Entry Name Progesterone-mediated oocyte maturation - Girardinichthys multiradiatus (darkedged splitfin)
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map gmu04914 Progesterone-mediated oocyte maturation
Ortholog table Other DBs Organism Girardinichthys multiradiatus (darkedged splitfin) [GN:
gmu ]
Gene 124870480 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
124877742 phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649 ]
124872596 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
124873683 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
124873763 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
124869460 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
124884243 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
124873577 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
124880409 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
124875686 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
124883132 gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
124856710 guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630 ]
124856802 guanine nucleotide-binding protein G(i) subunit alpha-1-like isoform X1 [KO:K04630 ]
124857223 gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630 ]
124867024 gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630 ]
124876656 cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602 ]
124858998 cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602 ]
124867180 cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602 ]
124873878 cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602 ]
124860452 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
124882148 hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079 ]
124874711 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
124883781 cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770 ]
124867922 mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679 ]
124880860 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
124869571 mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
124859411 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
124874570 anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351 ]
124876789 cdc23; cell division cycle protein 23 homolog isoform X1 [KO:K03355 ]
124881135 anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357 ]
124872709 cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference Authors Schmitt A, Nebreda AR.
Title Signalling pathways in oocyte meiotic maturation.
Journal J Cell Sci 115:2457-9 (2002)
Reference Authors Cato AC, Nestl A, Mink S.
Title Rapid actions of steroid receptors in cellular signaling pathways.
Journal Reference Authors Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal Reference Authors Nebreda AR, Ferby I.
Title Regulation of the meiotic cell cycle in oocytes.
Journal Reference Authors Ferrell JE Jr.
Title Xenopus oocyte maturation: new lessons from a good egg.
Journal Reference Authors Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal Reference Authors Duckworth BC, Weaver JS, Ruderman JV.
Title G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal Reference Authors Abrieu A, Doree M, Fisher D.
Title The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal J Cell Sci 114:257-67 (2001)
Related KO pathway LinkDB All DBs
