KEGG   PATHWAY: mcf05164
Entry
mcf05164                    Pathway                                
Name
Influenza A - Macaca fascicularis (crab-eating macaque)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcf05164  Influenza A
mcf05164

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102139613  tryptase beta-2 isoform X1 [KO:K01340] [EC:3.4.21.59]
102140229  tryptase beta-2 isoform X1 [KO:K01340] [EC:3.4.21.59]
102145643  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
101866288  PRSS2; trypsin-2 [KO:K01312] [EC:3.4.21.4]
102132890  putative trypsin-6 isoform X1 [KO:K01312] [EC:3.4.21.4]
102126989  putative trypsin-6 isoform X1 [KO:K01312] [EC:3.4.21.4]
102127372  trypsin-1 [KO:K01312] [EC:3.4.21.4]
102129692  trypsin-2-like [KO:K01312] [EC:3.4.21.4]
102130590  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
102137447  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
102128205  TMPRSS4; transmembrane protease serine 4 isoform X1 [KO:K09635] [EC:3.4.21.-]
102133163  TMPRSS11D; transmembrane protease serine 11D isoform X2 [KO:K09641] [EC:3.4.21.-]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102131636  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
102132392  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
102132016  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
102143958  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
101865515  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
102134770  DNAJC3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
102124745  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102117091  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
102141351  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
102135560  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
102134229  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
102132372  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
102130059  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101865725  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
102138517  TLR3; toll-like receptor 3 [KO:K05401]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102131731  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102135037  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
102136906  TLR4; toll-like receptor 4 isoform X2 [KO:K10160]
102139628  TLR7; toll-like receptor 7 [KO:K05404]
101866832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102140231  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
101926546  IL1A; interleukin-1 alpha isoform X2 [KO:K04383]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102127272  CXCL8; interleukin-8 [KO:K10030]
102135739  CCL2; C-C motif chemokine 2 [KO:K14624]
107127795  CCL5; C-C motif chemokine 5 [KO:K12499]
102134351  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102138837  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102146717  interferon alpha-17 [KO:K05414]
102140303  interferon alpha-1/13 [KO:K05414]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141744  interferon alpha-1/13 [KO:K05414]
102141352  interferon alpha-1/13-like [KO:K05414]
102143043  IFNA6; interferon alpha-6 [KO:K05414]
102144479  interferon alpha-14 [KO:K05414]
102144833  interferon alpha-4-like [KO:K05414]
102145208  interferon alpha-10 [KO:K05414]
102145962  interferon alpha-17 [KO:K05414]
102115289  interferon alpha-17 [KO:K05414]
102142148  IFNA2; interferon alpha-2 [KO:K05414]
123569038  interferon alpha-17-like [KO:K05414]
102146344  interferon alpha-17-like [KO:K05414]
102147079  interferon alpha-17-like [KO:K05414]
102115670  IFNB1; interferon beta [KO:K05415]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102123983  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102133020  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102137059  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
102138585  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
101926284  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
102135847  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102128291  IFNG; interferon gamma [KO:K04687]
101866179  IFNGR1; interferon gamma receptor 1 isoform X3 [KO:K05132]
102138221  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102129555  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102136468  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
102137481  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
102140649  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
102139994  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
102145413  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102132662  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
102144414  HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752]
102144039  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
102136862  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
102133044  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
123572852  H-2 class II histocompatibility antigen, A-D alpha chain-like [KO:K06752]
123572854  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
123572909  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102142532  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
102144771  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102118885  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
102135101  IL18; interleukin-18 isoform X1 [KO:K05482]
102140695  IL33; interleukin-33 isoform X1 [KO:K12967]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101865999  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
101925733  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102140874  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101864918  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
102139560  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102133727  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102142357  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101864983  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
102120762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102129825  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102143674  SLC25A31; ADP/ATP translocase 4 isoform X2 [KO:K05863]
102138876  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102117102  cytochrome c-like [KO:K08738]
102120205  cytochrome c [KO:K08738]
102125088  cytochrome c-like [KO:K08738]
102136392  cytochrome c-like [KO:K08738]
102127614  cytochrome c-like [KO:K08738]
102141866  cytochrome c-like [KO:K08738]
107127908  cytochrome c-like [KO:K08738]
102120841  cytochrome c-like [KO:K08738]
102123704  cytochrome c-like [KO:K08738]
107130218  cytochrome c-like [KO:K08738]
102137473  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102126830  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102131983  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
102141375  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X2 [KO:K14404]
101867156  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
102123787  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
102118589  polyadenylate-binding protein 2-like [KO:K14396]
102133156  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
102146918  NXF3; nuclear RNA export factor 3 isoform X1 [KO:K14284]
101865792  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
102133037  nuclear RNA export factor 2 [KO:K14284]
102132398  nuclear RNA export factor 2 [KO:K14284]
102122866  NXT1; NTF2-related export protein 1 [KO:K14285]
101925148  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
102126742  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
123569134  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047]
101864841  RAE1; mRNA export factor [KO:K14298]
102130385  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
102135085  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
101865059  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102119088  farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102132328  LOW QUALITY PROTEIN: farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102135875  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102120642  actin, cytoskeletal 4-like [KO:K05692]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101925291  RAB11A; ras-related protein Rab-11A [KO:K07904]
101926365  RAB11B; ras-related protein Rab-11B [KO:K07905]
101925881  XPO1; exportin-1 isoform X1 [KO:K14290]
101925859  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
102126330  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
101864813  KPNA2; importin subunit alpha-1 [KO:K15043]
102127852  KPNA7; importin subunit alpha-8 isoform X2 [KO:K15043]
102120718  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
102129760  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
mcf00900  Terpenoid backbone biosynthesis
mcf03013  Nucleocytoplasmic transport
mcf03015  mRNA surveillance pathway
mcf04010  MAPK signaling pathway
mcf04110  Cell cycle
mcf04144  Endocytosis
mcf04210  Apoptosis
mcf04620  Toll-like receptor signaling pathway
mcf04621  NOD-like receptor signaling pathway
mcf04622  RIG-I-like receptor signaling pathway
mcf04630  JAK-STAT signaling pathway
mcf05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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