KEGG   PATHWAY: mcf05418
Entry
mcf05418                    Pathway                                
Name
Fluid shear stress and atherosclerosis - Macaca fascicularis (crab-eating macaque)
Description
Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions of endothelial cell (EC) genes and proteins that are protective against atherosclerosis. The key shear stress-induced transcription factors that govern the expression of these genes are Kruppel-like factor 2 (KLF2) and nuclear factor erythroid 2-like 2 (Nrf2). On the other hand, disturbed flow with associated reciprocating, low shear stress generally upregulates the EC genes and proteins that promote oxidative and inflammatory states in the artery wall, resulting in atherogenesis. Important transcriptional events that reflect this condition of ECs in disturbed flow include the activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).
Class
Human Diseases; Cardiovascular disease
Pathway map
mcf05418  Fluid shear stress and atherosclerosis
mcf05418

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101926380  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102123807  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101866865  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101926487  HSP90B1; endoplasmin [KO:K09487]
102136375  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
102143504  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101865646  CAV1; caveolin-1 isoform X2 [KO:K06278]
102122005  CAV2; caveolin-2 isoform X1 [KO:K12958]
102133753  CAV3; caveolin-3 [KO:K12959]
102119159  CALML6; calmodulin-like protein 6 [KO:K02183]
102114795  CALML3; calmodulin-like protein 3 [KO:K02183]
102146976  CALML5; calmodulin-like protein 5 [KO:K02183]
102131162  CALM1; calmodulin-1 [KO:K02183]
101866377  CALM3; calmodulin-3 [KO:K02183]
101865168  CALM2; calmodulin-2 [KO:K02183]
102122343  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102144138  calmodulin-1 [KO:K02183]
102123030  GPC1; glypican-1 isoform X1 [KO:K08107]
102126789  SDC1; syndecan-1 [KO:K06257]
102145988  SDC2; syndecan-2 [KO:K16336]
101866418  SDC4; syndecan-4 [KO:K16338]
102116382  TRPV4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
102118980  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
102138754  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
101926565  HMOX1; heme oxygenase 1 isoform X1 [KO:K00510] [EC:1.14.14.18]
102138414  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102115229  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101866044  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101865382  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
102146648  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102117319  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
102116720  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
102142224  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
102114846  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
102145837  GSTM4; glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102146042  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
101925101  GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
102145210  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
102146720  GSTM2; glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
102142998  glutathione S-transferase theta-1 isoform X4 [KO:K00799] [EC:2.5.1.18]
102130209  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
102120066  LOW QUALITY PROTEIN: glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
123572957  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
123572960  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102140658  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
102143668  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
102127415  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102121489  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
102144942  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
102116349  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
102130667  TXN; thioredoxin [KO:K03671]
102144480  thioredoxin-like [KO:K03671]
102144238  thioredoxin-like [KO:K03671]
102126253  thioredoxin-like [KO:K03671]
123573580  thioredoxin-like [KO:K03671]
102137373  NPPC; C-type natriuretic peptide [KO:K12336]
101865472  ASS1; argininosuccinate synthase [KO:K01940] [EC:6.3.4.5]
102139817  argininosuccinate synthase [KO:K01940] [EC:6.3.4.5]
102125064  THBD; thrombomodulin [KO:K03907]
102145462  PLAT; tissue-type plasminogen activator isoform X2 [KO:K01343] [EC:3.4.21.68]
102134170  CDH5; cadherin-5 [KO:K06533]
102136227  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102146984  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102143726  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
102144683  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102117792  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102118759  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
102133212  MAPK7; mitogen-activated protein kinase 7 isoform X3 [KO:K04464] [EC:2.7.11.24]
102138665  MEF2A; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
102135088  MEF2C; myocyte-specific enhancer factor 2C isoform X8 [KO:K04454]
107128140  KLF2; Krueppel-like factor 2 [KO:K17845]
102119413  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
102116249  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101925550  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
102131561  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X4 [KO:K12791]
