KEGG   PATHWAY: cpoc05203
Entry
cpoc05203                   Pathway                                
Name
Viral carcinogenesis - Cavia porcellus (domestic guinea pig)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
cpoc05203  Viral carcinogenesis
cpoc05203

Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100728509  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100727326  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100726889  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100732296  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100731200  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100734327  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100729390  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100713963  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100728649  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X5 [KO:K09048]
100719318  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100726957  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100724177  Ddb1; DNA damage-binding protein 1 [KO:K10610]
100727182  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
100733198  Ywhaq; 14-3-3 protein theta [KO:K16197]
100715125  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
100714396  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100725300  Ywhag; 14-3-3 protein gamma [KO:K16198]
100728374  Ywhah; 14-3-3 protein eta [KO:K16198]
100726895  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100717084  Stat3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
100716811  signal transducer and activator of transcription 5A [KO:K11223]
100716532  Stat5b; signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
100718309  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100719031  Hpn; serine protease hepsin isoform X1 [KO:K08665] [EC:3.4.21.106]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100724366  Rela; transcription factor p65 isoform X1 [KO:K04735]
100733398  Rel; LOW QUALITY PROTEIN: proto-oncogene c-Rel [KO:K09254]
100715820  Nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100730075  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100379269  Tp53; cellular tumor antigen p53 [KO:K04451]
100734034  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
100727568  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
100714324  Cdk2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100721167  Egr2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
100728858  Egr3; early growth response protein 3 isoform X1 [KO:K12497]
100728777  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100713613  Ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
100727417  Sp100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
100729110  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
100726317  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
100720449  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100723615  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
100731556  Ddx3x; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
100717384  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100735694  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100712694  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106027456  histone H2B type 1 [KO:K11252]
106027457  histone H2B type 1 [KO:K11252]
100735042  histone H2B subacrosomal variant-like [KO:K11252]
100728660  histone H2B type 2-F isoform X2 [KO:K11252]
100717788  histone H2B type 2-E-like [KO:K11252]
100718354  histone H2B type 2-E [KO:K11252]
100735982  histone H2B type 1 [KO:K11252]
100712609  histone H2B type 1 [KO:K11252]
100713990  histone H2B type 1-K [KO:K11252]
101787866  histone H2B type 1 [KO:K11252]
100728646  histone H2B type 3-A [KO:K11252]
100734596  histone H2B type 1-like [KO:K11252]
100717510  histone H2B type 2-E-like [KO:K11252]
100726109  histone H2B type 1-A [KO:K11252]
100729449  histone H2B type 1-B [KO:K11252]
100732199  histone H2B type 1 [KO:K11252]
100733033  histone H2B type 1 [KO:K11252]
100735546  histone H2B type 1 [KO:K11252]
100728920  histone H2B type 3-A-like [KO:K11252]
100728045  histone H4 [KO:K11254]
100731150  histone H4 [KO:K11254]
100732665  histone H4 [KO:K11254]
100733876  histone H4 [KO:K11254]
100734432  histone H4 [KO:K11254]
100736110  histone H4 [KO:K11254]
111756490  histone H4 [KO:K11254]
100730890  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
100715453  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
100732953  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100735946  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100726569  Tbpl2; TATA box-binding protein-like protein 2 [KO:K03120]
100733307  Tbp; TATA-box-binding protein [KO:K03120]
100719408  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
100726431  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
100724684  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100716535  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100717262  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100728254  Snw1; SNW domain-containing protein 1 [KO:K06063]
100714157  Gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
100732574  general transcription factor IIH subunit 2 isoform X1 [KO:K03142]
100720431  general transcription factor IIH subunit 2-like isoform X1 [KO:K03142]
100729404  LOW QUALITY PROTEIN: general transcription factor IIH subunit 2-like [KO:K03142]
100733552  Gtf2h2; general transcription factor IIH subunit 2 [KO:K03142]
100720023  Gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]
101787652  Gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
100715976  Gtf2e1; general transcription factor IIE subunit 1 [KO:K03136]
100720170  Gtf2e2; transcription initiation factor IIE subunit beta [KO:K03137]
100726680  Snd1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
100716770  Crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100734820  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100732994  Gtf2b; LOW QUALITY PROTEIN: transcription initiation factor IIB [KO:K03124]
100729808  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100730596  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100718785  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100732773  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100716489  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
100716947  Ccna2; cyclin-A2 [KO:K06627]
100720705  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100722297  Mrps18b; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
100723139  Traf1; TNF receptor-associated factor 1 [KO:K03172]
100733145  Traf2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100734492  Traf3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
100721722  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
