KEGG   PATHWAY: clud05146
Entry
clud05146                   Pathway                                
Name
Amoebiasis - Canis lupus dingo (dingo)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
clud05146  Amoebiasis
clud05146

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112664386  IL1B; interleukin-1 beta [KO:K04519]
112669932  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
112669967  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112646174  HSPB1; heat shock protein beta-1 [KO:K04455]
112663246  MUC2; LOW QUALITY PROTEIN: mucin-2 [KO:K10955]
112674906  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112655086  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
112669820  COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
112669822  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
112649263  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
112649264  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112656116  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112656117  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
112656719  FN1; fibronectin isoform X1 [KO:K05717]
112648045  LAMA1; laminin subunit alpha-1 [KO:K05637]
112644554  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
112647953  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112674230  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
112658627  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
112661476  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
112665771  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
112648343  LAMB3; laminin subunit beta-3 [KO:K06244]
112661363  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
112648478  LAMC1; laminin subunit gamma-1 [KO:K05635]
112648481  LAMC2; laminin subunit gamma-2 [KO:K06246]
112677344  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125755517  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
112644686  guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
112666259  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
112644688  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
112666258  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
112659377  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
112673608  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
112673609  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112676127  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5 [KO:K05858] [EC:3.1.4.11]
112652873  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112640230  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112645036  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112674185  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112674186  neuroendocrine secretory protein 55 [KO:K04632]
112648092  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
112650921  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
112670489  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112666620  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112640987  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112660999  RAB5A; ras-related protein Rab-5A [KO:K07887]
112678041  RAB5B; ras-related protein Rab-5B [KO:K07888]
112655680  RAB5C; ras-related protein Rab-5C [KO:K07889]
112660644  RAB7A; ras-related protein Rab-7a [KO:K07897]
112643201  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
112654591  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
112650004  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112658985  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112670562  IL6; interleukin-6 [KO:K05405]
112652150  growth-regulated protein homolog gamma-like isoform X2 [KO:K05505]
112652148  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
112650098  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
112652282  CXCL8; interleukin-8 [KO:K10030]
112641287  TNF; tumor necrosis factor [KO:K03156]
112645861  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
112651834  IL12B; interleukin-12 subunit beta [KO:K05425]
112642823  antigen-presenting glycoprotein CD1d [KO:K06448]
112642863  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1c-like [KO:K06448]
112642864  T-cell surface glycoprotein CD1b-like [KO:K06448]
112642937  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
112642940  CD1E; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
112677888  IFNG; interferon gamma [KO:K04687]
112668250  COL3A1; collagen alpha-1(III) chain [KO:K19720]
112662017  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112651562  VCL; vinculin isoform X2 [KO:K05700]
112645512  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
112658028  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
112657379  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
112641237  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
112677685  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
112669226  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
112640141  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112647631  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
112642575  PRDX1; peroxiredoxin-1 isoform X2 [KO:K13279] [EC:1.11.1.24]
112652217  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
112650687  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
112659367  SERPINB6; serpin B6 isoform X2 [KO:K13963]
112659383  SERPINB9; serpin B9 isoform X1 [KO:K13963]
112644012  SERPINB10; serpin B10 [KO:K13963]
112644019  serpin B13 [KO:K13963]
112657572  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
112648300  IL10; interleukin-10 [KO:K05443]
112645426  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
112643136  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
112657820  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
112647098  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
112647100  C8B; complement component C8 beta chain [KO:K03998]
112677467  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
112652759  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
clud00330  Arginine and proline metabolism
clud00590  Arachidonic acid metabolism
clud04144  Endocytosis
clud04210  Apoptosis
clud04510  Focal adhesion
clud04610  Complement and coagulation cascades
clud04612  Antigen processing and presentation
clud04620  Toll-like receptor signaling pathway
clud04672  Intestinal immune network for IgA production
clud04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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