KEGG   PATHWAY: mcf04932
Entry
mcf04932                    Pathway                                
Name
Non-alcoholic fatty liver disease - Macaca fascicularis (crab-eating macaque)
Description
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). NASH may further lead to cirrhosis and hepatocellular carcinoma (HCC). This map shows a stage-dependent progression of NAFLD. In the first stage of NAFLD, excess lipid accumulation has been demonstrated. The main cause is the induction of insulin resistance, which leads to a defect in insulin suppression of free fatty acids (FAAs) disposal. In addition, two transcription factors, SREBP-1c and PPAR-alpha, activate key enzymes of lipogenesis and increase the synthesis of FAAs in liver. In the second stage, as a consequence of the progression to NASH, the production of reactive oxygen species (ROS) is enhanced due to oxidation stress through mitochondrial beta-oxidation of fatty acids and endoplamic reticulum (ER) stress, leading to lipid peroxidation. The lipid peroxidation can further cause the production of cytokines (Fas ligand, TNF-alpha, IL-8 and TGF), promoting cell death, inflammation and fibrosis. The activation of JNK, which is induced by ER stress, TNF-alpha and FAAs, is also associated with NAFLD progression. Increased JNK promotes cytokine production and initiation of HCC.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
mcf04932  Non-alcoholic fatty liver disease
mcf04932

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102138971  IL6; interleukin-6 precursor [KO:K05405]
102117292  IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
102133184  INS; insulin [KO:K04526]
102139081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102117978  IRS1; insulin receptor substrate 1 [KO:K16172]
102122241  IRS2; insulin receptor substrate 2 [KO:K07187]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101926713  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102122176  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
102133330  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102140831  SREBF1; sterol regulatory element-binding protein 1 isoform X4 [KO:K07197]
102135776  MLXIPL; carbohydrate-responsive element-binding protein isoform X1 [KO:K09113]
102135300  MLX-interacting protein isoform X1 [KO:K09113]
102123856  MLX; max-like protein X isoform X1 [KO:K09113]
102116429  PKLR; pyruvate kinase PKLR isoform X5 [KO:K12406] [EC:2.7.1.40]
102136844  leptin isoform X1 [KO:K05424]
102115046  LEPR; leptin receptor isoform X1 [KO:K05062]
102123471  ADIPOQ; adiponectin isoform X1 [KO:K07296]
101866030  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
102130588  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
102143726  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
102144683  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101925338  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
102133927  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
102128414  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
102130217  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
101865279  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102133372  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
102120453  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102125726  cell division control protein 42 homolog [KO:K04393]
102124817  cell division control protein 42 homolog [KO:K04393]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101926191  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101925768  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
102116193  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102143716  FOS; proto-oncogene c-Fos [KO:K04379]
102126446  JUN; transcription factor AP-1 [KO:K04448]
101926546  IL1A; interleukin-1 alpha isoform X2 [KO:K04383]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102122252  XBP1; X-box-binding protein 1 isoform X1 [KO:K09027]
102119204  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
102136686  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102127272  CXCL8; interleukin-8 [KO:K10030]
102129546  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102117938  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102135074  BCL2L11; bcl-2-like protein 11 isoform X5 [KO:K16341]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102117102  cytochrome c-like [KO:K08738]
102120205  cytochrome c [KO:K08738]
102125088  cytochrome c-like [KO:K08738]
102136392  cytochrome c-like [KO:K08738]
102127614  cytochrome c-like [KO:K08738]
102141866  cytochrome c-like [KO:K08738]
107127908  cytochrome c-like [KO:K08738]
102120841  cytochrome c-like [KO:K08738]
102123704  cytochrome c-like [KO:K08738]
107130218  cytochrome c-like [KO:K08738]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102127213  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102124346  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102122521  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
102124686  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X3 [KO:K03943] [EC:7.1.1.2]
102117222  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102144790  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102122243  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
101925194  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102145434  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102122399  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102130049  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
102143510  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101925169  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102122883  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123570998  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123571785  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123574038  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123574384  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123575129  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123575527  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
102142948  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
102132705  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101865843  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
123573105  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
102142308  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102134019  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102116683  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102125333  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102118472  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
101866670  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102134986  acyl carrier protein, mitochondrial [KO:K03955]
101925928  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102138616  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101926508  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102114911  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123571832  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
101865240  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
107130321  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
102135950  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102135077  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
123568388  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
102129785  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102140432  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
101866824  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X2 [KO:K03961]
101925689  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102115854  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102123100  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102138041  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
102139978  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
102116573  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102133526  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102140374  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
102137623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101865238  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101925833  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
102135711  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102137128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
102146369  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
102143409  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
101867140  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123566851  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
101865852  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102119049  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
101866792  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X6 [KO:K03941] [EC:7.1.1.2]
102139017  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102116918  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102126003  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
