KEGG   PATHWAY: cpoc05165
Entry
cpoc05165                   Pathway                                
Name
Human papillomavirus infection - Cavia porcellus (domestic guinea pig)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
cpoc05165  Human papillomavirus infection
cpoc05165

Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100717026  Wnt1; LOW QUALITY PROTEIN: proto-oncogene Wnt-1 [KO:K03209]
100714996  Wnt2b; protein Wnt-2b [KO:K00182]
100719346  Wnt2; protein Wnt-2 [KO:K00182]
100726694  Wnt3a; protein Wnt-3a [KO:K00312]
100734613  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
100724855  Wnt4; protein Wnt-4 isoform X1 [KO:K00408]
100715484  Wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
100723890  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
100713618  Wnt6; protein Wnt-6 [KO:K00445]
100726062  Wnt7b; protein Wnt-7b [KO:K00572]
100719106  Wnt7a; protein Wnt-7a [KO:K00572]
100725534  Wnt8a; protein Wnt-8a [KO:K00714]
100724403  Wnt8b; protein Wnt-8b [KO:K00714]
100726329  Wnt9a; protein Wnt-9a [KO:K01064]
100729157  Wnt9b; protein Wnt-9b [KO:K01064]
100713337  Wnt10a; protein Wnt-10a [KO:K01357]
100728910  Wnt10b; protein Wnt-10b [KO:K01357]
100718108  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
100721822  Wnt16; protein Wnt-16 [KO:K01558]
100735394  Fzd7; frizzled-7 [KO:K02432]
100730489  Fzd1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
100726820  Fzd2; frizzled-2 [KO:K02235]
100716417  Fzd3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
100714941  Fzd4; frizzled-4 [KO:K02354]
100728348  Fzd5; frizzled-5 [KO:K02375]
100719748  Fzd6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
100735834  Fzd9; frizzled-9 [KO:K02842]
100731601  Fzd10; frizzled-10 [KO:K02842]
100728748  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100717450  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100723761  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100714392  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100718536  Axin1; axin-1 isoform X1 [KO:K02157]
100731715  Axin2; axin-2 isoform X1 [KO:K04385]
100723694  Apc; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100735498  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
100732604  Ctnnb1; catenin beta-1 [KO:K02105]
100724050  Csnk1a1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
100732437  Tert; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100712802  Tcf7; transcription factor 7 [KO:K02620]
100731379  Tcf7l1; transcription factor 7-like 1 [KO:K04490]
100715721  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100730511  Ube3a; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
100135634  Tlr3; toll-like receptor 3 precursor [KO:K05401]
100717594  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
100734492  Traf3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
100716187  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100731956  Tbk1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
100724910  Irf3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
100734449  interferon beta [KO:K05415]
100733284  interferon beta-like [KO:K05415]
111757491  Ifnb1; interferon beta [KO:K05415]
100716770  Crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100734820  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100719194  Tada3; transcriptional adapter 3 [KO:K11315]
100379269  Tp53; cellular tumor antigen p53 [KO:K04451]
100734036  Magi1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100723659  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100721421  Pard3; partitioning defective 3 homolog isoform X25 [KO:K04237]
100728300  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
100732023  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100723981  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
100731983  Prkci; protein kinase C iota type isoform X2 [KO:K06069] [EC:2.7.11.13]
100734946  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100734321  Scrib; protein scribble homolog isoform X2 [KO:K16175]
100732834  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
100732206  Dlg3; disks large homolog 3 isoform X3 [KO:K21098]
100728315  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
100717035  Llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
100721189  Crb3; protein crumbs homolog 3 [KO:K06090]
100730516  Patj; inaD-like protein [KO:K06092]
100715808  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100732530  Vwf; von Willebrand factor precursor [KO:K03900]
100727882  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
100720036  Thbs4; thrombospondin-4 [KO:K04659]
100720040  Comp; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
100735538  Thbs2; thrombospondin-2 [KO:K04659]
100714970  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100732865  Fn1; fibronectin isoform X1 [KO:K05717]
100733209  Col1a1; collagen alpha-1(I) chain [KO:K06236]
100719158  Col1a2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
100733907  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100718624  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
100718202  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100732595  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
100730120  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
100717641  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
100732315  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
100732068  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100716662  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100717588  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
100717027  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
100732346  Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
100734770  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
100725525  Col9a2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
100723407  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100716721  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100714826  Lama1; laminin subunit alpha-1 [KO:K05637]
100719656  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
100717292  Lama3; laminin subunit alpha-3 [KO:K06240]
100716529  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100721521  Lamb1; laminin subunit beta-1 [KO:K05636]
100732418  Lamb2; laminin subunit beta-2 [KO:K06243]
100735299  Lamb3; laminin subunit beta-3 [KO:K06244]
101787649  LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100734278  Lamc1; laminin subunit gamma-1 [KO:K05635]
100733999  Lamc2; laminin subunit gamma-2 [KO:K06246]
100729645  Lamc3; laminin subunit gamma-3 [KO:K06247]
100731923  Chad; chondroadherin [KO:K06248]
100723362  Reln; reelin [KO:K06249] [EC:3.4.21.-]
100715233  Spp1; LOW QUALITY PROTEIN: osteopontin [KO:K06250]
100727771  Vtn; vitronectin [KO:K06251]
100727512  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100729387  Tnn; tenascin-N isoform X2 [KO:K06252]
100713399  Tnr; tenascin-R isoform X1 [KO:K06252]
100725345  Tnc; tenascin isoform X1 [KO:K06252]
100730180  Ibsp; bone sialoprotein 2 [KO:K06253]
100729544  Itga1; integrin alpha-1 [KO:K06480]
