KEGG   PATHWAY: ggo04152
Entry
ggo04152                    Pathway                                
Name
AMPK signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
ggo04152  AMPK signaling pathway
ggo04152

Other DBs
GO: 2000479
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101144707  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
101145563  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101148020  CAB39; calcium-binding protein 39 [KO:K08272]
101141354  CAB39L; calcium-binding protein 39-like [KO:K08272]
101148661  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
101140589  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
101130896  LEP; leptin isoform X1 [KO:K05424]
101141324  LEPR; leptin receptor isoform X1 [KO:K05062]
101147428  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
101132819  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101141366  ADIPOQ; adiponectin isoform X2 [KO:K07296]
101154515  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
101139623  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
101137882  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101152987  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101126241  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101151966  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101132134  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101143913  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
101130530  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
101140929  PFKFB1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
101134985  PFKFB2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
101126566  PFKFB3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
101149226  PFKFB4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X2 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
101131264  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
101138625  FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
101131129  PFKL; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
101131633  PFKM; ATP-dependent 6-phosphofructokinase, muscle type isoform X4 [KO:K00850] [EC:2.7.1.11]
101142912  PFKP; ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
101152287  HNF4A; hepatocyte nuclear factor 4-alpha isoform X2 [KO:K07292]
101128335  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101125519  G6PC2; glucose-6-phosphatase 2 isoform X2 [KO:K01084] [EC:3.1.3.9]
101141013  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
101124608  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2 [KO:K01596] [EC:4.1.1.32]
101149666  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
101144410  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X4 [KO:K05870]
101128609  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101144135  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101144628  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101152081  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101153965  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101133629  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2 [KO:K07202]
101126286  ELAVL1; ELAV-like protein 1 [KO:K13088]
101130447  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101130228  CCNA2; cyclin-A2 [KO:K06627]
101136457  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101135987  EEF2K; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
101125447  EEF2; elongation factor 2 [KO:K03234]
101151399  FOXO1; forkhead box protein O1 isoform X1 [KO:K07201]
101153605  FOXO3; forkhead box protein O3 [KO:K09408]
101147879  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
101147700  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
101132203  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101131537  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
101145804  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
101136625  HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
101154562  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
101151060  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
101137945  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101138141  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
101145053  SCD5; stearoyl-CoA desaturase 5 isoform X2 [KO:K00507] [EC:1.14.19.1]
101135848  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101136977  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
101128037  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
101141306  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
101147238  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
101133876  CIDEA; cell death activator CIDE-A isoform X1 [KO:K25893]
101125226  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101152519  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101142397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101145146  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101140471  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
101135043  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101129571  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101132841  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101127833  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101147502  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101134784  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
115930163  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
115933053  uncharacterized protein LOC115933053 [KO:K11583]
115932828  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
101127596  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7 [KO:K11584]
101131887  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101134228  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101143530  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
101140159  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
101131914  TBC1D1; TBC1 domain family member 1 isoform X4 [KO:K18341]
101137989  RAB2A; ras-related protein Rab-2A isoform X1 [KO:K07877]
101128473  RAB8A; ras-related protein Rab-8A [KO:K07901]
101124896  RAB10; ras-related protein Rab-10 [KO:K07903]
101133992  RAB11B; ras-related protein Rab-11B [KO:K07905]
101127537  RAB14; ras-related protein Rab-14 [KO:K07881]
101132066  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101124855  CD36; platelet glycoprotein 4 [KO:K06259]
101154397  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
101154546  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101132604  INS; insulin isoform X1 [KO:K04526]
101144696  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101132740  IRS1; insulin receptor substrate 1 [KO:K16172]
101127585  IRS2; insulin receptor substrate 2 [KO:K07187]
109024862  IRS4; insulin receptor substrate 4 isoform X1 [KO:K17446]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101147096  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101147811  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101137934  TSC2; tuberin isoform X1 [KO:K07207]
101137273  TSC1; hamartin isoform X2 [KO:K07206]
101125222  RHEB; GTP-binding protein Rheb [KO:K07208]
101138990  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101137206  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
101151809  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101134525  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101126746  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101145454  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101134077  PPARG; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
101149691  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
ggo00010  Glycolysis / Gluconeogenesis
ggo00061  Fatty acid biosynthesis
ggo00500  Starch and sucrose metabolism
ggo01040  Biosynthesis of unsaturated fatty acids
ggo04110  Cell cycle
ggo04140  Autophagy - animal
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04910  Insulin signaling pathway
ggo04920  Adipocytokine signaling pathway
KO pathway
ko04152   
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