KEGG   PATHWAY: amex04148
Entry
amex04148                   Pathway                                
Name
Efferocytosis - Astyanax mexicanus (Mexican tetra)
Class
Cellular Processes; Transport and catabolism
Pathway map
amex04148  Efferocytosis
amex04148

Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
111189829  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103025383  caspase-3 [KO:K02187] [EC:3.4.22.56]
103041716  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
103043169  uncharacterized protein LOC103043169 [KO:K01370] [EC:3.4.22.36]
111188785  caspase-1-like [KO:K01370] [EC:3.4.22.36]
103039157  caspase-13-like [KO:K01370] [EC:3.4.22.36]
103021832  caspase-1-like [KO:K01370] [EC:3.4.22.36]
103030724  pannexin-1-like [KO:K03443]
103028710  pannexin-1-like [KO:K03443]
107197486  p2ry2; P2Y purinoceptor 2 [KO:K04269]
103027870  p2ry6; P2Y purinoceptor 6 [KO:K04272]
103047191  P2Y purinoceptor 12 [KO:K04298]
103040500  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
103043132  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
103023393  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
103038116  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
103024703  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
103041974  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
103039328  ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
103044029  ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
103028164  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
103038687  probable G-protein coupled receptor 132 [KO:K08426]
103046392  probable G-protein coupled receptor 132 [KO:K08426]
103037934  G-protein coupled receptor 4-like [KO:K08426]
103041996  disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
103041369  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
103043423  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
103027184  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
103041829  disintegrin and metalloproteinase domain-containing protein 10-like isoform X2 [KO:K06704] [EC:3.4.24.81]
103038616  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103034389  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
103031085  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103045210  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
103030248  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103029075  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103041608  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103033873  hypoxia-inducible factor 1-alpha-like [KO:K08268]
103041845  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
103027586  hypoxia-inducible factor 1-alpha-like [KO:K08268]
103022448  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
103047410  aryl hydrocarbon receptor nuclear translocator isoform X2 [KO:K09097]
103031828  epo; erythropoietin isoform X2 [KO:K05437]
103032190  erythropoietin-like [KO:K05437]
103040492  epor; erythropoietin receptor [KO:K05079]
103030056  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
103042604  jak2; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103041389  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103028158  CCAAT/enhancer-binding protein beta-like [KO:K10048]
103030663  pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103026166  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
103046247  retinoic acid receptor RXR-alpha-B [KO:K08524]
103033918  retinoic acid receptor RXR-gamma-A-like [KO:K08524]
103036996  LOW QUALITY PROTEIN: retinoic acid receptor RXR-alpha-A-like [KO:K08524]
103047215  lactadherin-like isoform X1 [KO:K17253]
103044962  lactadherin-like [KO:K17253]
103029975  gas6; growth arrest-specific protein 6 [KO:K05464]
103046773  mertk; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
103041379  cd36; platelet glycoprotein 4 [KO:K06259]
103029184  thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
103031445  thrombospondin-1-like [KO:K16857]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103030512  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103034574  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
103032345  LOW QUALITY PROTEIN: prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103035710  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
103029411  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
103030080  prostaglandin E2 receptor EP4 subtype [KO:K04261]
103033011  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
103025471  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
103043892  dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
103045261  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
103036831  creb1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
103024012  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
103033069  tgfb1; transforming growth factor beta-1 [KO:K13375]
103024607  transforming growth factor beta-1-like [KO:K13375]
103024029  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
103039228  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
103045170  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
103021660  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
103035335  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
103040450  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
103043420  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103033831  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
103030568  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
103044561  camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
103032713  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
103041877  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
103045689  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
103035641  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103035956  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103046996  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
103028137  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103042110  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103043112  LOW QUALITY PROTEIN: mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103040333  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103033501  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
103024512  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
103035394  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
103028645  dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103024574  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103033988  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103029669  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103044388  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103038175  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103023165  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103047588  tyrosine-protein phosphatase vhp-1-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103041459  ano3; LOW QUALITY PROTEIN: anoctamin-3 [KO:K19498]
103044829  ano5; anoctamin-5 isoform X1 [KO:K19480]
103022551  anoctamin-5-like [KO:K19480]
103030872  anoctamin-5-like isoform X2 [KO:K19480]
103022406  anoctamin-7-like isoform X1 [KO:K19501]
