KEGG ORTHOLOGY: K07887

ORTHOLOGY: K07887

Entry

K07887                      KO

Symbol

RAB5A

Name

Ras-related protein Rab-5A

Pathway

map04014

Ras signaling pathway

map04137

Mitophagy - animal

map04144

Endocytosis

map04145

Phagosome

map04148

Efferocytosis

map04962

Vasopressin-regulated water reabsorption

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

map05146

Amoebiasis

map05152

Tuberculosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07887  RAB5A; Ras-related protein Rab-5A
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K07887  RAB5A; Ras-related protein Rab-5A
   04145 Phagosome
    K07887  RAB5A; Ras-related protein Rab-5A
   04137 Mitophagy - animal
    K07887  RAB5A; Ras-related protein Rab-5A
   04148 Efferocytosis
    K07887  RAB5A; Ras-related protein Rab-5A
09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K07887  RAB5A; Ras-related protein Rab-5A
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K07887  RAB5A; Ras-related protein Rab-5A
   05152 Tuberculosis
    K07887  RAB5A; Ras-related protein Rab-5A
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K07887  RAB5A; Ras-related protein Rab-5A
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K07887  RAB5A; Ras-related protein Rab-5A
   05022 Pathways of neurodegeneration - multiple diseases
    K07887  RAB5A; Ras-related protein Rab-5A
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07887  RAB5A; Ras-related protein Rab-5A
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07887  RAB5A; Ras-related protein Rab-5A
   04031 GTP-binding proteins
    K07887  RAB5A; Ras-related protein Rab-5A
Membrane trafficking [BR:ko04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab GTPases
    K07887  RAB5A; Ras-related protein Rab-5A
Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab GTPases
    K07887  RAB5A; Ras-related protein Rab-5A
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of other body fluids (saliva and urine)
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of colorectal cancer cells
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of bladder cancer cells
   K07887  RAB5A; Ras-related protein Rab-5A
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Rab Family
   Rab5/17/22/31 [OT]
    K07887  RAB5A; Ras-related protein Rab-5A

Genes

HSA:	5868(RAB5A)

PTR:	460217(RAB5A)

PPS:	100972222(RAB5A)

GGO:	101144180(RAB5A)

PON:	100446432(RAB5A)

NLE:	100585666(RAB5A)

HMH:	116473751(RAB5A)

MCC:	697712(RAB5A)

MCF:	102144117(RAB5A)

MTHB:

126945267 126946715

MNI:	105488903(RAB5A)

CSAB:

103241745(RAB5A)

CATY:

105578300(RAB5A)

PANU:

100999279(RAB5A)

TGE:	112619083(RAB5A)

MLEU:

105530773(RAB5A)

RRO:	104665706(RAB5A)

RBB:	108521254(RAB5A)

TFN:	117077586 117084230(RAB5A)

PTEH:

111539482(RAB5A)

CANG:

105505780(RAB5A)

CJC:	100389972(RAB5A) 100894569

SBQ:	101034494(RAB5A)

CIMI:

108299936(RAB5A)

CSYR:

103275058(RAB5A)

MMUR:

105881575(RAB5A)

LCAT:

123628394(RAB5A)

PCOQ:

105826386(RAB5A)

OGA:	100949283(RAB5A)

MMU:	271457(Rab5a)

MCAL:

110312675(Rab5a)

MPAH:

110336058(Rab5a)

RNO:	100361891(Rab5al1) 64633(Rab5a)

MCOC:

116074344(Rab5a)

ANU:	117722351(Rab5a)

MUN:	110565695(Rab5a)

CGE:	100772343(Rab5a)

MAUA:

101838485(Rab5a)

PROB:

127236500(Rab5a)

PLEU:

114707466(Rab5a)

MORG:

121450580(Rab5a)

MFOT:

126515452

AAMP:

119822397(Rab5a)

NGI:	103734275(Rab5a)

HGL:	101710661(Rab5a)

CPOC:

100723790(Rab5a)

CCAN:

109692646(Rab5a) 109703335

DORD:

105989904(Rab5a)