101865119  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102145957  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X3 [KO:K00236]
102134309  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
102127185  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102127751  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102132064  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
102132017  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102133631  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
7857749  CYTB; cytochrome b [KO:K00412]
102145737  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
102117433  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102135041  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102136267  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
102123032  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102115384  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
102134501  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
102117303  cytochrome b-c1 complex subunit 7 [KO:K00417]
102131145  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 7-like [KO:K00417]
102133057  cytochrome b-c1 complex subunit 8 [KO:K00418]
102128183  cytochrome b-c1 complex subunit 8-like [KO:K00418]
102133949  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
102128659  cytochrome b-c1 complex subunit 10 isoform X2 [KO:K00420]
7857743  COX3; cytochrome c oxidase subunit III [KO:K02262]
7857739  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7857740  COX2; cytochrome c oxidase subunit II [KO:K02261]
102139855  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102138538  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
102144280  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
102135848  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102123322  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
102132790  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102118619  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102124626  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102141433  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102116497  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102139072  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
102130191  cytochrome c oxidase subunit 6B2 [KO:K02267]
102143756  cytochrome c oxidase subunit 6B1 [KO:K02267]
102121560  cytochrome c oxidase subunit 6B1-like [KO:K02267]
102137297  cytochrome c oxidase subunit 6C [KO:K02268]
102126517  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102132250  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102118608  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X3 [KO:K02270]
123571146  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102135667  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
123572206  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
123573518  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
102123270  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102124180  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
123573477  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102137362  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123567561  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123568376  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123569483  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123570224  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123572509  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123572831  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123573956  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
102129733  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123574408  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123574442  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123575162  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
102122063  cytochrome c oxidase subunit 8C, mitochondrial isoform X3 [KO:K02273]
102139510  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
Compound
C00031  D-Glucose
C00162  Fatty acid
Reference
PMID:23545492
  Authors
Naik A, Kosir R, Rozman D
  Title
Genomic aspects of NAFLD pathogenesis.
  Journal
Genomics 102:84-95 (2013)
DOI:10.1016/j.ygeno.2013.03.007
Reference
PMID:19352614
  Authors
Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L
  Title
Molecular mechanisms involved in NAFLD progression.
  Journal
J Mol Med (Berl) 87:679-95 (2009)
DOI:10.1007/s00109-009-0464-1
Reference
PMID:22705006
  Authors
Seki E, Brenner DA, Karin M
  Title
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
  Journal
Gastroenterology 143:307-20 (2012)
DOI:10.1053/j.gastro.2012.06.004
Reference
PMID:21038418
  Authors
Tilg H, Moschen AR
  Title
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis.
  Journal
Hepatology 52:1836-46 (2010)
DOI:10.1002/hep.24001
Reference
PMID:16364488
  Authors
Larter CZ, Farrell GC
  Title
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
  Journal
J Hepatol 44:253-61 (2006)
DOI:10.1016/j.jhep.2005.11.030
Reference
PMID:22570745
  Authors
Farrell GC, van Rooyen D, Gan L, Chitturi S
  Title
NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.
  Journal
Gut Liver 6:149-71 (2012)
DOI:10.5009/gnl.2012.6.2.149
Reference
PMID:20619513
  Authors
Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P
  Title
The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease.
  Journal
Clin Nutr 30:6-19 (2011)
DOI:10.1016/j.clnu.2010.06.001
Reference
PMID:20303879
  Authors
Hotamisligil GS
  Title
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.
  Journal
Cell 140:900-17 (2010)
DOI:10.1016/j.cell.2010.02.034
Reference
PMID:17498512
  Authors
Parekh S, Anania FA
  Title
Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.
  Journal
Gastroenterology 132:2191-207 (2007)
DOI:10.1053/j.gastro.2007.03.055
Reference
PMID:16374858
  Authors
Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, Czaja MJ
  Title
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
  Journal
Hepatology 43:163-72 (2006)
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Leung TM, Nieto N
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CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease.
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J Hepatol 58:395-8 (2013)
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PMID:14685853
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Virchows Arch 444:3-12 (2004)
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PMID:12891546
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Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.
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Gastroenterology 125:437-43 (2003)
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PMID:16406828
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Begriche K, Igoudjil A, Pessayre D, Fromenty B
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Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.
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Mitochondrion 6:1-28 (2006)
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PMID:9285483
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The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis.
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FASEB J 11:851-7 (1997)
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PMID:21145844
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Malhi H, Kaufman RJ
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Endoplasmic reticulum stress in liver disease.
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J Hepatol 54:795-809 (2011)
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PMID:18242193
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Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM
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Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.
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Free Radic Biol Med 44:1259-72 (2008)
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Mitochondrial involvement in non-alcoholic steatohepatitis.
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Mol Aspects Med 29:22-35 (2008)
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Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B
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Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.
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Hepatology 58:1497-507 (2013)
DOI:10.1002/hep.26226
Related
pathway
mcf00061  Fatty acid biosynthesis
mcf00190  Oxidative phosphorylation
mcf03320  PPAR signaling pathway
mcf04141  Protein processing in endoplasmic reticulum
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04668  TNF signaling pathway
mcf04920  Adipocytokine signaling pathway
mcf04930  Type II diabetes mellitus
KO pathway
ko04932   
LinkDB

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