KEGG   PATHWAY: cgob04910
Entry
cgob04910                   Pathway                                
Name
Insulin signaling pathway - Cottoperca gobio
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
cgob04910  Insulin signaling pathway
cgob04910

Organism
Cottoperca gobio [GN:cgob]
Gene
115018585  ins; insulin [KO:K04526]
115014742  insulin-like [KO:K04526]
115022820  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
115006808  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
115019302  insulin receptor substrate 1-B-like [KO:K16172]
115023495  insulin receptor substrate 1-B-like [KO:K16172]
115017676  insulin receptor substrate 2-like isoform X1 [KO:K07187]
115026042  irs2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
115023931  LOW QUALITY PROTEIN: insulin receptor substrate 2-B-like [KO:K07187]
115024036  LOW QUALITY PROTEIN: insulin receptor substrate 2-B-like [KO:K07187]
115006873  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115013163  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115007466  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115022195  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
115016511  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115022645  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115017742  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
115006815  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115022421  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115011128  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
115005248  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115024330  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
115018604  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115019820  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115027720  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115017525  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115026019  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115012285  LOW QUALITY PROTEIN: glycogen [starch] synthase, muscle-like [KO:K00693] [EC:2.4.1.11]
115028632  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
115024308  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
115014063  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
115027034  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
115023613  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
115005785  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
115024443  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
115013837  protein phosphatase 1 regulatory subunit 3C-like [KO:K07189]
115020507  ppp1r3c; protein phosphatase 1 regulatory subunit 3C [KO:K07189]
115008707  LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
115028086  ppp1r3a; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
115010691  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
115011340  protein phosphatase 1 regulatory subunit 3F-like isoform X1 [KO:K07189]
115025091  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
115017640  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
115025347  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
115003420  phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
115023692  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like isoform X1 [KO:K07190]
115007947  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
115019794  calm2; calmodulin-2 [KO:K02183]
115027066  calmodulin [KO:K02183]
115009242  calmodulin-like protein 4 [KO:K02183]
115003784  calm1; calmodulin-1 isoform X1 [KO:K02183]
115004906  calml4; calmodulin-like protein 4 [KO:K02183]
115017352  calm3; calmodulin-3 [KO:K02183]
115019024  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
115027242  LOW QUALITY PROTEIN: glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
115023526  pygm; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
115024054  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
115011693  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115006619  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115022186  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115011777  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
115024612  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
115012490  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
115008059  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
115009743  prkar2b; cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
115010425  prkar2a; cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
115021198  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
115015627  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
115010493  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
115022826  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
115023591  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
115018067  flotillin-2 [KO:K07192]
115018520  flotillin-2a isoform X1 [KO:K07192]
115016082  flotillin-1 isoform X1 [KO:K07192]
115021858  flotillin-1-like [KO:K07192]
115018020  LOW QUALITY PROTEIN: SH2B adapter protein 2-like [KO:K07193]
115019781  sorbs1; sorbin and SH3 domain-containing protein 1 [KO:K06086]
115018877  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
115017572  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
115018518  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
115017907  adapter molecule crk-like isoform X1 [KO:K04438]
115019204  adapter molecule crk-like [KO:K04438]
115016623  crkl; crk-like protein [KO:K04438]
115016717  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
115005563  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1-like [KO:K06277]
115019780  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
115024480  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
115012416  trip10; cdc42-interacting protein 4 isoform X1 [KO:K07196]
115009334  cdc42-interacting protein 4 homolog [KO:K07196]
115012418  srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
115019451  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
115012970  acacb; LOW QUALITY PROTEIN: acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
115006227  hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
115026145  putative hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
115026152  LOW QUALITY PROTEIN: hexokinase-1-like [KO:K00844] [EC:2.7.1.1]
115014041  hexokinase-2-like isoform X1 [KO:K00844] [EC:2.7.1.1]
115013132  gck; glucokinase isoform X1 [KO:K12407] [EC:2.7.1.2]
115006880  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
115016657  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
115013041  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
115017136  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
115023062  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
115019864  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
115008620  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
115026668  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
115021980  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
115019246  LOW QUALITY PROTEIN: forkhead box protein O1-A-like [KO:K07201]
115017485  forkhead box protein O1-A-like [KO:K07201]
115023833  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
115024557  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
115024688  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
115024697  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
115026106  g6pc2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
115013904  LOW QUALITY PROTEIN: fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
115017155  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
115025351  LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
115008379  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
115010675  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115016810  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
115018012  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
115018618  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
115013736  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
115015311  rps6; 40S ribosomal protein S6 [KO:K02991]
115014102  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
115016939  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
115019838  eukaryotic translation initiation factor 4E-like [KO:K03259]
115027016  eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
115014978  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
115022475  eif4e2; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2 [KO:K03259]
115005256  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
115016568  tsc1; hamartin isoform X1 [KO:K07206]
115004749  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
115015359  tsc2; tuberin isoform X1 [KO:K07207]
115008795  GTP-binding protein Rheb-like [KO:K07208]
115023076  rheb; GTP-binding protein Rheb [KO:K07208]
115023677  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
115020898  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
115007109  shc2; SHC-transforming protein 2 [KO:K17447]
115016959  shc3; SHC-transforming protein 3 [KO:K17448]
115023683  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
115012209  growth factor receptor-bound protein 2 [KO:K04364]
115027245  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
115009535  hras; GTPase HRas [KO:K02833]
115012331  GTPase HRas-like [KO:K07827]
115009461  kras; GTPase KRas [KO:K07827]
115028355  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115010471  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
115009830  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115007241  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115022522  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115012254  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115013460  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
115006668  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
115007031  MAP kinase-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K04372] [EC:2.7.11.1]
115005792  ETS domain-containing protein Elk-3-like [KO:K04375]
115010566  suppressor of cytokine signaling 1-like [KO:K04694]
115011593  socs1; suppressor of cytokine signaling 1 [KO:K04694]
115004548  suppressor of cytokine signaling 2-like [KO:K04695]
115012646  suppressor of cytokine signaling 3-like [KO:K04696]
115025045  suppressor of cytokine signaling 3-like [KO:K04696]
115006088  socs4; suppressor of cytokine signaling 4 [KO:K04697]
115006848  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
115022102  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
115024543  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115020041  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115015104  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115016627  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115013798  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115014723  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like isoform X1 [KO:K15909] [EC:3.1.3.86]
115017518  inppl1; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
115019877  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
cgob00010  Glycolysis / Gluconeogenesis
cgob00061  Fatty acid biosynthesis
cgob00500  Starch and sucrose metabolism
cgob04010  MAPK signaling pathway
cgob04070  Phosphatidylinositol signaling system
cgob04210  Apoptosis
KO pathway
ko04910   
LinkDB

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