DSP:	122108082(Rab5a)

PLOP:

125358649(Rab5a)

NCAR:

124968730 124970797

MMMA:

107149587(Rab5a)

OCU:

100350923

OPI:	101522222(RAB5A)

TUP:	102473232(RAB5A)

GVR:	103599706(RAB5A)

CFA:	404008(RAB5A)

CLUD:

112660999(RAB5A)

VVP:	112925603(RAB5A)

VLG:	121478865(RAB5A)

NPO:	129507132(RAB5A)

AML:	100481281(RAB5A)

UMR:	103679620(RAB5A)

UAH:	113253888(RAB5A)

UAR:	123788339(RAB5A)

ELK:

111155079

LLV:

125104900

MPUF:

101684536(RAB5A)

MNP:	132011760(RAB5A)

MLK:	131824499(RAB5A)

NVS:	122909015(RAB5A)

ORO:	101370301(RAB5A)

EJU:	114205639(RAB5A)

ZCA:	113916627(RAB5A)

MLX:	118003146(RAB5A)

NSU:	110570855(RAB5A)

LWW:	102744182(RAB5A)

FCA:	101099995(RAB5A)

PYU:	121033616(RAB5A)

PCOO:

112850392(RAB5A)

PBG:	122492036(RAB5A)

PVIV:

125174851(RAB5A)

LRUF:

124526069

PTG:	102956448(RAB5A)

PPAD:

109258513(RAB5A)

PUC:

125921347

AJU:

106981292

HHV:	120222031(RAB5A)

BTA:	539764(RAB5A)

BOM:	102272703(RAB5A)

BIU:	109561892(RAB5A)

BBUB:

102409692(RAB5A)

BBIS:

105000723(RAB5A)

CHX:	102184478(RAB5A)

OAS:	100302084(RAB5A)

BTAX:

128060293(RAB5A)

ODA:	120880188(RAB5A)

CCAD:

122445528(RAB5A)

MBEZ:

129549747(RAB5A)

SSC:	100144499(RAB5A)

CFR:	102515139(RAB5A)

CBAI:

105072592(RAB5A)

CDK:	105085148(RAB5A)

VPC:	102538668(RAB5A)

BACU:

103004707(RAB5A)

BMUS:

118894315(RAB5A) 118895818

LVE:	103075981(RAB5A)

OOR:	101273864(RAB5A) 101275059

DLE:	111164777(RAB5A)

PCAD:

102984481(RAB5A)

PSIU:

116753147(RAB5A)

NASI:

112397778(RAB5A)

ECB:	100051997(RAB5A)

EPZ:	103559349(RAB5A)

EAI:	106831752(RAB5A)

MYB:	102239794(RAB5A)

MYD:	102755118(RAB5A)

MMYO:

118668224(RAB5A)

MLF:	102439178(RAB5A)

PKL:	118715392(RAB5A)

EFUS:

103296869(RAB5A)

MNA:	107526355(RAB5A)

DRO:	112309570(RAB5A)

SHON:

119004015(RAB5A)

AJM:	119048325(RAB5A) 119050791

PDIC:

114501435(RAB5A)

PHAS:

123815479 123830616(RAB5A)

MMF:	118633623(RAB5A)

PPAM:

129088376(RAB5A)

HAI:	109393991(RAB5A)

RFQ:	117017475 117036886(RAB5A)

PALE:

102896851(RAB5A)

PGIG:

120581665(RAB5A)

PVP:	105289298(RAB5A)

RAY:	107497819(RAB5A)

MJV:	108409860(RAB5A)

TOD:	119257198(RAB5A)

SARA:

101546359(RAB5A)

SETR:

125997961(RAB5A)

LAV:	100676912(RAB5A)

TMU:

101358523

ETF:	101652509(RAB5A) 101652923

DNM:	101424456(RAB5A)

MDO:	100024447(RAB5A)

GAS:	123248760(RAB5A)

SHR:	100925458(RAB5A)

AFZ:

127539208

PCW:	110209035(RAB5A)

OAA:	100076995(RAB5A)

GGA:	420649(RAB5A)

