KEGG   PATHWAY: myd04015
Entry
myd04015                    Pathway                                
Name
Rap1 signaling pathway - Myotis davidii (David's myotis)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
myd04015  Rap1 signaling pathway
myd04015

Other DBs
GO: 0007264
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102774675  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102772411  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102757500  MRAS; muscle RAS oncogene homolog [KO:K07831]
102755260  RAPGEF5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
102751768  DOCK4; dedicator of cytokinesis 4 [KO:K17697]
102751770  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102771313  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102759239  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102754756  CALM1; calmodulin 1 [KO:K02183]
102772033  CALM3; calmodulin 3 [KO:K02183]
102772812  CALML3; calmodulin like 3 [KO:K02183]
102773102  CALML5; calmodulin like 5 [KO:K02183]
102756281  CALM2; calmodulin 2 [KO:K02183]
102772521  CALML6; calmodulin like 6 [KO:K02183]
102764405  calmodulin-like [KO:K02183]
102755062  CALML4; calmodulin like 4 [KO:K02183]
102770826  F2R; coagulation factor II thrombin receptor [KO:K03914]
102757438  F2RL3; F2R like thrombin/trypsin receptor 3 [KO:K04236]
102759055  P2RY1; purinergic receptor P2Y1 [KO:K04270]
102762844  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102761006  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102753374  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102762209  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102756094  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102759680  ADORA2A; adenosine A2a receptor [KO:K04266]
102773620  ADORA2B; adenosine A2b receptor [KO:K04267]
102774843  guanine nucleotide-binding protein G(s) subunit alpha isoforms short [KO:K04632]
102775507  neuroendocrine secretory protein 55 [KO:K04632]
102759978  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102774384  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102757252  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102762536  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102760678  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102766123  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102764043  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102765722  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102760324  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102768579  RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
102765492  RAPGEF4; Rap guanine nucleotide exchange factor 4 [KO:K04351]
102760847  GNAQ; G protein subunit alpha q [KO:K04634]
102751685  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102751959  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102755123  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102760520  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102754347  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102766192  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102758044  EGF; epidermal growth factor [KO:K04357]
102766495  FGF1; fibroblast growth factor 1 [KO:K18496]
102762815  FGF2; fibroblast growth factor 2 [KO:K18497]
102754856  FGF6; fibroblast growth factor 6 [KO:K04358]
102760407  FGF7; fibroblast growth factor 7 [KO:K04358]
102764131  FGF8; fibroblast growth factor 8 [KO:K04358]
102753348  FGF9; fibroblast growth factor 9 [KO:K04358]
102769868  FGF5; fibroblast growth factor 5 [KO:K04358]
102755169  FGF17; fibroblast growth factor 17 [KO:K04358]
102769456  FGF16; fibroblast growth factor 16 [KO:K04358]
102757267  FGF3; fibroblast growth factor 3 [KO:K04358]
102751896  FGF18; fibroblast growth factor 18 [KO:K04358]
102754068  FGF22; fibroblast growth factor 22 [KO:K04358]
102766184  FGF10; fibroblast growth factor 10 [KO:K04358]
102768942  FGF21; fibroblast growth factor 21 [KO:K22429]
102769020  NGF; nerve growth factor [KO:K02582]
102753598  INS; insulin [KO:K04526]
102752580  IGF1; insulin like growth factor 1 [KO:K05459]
102762551  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102752730  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102766117  PDGFC; platelet derived growth factor C [KO:K05450]
102772727  PDGFD; platelet derived growth factor D [KO:K05450]
102766818  CSF1; colony stimulating factor 1 [KO:K05453]
102756911  KITLG; KIT ligand [KO:K05461]
102771975  VEGFA; vascular endothelial growth factor A [KO:K05448]
102755405  VEGFB; vascular endothelial growth factor B [KO:K16858]
102761298  PGF; placental growth factor [KO:K16859]
102770606  VEGFC; vascular endothelial growth factor C [KO:K05449]
102764314  VEGFD; vascular endothelial growth factor D [KO:K05449]
102765945  HGF; hepatocyte growth factor [KO:K05460]
102764294  ANGPT1; angiopoietin 1 [KO:K05465]
102768197  ANGPT2; angiopoietin 2 [KO:K05466]
102762702  ANGPT4; angiopoietin 4 [KO:K05467]
102758595  EFNA5; ephrin A5 [KO:K05462]
102760889  EFNA4; ephrin A4 [KO:K05462]
102761173  EFNA3; ephrin A3 [KO:K05462]
102757196  EFNA1; ephrin A1 [KO:K05462]
102758556  EFNA2; ephrin A2 [KO:K05462]
102775204  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102759202  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102763283  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102759469  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102774816  NGFR; nerve growth factor receptor [KO:K02583]
102766590  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102770795  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102761943  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102764172  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102763897  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102761085  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102760394  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102755891  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102756633  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102760801  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102753524  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102773744  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102756217  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102758195  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102761799  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102755223  RAPGEF1; Rap guanine nucleotide exchange factor 1 [KO:K06277]
