KEGG   PATHWAY: nfu04068
Entry
nfu04068                    Pathway                                
Name
FoxO signaling pathway - Nothobranchius furzeri (turquoise killifish)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
nfu04068  FoxO signaling pathway
nfu04068

Other DBs
GO: 0009267
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107379821  transforming growth factor beta-1-like isoform X1 [KO:K13375]
107377547  transforming growth factor beta-2-like [KO:K13376]
107377518  transforming growth factor beta-3-like [KO:K13377]
107392404  tgfb3; transforming growth factor beta-3 [KO:K13377]
107374334  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107389601  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107394548  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107372384  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107379013  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107394046  mothers against decapentaplegic homolog 4-like [KO:K04501]
107373891  mothers against decapentaplegic homolog 4-like [KO:K04501]
107388715  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107384096  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107374929  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107393439  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
107393579  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
107396458  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
107384083  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
107390279  prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
107383943  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
107381102  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
107373612  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
107385688  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
107372837  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
107394986  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
107375004  skp2; S-phase kinase-associated protein 2 [KO:K03875]
107387038  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
107387053  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
107376486  crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
107376331  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
107390552  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107388223  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107375374  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
107376398  usp7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
107377390  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
107374715  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107375912  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107375638  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107388204  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107384961  serine/threonine-protein kinase 4-like [KO:K04411]
107386743  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
107391385  insulin-like growth factor I [KO:K05459]
107388825  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107382005  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107383905  insulin-like [KO:K04526]
107386784  insulin-like [KO:K04526]
107383587  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107392644  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107386495  insulin receptor substrate 1-B-like [KO:K16172]
107377348  insulin receptor substrate 1-B-like [KO:K16172]
107389850  irs2; insulin receptor substrate 2 [KO:K07187]
107381024  insulin receptor substrate 2-like isoform X1 [KO:K07187]
107380884  insulin receptor substrate 1-B-like isoform X1 [KO:K07187]
107377017  insulin receptor substrate 2-B-like [KO:K07187]
107392966  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107384477  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107388064  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107372394  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107390759  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107392821  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107386134  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
107374862  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107374040  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107384414  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107388035  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107387313  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107375593  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
107394259  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107376033  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107387492  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107375824  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107395449  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107397194  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107392461  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107379638  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
107372622  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
107377484  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
107390595  sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
107382892  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
107380205  foxo1; forkhead box protein O1 [KO:K07201]
107386483  forkhead box protein O1-A-like [KO:K07201]
107394364  forkhead box protein O6-like [KO:K09408]
107377534  foxo3; forkhead box protein O3 [KO:K09408]
107391983  forkhead box protein O3-like [KO:K09408]
107378306  forkhead box protein O4-like [KO:K12358]
107379380  forkhead box protein O3-like [KO:K17847]
107377567  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
107391977  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
107396792  homer protein homolog 3-like isoform X1 [KO:K15010]
107374851  homer1; homer protein homolog 1 [KO:K15010]
107392834  homer3; homer protein homolog 3 isoform X1 [KO:K15010]
107393910  homer protein homolog 1-like isoform X1 [KO:K15010]
107381704  homer2; homer protein homolog 2 [KO:K15010]
107391110  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
107385648  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
107376305  csnk1e; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
107388239  casein kinase I isoform epsilon-like isoform X1 [KO:K08960] [EC:2.7.11.1]
107383629  interleukin-6-like [KO:K05405]
107385951  il10; interleukin-10 [KO:K05443]
107378443  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107374766  egf; pro-epidermal growth factor [KO:K04357]
107383161  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
107383833  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107376249  grb2; growth factor receptor-bound protein 2 [KO:K04364]
107395003  sos1; son of sevenless homolog 1 [KO:K03099]
107391733  sos2; son of sevenless homolog 2 [KO:K03099]
107389003  hras; GTPase HRas [KO:K02833]
107388963  kras; GTPase KRas isoform X1 [KO:K07827]
107376655  GTPase HRas-like [KO:K07827]
107381355  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107391092  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107393473  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107388720  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107393294  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107386038  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107376681  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107390818  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
107391292  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
107389066  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107397053  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
107397054  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107385560  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
107391338  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107385661  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
107391805  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
107391659  foxg1; forkhead box protein G1 [KO:K09385]
107380688  forkhead box protein G1-like [KO:K09385]
107396529  forkhead box protein G1-like [KO:K09385]
107375104  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
107381480  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
107377000  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
107374449  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
107378596  G1/S-specific cyclin-D2-like [KO:K10151]
107386279  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
107389327  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
107373809  cyclin-G2-like [KO:K10146]
107375093  cyclin-G2-like [KO:K10146]
107375282  cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
107382298  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
107385762  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
107384088  cyclin-dependent kinase inhibitor 1B-like [KO:K06625]
107388428  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
107384056  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
107389125  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
107389935  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
107394073  plk2; serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
107383991  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
107392333  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
107372320  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
107375027  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
107375063  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
107387371  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
107393104  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107394110  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
107392101  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
107396466  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107378854  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107375876  uncharacterized protein LOC107375876 [KO:K16341]
107383107  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
107392066  tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
107396215  B-cell lymphoma 6 protein-like [KO:K15618]
107387412  bcl6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
107376003  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
107374744  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
107379688  atg12; ubiquitin-like protein ATG12 [KO:K08336]
107379424  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
107381527  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107377387  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
107389278  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107380817  cat; catalase [KO:K03781] [EC:1.11.1.6]
107377632  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
107380541  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
107384949  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
107382700  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
107390053  g6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
107387634  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
107387635  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
107387672  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
107374989  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
107383603  klf2; Krueppel-like factor 2 [KO:K17845]
107393085  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
107393115  sphingosine 1-phosphate receptor 4-like [KO:K04293]
107388984  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
107388559  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
107377614  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
107378781  fbxo32; F-box only protein 32 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
nfu00010  Glycolysis / Gluconeogenesis
nfu00020  Citrate cycle (TCA cycle)
nfu00190  Oxidative phosphorylation
nfu04010  MAPK signaling pathway
nfu04110  Cell cycle
nfu04120  Ubiquitin mediated proteolysis
nfu04140  Autophagy - animal
nfu04210  Apoptosis
nfu04350  TGF-beta signaling pathway
nfu04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

DBGET integrated database retrieval system