100729266  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
100727374  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100734983  Itga3; integrin alpha-3 isoform X2 [KO:K06482]
100718628  Itga4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
100725679  Itga5; integrin alpha-5 [KO:K06484]
100731242  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
100716758  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
100721946  Itga8; integrin alpha-8 [KO:K06584]
100716659  Itga9; integrin alpha-9 [KO:K06585]
100719833  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
100730700  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
100728575  Itgav; integrin alpha-V [KO:K06487]
100719502  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100731365  Itgb3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
100718717  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
100713066  Itgb5; integrin beta-5 [KO:K06588]
100718631  Itgb6; integrin beta-6 isoform X2 [KO:K06589]
100727605  Itgb7; integrin beta-7 [KO:K06590]
100727946  Itgb8; integrin beta-8 [KO:K06591]
100732427  Pxn; paxillin isoform X1 [KO:K05760]
100135630  Tnf; tumor necrosis factor [KO:K03156]
100713890  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158]
100732953  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100714139  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100726403  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100730628  Fadd; FAS-associated death domain protein [KO:K02373]
100713334  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100718309  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100724451  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100724172  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
100720727  Ppp2cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100713478  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100734047  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
100733570  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100716856  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100731252  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100730883  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
100720531  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
100729010  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
100732627  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100727229  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
100735391  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
100723199  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100723810  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100732297  Tsc1; hamartin [KO:K07206]
100731690  Tsc2; tuberin isoform X1 [KO:K07207]
100734252  Rheb; GTP-binding protein Rheb [KO:K07208]
100724938  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100733182  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100727216  Rps6kb1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100722430  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100734553  Bak1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100734151  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100726506  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100720649  Foxo1; forkhead box protein O1 [KO:K07201]
100729359  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100720449  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100729808  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100730596  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100718785  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100717960  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100732773  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100734034  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
100727568  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
100714324  Cdk2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100716297  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
100727381  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
100713872  Rbl2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
100733985  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
100729531  E2f1; transcription factor E2F1 [KO:K17454]
100716489  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
100716947  Ccna2; cyclin-A2 [KO:K06627]
100717983  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100732693  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100713483  Vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
100726357  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100724538  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100722308  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100730075  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100724366  Rela; transcription factor p65 isoform X1 [KO:K04735]
100724684  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100723545  Nfx1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
100728529  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100715675  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100735611  Chd4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
100719575  Irf1; interferon regulatory factor 1 isoform X2 [KO:K09444]
100726569  Tbpl2; TATA box-binding protein-like protein 2 [KO:K03120]
100733307  Tbp; TATA-box-binding protein [KO:K03120]
100719408  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
100724396  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100723126  patr class I histocompatibility antigen, alpha chain E-like isoform X2 [KO:K06751]
100733898  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100733617  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-18 alpha chain-like [KO:K06751]
100723401  HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X2 [KO:K06751]
100723960  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100712777  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
100713317  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100728003  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
100733879  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100726524  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100724011  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100716597  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
100725980  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X2 [KO:K02148]
100716088  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
100725691  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
100722091  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
100730842  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
100712974  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100723558  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
100712761  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
100716527  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101787762  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100717816  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X5 [KO:K02154]
