KEGG   PATHWAY: llv05146
Entry
llv05146                    Pathway                                
Name
Amoebiasis - Lutra lutra (Eurasian river otter)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
llv05146  Amoebiasis
llv05146

Disease
H00360  Amoebiasis
Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125078405  [KO:K04735]
125078727  [KO:K13279] [EC:1.11.1.24]
125080409  [KO:K06243]
125081029  [KO:K08041] [EC:4.6.1.1]
125081177  [KO:K05405]
125081239  [KO:K06236]
125081309  [KO:K06245]
125081310  [KO:K05636]
125081727  [KO:K13963]
125081981  [KO:K04633]
125081996  [KO:K06240]
125082268  [KO:K02649]
125082297  [KO:K13963]
125082438  [KO:K05637]
125082701  [KO:K13963]
125083151  [KO:K04634]
125083152  [KO:K04636]
125083203  [KO:K10160]
125083608  [KO:K04345] [EC:2.7.11.11]
125083614  [KO:K03999]
125083897  [KO:K06247]
125085203  [KO:K05700]
125085480  [KO:K05635]
125085496  [KO:K06448]
125085497  [KO:K06448]
125085498  [KO:K06448]
125085499  [KO:K06448]
125085501  [KO:K06448]
125085502  [KO:K06448]
125085505  [KO:K06448]
125085506  [KO:K06448]
125085760  [KO:K13376]
125085931  [KO:K06244]
125086292  [KO:K07898]
125086393  [KO:K06246]
125086446  [KO:K05443]
125087072  [KO:K04637]
125087086  [KO:K04635]
125087087  [KO:K07889]
125087421  [KO:K06236]
125087644  [KO:K02677] [EC:2.7.11.13]
125087863  [KO:K13241] [EC:1.14.13.39]
125088625  [KO:K05699]
125089171  [KO:K19663] [EC:2.7.11.13]
125089683  [KO:K13375]
125090366  [KO:K19662] [EC:2.7.11.13]
125091026  [KO:K06461]
125091098  [KO:K04455]
125091274  [KO:K02187] [EC:3.4.22.56]
125091570  [KO:K06237]
125091771  [KO:K06237]
125093126  [KO:K10159]
125093174  [KO:K13279] [EC:1.11.1.24]
125093224  [KO:K02580]
125093301  [KO:K06464]
125093820  [KO:K05505]
125093821  [KO:K05505]
125093822  [KO:K05505]
125094403  [KO:K10030]
125094828  [KO:K06237]
125094830  [KO:K06237]
125095065  [KO:K05717]
125095149  [KO:K06237]
125095151  [KO:K06237]
125095183  [KO:K19720]
125096824  [KO:K00922] [EC:2.7.1.153]
125096844  [KO:K13279] [EC:1.11.1.24]
125097539  [KO:K04345] [EC:2.7.11.11]
125097541  [KO:K05725] [EC:2.7.10.2]
125097558  [KO:K02649]
125098886  [KO:K07888]
125099065  [KO:K03998]
125099083  [KO:K03997]
125099687  [KO:K05406]
125099801  [KO:K02649]
125100468  [KO:K05427]
125100627  [KO:K00922] [EC:2.7.1.153]
125100734  [KO:K04000]
125100878  [KO:K04391]
125101014  [KO:K05425]
125101767  [KO:K05637]
125101978  [KO:K06241]
125102264  [KO:K01476] [EC:3.5.3.1]
125102473  [KO:K13963]
125103137  [KO:K13963]
125103142  [KO:K03156]
125103650  [KO:K13377]
125103868  [KO:K00922] [EC:2.7.1.153]
125103887  [KO:K01476] [EC:3.5.3.1]
125104302  [KO:K05699]
125104802  [KO:K01319] [EC:3.4.21.20]
125104900  [KO:K07887]
125105190  [KO:K05858] [EC:3.1.4.11]
125106523  [KO:K07888]
125107054  [KO:K04687]
125107830  [KO:K07897]
125108177  [KO:K04632]
125108178  [KO:K04632]
125108402  [KO:K06240]
125108695  [KO:K05858] [EC:3.1.4.11]
125108912  [KO:K04386]
125108926  [KO:K05858] [EC:3.1.4.11]
125109148  [KO:K04519]
125109725  [KO:K04387]
125110237  [KO:K05858] [EC:3.1.4.11]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
llv00330  Arginine and proline metabolism
llv00590  Arachidonic acid metabolism
llv04144  Endocytosis
llv04210  Apoptosis
llv04510  Focal adhesion
llv04610  Complement and coagulation cascades
llv04612  Antigen processing and presentation
llv04620  Toll-like receptor signaling pathway
llv04672  Intestinal immune network for IgA production
llv04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

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