KEGG   PATHWAY: nnt04145
Entry
nnt04145                    Pathway                                
Name
Phagosome - Nestor notabilis (Kea)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
nnt04145  Phagosome
nnt04145

Other DBs
GO: 0045335
Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104400489  vesicle-associated membrane protein 3-like [KO:K13505]
104400314  STX12; syntaxin-12 [KO:K13813]
104408748  STX7; syntaxin-7 [KO:K08488]
104401036  actin, cytoplasmic 1 isoform X1 [KO:K05692]
104405778  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
104400125  STX18; syntaxin-18 [KO:K08492]
104404308  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
104406923  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104400940  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104410000  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104411289  EEA1; early endosome antigen 1 [KO:K12478]
104399438  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
104399585  TFRC; transferrin receptor protein 1 [KO:K06503]
104401879  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
104401093  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104407705  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104409045  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
104410207  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104412111  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104412189  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
104406174  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104402393  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104408395  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
104400760  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
104401671  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
104399687  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
104412119  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104406385  V-type proton ATPase subunit d 2 [KO:K02146]
104399409  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104401215  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104413539  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104410999  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
104400769  RAB7A; ras-related protein Rab-7a [KO:K07897]
104410804  RAB7B; ras-related protein Rab-7b [KO:K07898]
104413246  RILP; rab-interacting lysosomal protein [KO:K13883]
104411564  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104409865  cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
104410515  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104400377  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104402481  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104408311  LOW QUALITY PROTEIN: tubulin alpha-1C chain-like [KO:K07374]
104408312  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104401058  tubulin alpha-3 chain isoform X1 [KO:K07374]
104402183  tubulin alpha-8 chain [KO:K07374]
104402339  tubulin alpha-1B chain-like [KO:K07374]
104403243  tubulin beta-4B chain [KO:K07375]
104408966  TUBB6; tubulin beta-6 chain [KO:K07375]
104405736  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
104412202  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
104400079  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
104406940  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104403155  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104404829  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
104407111  LOW QUALITY PROTEIN: myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
104400510  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
104409361  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
104410743  protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
104401220  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
104410602  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
104399203  CALR3; calreticulin-3 [KO:K08057]
104399922  CANX; calnexin isoform X1 [KO:K08054]
104399396  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
104405561  ITGB2; integrin beta-2 [KO:K06464]
104413102  C3; complement C3 [KO:K03990]
104409470  COLEC11; collectin-11 isoform X1 [KO:K10066]
104406387  COLEC12; collectin-12 [KO:K10062]
104411348  LOW QUALITY PROTEIN: mannose-binding protein C-like [KO:K03991]
104411346  pulmonary surfactant-associated protein A-like [KO:K10067]
104411347  pulmonary surfactant-associated protein A-like [KO:K10067]
104400010  ITGAV; integrin alpha-V [KO:K06487]
104410325  ITGA2; integrin alpha-2 [KO:K06481]
104400538  integrin beta-1-like [KO:K05719]
104410905  ITGB3; integrin beta-3 [KO:K06493]
104399570  ITGB5; integrin beta-5 [KO:K06588]
104400129  THBS1; thrombospondin-1 [KO:K16857]
104404236  LOW QUALITY PROTEIN: thrombospondin-3-like [KO:K04659]
104408884  COMP; cartilage oligomeric matrix protein [KO:K04659]
104409358  THBS2; thrombospondin-2 [KO:K04659]
104405064  THBS4; thrombospondin-4 [KO:K04659]
104401150  TLR2; toll-like receptor 2 [KO:K10159]
104405963  TLR4; toll-like receptor 4 [KO:K10160]
104413202  MRC2; C-type mannose receptor 2 [KO:K06560]
104411333  MRC1; macrophage mannose receptor 1 [KO:K06560]
104411334  macrophage mannose receptor 1-like [KO:K06560]
104411335  macrophage mannose receptor 1-like [KO:K06560]
104411336  LOW QUALITY PROTEIN: macrophage mannose receptor 1-like [KO:K06560]
104411337  macrophage mannose receptor 1-like [KO:K06560]
104402868  hepatic lectin-like [KO:K06563]
104407103  MARCO; macrophage receptor MARCO [KO:K13884]
104410689  SCARB1; scavenger receptor class B member 1 [KO:K13885]
104400412  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
104404248  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104400851  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104405657  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104407536  NCF2; neutrophil cytosol factor 2 [KO:K08010]
104407403  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
nnt04142  Lysosome
nnt04144  Endocytosis
nnt04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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