Entry Name Influenza A - Lynx rufus (bobcat)
Description Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Lynx rufus (bobcat) [GN:
lruf ]
Gene 124513268 calcium-binding and coiled-coil domain-containing protein 2-like isoform X1 [KO:K21348 ]
124524270 LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842 ]
124526006 myeloid differentiation primary response protein MyD88 [KO:K04729 ]
124515343 signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
124501367 signal transducer and activator of transcription 2-like [KO:K11221 ]
124527968 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
124527969 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
124527970 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
124528564 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
124528600 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
124528621 HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752 ]
124528730 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
124528769 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
124528840 HLA class II histocompatibility antigen, DM alpha chain-like isoform X1 [KO:K06752 ]
124529193 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
124529194 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
124514229 NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
124517853 apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
124517840 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
124514527 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
124523730 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
124514827 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
124526454 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
124505594 LOW QUALITY PROTEIN: uncharacterized protein LOC124505594 [KO:K04722 ]
124518681 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
124501088 LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
124511385 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
124505439 LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862 ]
124519245 cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404 ]
124512829 putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404 ]
124509298 LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284 ]
124509299 LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284 ]
124511100 heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047 ]
124503761 radical S-adenosyl methionine domain-containing protein 2-like [KO:K15045 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Edinger TO, Pohl MO, Stertz S
Title Entry of influenza A virus: host factors and antiviral targets.
Journal Reference Authors Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal J Mol Genet Med 3:167-75 (2008)
Reference Authors Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal Reference Authors Thanh TT, van Doorn HR, de Jong MD
Title Human H5N1 influenza: current insight into pathogenesis.
Journal Reference Authors Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title Influenza A induced cellular signal transduction pathways.
Journal Reference Authors Hale BG, Albrecht RA, Garcia-Sastre A
Title Innate immune evasion strategies of influenza viruses.
Journal Reference Authors Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal Reference Authors Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title Interplay between influenza A virus and the innate immune signaling.
Journal Reference Authors van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title Evasion of influenza A viruses from innate and adaptive immune responses.
Journal Reference Authors Long JS, Mistry B, Haslam SM, Barclay WS
Title Host and viral determinants of influenza A virus species specificity.
Journal Reference Authors Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title Host Immune Response to Influenza A Virus Infection.
Journal Reference Authors Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal Reference Authors Ichinohe T, Iwasaki A, Hasegawa H
Title Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal Reference Authors Le Sage V, Cinti A, Amorim R, Mouland AJ
Title Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Varga ZT, Palese P
Title The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal Reference Authors Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title The induction and consequences of Influenza A virus-induced cell death.
Journal Reference Authors Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal Reference Authors Dai X, Zhang L, Hong T
Title Host cellular signaling induced by influenza virus.
Journal Reference Authors Li J, Yu M, Zheng W, Liu W
Title Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal Reference Authors Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal Reference Authors Paterson D, Fodor E
Title Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal Related lruf04620 Toll-like receptor signaling pathway
lruf04621 NOD-like receptor signaling pathway
lruf04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
