KEGG   PATHWAY: mmf05167
Entry
mmf05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Molossus molossus (Pallas's mastiff bat)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmf05167  Kaposi sarcoma-associated herpesvirus infection
mmf05167

Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118615878  C3; complement C3 [KO:K03990]
118622536  TLR3; toll-like receptor 3 [KO:K05401]
118615402  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118633499  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118637482  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
118624185  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118643167  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118629333  interferon omega-1-like [KO:K05414]
118629850  interferon alpha-14-like [KO:K05414]
118639395  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118641604  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118624243  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118629329  IFNB1; interferon beta [KO:K05415]
118617107  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118617288  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118626049  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118615353  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118625659  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118623876  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118631124  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118630454  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118641186  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118641187  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118621004  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118621005  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118637117  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118634140  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118638860  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
118620458  IL6; interleukin-6 isoform X1 [KO:K05405]
118615980  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
118633347  C-C chemokine receptor type 3-like [KO:K04178]
118633424  C-C chemokine receptor type 5-like [KO:K04180]
118633353  C-C chemokine receptor type 1-like [KO:K04176]
118633375  CCR4; C-C chemokine receptor type 4 [KO:K04179]
118633459  CCR8; C-C chemokine receptor type 8 [KO:K04183]
118632575  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118628258  FADD; FAS-associated death domain protein [KO:K02373]
118625346  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118624690  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118638701  BAX; apoptosis regulator BAX [KO:K02159]
118621850  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118620489  cytochrome c [KO:K08738]
118638529  cytochrome c-like [KO:K08738]
118615920  cytochrome c-like [KO:K08738]
118626427  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118622705  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118623904  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118639212  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118629846  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118617230  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118628367  RELA; transcription factor p65 [KO:K04735]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118621843  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118624208  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118620055  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118622512  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118618748  E2F1; transcription factor E2F1 [KO:K17454]
118626004  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
118626466  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
118621148  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
118621233  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118639188  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118639189  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118621177  IFNGR1; interferon gamma receptor 1 [KO:K05132]
118615517  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
118617834  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
118624661  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
118617343  ubiquitin-like [KO:K02927]
118626147  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118626149  ubiquitin [KO:K02927]
118627687  ubiquitin-like [KO:K02927]
118623534  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118623571  ubiquitin-like isoform X1 [KO:K02927]
118631170  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
118631901  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118641724  ubiquitin-like [KO:K02977]
118623566  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118630702  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
118641256  UBB; polyubiquitin-B [KO:K04551]
118636309  polyubiquitin-like [KO:K04551]
118639992  UBC; polyubiquitin-C [KO:K08770]
118640494  BECN2; beclin-2 [KO:K08334]
118634172  BECN1; beclin-1 [KO:K08334]
118617072  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
118618488  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118617488  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
118640747  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118618750  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
118638990  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
118643409  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118641555  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118624402  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118616885  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118617165  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
118629739  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118627522  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118640651  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118626418  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118638371  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118615888  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118639405  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118621254  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118629801  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118619968  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118626713  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118616113  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118642671  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118620007  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118634527  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118615385  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118627941  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
118627223  JUN; transcription factor AP-1 [KO:K04448]
118618599  FOS; proto-oncogene c-Fos [KO:K04379]
118619840  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118634593  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
118634929  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118627075  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118618940  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118642157  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118615122  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118632456  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118617172  CD200R1; cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
118641349  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118618187  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
118631367  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118633861  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118615560  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118639621  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118618299  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118632878  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118623451  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118621173  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118640095  calmodulin-like [KO:K02183]
118640172  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118617946  CALM1; calmodulin-1 [KO:K02183]
118619605  calmodulin-1 [KO:K02183]
118627560  calmodulin-like [KO:K02183]
118628169  calmodulin-1-like [KO:K02183]
118636313  calmodulin-1-like [KO:K02183]
118643424  CALML6; calmodulin-like protein 6 [KO:K02183]
118630484  CALM2; calmodulin-2 [KO:K02183]
118638252  CALM3; calmodulin-3 [KO:K02183]
118631897  calmodulin-like protein 3 [KO:K02183]
118634685  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118643595  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118632179  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118630745  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118618649  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118618225  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118639385  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118627722  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118626319  C-X-C motif chemokine 15-like [KO:K10030]
118636257  interleukin-8-like [KO:K10030]
118643469  CXCL8; interleukin-8 [KO:K10030]
118637857  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118626364  growth-regulated protein homolog gamma-like [KO:K05505]
118643206  growth-regulated protein homolog [KO:K05505]
118643274  growth-regulated protein homolog gamma-like [KO:K05505]
118617846  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
118616042  FGF2; fibroblast growth factor 2 [KO:K18497]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118623957  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118622259  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
118642413  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
118629676  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118634787  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118617870  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118632900  CTNNB1; catenin beta-1 [KO:K02105]
118643629  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118630569  TCF7L1; transcription factor 7-like 1 [KO:K04490]
118632022  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
118637343  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
118624959  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Virology 428:112-20 (2012)
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J Mol Med (Berl) 82:223-31 (2004)
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Related
pathway
mmf04010  MAPK signaling pathway
mmf04064  NF-kappa B signaling pathway
mmf04110  Cell cycle
mmf04115  p53 signaling pathway
mmf04140  Autophagy - animal
mmf04144  Endocytosis
mmf04151  PI3K-Akt signaling pathway
mmf04210  Apoptosis
mmf04310  Wnt signaling pathway
mmf04610  Complement and coagulation cascades
mmf04620  Toll-like receptor signaling pathway
mmf04630  JAK-STAT signaling pathway
mmf04650  Natural killer cell mediated cytotoxicity
mmf04668  TNF signaling pathway
KO pathway
ko05167   
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