KEGG   PATHWAY: csab05167
Entry
csab05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Chlorocebus sabaeus (green monkey)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05167

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103234342  C3; complement C3 [KO:K03990]
103236634  TLR3; toll like receptor 3 [KO:K05401]
103233731  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
103229744  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103230198  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103238638  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103226003  IRF7; interferon regulatory factor 7 [KO:K09447]
103219368  IFNA2; interferon alpha 2 [KO:K05414]
103219366  interferon alpha-1/13-like [KO:K05414]
103219367  IFNA8; interferon alpha 8 [KO:K05414]
103219370  interferon alpha-1/13 [KO:K05414]
103219372  interferon alpha-6 [KO:K05414]
103219377  interferon alpha-14 [KO:K05414]
103219378  interferon alpha-4-like [KO:K05414]
103219379  interferon alpha-4 [KO:K05414]
103219381  interferon alpha-17-like [KO:K05414]
103235050  IRF3; interferon regulatory factor 3 [KO:K05411]
103231770  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103223371  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103219383  IFNB1; interferon beta 1 [KO:K05415]
103216875  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103216889  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103224682  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103234360  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
103217529  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103238525  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103228710  IRF9; interferon regulatory factor 9 [KO:K04693]
103220482  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103221595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103221596  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103223551  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103223553  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103230194  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103243132  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103234667  ZFP36; ZFP36 ring finger protein [KO:K15308]
103226390  IL6; interleukin 6 [KO:K05405]
103244503  CSF2; colony stimulating factor 2 [KO:K05427]
103227533  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
103227535  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
103227531  CCR1; C-C motif chemokine receptor 1 [KO:K04176]
103241836  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
103221038  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
103216224  FAS; Fas cell surface death receptor [KO:K04390]
103245758  FADD; Fas associated via death domain [KO:K02373]
103217637  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103222876  BID; BH3 interacting domain death agonist [KO:K04726]
103235004  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103221651  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103239827  cytochrome c [KO:K08738]
103225665  cytochrome c-like [KO:K08738]
103228018  cytochrome c-like [KO:K08738]
103244190  cytochrome c-like [KO:K08738]
103224843  cytochrome c-like [KO:K08738]
103240990  cytochrome c-like [KO:K08738]
103219556  cytochrome c-like [KO:K08738]
103225550  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103233291  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103239600  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103242323  TP53; tumor protein p53 [KO:K04451]
103221583  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103238589  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103226555  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103214406  RB1; RB transcriptional corepressor 1 [KO:K06618]
103248605  E2F1; E2F transcription factor 1 [KO:K17454]
103225395  E2F2; E2F transcription factor 2 [KO:K09389]
103222084  E2F3; E2F transcription factor 3 [KO:K06620]
103247140  Chsa-A; HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751]
103221837  Chsa-A; popy class I histocompatibility antigen, alpha chain E [KO:K06751]
103221775  Chsa-B; HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
103221786  Chsa-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103221863  mamu class I histocompatibility antigen, alpha chain F-like [KO:K06751]
103222361  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103222362  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103247147  HLA class I histocompatibility antigen, B-45 alpha chain-like [KO:K06751]
103240303  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103233893  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103228192  CD86; CD86 molecule [KO:K05413]
103221769  MHC class I polypeptide-related sequence B-like [KO:K07985]
103221768  MHC class I polypeptide-related sequence B-like [KO:K07985]
103218564  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
103226351  ubiquitin-like [KO:K02927]
103234186  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
103241789  ubiquitin-like [KO:K02927]
103237381  ubiquitin-like [KO:K02927]
103220242  RPS27A; ribosomal protein S27a [KO:K02977]
103242447  UBB; ubiquitin B [KO:K04551]
103239352  UBC; ubiquitin C [KO:K04551]
103243387  BECN1; beclin 1 [KO:K08334]
103230857  beclin-2 [KO:K08334]
103229035  ATG14; autophagy related 14 [KO:K17889]
103222505  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103228318  ATG3; autophagy related 3 [KO:K08343]
103233426  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
103230861  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
103248775  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
103219881  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103226542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103229134  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
103224726  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103229352  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103226710  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
103242368  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
103242366  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103244634  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [KO:K12365]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103228312  CD200R1; CD200 receptor 1 [KO:K21668]
103228314  CD200R1L; CD200 receptor 1 like [KO:K21668]
103219736  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103248155  HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
103236819  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103242403  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103233823  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103233371  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103245987  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103218776  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103221654  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103245424  CALML4; calmodulin like 4 [KO:K02183]
103237820  CALML5; calmodulin like 5 [KO:K02183]
103237822  CALML3; calmodulin like 3 [KO:K02183]
103229541  CALM1; calmodulin 1 [KO:K02183]
103234915  CALM3; calmodulin 3 [KO:K02183]
103220326  CALM2; calmodulin 2 [KO:K02183]
103236040  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103215997  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103215459  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103220127  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103219106  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103244028  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
103244215  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
103233238  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
103228734  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
103235786  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103230420  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103235789  CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]
103235792  growth-regulated protein homolog gamma-like [KO:K05505]
103235798  CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]
103236682  growth-regulated alpha protein-like [KO:K05505]
103218408  RCAN1; regulator of calcineurin 1 [KO:K17901]
103236710  FGF2; fibroblast growth factor 2 [KO:K18497]
103221446  VEGFA; vascular endothelial growth factor A [KO:K05448]
103223339  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103215294  ANGPT2; angiopoietin 2 [KO:K05466]
103221611  IL6ST; interleukin 6 signal transducer [KO:K05060]
103219496  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103243410  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103227444  CTNNB1; catenin beta 1 [KO:K02105]
103244543  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
103219950  TCF7L1; transcription factor 7 like 1 [KO:K04490]
103216817  TCF7L2; transcription factor 7 like 2 [KO:K04491]
103236088  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103246489  CCND1; cyclin D1 [KO:K04503]
103237430  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Biochim Biophys Acta 1602:1-22 (2002)
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J Virol 78:7667-76 (2004)
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Curr Opin Virol 20:11-19 (2016)
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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J Virol 88:13161-72 (2014)
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J Virol 81:42-58 (2007)
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Viruses 7:116-53 (2015)
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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pathway
csab04010  MAPK signaling pathway
csab04064  NF-kappa B signaling pathway
csab04110  Cell cycle
csab04115  p53 signaling pathway
csab04140  Autophagy - animal
csab04144  Endocytosis
csab04151  PI3K-Akt signaling pathway
csab04210  Apoptosis
csab04310  Wnt signaling pathway
csab04610  Complement and coagulation cascades
csab04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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