KEGG   PATHWAY: els04068
Entry
els04068                    Pathway                                
Name
FoxO signaling pathway - Esox lucius (northern pike)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
els04068  FoxO signaling pathway
els04068

Other DBs
GO: 0009267
Organism
Esox lucius (northern pike) [GN:els]
Gene
105010856  transforming growth factor beta-1 proprotein [KO:K13375]
105027026  transforming growth factor beta-1 proprotein [KO:K13375]
105007294  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
105026733  transforming growth factor beta-2 proprotein [KO:K13376]
105015709  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
105029941  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
105019479  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105024259  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105012782  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105023521  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105030836  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
105031060  mothers against decapentaplegic homolog 4 [KO:K04501]
105014576  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
105025164  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
105012677  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
105005850  smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105013596  mothers against decapentaplegic homolog 3 [KO:K23605]
105011530  serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
105020679  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105015246  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105011784  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105020860  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
105014960  5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
105014211  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105027313  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
105018996  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
105017212  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
105027970  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
105023716  5'-AMP-activated protein kinase subunit gamma-3-like isoform X1 [KO:K07200]
105008258  serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
105014125  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
105025175  skp2; S-phase kinase-associated protein 2 [KO:K03875]
105017801  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
105029145  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
105012109  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
105021653  crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105025802  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105025106  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
105028637  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
105013471  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
105020675  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
105006595  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105031053  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105024911  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
105025816  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105027233  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
105010087  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105030158  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
105016672  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105023472  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105025960  insulin [KO:K04526]
105021727  insulin [KO:K04526]
105005877  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105022623  insulin receptor [KO:K04527] [EC:2.7.10.1]
105020633  insulin receptor substrate 1-B isoform X1 [KO:K16172]
105023953  insulin receptor substrate 1-B [KO:K16172]
105009026  insulin receptor substrate 2 [KO:K07187]
105030862  insulin receptor substrate 2-B-like [KO:K07187]
105016500  irs2; insulin receptor substrate 2 [KO:K07187]
105024652  insulin receptor substrate 2-A-like [KO:K07187]
105026926  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105025897  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105028918  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105009929  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
105029118  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
105024545  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105026229  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105015144  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105021974  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109614581  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
105025378  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105021296  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
105006906  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105010696  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105014298  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105010650  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105006284  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105023568  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105017614  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105015651  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105024916  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105021234  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105021541  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105012349  serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
105018004  sgk1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
105018926  serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
105026341  sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
105019586  sgk3; serine/threonine-protein kinase Sgk3 isoform X2 [KO:K13304] [EC:2.7.11.1]
105007737  forkhead box protein O1-A [KO:K07201]
105008116  foxo1; forkhead box protein O1 [KO:K07201]
105017479  foxo3; forkhead box protein O3 [KO:K09408]
105015400  forkhead box protein O3-like isoform X2 [KO:K09408]
105029260  forkhead box protein O4 [KO:K12358]
114839107  foxo4; forkhead box protein O4 [KO:K12358]
105006557  forkhead box protein O3 [KO:K17847]
105029905  grm1; metabotropic glutamate receptor 1 isoform X2 [KO:K04603]
105026509  homer2; homer protein homolog 2 isoform X2 [KO:K15010]
105026210  homer protein homolog 3 isoform X1 [KO:K15010]
105029218  homer protein homolog 1 isoform X3 [KO:K15010]
105015177  homer1; homer protein homolog 1 [KO:K15010]
105024426  homer protein homolog 3-like isoform X1 [KO:K15010]
105013611  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K17848]
105025774  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
105025098  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
105012469  LOW QUALITY PROTEIN: interleukin-6-like [KO:K05405]
105013217  il10; interleukin-10 [KO:K05443]
105013350  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105027559  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
105027310  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
105019998  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105012273  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105013161  growth factor receptor-bound protein 2 [KO:K04364]
105025539  sos2; son of sevenless homolog 2 [KO:K03099]
105026828  son of sevenless homolog 1 isoform X3 [KO:K03099]
105018344  hras; GTPase HRas [KO:K02833]
105022136  kras; GTPase KRas isoform X1 [KO:K07827]
105029053  GTPase HRas-like [KO:K07827]
105006078  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105013076  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
105029139  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
105014388  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105006978  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105011557  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105020581  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
105012809  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105006515  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105007426  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
105023895  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
105018147  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105020225  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105020226  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105013860  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105023872  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105016957  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
105029100  protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
114840431  LOW QUALITY PROTEIN: protein arginine N-methyltransferase 1-like [KO:K11434] [EC:2.1.1.319]
105010430  forkhead box protein G1-like [KO:K09385]
105023594  foxg1; forkhead box protein G1 [KO:K09385]
105015046  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105016586  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
105023569  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
105029411  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
105017289  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105018279  G1/S-specific cyclin-D1 [KO:K04503]
105018224  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
105012998  G1/S-specific cyclin-D2-like [KO:K10151]
105020240  G1/S-specific cyclin-D2 [KO:K10151]
105023999  ccng2; cyclin-G2 [KO:K10146]
105021059  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
105012138  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
105017129  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
105029077  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
105018460  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105020266  cyclin-dependent kinase inhibitor 1B [KO:K06624]
105023450  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105018165  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105029645  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
105021744  plk2; serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
105014278  serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
105022688  serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
105015587  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
105030709  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105011357  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105011762  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
105015060  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
105024086  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105011736  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105014159  tumor necrosis factor [KO:K04389]
105010387  bcl2l11; bcl-2-like protein 11 [KO:K16341]
105022065  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105030368  B-cell lymphoma 6 protein isoform X1 [KO:K15618]
105029547  bcl6; B-cell lymphoma 6 protein isoform X2 [KO:K15618]
105009692  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
105027925  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
105019030  atg12; ubiquitin-like protein ATG12 [KO:K08336]
105020670  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105019048  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105008592  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105019088  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105029592  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
105026601  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
105029617  catalase-like [KO:K03781] [EC:1.11.1.6]
105029015  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
105021770  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105019502  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
105030571  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105007052  glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105007579  glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105007595  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
105021182  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
105014762  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
105011465  klf2; Krueppel-like factor 2 [KO:K17845]
105022513  Krueppel-like factor 2 isoform X2 [KO:K17845]
105011380  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
105011419  sphingosine 1-phosphate receptor 4 [KO:K04293]
105018380  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
105018379  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
105023509  fbxo32; F-box only protein 32 [KO:K10305]
105030304  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
els00010  Glycolysis / Gluconeogenesis
els00020  Citrate cycle (TCA cycle)
els00190  Oxidative phosphorylation
els04010  MAPK signaling pathway
els04110  Cell cycle
els04120  Ubiquitin mediated proteolysis
els04140  Autophagy - animal
els04210  Apoptosis
els04350  TGF-beta signaling pathway
els04910  Insulin signaling pathway
KO pathway
ko04068   
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