102751761  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102771627  CDH1; cadherin-1 [KO:K05689]
102763531  cadherin-1 [KO:K05689]
102773658  CTNNB1; catenin beta 1 [KO:K02105]
102752545  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102767027  MAGI3; membrane associated guanylate kinase, WW and PDZ domain containing 3 [KO:K06112]
102762387  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102769591  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
107184444  uncharacterized LOC107184444 [KO:K10784]
102759035  T-cell receptor beta chain V region C5 [KO:K10785]
102762878  LAT; linker for activation of T-cells [KO:K07362]
102766248  FYB; FYN binding protein [KO:K17698]
102757528  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
102753917  SKAP1; src kinase associated phosphoprotein 1 [KO:K17699]
102756475  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102765661  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102757004  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102756030  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102773686  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
102753805  serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
102760258  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
102757935  DRD2; dopamine receptor D2 [KO:K04145]
102773293  CNR1; cannabinoid receptor 1 [KO:K04277]
102765504  GNAI3; G protein subunit alpha i3 [KO:K04630]
102766400  GNAI1; G protein subunit alpha i1 [KO:K04630]
102754275  GNAI2; G protein subunit alpha i2 [KO:K04630]
102765603  GNAO1; G protein subunit alpha o1 [KO:K04534]
102759172  RAP1GAP; RAP1 GTPase activating protein [KO:K17700]
102753766  SIPA1L1; signal induced proliferation associated 1 like 1 [KO:K17701]
102770995  SIPA1; signal-induced proliferation-associated 1 [KO:K08013]
102754882  SIPA1L2; signal induced proliferation associated 1 like 2 [KO:K17702]
102765732  SIPA1L3; signal induced proliferation associated 1 like 3 [KO:K17703]
102762179  ID1; inhibitor of DNA binding 1, HLH protein [KO:K04680]
102758170  THBS1; thrombospondin 1 [KO:K16857]
102771781  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
102766224  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
102753958  RALA; RAS like proto-oncogene A [KO:K07834]
102765818  RALB; RAS like proto-oncogene B [KO:K07835]
102759477  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102768116  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102760578  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102766753  APBB1IP; amyloid beta precursor protein binding family B member 1 interacting protein [KO:K17704]
102762143  TLN1; talin 1 [KO:K06271]
102772298  TLN2; talin 2 [KO:K06271]
102767172  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102761706  ITGB3; integrin subunit beta 3 [KO:K06493]
102751567  PFN4; profilin family member 4 [KO:K05759]
102759225  PFN1; profilin 1 [KO:K05759]
102765189  PFN2; profilin 2 [KO:K05759]
102751694  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
102767765  ENAH; enabled homolog (Drosophila) [KO:K05746]
102755389  EVL; Enah/Vasp-like [KO:K23487]
102772396  ACTB; actin beta [KO:K05692]
102766109  ACTG1; actin gamma 1 [KO:K05692]
102761561  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
102751353  RHOA; ras homolog family member A [KO:K04513]
102769511  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102767098  FARP2; FERM, ARH/RhoGEF and pleckstrin domain protein 2 [KO:K06082]
102758165  CDC42; cell division cycle 42 [KO:K04393]
102758091  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102759764  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102763071  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102758013  PARD3; par-3 family cell polarity regulator [KO:K04237]
102771222  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
102755645  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
102766949  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
102773944  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
102771436  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
102761358  AFDN; afadin, adherens junction formation factor [KO:K05702]
102763718  CTNND1; catenin delta 1 [KO:K05690]
102759651  KRIT1; KRIT1, ankyrin repeat containing [KO:K17705]
102765390  RGS14; regulator of G-protein signaling 14 [KO:K17706]
102752605  RASSF5; Ras association domain family member 5 [KO:K08015]
102754113  ITGAL; integrin subunit alpha L [KO:K05718]
102760033  ITGB2; integrin subunit beta 2 [KO:K06464]
102757018  ITGB1; integrin subunit beta 1 [KO:K05719]
102760422  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102765923  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102759247  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102770309  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102770021  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102755728  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102756012  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102754476  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102770869  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
myd04010  MAPK signaling pathway
myd04014  Ras signaling pathway
myd04020  Calcium signaling pathway
myd04151  PI3K-Akt signaling pathway
myd04510  Focal adhesion
myd04520  Adherens junction
myd04660  T cell receptor signaling pathway
myd04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
LinkDB

DBGET integrated database retrieval system