KEGG   PATHWAY: bbel04144
Entry
bbel04144                   Pathway                                
Name
Endocytosis - Branchiostoma belcheri (Belcher's lancelet)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
bbel04144  Endocytosis
bbel04144

Other DBs
GO: 0006897
Organism
Branchiostoma belcheri (Belcher's lancelet) [GN:bbel]
Gene
109485293  ADP-ribosylation factor 6 [KO:K07941]
109468575  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
109482504  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
109467279  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
109484695  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
109467997  clathrin light chain A-like isoform X1 [KO:K04644]
109464678  clathrin heavy chain 1 isoform X1 [KO:K04646]
109470275  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
109479855  LOW QUALITY PROTEIN: AP-2 complex subunit mu-like [KO:K11826]
109483759  AP-2 complex subunit sigma [KO:K11827]
109471817  LOW QUALITY PROTEIN: TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
109475792  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
109475234  uncharacterized protein LOC109475234 [KO:K04679]
109468845  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
109465242  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
109485268  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
109461945  uncharacterized protein LOC109461945 [KO:K05094] [EC:2.7.10.1]
109462000  fibroblast growth factor receptor homolog 1-like [KO:K05094] [EC:2.7.10.1]
109484937  tyrosine-protein kinase shark-like isoform X1 [KO:K05094] [EC:2.7.10.1]
109469556  proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05094] [EC:2.7.10.1]
109477751  proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05094] [EC:2.7.10.1]
109477847  LOW QUALITY PROTEIN: uncharacterized protein LOC109477847 [KO:K05094] [EC:2.7.10.1]
109485991  fibroblast growth factor receptor 2-like [KO:K05094] [EC:2.7.10.1]
109478455  fibroblast growth factor receptor 4-like [KO:K05094] [EC:2.7.10.1]
109462486  insulin-like peptide receptor [KO:K05094] [EC:2.7.10.1]
109462690  uncharacterized protein LOC109462690 [KO:K05094] [EC:2.7.10.1]
109478608  macrophage colony-stimulating factor 1 receptor 1-like isoform X1 [KO:K05094] [EC:2.7.10.1]
109487033  tyrosine-protein kinase STYK1-like [KO:K05094] [EC:2.7.10.1]
109463114  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
109479584  tyrosine kinase receptor Cad96Ca-like [KO:K05094] [EC:2.7.10.1]
109487226  tyrosine-protein kinase ABL1-like [KO:K05094] [EC:2.7.10.1]
109487272  tyrosine-protein kinase SRK3-like [KO:K05094] [EC:2.7.10.1]
109463447  fibroblast growth factor receptor homolog 1-like [KO:K05094] [EC:2.7.10.1]
109463627  putative wall-associated receptor kinase-like 11 [KO:K05094] [EC:2.7.10.1]
109463784  fibroblast growth factor receptor 4-like [KO:K05094] [EC:2.7.10.1]
109480435  epidermal growth factor receptor-like [KO:K05094] [EC:2.7.10.1]
109480578  putative wall-associated receptor kinase-like 11 [KO:K05094] [EC:2.7.10.1]
109472572  uncharacterized protein LOC109472572 [KO:K05094] [EC:2.7.10.1]
109473202  uncharacterized protein LOC109473202 [KO:K05094] [EC:2.7.10.1]
109481495  tyrosine-protein kinase receptor Tie-2-like [KO:K05094] [EC:2.7.10.1]
109481519  tyrosine-protein kinase receptor Tie-1-like [KO:K05094] [EC:2.7.10.1]
109481609  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
109466364  uncharacterized protein LOC109466364 [KO:K05094] [EC:2.7.10.1]
109466474  uncharacterized protein LOC109466474 [KO:K05094] [EC:2.7.10.1]
109466538  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
109474130  ephrin type-B receptor 3-like [KO:K05094] [EC:2.7.10.1]
109474131  tyrosine-protein kinase Abl-like [KO:K05094] [EC:2.7.10.1]
109474691  tyrosine-protein kinase SRK3-like [KO:K05094] [EC:2.7.10.1]
109483006  putative wall-associated receptor kinase-like 11 [KO:K05094] [EC:2.7.10.1]
109467161  tyrosine-protein kinase STYK1-like [KO:K05094] [EC:2.7.10.1]
109475341  neuronal cell adhesion molecule-like [KO:K05094] [EC:2.7.10.1]
109483169  LOW QUALITY PROTEIN: uncharacterized protein LOC109483169 [KO:K05094] [EC:2.7.10.1]
109467575  fibroblast growth factor receptor 4-like [KO:K05094] [EC:2.7.10.1]
109467608  fibroblast growth factor receptor-like [KO:K05094] [EC:2.7.10.1]
109468203  LOW QUALITY PROTEIN: uncharacterized protein LOC109468203 [KO:K05094] [EC:2.7.10.1]
109468208  epidermal growth factor receptor-like [KO:K05094] [EC:2.7.10.1]
109476663  uncharacterized protein LOC109476663 [KO:K05094] [EC:2.7.10.1]
109469200  uncharacterized protein LOC109469200 [KO:K05095] [EC:2.7.10.1]