PCOC:

116227097(RAB5A)

MGP:	100543312(RAB5A)

CJO:	107309277(RAB5A)

TPAI:

128085178(RAB5A)

LMUT:

125695933(RAB5A)

NMEL:

110393039(RAB5A)

APLA:

101789931(RAB5A)

ACYG:

106030269(RAB5A)

CATA:

118252824(RAB5A)

AFUL:

116485829(RAB5A)

TGU:	100230163(RAB5A)

LSR:	110474606(RAB5A)

SCAN:

103812923(RAB5A)

PMOA:

120503502(RAB5A)

OTC:	121339556(RAB5A)

PRUF:

121353028(RAB5A)

GFR:	102042464(RAB5A)

FAB:	101819219(RAB5A)

OMA:	130249109(RAB5A)

PHI:	102107036(RAB5A)

PMAJ:

107200272(RAB5A)

CCAE:

111923465(RAB5A)

CCW:	104689064(RAB5A)

CBRC:

103614122(RAB5A)

ETL:	114069095(RAB5A)

ZAB:	102063112(RAB5A)

ACHL:

103809148(RAB5A)

SVG:	106857354(RAB5A)

MMEA:

130582771(RAB5A)

HRT:	120751546(RAB5A)

FPG:	101922651(RAB5A)

FCH:	102055723(RAB5A)

CLV:	102087403(RAB5A)

EGZ:	104126123(RAB5A)

NNI:	104013901(RAB5A)

PCRI:

104032836(RAB5A)

PLET:

104620435(RAB5A)

EHS:	104504918(RAB5A)

PCAO:

104050986(RAB5A)

ACUN:

113476514(RAB5A)

TALA:

104361239(RAB5A)

PADL:

103921524(RAB5A)

AFOR:

103906647(RAB5A)

ACHC:

115339064(RAB5A)

HALD:

104312326(RAB5A)

HLE:	104843133(RAB5A)

AGEN:

126037936

GCL:

127030006

CCRI:

104156550(RAB5A)

CSTI:

104551906(RAB5A)

CMAC:

104483545(RAB5A)

MUI:	104548876(RAB5A)

BREG:

104634026(RAB5A)

FGA:	104074858(RAB5A)

GSTE:

104254657

LDI:	104353058(RAB5A)

MNB:	103782211(RAB5A)

OHA:	104333312(RAB5A)

NNT:	104400940(RAB5A)

SHAB:

115604163(RAB5A)

DPUB:

104303103(RAB5A)

PGUU:

104467365(RAB5A)

ACAR:

104525751(RAB5A)

CPEA:

104397548(RAB5A)

AVIT:

104269311(RAB5A)

CVF:	104289902(RAB5A)

RTD:	128905317(RAB5A)

CUCA:

104067570(RAB5A)

TEO:	104381290(RAB5A)

BRHI:

104493680(RAB5A)

AAM:	106483486(RAB5A)

AROW:

112972069(RAB5A)

NPD:	112957210(RAB5A)

TGT:	104575960(RAB5A)

DNE:	112985288(RAB5A)

SCAM:

104145066(RAB5A)

ASN:	102388201(RAB5A)

AMJ:	102571945(RAB5A)

CPOO:

109310618(RAB5A)

GGN:	109291670(RAB5A)

PSS:	102447823(RAB5A)

CMY:	102943972(RAB5A)

CCAY:

125631613(RAB5A)

DCC:	119852294(RAB5A)

CPIC:

101947027(RAB5A)

TST:	117872380(RAB5A)

CABI:

116816616(RAB5A)

MRV:	120398106(RAB5A)

ACS:	100552994(rab5a)

ASAO:

132778704(RAB5A)

PVT:	110086461(RAB5A)

SUND:

121934513(RAB5A)

PBI:	103058604(RAB5A)

PMUR:

107282901(RAB5A)

CTIG:

120310459(RAB5A)

TSR:	106537670(RAB5A)

PGUT:

117655132(RAB5A)

APRI:

131198762(RAB5A)

PTEX:

113441268(RAB5A)

NSS:	113415948(RAB5A)