101865630  RHOA; transforming protein RhoA [KO:K04513]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102120642  actin, cytoskeletal 4-like [KO:K05692]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102116284  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102146317  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102143926  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
102140498  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102125035  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101925060  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102143716  FOS; proto-oncogene c-Fos [KO:K04379]
102126446  JUN; transcription factor AP-1 [KO:K04448]
101865544  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
102117693  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102116556  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102118013  LOW QUALITY PROTEIN: putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
102123755  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
102135739  CCL2; C-C motif chemokine 2 [KO:K14624]
102131307  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
102138837  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102143564  SELE; E-selectin [KO:K06494]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101926546  IL1A; interleukin-1 alpha isoform X2 [KO:K04383]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102128291  IFNG; interferon gamma [KO:K04687]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102115765  EDN1; endothelin-1 [KO:K16366]
102140241  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102132568  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
102132657  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
102121129  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
102118668  ACVR2B; activin receptor type-2B isoform X3 [KO:K13596] [EC:2.7.11.30]
102134051  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
102122481  BMPR1A; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
102136230  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
102116010  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
102143777  cytochrome b-245 light chain isoform X2 [KO:K08009]
102124562  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102123175  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102137056  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102143597  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101925905  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102139847  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X6 [KO:K16065] [EC:2.3.2.27]
102135998  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
101865391  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
102145589  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
102127559  small ubiquitin-related modifier 1-like [KO:K12160]
102130101  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
102128732  small ubiquitin-related modifier 2-like [KO:K12160]
102114961  small ubiquitin-related modifier 5 [KO:K12160]
102127280  small ubiquitin-related modifier 3-like [KO:K12160]
102136873  small ubiquitin-related modifier 2-like [KO:K12160]
102115387  small ubiquitin-related modifier 1-like [KO:K12160]
102115083  small ubiquitin-related modifier 2-like [KO:K12160]
102117921  small ubiquitin-related modifier 2-like [KO:K12160]
102138212  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
Compound
C00076  Calcium cation
C00272  Tetrahydrobiopterin
C00518  Hyaluronate
C00533  Nitric oxide
C00607  Chondroitin sulfate
C00704  Superoxide
C00925  Heparan sulfate
C16845  Peroxynitrite
Reference
PMID:21050140
  Authors
Nigro P, Abe J, Berk BC
  Title
Flow shear stress and atherosclerosis: a matter of site specificity.
  Journal
Antioxid Redox Signal 15:1405-14 (2011)
DOI:10.1089/ars.2010.3679
Reference
PMID:26597822
  Authors
McSweeney SR, Warabi E, Siow RC
  Title
Nrf2 as an Endothelial Mechanosensitive Transcription Factor: Going With the Flow.
  Journal
Hypertension 67:20-9 (2016)
DOI:10.1161/HYPERTENSIONAHA.115.06146
Reference
PMID:22076424
  Authors
Heo KS, Fujiwara K, Abe J
  Title
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
  Journal
Circ J 75:2722-30 (2011)
DOI:10.1253/circj.CJ-11-1124
Reference
PMID:24573382
  Authors
Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I
  Title
Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress.
  Journal
Thromb Haemost 112:183-95 (2014)
DOI:10.1160/TH13-11-0908
Reference
PMID:21457103
  Authors
Noguchi N, Jo H
  Title
Redox going with vascular shear stress.
  Journal
Antioxid Redox Signal 15:1367-8 (2011)
DOI:10.1089/ars.2011.4011
Reference
PMID:25165867
  Authors
Li X, Yang Q, Wang Z, Wei D
  Title
Shear stress in atherosclerotic plaque determination.
  Journal
DNA Cell Biol 33:830-8 (2014)
DOI:10.1089/dna.2014.2480
Reference
PMID:17599600
  Authors
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH
  Title
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
  Journal
J Am Coll Cardiol 49:2379-93 (2007)
DOI:10.1016/j.jacc.2007.02.059
Reference
PMID:21733876
  Authors
Lu D, Kassab GS
  Title
Role of shear stress and stretch in vascular mechanobiology.
  Journal
J R Soc Interface 8:1379-85 (2011)
DOI:10.1098/rsif.2011.0177
Reference
PMID:27027326
  Authors
Givens C, Tzima E
  Title
Endothelial Mechanosignaling: Does One Sensor Fit All?
  Journal
Antioxid Redox Signal 25:373-88 (2016)
DOI:10.1089/ars.2015.6493
Reference
PMID:16765337
  Authors
Paravicini TM, Touyz RM
  Title
Redox signaling in hypertension.
  Journal
Cardiovasc Res 71:247-58 (2006)
DOI:10.1016/j.cardiores.2006.05.001
Reference
PMID:19151844
  Authors
Boon RA, Horrevoets AJ
  Title
Key transcriptional regulators of the vasoprotective effects of shear stress.
