KEGG   PATHWAY: hgl04152
Entry
hgl04152                    Pathway                                
Name
AMPK signaling pathway - Heterocephalus glaber (naked mole-rat)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
hgl04152  AMPK signaling pathway
hgl04152

Other DBs
GO: 2000479
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101718269  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101707198  Stk11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
101725880  Cab39l; calcium binding protein 39 like [KO:K08272]
101696725  Cab39; calcium binding protein 39 [KO:K08272]
101707102  Strada; STE20-related kinase adaptor alpha [KO:K08271]
101700434  Stradb; STE20-related kinase adaptor beta [KO:K17532]
101722703  Lep; leptin [KO:K05424]
101705981  Lepr; leptin receptor [KO:K05062]
101723556  Camkk2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
101712485  Adra1a; adrenoceptor alpha 1A [KO:K04135]
101718713  Adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296]
101726203  Adipor2; adiponectin receptor 2 [KO:K07297]
101709580  Adipor1; adiponectin receptor 1 [KO:K07297]
101698482  Prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
101722998  Prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
101705863  Prkab1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
101720100  Prkab2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
101699641  Prkag2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
101699667  Prkag3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
101721085  Prkag1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
101701867  Pfkfb1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
101722273  Pfkfb2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
101721976  Pfkfb3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
101716744  Pfkfb4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
101707693  Fbp2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
101708632  Fbp1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
101724978  Pfkl; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
101709405  Pfkp; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
101705614  Pfkm; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
101710133  Hnf4a; hepatocyte nuclear factor 4 alpha [KO:K07292]
101715644  G6pc2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
101708598  G6pc; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
101723886  G6pc3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
101708730  Pck1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
101706336  Pck2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
101709168  Crtc2; CREB regulated transcription coactivator 2 [KO:K16333]
101712503  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
101715715  Creb3l2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
101698748  Creb3l1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
101716023  Creb3l3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
101706643  Creb3l4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
101718447  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
101703315  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
101703716  Ppargc1a; PPARG coactivator 1 alpha [KO:K07202]
101713794  Elavl1; ELAV like RNA binding protein 1 [KO:K13088]
101712621  Ccnd1; cyclin D1 [KO:K04503]
101717784  Ccna2; cyclin A2 [KO:K06627]
101718933  Ccna1; cyclin A1 [KO:K06627]
101709310  Eef2k; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
101710545  Eef2; eukaryotic translation elongation factor 2 [KO:K03234]
101707441  Foxo1; forkhead box O1 [KO:K07201]
101699251  Foxo3; forkhead box O3 [KO:K09408]
101720282  Sirt1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
101714675  Slc2a4; solute carrier family 2 member 4 [KO:K07191]
101699800  Gys2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
101712358  Gys1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
101709284  Lipe; lipase E, hormone sensitive type [KO:K07188] [EC:3.1.1.79]
101717005  Hmgcr; 3-hydroxy-3-methylglutaryl-CoA reductase [KO:K00021] [EC:1.1.1.34]
101705277  Srebf1; sterol regulatory element binding transcription factor 1 [KO:K07197]
101698314  Fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
101706028  Acaca; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101720934  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
101720544  Scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
101715076  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
101717399  Acacb; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101716006  Mlycd; malonyl-CoA decarboxylase [KO:K01578] [EC:4.1.1.9]
101716055  Cpt1a; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
101724285  Cpt1b; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
101719936  Cpt1c; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
101719851  Cidea; cell death-inducing DFFA-like effector a [KO:K25893]
101707511  Ppp2ca; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
101726191  Ppp2cb; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
101722244  Ppp2r1b; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
101703470  Ppp2r1a; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
101709789  Ppp2r2d; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
101711517  Ppp2r2c; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
101708645  Ppp2r2a; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
101700573  Ppp2r2b; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
101697272  Ppp2r3a; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
101709952  Ppp2r3c; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
101726501  Ppp2r3b; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
101726315  Ppp2r5c; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
101711583  Ppp2r5e; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
101724057  Ppp2r5d; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
101706140  Ppp2r5b; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
101712512  Ppp2r5a; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
101704930  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
101713688  Tbc1d1; TBC1 domain family member 1 [KO:K18341]
101698057  Rab2a; RAB2A, member RAS oncogene family [KO:K07877]
101709178  Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
101723412  Rab10; RAB10, member RAS oncogene family [KO:K07903]
101719702  Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
101709151  Rab14; RAB14, member RAS oncogene family [KO:K07881]
101709472  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101703900  Cd36; CD36 molecule [KO:K06259]
101707684  Igf1; insulin like growth factor 1 [KO:K05459]
101710224  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101719971  Ins; insulin [KO:K04526]
101722168  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101708189  Irs1; insulin receptor substrate 1 [KO:K16172]
101719081  Irs2; insulin receptor substrate 2 [KO:K07187]
101719321  Irs4; insulin receptor substrate 4 [KO:K17446]
101711934  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101715249  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101712941  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101718815  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
101717096  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101703691  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
101709940  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101700695  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101719164  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101701289  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101713968  Tsc2; tuberous sclerosis 2 [KO:K07207]
101708424  Tsc1; tuberous sclerosis 1 [KO:K07206]
101701441  Rheb; Ras homolog enriched in brain [KO:K07208]
101725626  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
101724257  Rptor; regulatory associated protein of MTOR complex 1 [KO:K07204]
101712955  Akt1s1; AKT1 substrate 1 [KO:K16184]
101702911  Rps6kb2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
101724077  Rps6kb1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
101710614  Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
101711078  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
101714353  Ulk1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
hgl00010  Glycolysis / Gluconeogenesis
hgl00061  Fatty acid biosynthesis
hgl00500  Starch and sucrose metabolism
hgl01040  Biosynthesis of unsaturated fatty acids
hgl04110  Cell cycle
hgl04140  Autophagy - animal
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04910  Insulin signaling pathway
hgl04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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