KEGG   PATHWAY: mamb04260
Entry
mamb04260                   Pathway                                
Name
Cardiac muscle contraction - Megalobrama amblycephala (Wuchang bream)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
mamb04260  Cardiac muscle contraction
mamb04260

Other DBs
GO: 0060048
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125245652  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125280569  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125256332  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
125279615  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
125280153  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
125263059  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
125279856  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
125279347  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
125265204  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
125259658  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
125260718  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
125270203  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
125274289  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
125246166  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
125253992  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
125263541  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
125273627  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
125280528  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
125256832  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
125245646  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
125247226  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
125278128  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
125266360  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
125274423  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
125276133  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
125271236  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125272720  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125278127  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
125266368  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
125274045  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
125268429  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
125242825  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
125275283  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
125243929  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
125275282  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
125243269  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
125275280  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a isoform X1 [KO:K04873]
125255265  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
125268153  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
125265879  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
125270399  casq2; calsequestrin-2 [KO:K23445]
125272292  calsequestrin-2-like [KO:K23445]
125278338  trdn; triadin isoform X1 [KO:K23449]
125255968  protein Ycf2 [KO:K23450]
125272172  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
125253412  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
125280727  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
125266787  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
125255152  atp2a1l; LOW QUALITY PROTEIN: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
125275414  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
125260182  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
125260244  tnnc1b; troponin C type 1b (slow) [KO:K05865]
125260772  tnnc1a; troponin C type 1a (slow) [KO:K05865]
125244846  tnnt2c; troponin T2c, cardiac [KO:K12045]
125246231  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
125246775  tnnt2d; troponin T2d, cardiac [KO:K12045]
125273332  tnnt2b; troponin T, cardiac muscle isoforms isoform X1 [KO:K12045]
125260653  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
125264697  tpma; tropomyosin alpha-1 chain [KO:K10373]
125248028  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
125275476  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K10373]
125256035  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
125250167  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
125251081  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
125277823  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
125271770  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
125279027  actc2; actin, alpha, cardiac muscle 2 [KO:K12314]
125247186  acte1; beta-actin-like protein 2 [KO:K12314]
125269229  actc1b; actin, alpha cardiac muscle 1b [KO:K12314]
125276877  acta1b; LOW QUALITY PROTEIN: actin alpha 1, skeletal muscle b [KO:K12314]
125258282  myosin-7-like isoform X1 [KO:K17751]
125258283  myosin-7-like [KO:K17751]
125258286  myosin-7-like [KO:K17751]
125258287  myosin-7-like [KO:K17751]
125258289  myosin-7-like [KO:K17751]
125258290  myosin-7-like [KO:K17751]
125278595  myh6; myosin-6 [KO:K17751]
125250268  myosin-7-like [KO:K17751]
125250269  myosin-7 [KO:K17751]
125279421  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
125266219  myl2a; myosin regulatory light chain 2a [KO:K10351]
125244942  myosin light chain 4-like [KO:K12750]
125272620  myl4; myosin light chain 4 [KO:K12750]
125255421  zgc:163073; myosin light chain 4 [KO:K12750]
125267619  cmlc1; cardiac myosin light chain-1 [KO:K12750]
125267651  myosin light chain 4-like [KO:K12750]
125264883  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
125254801  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
5912300  CYTB; cytochrome b [KO:K00412]
125273572  cytochrome c1, heme protein, mitochondrial [KO:K00413]
125265619  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
125254943  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
125267618  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
125274100  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
125251022  cytochrome b-c1 complex subunit 6, mitochondrial-like isoform X1 [KO:K00416]
125275093  cytochrome b-c1 complex subunit 7 [KO:K00417]
125258802  cytochrome b-c1 complex subunit 8 [KO:K00418]
125252625  cytochrome b-c1 complex subunit 9 [KO:K00419]
125250534  cytochrome b-c1 complex subunit 10 [KO:K00420]
5912301  COX3; cytochrome c oxidase subunit III [KO:K02262]
5912298  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5912295  COX2; cytochrome c oxidase subunit II [KO:K02261]
125258129  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
125260780  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
125261102  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
125247779  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
125254308  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
125262347  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
125280451  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
125276491  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
125280067  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
125276676  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
125243074  cytochrome c oxidase subunit 6B1 [KO:K02267]
125257492  cytochrome c oxidase subunit 6B1 [KO:K02267]
125271052  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
125278706  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
125249323  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
125255702  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
125268375  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
125253410  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
125267467  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
125278743  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
125278753  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
125252677  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
125246911  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
125252457  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
125265625  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
125266386  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
125248568  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
125256374  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
125268722  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
125277288  slc8a3; LOW QUALITY PROTEIN: sodium/calcium exchanger 3 [KO:K05849]
125259008  slc9a6a; sodium/hydrogen exchanger 6a [KO:K12041]
125273666  slc9a7; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 7 [KO:K12041]
125260723  slc9a6b; sodium/hydrogen exchanger 6b [KO:K12041]
125242886  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
125270184  atp1a1b; sodium/potassium-transporting ATPase subunit alpha-1b [KO:K01539] [EC:7.2.2.13]
125272943  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
125272945  atp1a1a.2; sodium/potassium-transporting ATPase subunit alpha-1a.2 [KO:K01539] [EC:7.2.2.13]
125272946  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
125272947  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
125275671  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a isoform X1 [KO:K01539] [EC:7.2.2.13]
125250487  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
125269314  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
125259473  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
125272780  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
125273934  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
125266966  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
125248520  atp1b3b; sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
125251292  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a isoform X1 [KO:K01540]
125260241  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
125266349  fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
125242798  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
125276063  slc9a1b; sodium/hydrogen exchanger 1b [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
mamb04020  Calcium signaling pathway
KO pathway
ko04260   
LinkDB

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