KEGG   PATHWAY: csav04148
Entry
csav04148                   Pathway                                
Name
Efferocytosis - Cannabis sativa (hemp)
Class
Cellular Processes; Transport and catabolism
Pathway map
csav04148  Efferocytosis
csav04148

Organism
Cannabis sativa (hemp) [GN:csav]
Gene
115706893  sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
115719249  mitogen-activated protein kinase homolog NTF6 [KO:K04371] [EC:2.7.11.24]
115704245  mitogen-activated protein kinase kinase 6 [KO:K04368] [EC:2.7.12.2]
115704458  mitogen-activated protein kinase kinase 6-like [KO:K04368] [EC:2.7.12.2]
115720751  uncharacterized protein LOC115720751 [KO:K17398] [EC:2.1.1.37]
115725115  calcium-transporting ATPase 3, endoplasmic reticulum-type [KO:K05853] [EC:7.2.2.10]
115699615  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115714800  phospholipid-transporting ATPase 3 isoform X1 [KO:K14802] [EC:7.6.2.1]
115705589  LOW QUALITY PROTEIN: phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
115705590  LOW QUALITY PROTEIN: phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
115697966  putative ALA-interacting subunit 2 [KO:K26935]
115705213  ALA-interacting subunit 3 [KO:K26935]
115701346  rac-like GTP-binding protein RAC2 [KO:K04392]
115702152  rac-like GTP-binding protein ARAC7 [KO:K04392]
115702674  rac-like GTP-binding protein ARAC1 [KO:K04392]
115704802  rac-like GTP-binding protein 5 [KO:K04392]
115708795  rac-like GTP-binding protein ARAC8 [KO:K04392]
115696963  rac-like GTP-binding protein RAC13 [KO:K04392]
115697760  rac-like GTP-binding protein RAC2 [KO:K04392]
115710531  rac-like GTP-binding protein 5 isoform X1 [KO:K04392]
115725289  rac-like GTP-binding protein RHO1 [KO:K04392]
115725417  rac-like GTP-binding protein ARAC1 isoform X1 [KO:K04392]
115725419  rac-like GTP-binding protein RHO1 [KO:K04392]
115723072  rac-like GTP-binding protein ARAC1 [KO:K04392]
115719091  calreticulin-3 [KO:K08057]
115718493  calreticulin [KO:K08057]
115700857  ras-related protein RHN1-like [KO:K07887]
115722342  ras-related protein RHN1 [KO:K07887]
115705959  ras-related protein RABF1 [KO:K07887]
115705341  ras-related protein RHN1-like isoform X1 [KO:K07887]
115703584  ras-related protein RHN1 isoform X1 [KO:K07887]
115697776  ras-related protein RABF2a [KO:K07887]
115709917  LOW QUALITY PROTEIN: vacuolar sorting protein 3-like [KO:K20177]
115711231  vacuolar sorting protein 3-like [KO:K20177]
115703640  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
115698832  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
115699497  protein VACUOLELESS1 [KO:K20180]
115699099  vacuolar sorting protein 18 [KO:K20181]
115705939  vacuolar protein-sorting-associated protein 33 homolog isoform X1 [KO:K20182]
115714395  vacuolar sorting protein 39 isoform X1 [KO:K20183]
115701227  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
115707849  ras-related protein Rab7 [KO:K07897]
115707850  ras-related protein Rab7 [KO:K07897]
115712273  ras-related protein Rab7 [KO:K07897]
115712411  ras-related protein Rab7 [KO:K07897]
115714426  uncharacterized protein LOC115714426 [KO:K23678]
115706405  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
115714249  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
115716222  cytochrome b-c1 complex subunit Rieske-4, mitochondrial [KO:K00411] [EC:7.1.1.8]
115722866  triacylglycerol lipase 2 isoform X1 [KO:K01052] [EC:3.1.1.13]
115702984  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
115703013  triacylglycerol lipase 1-like [KO:K01052] [EC:3.1.1.13]
115723680  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
115723681  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
csav00010  Glycolysis / Gluconeogenesis
csav04145  Phagosome
KO pathway
ko04148   
LinkDB

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