  Journal
Hamostaseologie 29:39-40, 41-3 (2009)
Reference
PMID:24947523
  Authors
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J, Evans PC
  Title
Mechanoresponsive networks controlling vascular inflammation.
  Journal
Arterioscler Thromb Vasc Biol 34:2199-205 (2014)
DOI:10.1161/ATVBAHA.114.303424
Reference
PMID:26822720
  Authors
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR
  Title
Role of biomechanical forces in the natural history of coronary atherosclerosis.
  Journal
Nat Rev Cardiol 13:210-20 (2016)
DOI:10.1038/nrcardio.2015.203
Reference
PMID:24876354
  Authors
Zhou J, Li YS, Chien S
  Title
Shear stress-initiated signaling and its regulation of endothelial function.
  Journal
Arterioscler Thromb Vasc Biol 34:2191-8 (2014)
DOI:10.1161/ATVBAHA.114.303422
Reference
PMID:23429585
  Authors
Liu HB, Zhang J, Xin SY, Liu C, Wang CY, Zhao D, Zhang ZR
  Title
Mechanosensitive properties in the endothelium and their roles in the regulation of endothelial function.
  Journal
J Cardiovasc Pharmacol 61:461-70 (2013)
DOI:10.1097/FJC.0b013e31828c0933
Reference
PMID:20032497
  Authors
Boon RA, Leyen TA, Fontijn RD, Fledderus JO, Baggen JM, Volger OL, van Nieuw Amerongen GP, Horrevoets AJ
  Title
KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium.
  Journal
Blood 115:2533-42 (2010)
DOI:10.1182/blood-2009-06-228726
Reference
PMID:20353494
  Authors
Whyte JJ, Laughlin MH
  Title
The effects of acute and chronic exercise on the vasculature.
  Journal
Acta Physiol (Oxf) 199:441-50 (2010)
DOI:10.1111/j.1748-1716.2010.02127.x
Reference
PMID:25638487
  Authors
Quillon A, Fromy B, Debret R
  Title
Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals.
  Journal
Nitric Oxide 45:20-6 (2015)
DOI:10.1016/j.niox.2015.01.006
Reference
PMID:15388638
  Authors
Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassegue B, Griendling KK, Jo H
  Title
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.
  Journal
Circ Res 95:773-9 (2004)
DOI:10.1161/01.RES.0000145728.22878.45
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22003002
  Authors
Johnson BD, Mather KJ, Wallace JP
  Title
Mechanotransduction of shear in the endothelium: basic studies and clinical implications.
  Journal
Vasc Med 16:365-77 (2011)
DOI:10.1177/1358863X11422109
Reference
PMID:23555159
  Authors
Hu LS, George J, Wang JH
  Title
Current concepts on the role of nitric oxide in portal hypertension.
  Journal
World J Gastroenterol 19:1707-17 (2013)
DOI:10.3748/wjg.v19.i11.1707
Reference
PMID:23084990
  Authors
Collins C, Guilluy C, Welch C, O'Brien ET, Hahn K, Superfine R, Burridge K, Tzima E
  Title
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.
  Journal
Curr Biol 22:2087-94 (2012)
DOI:10.1016/j.cub.2012.08.051
Reference
PMID:24190880
  Authors
Conway DE, Schwartz MA
  Title
Flow-dependent cellular mechanotransduction in atherosclerosis.
  Journal
J Cell Sci 126:5101-9 (2013)
DOI:10.1242/jcs.138313
Reference
PMID:26212910
  Authors
Chen J, Green J, Yurdagul A Jr, Albert P, McInnis MC, Orr AW
  Title
alphavbeta3 Integrins Mediate Flow-Induced NF-kappaB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation.
  Journal
Am J Pathol 185:2575-89 (2015)
DOI:10.1016/j.ajpath.2015.05.013
Reference
PMID:20538799
  Authors
Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC
  Title
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
  Journal
Blood 116:1971-9 (2010)
DOI:10.1182/blood-2010-02-269134
Related
pathway
mcf04010  MAPK signaling pathway
mcf04064  NF-kappa B signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04270  Vascular smooth muscle contraction
mcf04510  Focal adhesion
mcf04514  Cell adhesion molecules
mcf04670  Leukocyte transendothelial migration
KO pathway
ko05418   
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