KEGG   PATHWAY: caty04722
Entry
caty04722                   Pathway                                
Name
Neurotrophin signaling pathway - Cercocebus atys (sooty mangabey)
Description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Class
Organismal Systems; Nervous system
Pathway map
caty04722  Neurotrophin signaling pathway
caty04722

Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105572781  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105595271  NTF4; neurotrophin-4 [KO:K12457]
105583006  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105584243  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105592428  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
105593393  SH2B2; SH2B adapter protein 2 isoform X1 [KO:K07193]
105573184  SH2B3; SH2B adapter protein 3 isoform X1 [KO:K12459]
105598581  SH2B1; SH2B adapter protein 1 isoform X1 [KO:K12459]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105589671  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105593758  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105594925  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105574798  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105575082  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105596570  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105572871  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105587548  KIDINS220; kinase D-interacting substrate of 220 kDa isoform X1 [KO:K12460]
105581010  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
105598246  CRKL; crk-like protein [KO:K04438]
105584307  CRK; adapter molecule crk isoform X1 [KO:K04438]
105594162  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
105594391  RAP1A; ras-related protein Rap-1A [KO:K04353]
105600503  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105590736  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105600975  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105593716  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
105592690  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105592727  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105586882  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105586884  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105576691  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105585292  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105585293  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105593504  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105591876  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
105584282  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
105588205  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
105580774  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105594400  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
105589068  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105591016  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105581343  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105577493  BAD; bcl2-associated agonist of cell death [KO:K02158]
105589738  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105573290  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105586974  IRS1; insulin receptor substrate 1 [KO:K16172]
105588401  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105589398  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105585581  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105600970  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105594435  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105595186  CALM3; calmodulin isoform X1 [KO:K02183]
105596563  CALM1; calmodulin [KO:K02183]
105581752  calmodulin-like [KO:K02183]
105597438  CALML3; calmodulin-like protein 3 [KO:K02183]
105597439  CALML5; calmodulin-like protein 5 [KO:K02183]
105590605  CALM2; calmodulin [KO:K02183]
105571464  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
105596908  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105589879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105597344  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105576638  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
105576174  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
105573167  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105591792  MATK; megakaryocyte-associated tyrosine-protein kinase isoform X1 [KO:K08888] [EC:2.7.10.2]
105579459  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105585109  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
105588591  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
105574549  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105571986  cell division control protein 42 homolog [KO:K04393]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105599635  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105600400  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105589128  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105595973  JUN; transcription factor AP-1 [KO:K04448]
105582225  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105595265  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105594469  TP73; tumor protein p73 isoform X1 [KO:K10148]
105586809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105593269  ZNF274; neurotrophin receptor-interacting factor homolog isoform X1 [KO:K12458]
105573247  PRDM4; PR domain zinc finger protein 4 isoform X1 [KO:K12463] [EC:2.1.1.-]
105579104  melanoma-associated antigen D1 [KO:K12464]
105574317  NGFRAP1; protein BEX3 isoform X1 [KO:K12465]
105584325  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105572870  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
105598716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105585776  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
105600519  IRAK3; interleukin-1 receptor-associated kinase 3 isoform X1 [KO:K04732] [EC:2.7.11.1]
105574390  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105594332  SORT1; LOW QUALITY PROTEIN: sortilin [KO:K12388]
105599553  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
105576920  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11399424
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7
Reference
PMID:16699811
  Authors
Arevalo JC, Wu SH
  Title
Neurotrophin signaling: many exciting surprises!
  Journal
Cell Mol Life Sci 63:1523-37 (2006)
DOI:10.1007/s00018-006-6010-1
Reference
PMID:14704852
  Authors
Teng KK, Hempstead BL
  Title
Neurotrophins and their receptors: signaling trios in complex biological systems.
  Journal
Cell Mol Life Sci 61:35-48 (2004)
DOI:10.1007/s00018-003-3099-3
Reference
PMID:11529497
  Authors
Miller FD, Kaplan DR
  Title
Neurotrophin signalling pathways regulating neuronal apoptosis.
  Journal
Cell Mol Life Sci 58:1045-53 (2001)
DOI:10.1007/PL00000919
Reference
PMID:10851172
  Authors
Kaplan DR, Miller FD
  Title
Neurotrophin signal transduction in the nervous system.
  Journal
Curr Opin Neurobiol 10:381-91 (2000)
DOI:10.1016/S0959-4388(00)00092-1
Reference
PMID:16939974
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:16856873
  Authors
Zampieri N, Chao MV
  Title
Mechanisms of neurotrophin receptor signalling.
  Journal
Biochem Soc Trans 34:607-11 (2006)
DOI:10.1042/BST0340607
Reference
PMID:15499580
  Authors
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
  Title
From modulator to mediator: rapid effects of BDNF on ion channels.
  Journal
Bioessays 26:1185-94 (2004)
DOI:10.1002/bies.20118
Reference
PMID:10812966
  Authors
Yano H, Chao MV
  Title
Neurotrophin receptor structure and interactions.
  Journal
Pharm Acta Helv 74:253-60 (2000)
DOI:10.1016/s0031-6865(99)00036-9
Reference
PMID:10764727
  Authors
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
  Title
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
  Journal
J Biol Chem 275:17566-70 (2000)
DOI:10.1074/jbc.C000140200
Reference
PMID:10985348
  Authors
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
  Title
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
  Journal
Neuron 27:279-88 (2000)
DOI:10.1016/S0896-6273(00)00036-2
Related
pathway
caty04010  MAPK signaling pathway
caty04120  Ubiquitin mediated proteolysis
caty04210  Apoptosis
caty04720  Long-term potentiation
caty04810  Regulation of actin cytoskeleton
KO pathway
ko04722   
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