VKO:	123033046(RAB5A)

PMUA:

114607170(RAB5A)

PRAF:

128398376(RAB5A)

ZVI:	118091849(RAB5A)

HCG:	128330789(RAB5A)

GJA:	107123665(RAB5A)

STOW:

125440796(RAB5A)

EMC:	129337575(RAB5A)

XLA:	108719951(rab5a.S) 380227(rab5a.L)

XTR:	493430(rab5a)

NPR:	108797632(RAB5A)

RTEM:

120940247(RAB5A)

BBUF:

121001784(RAB5A)

BGAR:

122938335(RAB5A)

MUO:	115469933(RAB5A)

GSH:	117353992(RAB5A)

DRE:	337737(rab5aa) 393945(rab5ab)

SRX:	107707637 107716989 107739563 107748683

SANH:

107671429 107688205 107688329 107696885

SGH:	107592022 107592111 107593606

CCAR:

109066323 109102285 109105139 109105144

CAUA:

113059371 113062247 113115675 113120091

CGIB:

127935161 127975156 127978574 128031088

PTET:

122323580(rab5aa) 122345240 122360523 122360982

LROH:

127178892(rab5ab) 127181597(rab5aa)

OMC:	131522155(rab5ab) 131525403(rab5aa)

PPRM:

120483794(rab5aa) 120491156(rab5ab)

RKG:	130076413(rab5ab) 130085141(rab5aa)

MAMB:

125243050(rab5ab) 125275421(rab5aa)

CIDE:

127497621 127501286

MASI:

127421416 127424906 127453220 127454174

TROS:

130557618(rab5ab) 130566701(rab5aa)

TDW:	130415325(rab5aa) 130432898(rab5ab)

MANU:

129448779(rab5ab) 129455445(rab5aa)

IPU:	100528297(rab5ab)

IFU:	128600069(rab5ab)

PHYP:

113532762 113535081

SMEO:

124375507(rab5ab) 124382072(rab5aa)

TFD:	113649573(rab5aa) 113649746(rab5ab)

TVC:	132840078(rab5ab) 132842940(rab5aa)

AMEX:

103027170 103038585

CMAO:

118798713(rab5ab) 118805874(rab5aa)

EEE:	113578813 113588725

CHAR:

105904716(rab5aa) 122132150

TRU:	101071138 101078239

TFS:	130517946 130532458

TNG:	GSTEN00017460G001 GSTEN00021960G001

LCO:	104923118 104931780(rab5a)

NCC:	104947906 104953323(rab5a)

TBEN:

117468499(rab5ab) 117477963(rab5aa)

CGOB:

115016257 115021364(rab5a)

PGEO:

117455002 117460554(rab5ab)

GACU:

117543275(rab5ab) 117562985

EMAC:

134861808(rab5ab) 134874815(rab5aa)

ELY:	117263853 117265762(rab5ab)

EFO:	125893047(rab5ab) 125904696

PLEP:

121945795(rab5ab) 121957446(rab5aa)

SLUC:

116036000(rab5ab) 116066840(rab5aa)

ECRA:

117945613(rab5ab) 117956770(rab5aa)

ESP:	116691143 116702199

PFLV:

114556504(rab5a) 114567838

GAT:	120810577(rab5ab) 120826032(rab5aa)

PPUG:

119197878(rab5ab) 119219417(rab5aa)

AFB:	129096752(rab5aa) 129109400(rab5ab)

CLUM:

117728044 117738981

PSWI:

130195853(rab5aa) 130212924

MSAM:

119897085(rab5ab) 119906669

SCHU:

122864828 122881230

CUD:	121513770(rab5ab) 121523937(rab5aa)

ALAT:

119006113(rab5ab) 119016765

MZE:	101476881 101481330

ONL:	100701272(rab5a) 100704868

OAU:	116311339(rab5ab) 116312049(rab5aa)

OLA:	101157247 101159835

OML:	112136549(rab5ab) 112162956(rab5aa)

CSAI:

133439379(rab5ab) 133461528(rab5aa)

