KEGG   PATHWAY: msam04068
Entry
msam04068                   Pathway                                
Name
FoxO signaling pathway - Micropterus salmoides (largemouth bass)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
msam04068  FoxO signaling pathway
msam04068

Other DBs
GO: 0009267
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882881  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
119896887  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119889077  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119910740  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119909133  transforming growth factor beta-3 proprotein-like [KO:K13377]
119905834  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
119903766  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119898112  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119907257  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
119891427  mothers against decapentaplegic homolog 4-like [KO:K04501]
119898232  mothers against decapentaplegic homolog 4-like [KO:K04501]
119907298  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
119887885  mothers against decapentaplegic homolog 4-like [KO:K04501]
119914352  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
119890083  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
119893375  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119902904  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
119901030  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119914607  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
119892213  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
119914299  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
119902893  prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
119897457  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
119904537  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
119885702  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
119887256  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
119902078  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
119902696  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
119883124  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
119895293  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
119914397  skp2; S-phase kinase-associated protein 2 [KO:K03875]
119894985  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119888249  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
119916588  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119884942  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119899431  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119889798  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
119916849  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
119885834  usp7; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
119912349  LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
119917030  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119888580  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915031  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915573  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119885604  serine/threonine-protein kinase 4-like [KO:K04411]
119917907  igf1; insulin-like growth factor I [KO:K05459]
119905971  insulin-like growth factor I [KO:K05459]
119894125  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
119889848  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
119894945  ins; insulin [KO:K04526]
119888918  insb; preproinsulin b [KO:K04526]
119901871  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
119900689  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
119911745  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
119896161  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
119904232  irs2b; insulin receptor substrate 2 [KO:K07187]
119911576  insulin receptor substrate 2-B [KO:K07187]
119901737  insulin receptor substrate 2-like isoform X1 [KO:K07187]
119883088  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
119905617  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119900335  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
119912407  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119902325  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119891547  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
119900224  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
119900503  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
119914041  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119902234  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
119902368  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
119915538  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119917364  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119915458  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119891193  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119917190  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119884419  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119896812  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
119910551  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119882692  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119916983  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119898122  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119895081  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
119897652  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
119908795  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119909745  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
119905869  sgk2a; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
119909488  sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
119883199  foxo1a; forkhead box protein O1-A [KO:K07201]
119895711  forkhead box protein O1-A-like [KO:K07201]
119906675  foxo6b; forkhead box protein O6b [KO:K09408]
119909093  foxo3b; forkhead box protein O3B [KO:K09408]
119910264  foxo3a; forkhead box protein O3a [KO:K09408]
119889186  foxo4; forkhead box protein O4 [KO:K12358]
119897312  forkhead box protein O3-like [KO:K17847]
119910801  metabotropic glutamate receptor 1-like [KO:K04603]
119908408  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
119890030  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
119891923  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
119900487  homer3b; homer protein homolog 3b isoform X1 [KO:K15010]
119902225  homer protein homolog 3 isoform X1 [KO:K15010]
119915127  homer protein homolog 1-like [KO:K15010]
119905108  agap2; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
119886960  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
119916255  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
119884611  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
119903250  interleukin-6-like [KO:K05405]
119885912  il10; interleukin-10 [KO:K05443]
119892323  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119888559  egf; pro-epidermal growth factor [KO:K04357]
119913984  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
119901961  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
119883760  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119899870  son of sevenless homolog 1-like isoform X1 [KO:K03099]
119910225  sos2; son of sevenless homolog 2 [KO:K03099]
119893575  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
119893343  kras; GTPase KRas [KO:K07827]
119886647  zgc:55558 [KO:K07827]
119882013  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
119917992  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119905315  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119891482  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
119893612  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119900881  map2k2a; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119902918  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
119891295  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119886325  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119891584  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
119905572  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
119918284  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119906000  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119918532  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
119886184  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
119915355  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119886002  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
119919128  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
119910460  foxg1a; forkhead box protein G1 [KO:K09385]
119882421  foxg1c; forkhead box protein G1c [KO:K09385]
119914274  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
119889984  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
119890537  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
119882693  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
119911184  G2/mitotic-specific cyclin-B3-like [KO:K21771]
119912588  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
119890260  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119894289  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
119918426  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
119894029  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
119908399  ccndx; cyclin Dx [KO:K10151]
119892496  cyclin-G2-like [KO:K10146]
119914473  ccng2; cyclin-G2 [KO:K10146]
119898939  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119899190  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
119918434  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
119886232  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
119917913  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
119894302  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
119893339  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119898697  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
119891313  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
119902124  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
119910029  plk4; serine/threonine-protein kinase PLK4 isoform X1 [KO:K08863] [EC:2.7.11.21]
119910438  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119892201  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119901218  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119902265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
119888990  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119915100  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119915101  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
119901000  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119888531  cd40lg; CD40 ligand [KO:K04389]
119917176  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119910909  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
119912960  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
119901160  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
119902303  bcl6ab; BCL6A transcription repressor b isoform X1 [KO:K15618]
119917137  bnip4; BCL2 interacting protein 4 [KO:K15464]
119914785  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
119890309  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119897470  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
119912074  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
119894273  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119887495  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119893048  cat; catalase [KO:K03781] [EC:1.11.1.6]
119909030  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
119882548  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
119882713  phosphoenolpyruvate carboxykinase [GTP], mitochondrial-like [KO:K01596] [EC:4.1.1.32]
119886115  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
119907673  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
119918811  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
119915391  g6pc3; LOW QUALITY PROTEIN: glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
119915799  LOW QUALITY PROTEIN: glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
119915800  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
119914859  interleukin-7 receptor subunit alpha-like [KO:K05072]
119914860  interleukin-7 receptor subunit alpha-like [KO:K05072]
119901321  Krueppel-like factor 2 [KO:K17845]
119901324  Krueppel-like factor 2 [KO:K17845]
119901857  Krueppel-like factor 2 [KO:K17845]
119889328  sphingosine 1-phosphate receptor 1 [KO:K04288]
119900695  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
119893086  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
119893179  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
119897925  fbxo32; F-box only protein 32 [KO:K10305]
119909262  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
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J Biol Chem 287:30436-43 (2012)
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PMID:21238503
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Huang H, Tindall DJ
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Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
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Biochim Biophys Acta 1813:1961-4 (2011)
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Greer EL, Brunet A
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Oncogene 24:7410-25 (2005)
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Mol Cell 32:221-31 (2008)
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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
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Nat Cell Biol 8:1064-73 (2006)
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Cancer Biol Ther 12:253-9 (2011)
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Related
pathway
msam00010  Glycolysis / Gluconeogenesis
msam00020  Citrate cycle (TCA cycle)
msam00190  Oxidative phosphorylation
msam04010  MAPK signaling pathway
msam04110  Cell cycle
msam04120  Ubiquitin mediated proteolysis
msam04140  Autophagy - animal
msam04210  Apoptosis
msam04350  TGF-beta signaling pathway
msam04910  Insulin signaling pathway
KO pathway
ko04068   
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