100735854  Atp6v0a4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100712820  Tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100733139  Atp6v0d1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
100717063  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X3 [KO:K02146]
100713097  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
100726215  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
100735418  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100720289  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100724336  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
100714471  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
100725363  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100715453  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
100721165  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100726398  Sos2; son of sevenless homolog 2 [KO:K03099]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100728923  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100135607  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100192398  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100732158  neuroendocrine secretory protein 55-like [KO:K04632]
100732436  guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
100735694  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100712694  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100730890  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
100727326  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100731200  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100734327  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100729390  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100713963  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100728649  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X5 [KO:K09048]
100719318  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100725123  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X7 [KO:K10691] [EC:2.3.2.27]
100719864  Tubg1; tubulin gamma-1 chain [KO:K10389]
100720136  tubulin gamma-2 chain isoform X1 [KO:K10389]
100736056  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
100726990  interferon alpha-17-like [KO:K05414]
100728098  interferon alpha-4 [KO:K05414]
100729220  interferon alpha-21-like [KO:K05414]
100735600  interferon alpha-21-like [KO:K05414]
100722772  interferon alpha-1-like [KO:K05414]
100734117  interferon alpha-4-like [KO:K05414]
100718817  interferon alpha-17-like [KO:K05414]
100716684  interferon alpha-4-like [KO:K05414]
100728479  interferon alpha-17-like [KO:K05414]
100722040  interferon alpha-5-like [KO:K05414]
100717234  interferon alpha-17-like [KO:K05414]
100720391  interferon alpha-4-like [KO:K05414]
100725261  interferon alpha-4 [KO:K05414]
100730474  interferon alpha-4-like [KO:K05414]
100734169  interferon alpha-10-like [KO:K05414]
100721849  interferon alpha-17-like [KO:K05414]
100717707  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
100724988  interferon alpha-17-like [KO:K05414]
100714884  interferon alpha-13-like [KO:K05414]
100715784  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100716349  Ifnar2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100726895  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100715734  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100724708  Stat1; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100719719  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100714136  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100717384  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100722668  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
100734390  Oasl; 2'-5'-oligoadenylate synthase-like protein isoform X2 [KO:K14608]
100730982  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
100717337  interferon-induced GTP-binding protein Mx2-like isoform X1 [KO:K14754]
100731608  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
100721736  Jag1; protein jagged-1 [KO:K06052]
100724583  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
100715372  Notch2; neurogenic locus notch homolog protein 2 [KO:K20994]
100716867  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
100712850  Notch4; neurogenic locus notch homolog protein 4 isoform X4 [KO:K20996]
100728153  Psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
100730084  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
100731745  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
100715492  Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
100727311  uncharacterized protein LOC100727311 [KO:K05948] [EC:2.4.1.222]
100722901  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe-like [KO:K05948] [EC:2.4.1.222]
100725960  Maml1; mastermind-like protein 1 [KO:K06061]
100719538  Maml3; mastermind-like protein 3 [KO:K06061]
100722455  Maml2; mastermind-like protein 2 [KO:K06061]
100716535  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100717262  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100734567  Hes1; transcription factor HES-1 [KO:K06054]
100724940  Hes2; transcription factor HES-2 [KO:K09087]
100728444  Hes6; transcription cofactor HES-6 isoform X1 [KO:K09087]
100731446  Hes7; transcription factor HES-7 [KO:K09087]
100734445  Hes3; LOW QUALITY PROTEIN: transcription factor HES-3 [KO:K09088]
100725154  Hes5; transcription factor HES-5 [KO:K06055]
100718167  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein isoform X2 [KO:K09091]
100727826  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
100734127  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
PMID:11753669
  Authors
DiMaio D, Mattoon D
  Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
  Journal
Oncogene 20:7866-73 (2001)
DOI:10.1038/sj.onc.1204915
Reference
PMID:22262402
  Authors
Ganguly N
  Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
  Journal
Cell Oncol (Dordr) 35:67-76 (2012)
DOI:10.1007/s13402-011-0069-x
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:23403708
  Authors
De Marco F
  Title
Oxidative stress and HPV carcinogenesis.
  Journal
Viruses 5:708-31 (2013)
DOI:10.3390/v5020708
Reference
PMID:26643553
  Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
  Title
Breaking the DNA damage response to improve cervical cancer treatment.
  Journal
Cancer Treat Rev 42:30-40 (2016)
DOI:10.1016/j.ctrv.2015.11.008
Reference
PMID:19861444
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
PMID:11325599
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
PMID:10702232
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
cpoc04064  NF-kappa B signaling pathway
cpoc04110  Cell cycle
cpoc04115  p53 signaling pathway
cpoc04150  mTOR signaling pathway
cpoc04151  PI3K-Akt signaling pathway
cpoc04210  Apoptosis
cpoc04310  Wnt signaling pathway
cpoc04330  Notch signaling pathway
cpoc04510  Focal adhesion
cpoc04520  Adherens junction
cpoc04530  Tight junction
cpoc04612  Antigen processing and presentation
cpoc04620  Toll-like receptor signaling pathway
cpoc04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

DBGET integrated database retrieval system