KEGG   PATHWAY: lang03015
Entry
lang03015                   Pathway                                
Name
mRNA surveillance pathway - Lupinus angustifolius (narrow-leaved blue lupine)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
lang03015  mRNA surveillance pathway
lang03015

Other DBs
GO: 0071028
Organism
Lupinus angustifolius (narrow-leaved blue lupine) [GN:lang]
Gene
109358656  nuclear cap-binding protein subunit 1-like [KO:K12882]
109338153  nuclear cap-binding protein subunit 1-like [KO:K12882]
109339168  nuclear cap-binding protein subunit 2-like [KO:K12883]
109339172  nuclear cap-binding protein subunit 2-like [KO:K12883]
109329238  regulator of nonsense transcripts UPF3-like [KO:K14328]
109345707  regulator of nonsense transcripts UPF3-like [KO:K14328]
109333425  RNA-binding protein 8A-B-like [KO:K12876]
109331889  RNA-binding protein 8A-like [KO:K12876]
109356539  protein mago nashi homolog [KO:K12877]
109347559  protein mago nashi homolog [KO:K12877]
109345040  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
109340509  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
109334719  FHA domain-containing protein DDL-like [KO:K13025] [EC:5.6.2.7]
109340838  histone deacetylase complex subunit SAP18 [KO:K14324]
109340737  pinin-like [KO:K13114]
109350719  pinin-like [KO:K13114]
109343649  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109343650  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109328401  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109334282  serine/arginine-rich splicing factor SR45-like [KO:K14325]
109348019  serine/arginine-rich splicing factor SR45-like [KO:K14325]
109345127  THO complex subunit 4C-like [KO:K12881]
109351061  THO complex subunit 4A [KO:K12881]
109358307  THO complex subunit 4A-like [KO:K12881]
109353802  THO complex subunit 4B-like [KO:K12881]
109330001  THO complex subunit 4D-like [KO:K12881]
109360995  DEAD-box ATP-dependent RNA helicase 38-like [KO:K18655] [EC:5.6.2.7]
109336589  DEAD-box ATP-dependent RNA helicase 38-like [KO:K18655] [EC:5.6.2.7]
109328160  protein GLE1 [KO:K18723]
109327978  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
109327129  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
109343731  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
109347780  DEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
109349048  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
109357261  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
109359771  partner of Y14 and mago-like [KO:K14294]
109338922  partner of Y14 and mago-like [KO:K14294]
109325275  serine/arginine repetitive matrix protein 1-like [KO:K13171]
109355401  serine/arginine repetitive matrix protein 1-like [KO:K13171]
109351573  serine/arginine repetitive matrix protein 1-like [KO:K13171]
109340917  mRNA-capping enzyme-like [KO:K13917] [EC:2.7.7.50 3.6.1.74]
109339089  mRNA-capping enzyme-like [KO:K13917] [EC:2.7.7.50 3.6.1.74]
109328308  mRNA cap guanine-N7 methyltransferase 2 [KO:K00565] [EC:2.1.1.56]
109325350  mRNA cap guanine-N7 methyltransferase 1-like [KO:K00565] [EC:2.1.1.56]
109352190  mRNA cap guanine-N7 methyltransferase 1-like [KO:K00565] [EC:2.1.1.56]
109339152  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
109360820  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
109357243  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
109362461  polyadenylate-binding protein 3-like [KO:K14396]
109346136  polyadenylate-binding protein 2-like [KO:K14396]
109336686  polyadenylate-binding protein 1-like [KO:K14396]
109361229  polyadenylate-binding protein 2-like [KO:K14396]
109342041  polyadenylate-binding protein 1-like [KO:K14396]
109331936  polyadenylate-binding protein 2-like [KO:K14396]
109349274  polyadenylate-binding protein 2-like [KO:K14396]
109346801  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
109326274  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
109353889  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
109334641  cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398]
109350305  cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398]
109350309  uncharacterized PE-PGRS family protein PE_PGRS54-like [KO:K14398]
109334540  cleavage and polyadenylation specificity factor subunit CG7185-like [KO:K14398]
109328011  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
109329740  nuclear poly(A) polymerase 3-like [KO:K14376] [EC:2.7.7.19]
109343557  nuclear poly(A) polymerase 1-like [KO:K14376] [EC:2.7.7.19]
109334888  nuclear poly(A) polymerase 3-like [KO:K14376] [EC:2.7.7.19]
109344228  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
109336923  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
109337727  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
109348325  nuclear poly(A) polymerase 1-like [KO:K14376] [EC:2.7.7.19]
109345540  nuclear poly(A) polymerase 3-like [KO:K14376] [EC:2.7.7.19]
109358654  nuclear poly(A) polymerase 4-like [KO:K14376] [EC:2.7.7.19]
109358110  nuclear poly(A) polymerase 1-like [KO:K14376] [EC:2.7.7.19]
109355315  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
109346450  polyadenylation and cleavage factor homolog 4-like [KO:K14400]
109357035  polyadenylation and cleavage factor homolog 4-like [KO:K14400]
109348340  uncharacterized LOC109348340 [KO:K14400]
109347524  pre-mRNA cleavage complex 2 protein Pcf11-like [KO:K14400]
109329948  polyadenylation and cleavage factor homolog 4-like [KO:K14400]
109336368  polyadenylation and cleavage factor homolog 4 [KO:K14400]
109352074  cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
109352227  cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
109334515  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
109348003  GATA zinc finger domain-containing protein 14 [KO:K14404]
109345508  30-kDa cleavage and polyadenylation specificity factor 30-like [KO:K14404]
109329857  30-kDa cleavage and polyadenylation specificity factor 30-like [KO:K14404]
109355041  flowering time control protein FY-like [KO:K15542]
109325723  flowering time control protein FY-like [KO:K15542]
109357647  WD repeat-containing protein 82 [KO:K14962]
109337823  WD repeat-containing protein 82-B [KO:K14962]
109335623  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109355049  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109337641  serine/threonine-protein phosphatase PP1 isozyme 3-like [KO:K06269] [EC:3.1.3.16]
109363039  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109336524  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109345385  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109349945  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
109360288  serine/threonine-protein phosphatase PP1 isozyme 4-like [KO:K06269] [EC:3.1.3.16]
109332388  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
109331829  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109340091  serine/threonine-protein phosphatase PP1 isozyme 4 [KO:K06269] [EC:3.1.3.16]
