KEGG   PATHWAY: agen04148
Entry
agen04148                   Pathway                                
Name
Efferocytosis - Accipiter gentilis (Northern goshawk)
Class
Cellular Processes; Transport and catabolism
Pathway map
agen04148  Efferocytosis
agen04148

Organism
Accipiter gentilis (Northern goshawk) [GN:agen]
Gene
126036926  caspase-3 [KO:K02187] [EC:3.4.22.56]
126042810  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
126051633  caspase-3-like [KO:K04397] [EC:3.4.22.60]
126039307  caspase-1-like [KO:K01370] [EC:3.4.22.36]
126048410  pannexin-1 [KO:K03443]
126048244  P2Y purinoceptor 2 [KO:K04269]
126048246  P2Y purinoceptor 6 [KO:K04272]
126039934  P2Y purinoceptor 12 [KO:K04298]
126044038  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
126035035  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
126041699  sphingosine 1-phosphate receptor 1 [KO:K04288]
126047740  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
126041732  phospholipid-transporting ATPase ABCA7 [KO:K05641]
126036024  phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
126050675  probable G-protein coupled receptor 132 [KO:K08426]
126046408  disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
126043583  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
126040527  fractalkine-like [KO:K05508]
126045768  CX3C chemokine receptor 1 [KO:K04192]
126045483  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
126048721  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
126040608  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126050720  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
126040212  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
126036433  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
126040843  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126045520  CCAAT/enhancer-binding protein beta [KO:K10048]
126049793  peroxisome proliferator-activated receptor gamma [KO:K08530]
126052423  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
126043858  lactadherin isoform X1 [KO:K17253]
126052856  growth arrest-specific protein 6 [KO:K05464]
126038667  tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
126044289  platelet glycoprotein 4 [KO:K06259]
126049295  thrombospondin-1 [KO:K16857]
126043484  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126041897  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
126042066  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
126050607  prostaglandin E2 receptor EP2 subtype [KO:K04259]
126035819  prostaglandin E2 receptor EP4 subtype [KO:K04261]
126046238  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
126038675  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
126036615  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126039205  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
126040478  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
126037514  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
126045012  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126042437  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126050962  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126051460  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126044349  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126044350  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126052497  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
126052499  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126052287  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
126043077  polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
126049569  dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126044641  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126047283  dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126048005  dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126042698  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
126044253  anoctamin-6 [KO:K19500]
126047257  anoctamin-3 [KO:K19498]
126034548  anoctamin-4 isoform X1 [KO:K19499]
126046877  anoctamin-5 isoform X1 [KO:K19480]
126039381  LOW QUALITY PROTEIN: anoctamin-7 [KO:K19501]
126047157  anoctamin-9 [KO:K19503]
126041758  basigin isoform X1 [KO:K06535]
126046869  XK-related protein 8 [KO:K26813]
126050622  XK-related protein 9 isoform X1 [KO:K26814]
126045473  XK-related protein 7 [KO:K26811]
126050108  XK-related protein 4 [KO:K26811]
126046584  XK-related protein 6 [KO:K26811]
126048259  phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
126053013  phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
126049999  phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
126039780  phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
126052936  phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
126046012  cell cycle control protein 50A [KO:K26935]
126049005  vitamin K-dependent protein S isoform X1 [KO:K03908]
126042812  integrin alpha-V [KO:K06487]
126038651  integrin beta-3 [KO:K06493]
126042678  integrin beta-5 [KO:K06588]
126036608  tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
126049212  tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
126049173  adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
126050781  T-cell immunoglobulin and mucin domain-containing protein 4-like [KO:K26936]
126051026  hepatitis A virus cellular receptor 1 homolog isoform X1 [KO:K20413]
126049561  stabilin-1 isoform X1 [KO:K19020]
126048037  stabilin-2 [KO:K19013]
126046742  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126041069  breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
126039311  adapter molecule crk isoform X1 [KO:K04438]
126040586  crk-like protein [KO:K04438]
126045288  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
126042438  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
126033973  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126041053  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126042457  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
126051703  disintegrin and metalloproteinase domain-containing protein 9-like isoform X1 [KO:K06834] [EC:3.4.24.-]
126041626  calreticulin-3 [KO:K08057]
126042840  calreticulin [KO:K08057]
126037716  complement C1q subcomponent subunit A isoform X1 [KO:K03986]
126037689  complement C1q subcomponent subunit B-like isoform X1 [KO:K03987]
126046236  prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
126043337  multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
126036536  multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
126039234  scavenger receptor class F member 1 [KO:K24318]
126041033  PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
126039621  ras-related protein Rab-17 isoform X1 [KO:K07909]
126037936  ras-related protein Rab-5A [KO:K07887]
126046467  ras-related protein Rab-5B [KO:K07888]
126038680  ras-related protein Rab-5C [KO:K07889]
126052843  transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
126039309  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
126038825  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
126051660  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
126049499  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
126040959  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
126052051  ras-related protein Rab-14 isoform X1 [KO:K07881]
126049147  vam6/Vps39-like protein isoform X1 [KO:K20183]
126045390  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
126049642  ras-related protein Rab-7a [KO:K07897]
126052109  ras-related protein Rab-7b isoform X1 [KO:K07898]
126045085  lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
126039711  lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
126049526  arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
126046500  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
126043002  cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
126049443  oxysterols receptor LXR-alpha [KO:K08536]
126047234  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
126044506  carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
126041078  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126042538  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
126042171  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
126052461  interleukin-10 [KO:K05443]
126042997  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
126042998  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
126040615  phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
126051897  peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
126035005  solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
126052163  monocarboxylate transporter 1 [KO:K08179]
126038455  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
126049113  leukocyte surface antigen CD47 isoform X1 [KO:K06266]
126045984  signal transducer CD24 [KO:K06469]
126043358  platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
126045855  tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X1 [KO:K06551]
126045863  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
126049045  tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
126038362  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
126041017  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
agen00010  Glycolysis / Gluconeogenesis
agen04140  Autophagy - animal
agen04145  Phagosome
KO pathway
ko04148   
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