Entry
Name
Fluid shear stress and atherosclerosis - Myotis myotis (greater mouse-eared bat)
Description
Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions of endothelial cell (EC) genes and proteins that are protective against atherosclerosis. The key shear stress-induced transcription factors that govern the expression of these genes are Kruppel-like factor 2 (KLF2) and nuclear factor erythroid 2-like 2 (Nrf2). On the other hand, disturbed flow with associated reciprocating, low shear stress generally upregulates the EC genes and proteins that promote oxidative and inflammatory states in the artery wall, resulting in atherogenesis. Important transcriptional events that reflect this condition of ECs in disturbed flow include the activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).
Class
Human Diseases; Cardiovascular disease
BRITE hierarchy
Pathway map
mmyo05418 Fluid shear stress and atherosclerosis
Ortholog table
Organism
Myotis myotis (greater mouse-eared bat) [GN:
mmyo ]
Gene
118654244 LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079 ]
118678394 TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
118663270 LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1 [KO:K10456 ]
118661195 NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638 ]
118671585 PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471 ]
118677590 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118668125 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118675045 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118675217 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
118656203 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
118657573 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
118679185 MEF2A; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260 ]
118655801 MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
118673001 ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791 ]
118649937 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
118679031 IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387 ]
118671867 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
118658213 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
118651562 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
118657696 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
118671203 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
Compound
Reference
Authors
Nigro P, Abe J, Berk BC
Title
Flow shear stress and atherosclerosis: a matter of site specificity.
Journal
Reference
Authors
McSweeney SR, Warabi E, Siow RC
Title
Nrf2 as an Endothelial Mechanosensitive Transcription Factor: Going With the Flow.
Journal
Reference
Authors
Heo KS, Fujiwara K, Abe J
Title
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
Journal
Reference
Authors
Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I
Title
Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress.
Journal
Reference
Authors
Noguchi N, Jo H
Title
Redox going with vascular shear stress.
Journal
Reference
Authors
Li X, Yang Q, Wang Z, Wei D
Title
Shear stress in atherosclerotic plaque determination.
Journal
Reference
Authors
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH
Title
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Journal
Reference
Authors
Lu D, Kassab GS
Title
Role of shear stress and stretch in vascular mechanobiology.
Journal
Reference
Authors
Givens C, Tzima E
Title
Endothelial Mechanosignaling: Does One Sensor Fit All?
Journal
Reference
Authors
Paravicini TM, Touyz RM
Title
Redox signaling in hypertension.
Journal
Reference
Authors
Boon RA, Horrevoets AJ
Title
Key transcriptional regulators of the vasoprotective effects of shear stress.
Journal
Hamostaseologie 29:39-40, 41-3 (2009)
Reference
Authors
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J, Evans PC
Title
Mechanoresponsive networks controlling vascular inflammation.
Journal
Reference
Authors
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR
Title
Role of biomechanical forces in the natural history of coronary atherosclerosis.
Journal
Reference
Authors
Zhou J, Li YS, Chien S
Title
Shear stress-initiated signaling and its regulation of endothelial function.
Journal
Reference
Authors
Liu HB, Zhang J, Xin SY, Liu C, Wang CY, Zhao D, Zhang ZR
Title
Mechanosensitive properties in the endothelium and their roles in the regulation of endothelial function.
Journal
Reference
Authors
Boon RA, Leyen TA, Fontijn RD, Fledderus JO, Baggen JM, Volger OL, van Nieuw Amerongen GP, Horrevoets AJ
Title
KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium.
Journal
Reference
Authors
Whyte JJ, Laughlin MH
Title
The effects of acute and chronic exercise on the vasculature.
Journal
Reference
Authors
Quillon A, Fromy B, Debret R
Title
Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals.
Journal
Reference
Authors
Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassegue B, Griendling KK, Jo H
Title
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.
Journal
Reference
Authors
Hopkins PN
Title
Molecular biology of atherosclerosis.
Journal
Reference
Authors
Johnson BD, Mather KJ, Wallace JP
Title
Mechanotransduction of shear in the endothelium: basic studies and clinical implications.
Journal
Reference
Authors
Hu LS, George J, Wang JH
Title
Current concepts on the role of nitric oxide in portal hypertension.
Journal
Reference
Authors
Collins C, Guilluy C, Welch C, O'Brien ET, Hahn K, Superfine R, Burridge K, Tzima E
Title
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.
Journal
Reference
Authors
Conway DE, Schwartz MA
Title
Flow-dependent cellular mechanotransduction in atherosclerosis.
Journal
Reference
Authors
Chen J, Green J, Yurdagul A Jr, Albert P, McInnis MC, Orr AW
Title
alphavbeta3 Integrins Mediate Flow-Induced NF-kappaB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation.
Journal
Reference
Authors
Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC
Title
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
Journal
Related pathway
mmyo04670 Leukocyte transendothelial migration
KO pathway
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