Entry
Name
Human immunodeficiency virus 1 infection - Chlorocebus sabaeus (green monkey)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
csab05170 Human immunodeficiency virus 1 infection
Ortholog table
Organism
Chlorocebus sabaeus (green monkey) [GN:
csab ]
Gene
103216409 BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362 ]
103234391 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
103224900 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
103222594 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
103229352 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379 ]
103224726 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
103220127 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
103219106 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
103226542 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
103246815 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392 ]
103223272 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
103243748 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861 ]
103223342 TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403 ]
103240159 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404 ]
103232832 IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210 ]
103247808 DNA dC->dU-editing enzyme APOBEC-3A-like [KO:K18750 ] [EC:3.5.4.-]
103223331 APOBEC3D; apolipoprotein B mRNA editing enzyme catalytic subunit 3D [KO:K18750 ] [EC:3.5.4.-]
103223333 APOBEC3C; apolipoprotein B mRNA editing enzyme catalytic subunit 3C [KO:K18750 ] [EC:3.5.4.-]
103223335 APOBEC3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H [KO:K18750 ] [EC:3.5.4.-]
103223334 APOBEC3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G [KO:K18750 ] [EC:3.5.4.-]
108663998 APOBEC3B; apolipoprotein B mRNA editing enzyme catalytic subunit 3B [KO:K18750 ] [EC:3.5.4.-]
103216548 SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [KO:K22544 ] [EC:3.1.5.-]
103247140 Chsa-A; HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751 ]
103221837 Chsa-A; popy class I histocompatibility antigen, alpha chain E [KO:K06751 ]
103221775 Chsa-B; HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751 ]
103221786 Chsa-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
103221863 mamu class I histocompatibility antigen, alpha chain F-like [KO:K06751 ]
103222361 HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751 ]
103222362 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
103247147 HLA class I histocompatibility antigen, B-45 alpha chain-like [KO:K06751 ]
103223137 AP1B1; adaptor related protein complex 1 beta 1 subunit [KO:K12392 ]
103233178 AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391 ]
103231482 AP1G2; adaptor related protein complex 1 gamma 2 subunit [KO:K12391 ]
103234103 AP1M1; adaptor related protein complex 1 mu 1 subunit [KO:K12393 ]
103233903 AP1M2; adaptor related protein complex 1 mu 2 subunit [KO:K12393 ]
103246696 AP1S1; adaptor related protein complex 1 sigma 1 subunit [KO:K12394 ]
103231646 AP1S2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394 ]
103217955 AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
Title
HIV persistence: chemokines and their signalling pathways.
Journal
Reference
Authors
Abbas W, Herbein G
Title
Plasma membrane signaling in HIV-1 infection.
Journal
Reference
Authors
Wu Y, Yoder A
Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
Journal
Reference
Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
Journal
Reference
Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
Journal
Reference
Authors
Das SR, Jameel S
Title
Biology of the HIV Nef protein.
Journal
Indian J Med Res 121:315-32 (2005)
Reference
Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
Journal
Reference
Authors
Magadan JG, Bonifacino JS
Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Journal
Reference
Authors
Kumar A, Herbein G
Title
The macrophage: a therapeutic target in HIV-1 infection.
Journal
Reference
Authors
Yokota S, Okabayashi T, Fujii N
Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
Journal
Reference
Authors
Sauter D, Kirchhoff F
Title
HIV replication: a game of hide and sense.
Journal
Reference
Authors
Altfeld M, Gale M Jr
Title
Innate immunity against HIV-1 infection.
Journal
Reference
Authors
Pasquereau S, Kumar A, Herbein G
Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
Journal
Reference
Authors
Herbein G, Khan KA
Title
Is HIV infection a TNF receptor signalling-driven disease?
Journal
Reference
Authors
Kumar A, Abbas W, Herbein G
Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Journal
Reference
Authors
Abbas W, Herbein G
Title
T-Cell Signaling in HIV-1 Infection.
Journal
Reference
Authors
Cummins NW, Badley AD
Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
Journal
Reference
Authors
Gougeon ML
Title
Apoptosis as an HIV strategy to escape immune attack.
Journal
Reference
Authors
Fevrier M, Dorgham K, Rebollo A
Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
Journal
Reference
Authors
Ross TM
Title
Using death to one's advantage: HIV modulation of apoptosis.
Journal
Reference
Authors
Hurley JH, Bonifacino JS
Title
Nef-arious goings-on at the Golgi.
Journal
Reference
Authors
Wonderlich ER, Leonard JA, Collins KL
Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
Journal
Reference
Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
Journal
Reference
Authors
Pereira EA, daSilva LL
Title
HIV-1 Nef: Taking Control of Protein Trafficking.
Journal
Reference
Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
Journal
Reference
Authors
Bagga S, Bouchard MJ
Title
Cell cycle regulation during viral infection.
Journal
Reference
Authors
Andersen JL, Planelles V
Title
The role of Vpr in HIV-1 pathogenesis.
Journal
Reference
Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
Journal
Reference
Authors
Takaori-Kondo A, Shindo K
Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
Journal
Reference
Authors
Malim MH
Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
Journal
Reference
Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
Journal
Related pathway
csab04141 Protein processing in endoplasmic reticulum
csab04612 Antigen processing and presentation
csab04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
All DBs