KEGG   PATHWAY: emac04217
Entry
emac04217                   Pathway                                
Name
Necroptosis - Eleginops maclovinus (Patagonian blennie)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
emac04217  Necroptosis
emac04217

Organism
Eleginops maclovinus (Patagonian blennie) [GN:emac]
Gene
134875099  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
134861275  tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
134868152  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
134863890  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
134868188  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
134873839  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
134864101  traf5; TNF receptor-associated factor 5 [KO:K09849]
134866131  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
134871736  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
134859884  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
134884207  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
134882566  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
134858125  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
134866247  rnf31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
134866599  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
134858927  si:ch211-189a15.5; uncharacterized protein si:ch211-189a15.5 [KO:K17595]
134862509  spata2; spermatogenesis-associated protein 2 [KO:K17595]
134875385  spata2l; spermatogenesis associated 2-like [KO:K17595]
134863198  cylda; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
134869346  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
134883457  cyldb; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
134875742  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
134863816  fadd; protein FADD [KO:K02373]
134865670  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
134865672  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
134866816  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
134866999  CASP8 and FADD-like apoptosis regulator [KO:K04724]
134876137  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
134882996  ankyrin repeat and protein kinase domain-containing protein 1-like isoform X1 [KO:K08847] [EC:2.7.11.1]
134860878  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
134868487  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
134858876  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
134864611  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
134870311  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
134873553  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
134876252  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
134864594  slc25a4; ADP/ATP translocase 1 [KO:K05863]
134859414  slc25a5; ADP/ATP translocase 2 [KO:K05863]
134871960  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
134859507  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
134872110  vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
134858720  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
134871239  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
134868313  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
134873221  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
134859226  glutamate dehydrogenase, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
134870867  glud1b; glutamate dehydrogenase 1b [KO:K00261] [EC:1.4.1.3]
134868986  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
134865981  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
134869941  glulb; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
134872461  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
134875846  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
134882054  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
134868533  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
134859047  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
134859865  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
134870548  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
134863528  fth1a; ferritin, heavy polypeptide 1a [KO:K00522] [EC:1.16.3.1]
134858546  fth1b; ferritin, heavy polypeptide 1b isoform X1 [KO:K00522] [EC:1.16.3.1]
134871180  zgc:56095; ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
134878078  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
134869348  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
134859157  pla2g4f.1; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
134859161  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
134877421  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
134877519  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
134872647  capn1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
134863798  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
134858873  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
134872154  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
134881361  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
134881449  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
134863186  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
134858433  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
134858435  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134862697  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134862887  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134872602  smpd1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
134883499  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
134874147  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
134879179  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
134873861  si:dkey-32e23.4; LOW QUALITY PROTEIN: dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
134882661  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
134879956  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
134874249  interleukin-1 beta-like [KO:K04519]
134870578  chmp2a; charged multivesicular body protein 2a [KO:K12191]
134867260  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
134881913  chmp3; charged multivesicular body protein 3 [KO:K12193]
134867406  charged multivesicular body protein 4b [KO:K12194]
134873759  charged multivesicular body protein 4b-like [KO:K12194]
134882345  charged multivesicular body protein 4c [KO:K12194]
134884080  chmp4c; charged multivesicular body protein 4c [KO:K24782]
134871222  chmp6b; charged multivesicular body protein 6 [KO:K12195]
134877719  charged multivesicular body protein 6-like [KO:K12195]
134869476  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
134865929  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
134880523  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
134860023  charged multivesicular body protein 1b-like isoform X1 [KO:K12197]
134871572  charged multivesicular body protein 1b [KO:K12197]
134882374  chmp1a; charged multivesicular body protein 1a [KO:K12197]
134866166  chmp5a; charged multivesicular body protein 5 [KO:K12198]
134884152  chmp5b; charged multivesicular body protein 5 [KO:K12198]
134874242  chmp7; charged multivesicular body protein 7 [KO:K15053]
134862894  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
134872561  high mobility group-T protein-like [KO:K10802]
134880662  hmgb1b; high mobility group protein B1b [KO:K10802]
134883756  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
134881187  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
134868224  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
134869225  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
134859581  cd40lg; CD40 ligand [KO:K04389]
134859019  fas; tumor necrosis factor receptor superfamily member 26 [KO:K04390]
134870800  interferon a3-like [KO:K05414]
134871102  uncharacterized protein LOC134871102 [KO:K05414]
134878662  ifnphi1; interferon phi 1 [KO:K05414]
134867747  interferon alpha/beta receptor 2-like [KO:K05131]
134864299  ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
134858988  ifngr1l; interferon gamma receptor 1-like isoform X1 [KO:K05132]
134869978  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
134868102  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
134873775  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
134869599  jak3; tyrosine-protein kinase JAK2 isoform X1 [KO:K11218] [EC:2.7.10.2]
134878148  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
134861047  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
134867158  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
134883587  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
134877781  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
134867185  stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
134870424  signal transducer and activator of transcription 5B-like [KO:K11224]
134877780  stat5a; signal transducer and activator of transcription 5A isoform X1 [KO:K11224]
134870978  stat6; signal transducer and activator of transcription 6 [KO:K11225]
134858649  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
134858650  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
134866425  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
134865002  tlr3; toll-like receptor 3 [KO:K05401]
134869564  usp21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
134863208  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
134876491  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
134876789  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
134877154  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
134877185  parp1; LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
134863147  zgc:153993; apoptosis regulator BAX [KO:K02159]
134877792  apoptosis regulator BAX-like [KO:K02159]
134871807  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
134872391  histone H2A-like [KO:K11251]
134872392  histone H2A-like [KO:K11251]
134872393  histone H2A-like [KO:K11251]
134872486  core histone macro-H2A.1 isoform X1 [KO:K11251]
134859112  core histone macro-H2A.2 [KO:K11251]
134859376  histone H2A-like [KO:K11251]
134859799  late histone H2A.L3-like [KO:K11251]
134871119  histone H2AX-like [KO:K11251]
134871884  histone H2A [KO:K11251]
134872059  histone H2AX [KO:K11251]
134873163  histone H2A.V [KO:K11251]
134879299  histone H2A-like [KO:K11251]
134879301  histone H2A-like [KO:K11251]
134873490  histone H2A-like [KO:K11251]
134873500  histone H2A-like [KO:K11251]
134873507  histone H2A-like [KO:K11251]
134873513  histone H2A-like [KO:K11251]
134873524  histone H2A-like [KO:K11251]
134873531  histone H2A-like [KO:K11251]
134873538  histone H2A-like [KO:K11251]
134873545  histone H2A-like [KO:K11251]
134880464  histone H2A-like [KO:K11251]
134876180  histone H2A.Z [KO:K11251]
134868514  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
134868228  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
134873780  ppiaa; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
134865945  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
emac00250  Alanine, aspartate and glutamate metabolism
emac04210  Apoptosis
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system