KEGG   PATHWAY: caty05164
Entry
caty05164                   Pathway                                
Name
Influenza A - Cercocebus atys (sooty mangabey)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
caty05164  Influenza A
caty05164

Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105574008  tryptase alpha/beta-1-like isoform X1 [KO:K01340] [EC:3.4.21.59]
105574098  tryptase alpha/beta-1 [KO:K01340] [EC:3.4.21.59]
105594241  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
105584591  PRSS2; trypsin-2 [KO:K01312] [EC:3.4.21.4]
105584593  LOW QUALITY PROTEIN: putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
105584594  trypsin-1-like [KO:K01312] [EC:3.4.21.4]
105584595  putative trypsin-6 isoform X1 [KO:K01312] [EC:3.4.21.4]
105584597  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
105584598  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
105584599  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105584772  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105584773  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105575473  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
105582463  TMPRSS4; transmembrane protease serine 4 isoform X1 [KO:K09635] [EC:3.4.21.-]
105596091  TMPRSS11D; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105573163  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105573164  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
105573165  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105580392  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105601590  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
105574475  DNAJC3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
105597175  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105582856  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105583291  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
105590097  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
105576049  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
105582505  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
105582130  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105594400  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
105589068  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105579474  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
105594261  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
105591822  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105596732  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105600541  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105576636  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105595300  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105572093  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105572514  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
105600415  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105574716  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
105573904  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105574390  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105577208  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105591122  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
105591123  IL1B; interleukin-1 beta [KO:K04519]
105595383  IL6; interleukin-6 isoform X1 [KO:K05405]
105598171  IL12A; interleukin-12 subunit alpha [KO:K05406]
105581574  IL12B; interleukin-12 subunit beta [KO:K05425]
105573465  TNF; tumor necrosis factor [KO:K03156]
105596231  CXCL8; interleukin-8 [KO:K10030]
105589372  CCL2; C-C motif chemokine 2 [KO:K14624]
105589331  CCL5; C-C motif chemokine 5 [KO:K12499]
105576857  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
105601438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105591326  interferon alpha-1/13 [KO:K05414]
105591327  IFNA8; interferon alpha-8 [KO:K05414]
105591328  IFNA2; interferon alpha-2 [KO:K05414]
105591330  interferon alpha-1/13-like [KO:K05414]
105591332  interferon alpha-6 [KO:K05414]
105591336  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
105591337  LOW QUALITY PROTEIN: interferon alpha-21-like [KO:K05414]
105591338  interferon alpha-14 isoform X1 [KO:K05414]
105584002  IFNB1; interferon beta [KO:K05415]
105575378  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
105575579  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105595926  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105571283  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105577646  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105579958  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105587295  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105600246  IRF9; interferon regulatory factor 9 [KO:K04693]
105575470  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105575472  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105593498  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
105573504  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105600509  IFNG; interferon gamma [KO:K04687]
105600393  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
105575379  IFNGR2; interferon gamma receptor 2 [KO:K05133]
105584100  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105572166  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
105585184  HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752]
105600305  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
105600307  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
105593589  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
105589122  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
105574087  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
105574103  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
105590469  HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752]
105575000  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
105575001  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105575002  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
105575005  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
105575006  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
105575013  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105575014  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
105575015  HLA class II histocompatibility antigen, DQ alpha 1 chain-like isoform X1 [KO:K06752]
105575603  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
105575604  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
105575605  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
105575607  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
105583891  HLA class II histocompatibility antigen, DRB1-15 beta chain isoform X1 [KO:K06752]
105576724  HLA class II histocompatibility antigen, DRB1-4 beta chain isoform X1 [KO:K06752]
105576725  HLA class II histocompatibility antigen, DRB1-13 beta chain isoform X1 [KO:K06752]
105576726  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
105599484  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
105599574  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
105588753  caspase-1-like [KO:K01370] [EC:3.4.22.36]
105588757  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
105588688  IL18; interleukin-18 isoform X1 [KO:K05482]
105584074  IL33; interleukin-33 isoform X1 [KO:K12967]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105591815  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105587240  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
105573059  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105586081  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105579211  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
105579216  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105587157  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105583011  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105587262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
105577297  FADD; FAS-associated death domain protein [KO:K02373]
105580035  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105591256  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105595265  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105593255  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105599763  VDAC1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
105594248  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105587427  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105574783  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105598386  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105597193  uncharacterized protein LOC105597193 [KO:K08738]
105571593  cytochrome c-like [KO:K08738]
105588083  cytochrome c [KO:K08738]
105595720  cytochrome c-like [KO:K08738]
105589984  cytochrome c-like [KO:K08738]
105590205  cytochrome c-like [KO:K08738]
105573341  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105599419  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105593734  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105597738  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105577787  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404]
105584385  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
105589352  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
105598773  PABPN1; polyadenylate-binding protein 2 [KO:K14396]
105577534  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
105574326  NXF3; nuclear RNA export factor 3 isoform X1 [KO:K14284]
105574335  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
105592070  nuclear RNA export factor 2 [KO:K14284]
105581989  NXT1; NTF2-related export protein 1 [KO:K14285]
105598458  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
105598013  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
105585341  RAE1; mRNA export factor [KO:K14298]
105578812  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105587563  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
105593537  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
105590546  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105577106  LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [KO:K05692]
105588610  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105574978  LOW QUALITY PROTEIN: actin-like [KO:K05692]
105598339  ACTB; actin, cytoplasmic 1 [KO:K05692]
105600992  RAB11A; ras-related protein Rab-11A [KO:K07904]
105593819  RAB11B; ras-related protein Rab-11B [KO:K07905]
105576440  XPO1; exportin-1 isoform X1 [KO:K14290]
105589776  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
105573053  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
105599316  KPNA2; importin subunit alpha-1 [KO:K15043]
105584378  KPNA7; importin subunit alpha-8 [KO:K15043]
105595097  KPNA6; importin subunit alpha-7 [KO:K15042]
105581426  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
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J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
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Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
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J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
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A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
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Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
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Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
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Int J Biochem Cell Biol 40:2671-4 (2008)
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Reference
PMID:23977434
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Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
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Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
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Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
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Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
caty00900  Terpenoid backbone biosynthesis
caty03013  Nucleocytoplasmic transport
caty03015  mRNA surveillance pathway
caty04010  MAPK signaling pathway
caty04110  Cell cycle
caty04144  Endocytosis
caty04210  Apoptosis
caty04620  Toll-like receptor signaling pathway
caty04621  NOD-like receptor signaling pathway
caty04622  RIG-I-like receptor signaling pathway
caty04630  JAK-STAT signaling pathway
caty05416  Viral myocarditis
KO pathway
ko05164   
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