KEGG   PATHWAY: llv05146
Entry
llv05146                    Pathway                                
Name
Amoebiasis - Lutra lutra (Eurasian river otter)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
llv05146  Amoebiasis
llv05146

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125109148  interleukin-1 beta [KO:K04519]
125108912  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
125109725  interleukin-1 receptor type 2-like isoform X1 [KO:K04387]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125091098  heat shock protein beta-1 [KO:K04455]
125087421  collagen alpha-1(I) chain [KO:K06236]
125081239  collagen alpha-2(I) chain [KO:K06236]
125091570  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
125091771  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125094828  collagen alpha-2(IV) chain [KO:K06237]
125094830  collagen alpha-1(IV) chain [KO:K06237]
125095149  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
125095151  collagen alpha-3(IV) chain-like isoform X1 [KO:K06237]
125095065  fibronectin isoform X1 [KO:K05717]
125101767  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
125082438  laminin subunit alpha-1-like isoform X1 [KO:K05637]
125108402  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
125081996  laminin subunit alpha-3-like isoform X1 [KO:K06240]
125101978  laminin subunit alpha-4 isoform X1 [KO:K06241]
125081310  laminin subunit beta-1 isoform X1 [KO:K05636]
125080409  laminin subunit beta-2 [KO:K06243]
125085931  laminin subunit beta-3-like [KO:K06244]
125081309  laminin subunit beta-4-like isoform X1 [KO:K06245]
125085480  laminin subunit gamma-1 [KO:K05635]
125086393  laminin subunit gamma-2 [KO:K06246]
125083897  laminin subunit gamma-3-like isoform X1 [KO:K06247]
125091274  caspase-3 [KO:K02187] [EC:3.4.22.56]
125083151  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125087086  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
125083152  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
125087072  guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
125108695  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
125108926  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125110237  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
125105190  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125087644  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125090366  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
125089171  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125108178  neuroendocrine secretory protein 55 [KO:K04632]
125108177  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
125081981  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
125081029  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
125083608  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125097539  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125104900  ras-related protein Rab-5A [KO:K07887]
125106523  LOW QUALITY PROTEIN: ras-related protein Rab-5B-like [KO:K07888]
125098886  LOW QUALITY PROTEIN: ras-related protein Rab-5B-like [KO:K07888]
125087087  ras-related protein Rab-5C [KO:K07889]
125107830  ras-related protein Rab-7a [KO:K07897]
125086292  ras-related protein Rab-7b [KO:K07898]
125093126  toll-like receptor 2 [KO:K10159]
125083203  toll-like receptor 4 [KO:K10160]
125100878  monocyte differentiation antigen CD14-like [KO:K04391]
125081177  interleukin-6 [KO:K05405]
125093820  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
125093821  LOW QUALITY PROTEIN: growth-regulated alpha protein-like [KO:K05505]
125093822  growth-regulated alpha protein-like [KO:K05505]
125100468  granulocyte-macrophage colony-stimulating factor-like isoform X1 [KO:K05427]
125094403  interleukin-8 [KO:K10030]
125103142  tumor necrosis factor isoform X1 [KO:K03156]
125099687  interleukin-12 subunit alpha [KO:K05406]
125101014  interleukin-12 subunit beta [KO:K05425]
125085496  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125085497  T-cell surface glycoprotein CD1e, membrane-associated-like isoform X1 [KO:K06448]
125085498  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125085499  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125085501  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125085502  T-cell surface glycoprotein CD1b-like [KO:K06448]
125085505  antigen-presenting glycoprotein CD1d-like isoform X1 [KO:K06448]
125085506  T-cell surface glycoprotein CD1a-like [KO:K06448]
125107054  interferon gamma [KO:K04687]
125095183  collagen alpha-1(III) chain isoform X1 [KO:K19720]
125097541  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125085203  vinculin isoform X1 [KO:K05700]
125104302  alpha-actinin-1 isoform X1 [KO:K05699]
125088625  alpha-actinin-4 isoform X1 [KO:K05699]
125102264  arginase-1 [KO:K01476] [EC:3.5.3.1]
125103887  arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
125087863  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
125093301  integrin beta-2-like isoform X1 [KO:K06464]
125091026  integrin alpha-M-like isoform X1 [KO:K06461]
125099801  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125082268  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125097558  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125100627  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125103868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125096824  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125093174  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
125078727  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
125096844  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
125103137  serpin B6-like isoform X1 [KO:K13963]
125102473  serpin B9-like isoform X1 [KO:K13963]
125081727  serpin B3-like [KO:K13963]
125082701  serpin B10 [KO:K13963]
125082297  serpin B13-like [KO:K13963]
125104802  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
125086446  interleukin-10 [KO:K05443]
125089683  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125085760  LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein-like [KO:K13376]
125103650  transforming growth factor beta-3 proprotein [KO:K13377]
125099083  complement component C8 alpha chain-like [KO:K03997]
125099065  complement component C8 beta chain-like [KO:K03998]
125083614  complement component C8 gamma chain-like [KO:K03999]
125100734  complement component C9-like [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
llv00330  Arginine and proline metabolism
llv00590  Arachidonic acid metabolism
llv04144  Endocytosis
llv04210  Apoptosis
llv04510  Focal adhesion
llv04610  Complement and coagulation cascades
llv04612  Antigen processing and presentation
llv04620  Toll-like receptor signaling pathway
llv04672  Intestinal immune network for IgA production
llv04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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