109329624  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109329385  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109345819  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109352439  serine/threonine-protein phosphatase PP1 isozyme 3-like [KO:K06269] [EC:3.1.3.16]
109333416  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
109343078  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
109361474  cleavage stimulation factor subunit 50 [KO:K14406]
109335810  cleavage stimulating factor 64 [KO:K14407]
109347452  cleavage stimulation factor subunit 77 [KO:K14408]
109326678  uncharacterized LOC109326678 [KO:K06100]
109328126  uncharacterized LOC109328126 [KO:K06100]
109363330  symplekin [KO:K06100]
109326866  RNA-binding protein 1-like [KO:K14411]
109333679  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109329714  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109343848  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109346149  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109350100  RNA-binding protein Musashi homolog 1 [KO:K14411]
109328589  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109360253  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109342101  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109357145  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109340501  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109342157  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
109345449  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109360644  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109334512  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109327913  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109357551  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109352435  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109337085  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109344594  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
109337323  polyadenylate-binding protein 2-like [KO:K13126]
109352312  polyadenylate-binding protein 3-like [KO:K13126]
109332854  polyadenylate-binding protein 8-like [KO:K13126]
109346736  polyadenylate-binding protein 3-like [KO:K13126]
109347933  30S ribosomal protein 2, chloroplastic [KO:K13126]
109333657  polyadenylate-binding protein 7-like [KO:K13126]
109331421  polyadenylate-binding protein 8-like [KO:K13126]
109343206  polyadenylate-binding protein 8-like [KO:K13126]
109349386  polyadenylate-binding protein 2-like [KO:K13126]
109343891  polyadenylate-binding protein 8-like [KO:K13126]
109349456  polyadenylate-binding protein 2-like [KO:K13126]
109326423  polyadenylate-binding protein 2-like [KO:K13126]
109343099  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
109347481  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
109335832  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
109353275  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
109343562  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
109349707  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
109330491  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
109328080  regulator of nonsense transcripts UPF2-like [KO:K14327]
109326803  regulator of nonsense transcripts UPF2-like [KO:K14327]
109355443  serine/threonine-protein kinase SMG1-like [KO:K08873] [EC:2.7.11.1]
109341330  protein SMG7-like [KO:K14409]
109356828  protein SMG7-like [KO:K14409]
109360455  protein SMG7-like [KO:K14409]
109331429  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109338855  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109348260  serine/threonine-protein phosphatase PP2A-3 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109332621  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109356555  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
109362844  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109360380  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
109334229  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
109349241  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
109336407  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
109356506  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
109358218  protein phosphatase PP2A regulatory subunit A [KO:K03456]
109351369  protein phosphatase PP2A regulatory subunit A-like [KO:K03456]
109346337  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
109351246  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109342893  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109358650  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109357228  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109347844  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109363084  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
109345388  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
109336319  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
109343705  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
109354701  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
109339714  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
109350718  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109344143  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
109347607  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109354771  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
109345145  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109327800  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109326968  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109336521  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
109336751  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109354204  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109361118  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109336020  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109346553  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109334503  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109326800  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
109344370  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform-like [KO:K11584]
109343508  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform-like [KO:K11584]
109353592  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
109361591  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' iota isoform-like [KO:K11584]
109362740  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
109348533  HBS1-like protein [KO:K14416]
109345380  protein PELOTA 1 [KO:K06965]
109348352  protein PELOTA 1-like [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
lang03013  Nucleocytoplasmic transport
lang03018  RNA degradation
lang03040  Spliceosome
KO pathway
ko03015   
LinkDB

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