KEGG   PATHWAY: hgl04914
Entry
hgl04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Heterocephalus glaber (naked mole-rat)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
hgl04914  Progesterone-mediated oocyte maturation
hgl04914

Other DBs
GO: 0001556
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101723243  Pgr; progesterone receptor [KO:K08556]
101718815  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
101717096  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101703691  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
101711934  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101715249  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101712941  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101698286  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101715259  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101712980  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101705370  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101706002  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101715692  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
106007524  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101698645  Gnai2; G protein subunit alpha i2 [KO:K04630]
101702965  Gnai1; G protein subunit alpha i1 [KO:K04630]
101703043  Gnai3; G protein subunit alpha i3 [KO:K04630]
101711366  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
101718304  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
101713887  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
101719464  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
101702436  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
101698189  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
101712483  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
101698293  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
101714605  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
101707235  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101721558  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101724489  Aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
101721995  Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602]
101724060  Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602]
101726453  Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602]
101699004  Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602]
106009946  speedy protein E4-like [KO:K08694]
101698914  Spdya; speedy/RINGO cell cycle regulator family member A [KO:K08694]
101710938  speedy protein E4-like [KO:K08694]
101715466  Spdyc; speedy/RINGO cell cycle regulator family member C [KO:K08694]
101712571  speedy protein E4-like [KO:K08694]
101699058  speedy protein E4-like [KO:K08694]
101722663  speedy protein E4-like [KO:K08694]
101725353  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101718846  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101712597  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101717784  Ccna2; cyclin A2 [KO:K06627]
101718933  Ccna1; cyclin A1 [KO:K06627]
101702660  Mos; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
101725326  Hsp90aa1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
101710837  heat shock protein HSP 90-alpha-like [KO:K04079]
101726120  heat shock protein HSP 90-beta-like [KO:K04079]
101699803  Hsp90ab1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
101715628  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101706099  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101702687  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101712979  Rps6ka1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
101708473  Rps6ka2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
101722051  Rps6ka3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
101703020  Rps6ka6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
101721451  Pkmyt1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1]
101700598  G2/mitotic-specific cyclin-B1-like [KO:K05868]
101719153  Ccnb1; cyclin B1 [KO:K05868]
101696424  Ccnb2; cyclin B2 [KO:K21770]
101706141  Ccnb3; cyclin B3 [KO:K21771]
101700102  Stk10; serine/threonine kinase 10 [KO:K08837] [EC:2.7.11.1]
101721399  Plk1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
101699133  Cdc25a; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
101701077  Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
101712931  Cdc25c; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
101719971  Ins; insulin [KO:K04526]
101707684  Igf1; insulin like growth factor 1 [KO:K05459]
101710224  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101700695  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101719164  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101701289  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101724440  Pde3b; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
101718997  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
101723157  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
101702762  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
101721841  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101724275  Bub1; BUB1 mitotic checkpoint serine/threonine kinase [KO:K02178] [EC:2.7.11.1]
101711604  Mad1l1; MAD1 mitotic arrest deficient like 1 [KO:K06679]
101721329  Mad2l2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
101697340  Fzr1; fizzy/cell division cycle 20 related 1 [KO:K03364]
101720524  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
101719594  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
101717421  Cdc27; cell division cycle 27 [KO:K03350]
101699443  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
101724399  Anapc5; anaphase promoting complex subunit 5 [KO:K03352]
101724017  Cdc16; cell division cycle 16 [KO:K03353]
101720262  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
101711746  Cdc23; cell division cycle 23 [KO:K03355]
101724776  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
101713652  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
101705159  Cdc26; cell division cycle 26 [KO:K03359]
101724802  Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
101699532  Anapc15; anaphase promoting complex subunit 15 [KO:K25228]
101725384  Anapc16; anaphase promoting complex subunit 16 [KO:K25229]
101716422  Kif22; kinesin family member 22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
hgl04010  MAPK signaling pathway
hgl04110  Cell cycle
KO pathway
ko04914   
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