100713900  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100714653  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100716985  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100733139  Atp6v0d1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
100717063  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X3 [KO:K02146]
100730511  Ube3a; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
100734321  Scrib; protein scribble homolog isoform X2 [KO:K16175]
100732427  Pxn; paxillin isoform X1 [KO:K05760]
100734553  Bak1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100724910  Irf3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
100733985  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
100716297  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
100727381  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
100713872  Rbl2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
100729359  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100725123  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X7 [KO:K10691] [EC:2.3.2.27]
100728775  Jun; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
100735611  Chd4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
100728529  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100715675  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100718985  Hdac3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
100722799  Hdac5; histone deacetylase 5 isoform X6 [KO:K11406] [EC:3.5.1.98]
100713301  Hdac4; histone deacetylase 4 isoform X3 [KO:K11406] [EC:3.5.1.98]
100717988  Hdac6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
100734930  Hdac7; histone deacetylase 7 isoform X2 [KO:K11408] [EC:3.5.1.98]
100721893  Hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
100735647  Hdac9; LOW QUALITY PROTEIN: histone deacetylase 9 [KO:K11409] [EC:3.5.1.98]
100725246  Hdac10; LOW QUALITY PROTEIN: histone deacetylase 10 [KO:K18671] [EC:3.5.1.98]
100715203  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
100736056  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
100714136  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100719173  Dnaja3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
100719014  Kat2b; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
100716533  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
100729927  Gtf2a1; transcription initiation factor IIA subunit 1 [KO:K03122]
100726029  Gtf2a1l; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
100716605  Gtf2a2; transcription initiation factor IIA subunit 2 [KO:K03123]
100715998  Srf; serum response factor isoform X1 [KO:K04378]
100722308  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100723189  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
100730767  Rasa2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100733542  Rhoa; transforming protein RhoA [KO:K04513]
100726389  Scin; adseverin [KO:K05768]
100722590  Gsn; gelsolin isoform X1 [KO:K05768]
100721342  Actn1; alpha-actinin-1 isoform X2 [KO:K05699]
100733111  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
100717960  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100731972  cyclin-dependent kinase inhibitor 2A [KO:K06621]
100732246  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100719613  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100718545  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
100731466  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
100726301  protein VAC14 homolog [KO:K15305]
100731788  Ranbp1; ran-specific GTPase-activating protein isoform X2 [KO:K15306]
100731356  Polb; LOW QUALITY PROTEIN: DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
101788200  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100724018  Il6st; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060]
100716672  C-C chemokine receptor type 5 [KO:K04180]
100725278  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
100718618  C-C chemokine receptor type 3 [KO:K04178]
100379615  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
100715906  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100713334  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100734151  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100727696  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X1 [KO:K10131]
100135462  C3; complement C3 preproprotein [KO:K03990]
100724396  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100723126  patr class I histocompatibility antigen, alpha chain E-like isoform X2 [KO:K06751]
100733898  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100733617  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-18 alpha chain-like [KO:K06751]
100723401  HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X2 [KO:K06751]
100723960  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100712777  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
100713317  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
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Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
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Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
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Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
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Reference
PMID:9343405
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Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Reference
PMID:16039586
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Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
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Reference
PMID:21994562
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Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
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  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
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Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
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Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
cpoc03022  Basal transcription factors
cpoc03320  PPAR signaling pathway
cpoc04010  MAPK signaling pathway
cpoc04062  Chemokine signaling pathway
cpoc04064  NF-kappa B signaling pathway
cpoc04110  Cell cycle
cpoc04115  p53 signaling pathway
cpoc04142  Lysosome
cpoc04151  PI3K-Akt signaling pathway
cpoc04210  Apoptosis
cpoc04630  JAK-STAT signaling pathway
cpoc04662  B cell receptor signaling pathway
cpoc04810  Regulation of actin cytoskeleton
cpoc05160  Hepatitis C
cpoc05161  Hepatitis B
cpoc05165  Human papillomavirus infection
cpoc05166  Human T-cell leukemia virus 1 infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05169  Epstein-Barr virus infection
KO pathway
ko05203   
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