109462577  uncharacterized protein LOC109462577 isoform X1 [KO:K05095] [EC:2.7.10.1]
109463113  tyrosine-protein kinase receptor Tie-1-like [KO:K05095] [EC:2.7.10.1]
109471745  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
109471746  LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha-like [KO:K05095] [EC:2.7.10.1]
109472061  uncharacterized protein LOC109472061 [KO:K05095] [EC:2.7.10.1]
109473682  uncharacterized protein LOC109473682 [KO:K05095] [EC:2.7.10.1]
109484259  receptor tyrosine-protein kinase erbB-3-like [KO:K05095] [EC:2.7.10.1]
109484451  receptor tyrosine-protein kinase erbB-4-like [KO:K05095] [EC:2.7.10.1]
109479244  E3 ubiquitin-protein ligase CBL-B-B-like isoform X1 [KO:K04707] [EC:2.3.2.27]
109488103  SH3 domain-containing kinase-binding protein 1-like isoform X1 [KO:K12470]
109475294  hemicentin-2-like [KO:K12470]
109471937  endophilin-A3-like isoform X1 [KO:K11247]
109461579  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
109483427  epsin-1-like isoform X1 [KO:K12471]
109482853  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
109470544  LOW QUALITY PROTEIN: spartin-like [KO:K19366]
109480785  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
109461774  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
109486976  TNF receptor-associated factor 6-like isoform X1 [KO:K03175] [EC:2.3.2.27]
109478978  E3 ubiquitin-protein ligase NRDP1-like isoform X1 [KO:K11981] [EC:2.3.2.27]
109482673  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
109473552  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05633] [EC:2.3.2.26]
109486263  disabled homolog 1-like isoform X1 [KO:K12475]
109467794  beta-adrenergic receptor kinase 2-like isoform X1 [KO:K00910] [EC:2.7.11.15]
109475498  G protein-coupled receptor kinase 6-like isoform X1 [KO:K08291] [EC:2.7.11.16]
109463944  beta-arrestin-1-like isoform X1 [KO:K04439]
109482014  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
109483808  actin-related protein 2 [KO:K17260]
109461695  actin-related protein 3 isoform X1 [KO:K18584]
109487132  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
109474670  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
109487198  actin-related protein 2/3 complex subunit 3-like isoform X1 [KO:K05756]
109464969  actin-related protein 2/3 complex subunit 4 [KO:K05755]
109482601  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
109478678  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1-like [KO:K19475]
109464066  heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
109480383  heat shock 70 kDa protein 1B-like [KO:K03283]
109482766  heat shock 70 kDa protein-like [KO:K03283]
109469980  WASH complex subunit SWIP-like [KO:K18465]
109471851  WASH complex subunit strumpellin-like [KO:K18464]
109474817  WASH complex subunit FAM21-like isoform X1 [KO:K18462]
109477333  LOW QUALITY PROTEIN: WAS protein family homolog 1-like [KO:K18461]
109467417  WASH complex subunit CCDC53-like isoform X1 [KO:K18463]
109467111  F-actin-capping protein subunit alpha-1-like isoform X1 [KO:K10364]
109472676  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
109487133  vacuolar protein sorting-associated protein 29 [KO:K18467]
109473174  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
109473586  vacuolar protein sorting-associated protein 35-like isoform X1 [KO:K18468]
109473592  sorting nexin-3-like [KO:K17918]
109465022  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
109479151  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
109487884  ras-related protein Rab-7a [KO:K07897]
109483944  hepatocyte growth factor-regulated tyrosine kinase substrate-like isoform X1 [KO:K12182]
109469401  signal transducing adapter molecule 1-like isoform X1 [KO:K04705]
109484655  protein starmaker-like [KO:K12183]
109463403  protein ELC-like [KO:K12183]
109471763  tumor susceptibility gene 101 protein-like [KO:K12183]
109467482  tumor susceptibility gene 101 protein-like [KO:K12183]
109482477  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
109465283  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
109470708  vacuolar protein sorting-associated protein 37A-like [KO:K12185]
109487203  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
109478846  vacuolar-sorting protein SNF8-like [KO:K12188]
109486848  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
109478998  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
109462831  charged multivesicular body protein 6-B-like [KO:K12195]
109473765  charged multivesicular body protein 4c-like isoform X1 [KO:K12194]
109471531  charged multivesicular body protein 3-like [KO:K12193]
109464741  charged multivesicular body protein 3-like [KO:K12193]
