin ear containing, ARF binding protein 2 [KO:K12404]
106486400  [KO:K01319] [EC:3.4.21.20]
106486603  [KO:K01365] [EC:3.4.22.15]
106486768  IGF2R; insulin like growth factor 2 receptor [KO:K06564]
106486866  [KO:K04646]
106487037  CTSH; cathepsin H [KO:K01366] [EC:3.4.22.16]
106487046  [KO:K01197] [EC:3.2.1.35]
106487108  WDR7; WD repeat domain 7 [KO:K24738]
106487452  CLTA; clathrin light chain A [KO:K04644]
106487493  [KO:K04992]
106487546  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
106487578  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
106487784  AP3M2; adaptor related protein complex 3 mu 2 subunit [KO:K12398]
106487821  [KO:K01135] [EC:3.1.6.12]
106487829  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
106487831  [KO:K01052] [EC:3.1.1.13]
106487834  [KO:K01052] [EC:3.1.1.13]
106487926  TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
106488372  ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
106488475  [KO:K01382] [EC:3.4.23.34]
106488675  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
106488739  GNS; glucosamine (N-acetyl)-6-sulfatase [KO:K01137] [EC:3.1.6.14]
106488838  GNPTAB; N-acetylglucosamine-1-phosphate transferase alpha and beta subunits [KO:K08239] [EC:2.7.8.17]
106488849  GGA1; golgi associated, gamma adaptin ear containing, ARF binding protein 1 [KO:K12404]
106488991  GLB1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]
106489530  AP3D1; adaptor related protein complex 3 delta 1 subunit [KO:K12396]
106489617  CD164; CD164 molecule [KO:K06546]
106489802  SUMF1; sulfatase modifying factor 1 [KO:K13444] [EC:1.8.3.7]
106490075  ASAH1; N-acylsphingosine amidohydrolase 1 [KO:K12348] [EC:3.5.1.23]
106491087  NAGLU; N-acetyl-alpha-glucosaminidase [KO:K01205] [EC:3.2.1.50]
106491100  ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
106491260  CTSC; cathepsin C [KO:K01275] [EC:3.4.14.1]
106491310  [KO:K12316] [EC:3.2.1.20]
106491425  GALNS; galactosamine (N-acetyl)-6-sulfatase [KO:K01132] [EC:3.1.6.4]
106491625  CLN5; ceroid-lipofuscinosis, neuronal 5 [KO:K12390]
106491903  AP1S2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394]
106491981  MANBA; mannosidase beta [KO:K01192] [EC:3.2.1.25]
106492020  SCARB2; scavenger receptor class B member 2 [KO:K12384]
106492026  MFSD8; major facilitator superfamily domain containing 8 [KO:K12307]
106492078  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
106492487  SLC17A5; solute carrier family 17 member 5 [KO:K12301]
106492788  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
106493293  FUCA1; fucosidase, alpha-L- 1, tissue [KO:K01206] [EC:3.2.1.51]
106493355  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
106493574  GM2A; GM2 ganglioside activator [KO:K12383]
106493766  CTNS; cystinosin, lysosomal cystine transporter [KO:K12386]
106493948  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
106494257  ABCA2; ATP binding cassette subfamily A member 2 [KO:K05642]
106494270  [KO:K12393]
106494328  GBA; glucosylceramidase beta [KO:K01201] [EC:3.2.1.45]
106494469  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
106494753  LAPTM4A; lysosomal protein transmembrane 4 alpha [KO:K12387]
106494810  LAPTM5; lysosomal protein transmembrane 5 [KO:K12387]
106495129  HYAL3; hyaluronoglucosaminidase 3 [KO:K01197] [EC:3.2.1.35]
106495149  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
106495301  [KO:K01052] [EC:3.1.1.13]
106495347  GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
106495413  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
106495453  SORT1; sortilin 1 [KO:K12388]
106495613  AP3B2; adaptor related protein complex 3 beta 2 subunit [KO:K12397]
106495711  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
106495897  HYAL4; hyaluronoglucosaminidase 4 [KO:K01197] [EC:3.2.1.35]
106495899  [KO:K01197] [EC:3.2.1.35]
106495911  [KO:K01197] [EC:3.2.1.35]
106495921  ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
106496006  [KO:K12373] [EC:3.2.1.52]
106496138  [KO:K01134] [EC:3.1.6.8]
106496139  [KO:K01134] [EC:3.1.6.8]
106496143  [KO:K01134] [EC:3.1.6.8]
106496253  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
106496489  DMXL2; Dmx like 2 [KO:K24155]
106496561  AP4E1; adaptor related protein complex 4 epsilon 1 subunit [KO:K12400]
106496685  TLDC1; TBC/LysM-associated domain containing 1 [KO:K27947]
106496837  AP3S2; adaptor related protein complex 3 sigma 2 subunit [KO:K12399]
106496991  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
106497464  [KO:K12392]
106497597  CTSA; cathepsin A [KO:K13289] [EC:3.4.16.5]
106497657  ABCB9; ATP binding cassette subfamily B member 9 [KO:K05656]
106497686  ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
106497707  [KO:K12399]
106497748  [KO:K01279] [EC:3.4.14.9]
106497859  [KO:K01201] [EC:3.2.1.45]
106497902  FUCA2; fucosidase, alpha-L- 2, plasma [KO:K01206] [EC:3.2.1.51]
106498006  NCOA7; nuclear receptor coactivator 7 [KO:K25442]
106498057  [KO:K12399]
106498060  MAN2B1; mannosidase alpha class 2B member 1 [KO:K12311] [EC:3.2.1.24]
106498369  ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
106498815  AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
106498943  AP3M1; adaptor related protein complex 3 mu 1 subunit [KO:K12398]
106499064  SLC11A1; solute carrier family 11 member 1 [KO:K12347]
106499687  DNASE2B; deoxyribonuclease 2 beta [KO:K01158] [EC:3.1.22.1]
106499990  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
106500263  [KO:K12316] [EC:3.2.1.20]
106500335  CLTC; clathrin heavy chain [KO:K04646]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
aam00511  Other glycan degradation
aam00531  Glycosaminoglycan degradation
aam04130  SNARE interactions in vesicular transport
aam04140  Autophagy - animal
aam04144  Endocytosis
KO pathway
ko04142   

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