KEGG   PATHWAY: cfa05160
Entry
cfa05160                    Pathway                                
Name
Hepatitis C - Canis lupus familiaris (dog)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
cfa05160  Hepatitis C
cfa05160

Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
100683160  LDLR; low-density lipoprotein receptor [KO:K12473]
486241  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
611606  CD81; CD81 antigen isoform X2 [KO:K06508]
608226  CLDN15; claudin-15 isoform X1 [KO:K06087]
490048  CLDN6; claudin-6 [KO:K06087]
490049  CLDN9; claudin-9 [KO:K06087]
487751  CLDN14; claudin-14 [KO:K06087]
403648  CLDN3; claudin-3 [KO:K06087]
477079  CLDN18; claudin-18 isoform X1 [KO:K06087]
403649  CLDN2; claudin-2 [KO:K06087]
489466  CLDN7; claudin-7 [KO:K06087]
478401  CLDN8; claudin-8 [KO:K06087]
476963  CLDN10; claudin-10 isoform X3 [KO:K06087]
608935  CLDN20; claudin-20 [KO:K06087]
488160  CLDN11; claudin-11 [KO:K06087]
487720  CLDN17; claudin-17 [KO:K06087]
482919  claudin-22 [KO:K06087]
608218  CLDN16; claudin-16 isoform X2 [KO:K06087]
608207  CLDN1; claudin-1 [KO:K06087]
100686536  CLDN34; claudin-34 [KO:K06087]
100684266  CLDN5; claudin-5 [KO:K06087]
100687225  CLDN23; claudin-23 [KO:K06087]
100856416  CLDN4; claudin-4 [KO:K06087]
489401  CLDN25; putative claudin-25 [KO:K06087]
482918  CLDN24; putative claudin-24 [KO:K06087]
607005  CLDN19; claudin-19 isoform X2 [KO:K06087]
608397  CLDN12; claudin-12 [KO:K06087]
403844  OCLN; occludin [KO:K06088]
608778  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
611051  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
477490  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
490310  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
100855560  DDX58; antiviral innate immune response receptor RIG-I isoform X5 [KO:K12646] [EC:5.6.2.6]
485789  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
490867  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
481145  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
478950  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
476412  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
119864198  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
474181  IFNA7; interferon alpha-1/2 precursor [KO:K05414]
442934  IFNA5; interferon alpha-3 precursor [KO:K05414]
611406  interferon alpha-1/2-like isoform X1 [KO:K05414]
100686162  interferon alpha-2-like [KO:K05414]
100682977  interferon alpha-1/2 isoform X5 [KO:K05414]
100683045  LOW QUALITY PROTEIN: interferon alpha-1/2 isoform X5 [KO:K05414]
100683567  interferon alpha-1/2-like isoform X1 [KO:K05414]
100688005  interferon alpha-1/2 [KO:K05414]
100685213  interferon alpha-1/2 [KO:K05414]
100688084  interferon alpha-1/2 isoform X1 [KO:K05414]
481558  IFNB1; interferon beta precursor [KO:K05415]
403801  IFNG; interferon gamma precursor [KO:K04687]
482905  TLR3; toll-like receptor 3 [KO:K05401]
611852  TICAM1; TIR domain-containing adapter molecule 1 isoform X5 [KO:K05842]
100688110  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102152063  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
477796  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
482839  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
480291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
442859  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
483729  RELA; transcription factor p65 isoform X2 [KO:K04735]
403922  TNF; tumor necrosis factor [KO:K03156]
478432  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
100302056  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
611397  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
475756  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2 [KO:K08860] [EC:2.7.11.1]
478257  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X12 [KO:K16196] [EC:2.7.11.1]
488947  interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
606817  interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
475070  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
480361  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
490967  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
442949  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
609830  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100856468  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
442952  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
476714  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
488449  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
481111  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
607899  IRF9; interferon regulatory factor 9 [KO:K04693]
403745  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
403744  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
609005  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
484335  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
479444  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
477374  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X6 [KO:K04354]
610262  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
491587  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
478053  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
403608  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
482873  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
478350  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
403657  EGF; pro-epidermal growth factor precursor [KO:K04357]
404306  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
490682  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
403871  KRAS; GTPase KRas isoform X1 [KO:K07827]
403872  NRAS; GTPase NRas [KO:K07828]
475526  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
491857  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
475864  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
477237  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
607060  YWHAQ; 14-3-3 protein theta [KO:K16197]
479459  LOW QUALITY PROTEIN: 14-3-3 protein theta-like [KO:K16197]
100855903  14-3-3 protein zeta/delta-like isoform X3 [KO:K16197]
609669  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
480645  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
608573  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
100687866  YWHAH; 14-3-3 protein eta [KO:K16198]
489818  YWHAG; 14-3-3 protein gamma [KO:K16198]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
611939  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100856339  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
478575  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
477032  CTNNB1; catenin beta-1 [KO:K02105]
483763  BAD; bcl2-associated agonist of cell death [KO:K02158]
474890  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
100855704  CDK2; cyclin-dependent kinase 2 isoform X3 [KO:K02206] [EC:2.7.11.22]
481131  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
612475  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
609920  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
476915  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X5 [KO:K06618]
485839  E2F1; transcription factor E2F1 [KO:K17454]
100855664  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
488239  E2F3; transcription factor E2F3 [KO:K06620]
403634  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X5 [KO:K03158]
611262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
480673  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
442968  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
486469  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
611694  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
488473  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
403567  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
488471  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
100683675  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
403523  BAX; apoptosis regulator BAX [KO:K02159]
481744  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
475258  CYCS; cytochrome c [KO:K08738]
100689004  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
482620  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
487432  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
480512  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
491278  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
403654  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
483625  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
403924  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
cfa03320  PPAR signaling pathway
cfa04010  MAPK signaling pathway
cfa04144  Endocytosis
cfa04210  Apoptosis
cfa04514  Cell adhesion molecules
cfa04620  Toll-like receptor signaling pathway
cfa04622  RIG-I-like receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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