109463401  charged multivesicular body protein 2a [KO:K12191]
109486946  charged multivesicular body protein 2b-B-like [KO:K12192]
109486775  charged multivesicular body protein 7-like [KO:K15053]
109461629  vacuolar protein sorting-associated protein 4A-like [KO:K12196]
109468443  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
109481246  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
109476811  charged multivesicular body protein 1b-like [KO:K12197]
109463894  charged multivesicular body protein 1b-like [KO:K12197]
109473892  charged multivesicular body protein 1a-like [KO:K12197]
109461599  charged multivesicular body protein 5-like [KO:K12198]
109473820  IST1 homolog isoform X1 [KO:K19476]
109474283  programmed cell death 6-interacting protein-like isoform X1 [KO:K12200]
109469712  maspardin-like isoform X1 [KO:K19367]
109481228  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
109471916  sorting nexin-2-like isoform X1 [KO:K17917]
109471148  sorting nexin-6-like isoform X1 [KO:K17920]
109464957  sorting nexin-32-like [KO:K17920]
109464958  uncharacterized protein LOC109464958 [KO:K17920]
109478272  rho-related GTP-binding protein RhoA-C [KO:K04513]
109473567  ras-like GTP-binding protein RHO [KO:K04513]
109466815  ras-like GTP-binding protein Rho1 [KO:K04513]
109485581  uncharacterized protein LOC109485581 [KO:K13649]
109480990  uncharacterized protein LOC109480990 [KO:K13649]
109473455  folate receptor gamma-like [KO:K13649]
109466647  uncharacterized protein LOC109466647 [KO:K13649]
109467870  folate receptor gamma-like [KO:K13649]
109487551  caveolin-2-like [KO:K12958]
109472392  uncharacterized protein LOC109472392 [KO:K12959]
109472395  uncharacterized protein LOC109472395 [KO:K12959]
109466892  caveolin-3-like [KO:K12959]
109469988  early endosome antigen 1-like isoform X1 [KO:K12478]
109465402  ras-related protein Rab-5A-like isoform X1 [KO:K07888]
109467291  rab GTPase-binding effector protein 1-like [KO:K12480]
109476752  rabenosyn-5-like [KO:K12481]
109472095  rabenosyn-5-like [KO:K12481]
109472722  vacuolar segregation protein PEP7-like [KO:K12481]
109478632  RUN and FYVE domain-containing protein 2-like isoform X1 [KO:K12482]
109470138  EH domain-containing protein 1-like [KO:K12483]
109471891  vacuolar protein sorting-associated protein 45-like [KO:K12479]
109475796  sorting nexin-4-like [KO:K17919]
109482053  ras-related protein Rab-22A-like [KO:K07891]
109480747  ras-related protein Rab-10-like [KO:K07903]
109465373  ras-related protein Rab-10-like [KO:K07903]
109468954  ras-related protein Rab-8A-like [KO:K07901]
109464426  ras-related protein Rab-35-like isoform X1 [KO:K07876]
109472983  ras-related protein rab-11.1-like [KO:K07904]
109468744  ras-related protein Rab-11B isoform X1 [KO:K07904]
109467630  rab11 family-interacting protein 1-like [KO:K12484]
109462943  protrudin-like isoform X1 [KO:K19368]
109474537  kinesin heavy chain-like isoform X1 [KO:K10396]
109484405  rab11 family-interacting protein 4B-like isoform X1 [KO:K12485]
109478083  partitioning defective 3 homolog [KO:K04237]
109482019  partitioning defective 6 homolog gamma-like [KO:K06093]
109472632  protein kinase C iota type-like isoform X1 [KO:K06069] [EC:2.7.11.13]
109472700  cell division control protein 42 homolog [KO:K04393]
109476405  cdc42 homolog [KO:K04393]
109482374  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
109467428  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
109483065  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
109472622  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
109467847  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K18439]
109474157  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12491]
109485015  ADP-ribosylation factor GTPase-activating protein 1-like isoform X1 [KO:K12492]
109480287  ADP-ribosylation factor GTPase-activating protein 2-like isoform X1 [KO:K12493]
109481344  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
109477330  IQ motif and SEC7 domain-containing protein 2-like isoform X1 [KO:K12495]
109483367  cytohesin-1-like [KO:K18441]
109465959  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like isoform X1 [KO:K18442]
109478214  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
109471528  ADP-ribosylation factor-like isoform X1 [KO:K07937]
109474612  ADP-ribosylation factor 1 [KO:K07937]
109471400  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
bbel04070  Phosphatidylinositol signaling system
bbel04130  SNARE interactions in vesicular transport
bbel04142  Lysosome
bbel04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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