Entry Name Mitophagy - animal - Girardinichthys multiradiatus (darkedged splitfin)
Description Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Girardinichthys multiradiatus (darkedged splitfin) [GN:
gmu ]
Gene 124883760 ambra1b; activating molecule in BECN1-regulated autophagy protein 1B [KO:K17985 ]
124879678 tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771 ]
124863070 tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518 ]
124876100 si:dkey-71l1.1; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518 ]
124879267 tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518 ]
124859233 tomm20a; translocase of outer mitochondrial membrane 20 [KO:K17770 ]
124864264 mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870 ] [EC:3.6.5.-]
124868308 rhot1b; mitochondrial Rho GTPase 1b isoform X1 [KO:K07870 ] [EC:3.6.5.-]
124875170 rhot2; mitochondrial Rho GTPase 2 isoform X1 [KO:K07871 ] [EC:3.6.5.-]
124879282 tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347 ]
124866296 tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347 ]
124874965 calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348 ]
124884058 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
124865646 zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
124866701 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
124856160 map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
124860640 map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
124867996 map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
124882211 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
124872259 zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
124858748 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464 ]
124879659 samm50; sorting and assembly machinery component 50 homolog A [KO:K07277 ]
124882702 samm50l; sorting and assembly machinery component 50 homolog B [KO:K07277 ]
124881543 eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237 ]
124869150 atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
124873148 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
124883782 hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268 ]
124856337 mitfa; melanocyte inducing transcription factor a isoform X1 [KO:K09455 ]
124873344 mitfb; melanocyte inducing transcription factor b isoform X1 [KO:K09455 ]
124884211 rabgef1l; RAB guanine nucleotide exchange factor (GEF) 1, like [KO:K20131 ]
124856522 mon1bb; vacuolar fusion protein MON1 homolog B isoform X1 [KO:K20195 ]
124867877 zgc:136908; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525 ]
Compound Reference Authors Pickrell AM, Youle RJ
Title The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Journal Reference Authors Durcan TM, Fon EA
Title The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Journal Reference Authors Shirihai OS, Song M, Dorn GW 2nd
Title How mitochondrial dynamism orchestrates mitophagy.
Journal Reference Authors Hamacher-Brady A, Brady NR
Title Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
Journal Reference Authors Yamano K, Matsuda N, Tanaka K
Title The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
Journal Reference Authors Yamaguchi O, Murakawa T, Nishida K, Otsu K
Title Receptor-mediated mitophagy.
Journal Reference Authors Roberts RF, Tang MY, Fon EA, Durcan TM
Title Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
Journal Reference Authors Arena G, Valente EM
Title PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
Journal Related KO pathway LinkDB All DBs