103029593  anoctamin-7 isoform X2 [KO:K19501]
103044315  anoctamin-9 isoform X1 [KO:K19503]
103025065  anoctamin-9-like [KO:K19503]
103043475  bsg; basigin isoform X3 [KO:K06535]
103036187  XK-related protein 8-like [KO:K26813]
103036495  XK-related protein 8-like [KO:K26813]
103038108  xkr9; LOW QUALITY PROTEIN: XK-related protein 9 [KO:K26814]
103041158  xkr7; XK-related protein 7 [KO:K26811]
103046256  XK-related protein 7-like [KO:K26811]
103024990  xkr4; XK-related protein 4 [KO:K26811]
103023855  XK-related protein 6 [KO:K26811]
103041060  xkr6; XK-related protein 6 [KO:K26811]
103024439  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
103026348  atp8a1; phospholipid-transporting ATPase IA isoform X5 [KO:K14802] [EC:7.6.2.1]
103023721  probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
103025813  atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
103043353  atp11b; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
103045771  cell cycle control protein 50A-like [KO:K26935]
103037759  cell cycle control protein 50A [KO:K26935]
103030296  pros1; vitamin K-dependent protein S [KO:K03908]
103023542  itgav; integrin alpha-V [KO:K06487]
103043996  integrin beta-3-like [KO:K06493]
103028095  integrin beta-3 [KO:K06493]
103047818  itgb5; integrin beta-5 [KO:K06588]
103027673  axl; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
103029297  tyro3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
103029142  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
103021749  adgrb1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
103028673  hepatitis A virus cellular receptor 1 homolog isoform X1 [KO:K20413]
103046576  LOW QUALITY PROTEIN: stabilin-1 [KO:K19020]
103029502  stab2; stabilin-2 [KO:K19013]
103041623  ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103033402  focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
103028804  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103044277  crkl; crk-like protein [KO:K04438]
103038949  adapter molecule crk-like [KO:K04438]
103035530  crk; adapter molecule crk [KO:K04438]
103028188  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
103045859  engulfment and cell motility protein 1-like [KO:K12366]
103040913  dock1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
111194918  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111192975  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111192980  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103023232  ras-related protein Rac1-like [KO:K04392]
103034053  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103041718  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
103021525  adam9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
103040817  calreticulin-like [KO:K08057]
103031702  calreticulin [KO:K08057]
103024869  calreticulin-like [KO:K08057]
103023699  complement C1q subcomponent subunit A [KO:K03986]
103024341  complement C1q subcomponent subunit B [KO:K03987]
103024031  complement C1q subcomponent subunit C [KO:K03988]
103032800  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
103024753  low-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
103029924  megf11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
103024146  megf10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
103043589  scarf1; scavenger receptor class F member 1 [KO:K24318]
103031190  PTB domain-containing engulfment adapter protein 1-like isoform X1 [KO:K23285]
103046538  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
103038585  ras-related protein Rab-5A [KO:K07887]
103027170  ras-related protein Rab-5A [KO:K07887]
103034209  ras-related protein Rab-5B-like [KO:K07888]
103045387  rab5c; ras-related protein Rab-5C [KO:K07889]
103035226  ras-related protein Rab-5C [KO:K07889]
103023738  LOW QUALITY PROTEIN: transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
103022514  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
103032553  vps8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
103044271  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
103028448  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
103029409  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
103022932  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
103045876  ras-related protein Rab-14 [KO:K07881]
103026976  ras-related protein Rab-14 [KO:K07881]
103044853  vps39; vam6/Vps39-like protein [KO:K20183]
103035288  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
103037857  rab7a; ras-related protein Rab-7a [KO:K07897]
103043048  ras-related protein rab7 [KO:K07897]
103042533  ras-related protein Rab-7a-like [KO:K07897]
103037223  ras-related protein rab7-like [KO:K07897]
103038039  pqlc2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
103044486  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
103042158  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
103026254  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
103034469  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
111194838  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
103046335  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
103045179  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
103034249  cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
103047082  ch25h; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
103030650  LOW QUALITY PROTEIN: oxysterols receptor LXR-alpha [KO:K08536]
103025592  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
103024546  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
103035972  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
103027125  cpt1b; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
103022273  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
103039511  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
103029512  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
103031674  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103038228  pre-B-cell leukemia transcription factor 1 [KO:K09355]
103032747  il10; interleukin-10 [KO:K05443]
103023710  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
103040858  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
103043677  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
103026358  peroxisome proliferator-activated receptor delta-like [KO:K04504]
103044647  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
103042991  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
103036684  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
103033445  monocarboxylate transporter 1-like [KO:K08179]
103032899  monocarboxylate transporter 1-like [KO:K08179]
103033959  monocarboxylate transporter 1-like [KO:K08179]
103036792  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
103022302  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
103024160  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
103022912  ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
103022363  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
103032744  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
amex00010  Glycolysis / Gluconeogenesis
amex04140  Autophagy - animal
amex04145  Phagosome
KO pathway
ko04148   
LinkDB

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