KEGG   PATHWAY: esp00230
Entry
esp00230                    Pathway                                
Name
Purine metabolism - Etheostoma spectabile (orangethroat darter)
Class
Metabolism; Nucleotide metabolism
Pathway map
esp00230  Purine metabolism
esp00230

Module
esp_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:esp00230]
esp_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:esp00230]
esp_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:esp00230]
esp_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:esp00230]
esp_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:esp00230]
Other DBs
GO: 0006163 0042278
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669494  [KO:K12322] [EC:4.6.1.2]
116669672  nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
116669691  entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
116670076  nt5e; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
116670161  [KO:K01081] [EC:3.1.3.5]
116670207  ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
116670325  adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
116670453  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
116670554  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116670934  nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
116670952  [KO:K22600] [EC:4.6.1.2]
116671022  pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
116671045  [KO:K00940] [EC:2.7.4.6]
116671101  [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
116671147  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
116671189  [KO:K12320] [EC:4.6.1.2]
116671280  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
116671388  [KO:K00856] [EC:2.7.1.20]
116672553  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
116672582  urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
116672766  [KO:K00088] [EC:1.1.1.205]
116672811  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
116673289  [KO:K19572] [EC:3.5.4.4]
116673675  [KO:K12319] [EC:4.6.1.2]
116673898  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116673959  enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
116674146  prps2; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
116674241  [KO:K13761] [EC:3.1.4.35]
116676237  [KO:K01835] [EC:5.4.2.2]
116677631  [KO:K10807] [EC:1.17.4.1]
116678836  pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
116679195  [KO:K19021] [EC:3.1.4.17]
116679497  prune1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
116680650  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
116684073  pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
116684631  [KO:K13761] [EC:3.1.4.35]
116684799  [KO:K08045] [EC:4.6.1.1]
116684823  [KO:K00088] [EC:1.1.1.205]
116685874  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
116686433  [KO:K08043] [EC:4.6.1.1]
116686498  [KO:K01081] [EC:3.1.3.5]
116686868  [KO:K07127] [EC:3.5.2.17]
116686902  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
116687144  [KO:K12322] [EC:4.6.1.2]
116687253  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
116687429  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
116687456  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
116687501  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
116687564  [KO:K01490] [EC:3.5.4.6]
116688494  [KO:K01466] [EC:3.5.2.5]
116688551  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
116688642  [KO:K03783] [EC:2.4.2.1]
116689273  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
116689331  [KO:K00904] [EC:2.7.1.113]
116689497  [KO:K01509] [EC:3.6.1.-]
116689604  [KO:K13293] [EC:3.1.4.53]
116689693  gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
116689940  ak8; LOW QUALITY PROTEIN: adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
116690193  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
116690541  [KO:K01769] [EC:4.6.1.2]
116690645  [KO:K08042] [EC:4.6.1.1]
116691759  [KO:K01510] [EC:3.6.1.5]
116691788  [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116691898  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
116691915  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116692114  [KO:K07127] [EC:3.5.2.17]
116692318  [KO:K08046] [EC:4.6.1.1]
116692435  ampd3; LOW QUALITY PROTEIN: AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
116692569  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
116692597  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
116692749  ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
116692789  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
116692820  adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
116693603  [KO:K01490] [EC:3.5.4.6]
116693654  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
116693748  [KO:K19572] [EC:3.5.4.4]
116693865  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116694177  [KO:K19021] [EC:3.1.4.17]
116694432  [KO:K03783] [EC:2.4.2.1]
116694691  [KO:K00088] [EC:1.1.1.205]
116694716  [KO:K00760] [EC:2.4.2.8]
116694953  pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116695174  [KO:K00942] [EC:2.7.4.8]
116695206  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
116695224  pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
116695422  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
116695526  pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
116695549  [KO:K08041] [EC:4.6.1.1]
116695595  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
116695616  ppat; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
116695973  [KO:K00365] [EC:1.7.3.3]
116696060  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
116696126  [KO:K12324] [EC:4.6.1.2]
116696145  [KO:K13293] [EC:3.1.4.53]
116696161  ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
116696469  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
116696542  pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K08718] [EC:3.1.4.35]
116697031  [KO:K00948] [EC:2.7.6.1]
116697176  [KO:K13293] [EC:3.1.4.53]
116697210  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
116697365  [KO:K01769] [EC:4.6.1.2]
116697860  [KO:K13761] [EC:3.1.4.35]
116697904  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116698065  [KO:K13760]
116698212  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116698345  pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
116698375  [KO:K08045] [EC:4.6.1.1]
116698514  [KO:K13755] [EC:3.1.4.17]
116698546  [KO:K13293] [EC:3.1.4.53]
116698871  adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116698937  guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
116699014  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
116699018  [KO:K03783] [EC:2.4.2.1]
116699106  [KO:K08041] [EC:4.6.1.1]
116699123  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
116699152  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
116699326  [KO:K01835] [EC:5.4.2.2]
116699442  [KO:K08043] [EC:4.6.1.1]
116699844  [KO:K13293] [EC:3.1.4.53]
116699956  [KO:K01939] [EC:6.3.4.4]
116700609  [KO:K10807] [EC:1.17.4.1]
116701361  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
116701410  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116701440  [KO:K01081] [EC:3.1.3.5]
116701815  gmpr; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
116701890  ak2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
116702456  [KO:K12320] [EC:4.6.1.2]
116702564  [KO:K12304] [EC:3.6.1.6]
116702848  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116702916  [KO:K13293] [EC:3.1.4.53]
116703020  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
116703562  [KO:K13760]
116703758  nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
116703771  [KO:K00940] [EC:2.7.4.6]
116703775  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
116703907  [KO:K13756] [EC:3.1.4.35]
116703951  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
116704118  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
116704249  entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
116704376  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
116704449  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
116704722  dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116704772  [KO:K01081] [EC:3.1.3.5]
116704875  [KO:K13757] [EC:3.1.4.35]
116704974  [KO:K12304] [EC:3.6.1.6]
116705101  [KO:K01939] [EC:6.3.4.4]
116705202  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
116705385  [KO:K00856] [EC:2.7.1.20]
116705420  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116705531  ntpcr; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
116705659  [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
116705853  [KO:K08048] [EC:4.6.1.1]
116706049  [KO:K13762] [EC:3.1.4.35]
116706307  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
116706353  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116706406  pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
116706519  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
116706561  [KO:K08043] [EC:4.6.1.1]
116706588  [KO:K13760]
116706628  [KO:K08049] [EC:4.6.1.1]
116706760  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
116706769  [KO:K01511] [EC:3.6.1.6]
116706789  [KO:K19970] [EC:3.1.3.5]
116706802  [KO:K10808] [EC:1.17.4.1]
116706856  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
116706863  [KO:K01081] [EC:3.1.3.5]
116706954  [KO:K03783] [EC:2.4.2.1]
116706978  [KO:K12304] [EC:3.6.1.6]
116707014  [KO:K00364] [EC:1.7.1.7]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
esp00030  Pentose phosphate pathway
esp00220  Arginine biosynthesis
esp00250  Alanine, aspartate and glutamate metabolism
esp00260  Glycine, serine and threonine metabolism
esp00340  Histidine metabolism
esp00630  Glyoxylate and dicarboxylate metabolism
esp00730  Thiamine metabolism
esp00740  Riboflavin metabolism
esp00790  Folate biosynthesis
KO pathway
ko00230   

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