XMA:	102221989 102233132

XCO:	114141653 114156258

XHE:	116717259 116730690(rab5a)

PRET:

103472355(rab5a) 103477863

PFOR:

103135088 103153896(rab5a)

PLAI:

106939424(rab5a) 106961574

PMEI:

106927543 106929564

GAF:	122830625(rab5ab) 122843641

PPRL:

129371007(rab5ab) 129375108

CVG:	107082990 107083283(rab5a)

CTUL:

119785928(rab5aa) 119790066(rab5ab)

GMU:	124865722(rab5ab) 124879818(rab5aa)

NFU:	107379171 107394767

KMR:	108241608(rab5aa) 108249324

ALIM:

106523087(rab5a)

NWH:	119409622(rab5ab) 119425663(rab5aa)

AOCE:

111566129 111578364

MCEP:

125016640(rab5ab) 125019807(rab5aa)

CSEM:

103388351 103394455

POV:	109631800 109642220

SSEN:

122774669(rab5ab) 122786010(rab5aa)

HHIP:

117770628 117777113(rab5ab)

HSP:	118113846(rab5ab) 118125278

SMAU:

118285158(rab5ab) 118292120(rab5aa)

LCF:	108895551 108897856 108899526(rab5ab)

SDU:	111223299 111236892(rab5a)

SLAL:

111652636 111659338

XGL:	120784336(rab5ab) 120786746

HCQ:

109521099

SSCV:

125974838

SBIA:

133500567 133501741

PEE:	133395641 133401588(rab5ab)

PTAO:

133471060 133479251

BPEC:

110167156 110175549

MALB:

109963944 109965590

BSPL:

114843335(rab5ab) 114865393(rab5aa)

SJO:	128366676(rab5ab) 128374415(rab5aa)

SASA:

100195116(rab5a) 106570504 106582071 106588886

STRU:

115173975 115175487 115176952 115178119(rab5a)

OTW:	112223008 112229448 112229874(rab5ab) 112264392

OMY:	110487983 110488005 110496594 110515550

OGO:	123997685 124005328 124012650 124043222

ONE:	115104564(rab5a) 115123914 115131286 115141120

OKI:	109902072 109903357 109907241(rab5a) 109909003

OKE:	118364387 118367439 118372221

SALP:

111955241 111955731 111958830 111958844

SNH:	120022103 120026865 120031248(rab5ab) 120048378

CCLU:

121560121 121572062 121586705

ELS:	105012610 105021874

SFM:	108927321 108933441

PKI:	111839052 111842739

AANG:

118207179(rab5ab) 118233394(rab5aa)

LOC:	102696266(rab5a)

PSPA:

121313657 121315137

ARUT:

117394839 117400548

PSEX:

120515347(rab5aa)

LCM:	102365669(RAB5A)

CMK:	103181250(rab5aa)

RTP:

109936986

CPLA:

122549941

HOC:

132815754

LERI:

129709834(rab5aa)

PMRN:

116941038 116941039 116948251 116948277

LRJ:

AJC:

ALAB:

AFLR:

BBIF:

BVK:

BVAN:

BAFF:

BPYO:

BPAS:

FVI:

MGEN:

NMEA:

LHT:

LBD:

AGIF:

CINS:

VCAN:

MQU:

LSM:

LGI:	LOTGIDRAFT_131980

DPOL:

127857858

OSN:

115228380

OVI:	T265_07070

XEN:

124453295

ACAN:

ACA1_054710

TOT:	TOT_010000586

» show all

Reference

PMID:10818110

Authors

Hoffenberg S, Liu X, Nikolova L, Hall HS, Dai W, Baughn RE, Dickey BF, Barbieri MA, Aballay A, Stahl PD, Knoll BJ

Title

A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.

Journal

J Biol Chem 275:24661-9 (2000)
DOI:10.1074/jbc.M909600199

Sequence

[hsa:5868]

Reference

PMID:2501306

Authors

Zahraoui A, Touchot N, Chardin P, Tavitian A

Title

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

Journal

J Biol Chem 264:12394-401 (1989)

Sequence

[hsa:5868]

LinkDB

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