KEGG   PATHWAY: bta04914
Entry
bta04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Bos taurus (cow)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
bta04914  Progesterone-mediated oocyte maturation
bta04914

Other DBs
GO: 0001556
Organism
Bos taurus (cow) [GN:bta]
Gene
100848466  PGR; progesterone receptor [KO:K08556]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
504437  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
514174  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X3 [KO:K02602]
537016  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
538794  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
538880  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
513874  SPDYC; speedy protein C isoform X1 [KO:K08694]
616408  SPDYA; speedy protein A [KO:K08694]
618542  speedy protein E4 [KO:K08694]
112448731  putative speedy protein E7 [KO:K08694]
519217  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
281061  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
281667  CCNA2; cyclin-A2 [KO:K06627]
521939  CCNA1; cyclin-A1 [KO:K06627]
444869  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
767874  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
281832  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
533908  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
511190  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
526227  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
517953  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
522613  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
327679  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
132345077  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
281668  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100301478  CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
526376  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
538238  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
520188  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
505847  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
507731  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
280829  INS; insulin preproprotein [KO:K04526]
281239  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
281848  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
533323  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
541140  KRAS; GTPase KRas [KO:K07827]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
514777  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
517837  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
337870  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
506605  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
530333  FZR1; fizzy-related protein homolog [KO:K03364]
535565  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100336564  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
540660  CDC27; cell division cycle protein 27 homolog [KO:K03350]
514572  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
540537  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
614342  CDC16; cell division cycle protein 16 homolog [KO:K03353]
535072  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
512651  CDC23; cell division cycle protein 23 homolog [KO:K03355]
783986  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
616275  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
777693  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
614347  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101905242  anaphase-promoting complex subunit 15 [KO:K25228]
505356  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
540089  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
506294  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
bta04010  MAPK signaling pathway
bta04110  Cell cycle
KO pathway
ko04914   
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