KEGG   PATHWAY: nss04820
Entry
nss04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Notechis scutatus (mainland tiger snake)
Class
Cellular Processes; Cell motility
Pathway map
nss04820  Cytoskeleton in muscle cells
nss04820

Organism
Notechis scutatus (mainland tiger snake) [GN:nss]
Gene
113417338  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113413442  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
113412414  COL3A1; collagen alpha-1(III) chain [KO:K19720]
113414720  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
113425309  collagen alpha-1(V) chain-like [KO:K19721]
113416139  COL5A3; collagen alpha-3(V) chain [KO:K19721]
113416347  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
113427870  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
113412413  COL5A2; collagen alpha-2(V) chain [KO:K19721]
113416018  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
113410521  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
113422460  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
113431360  DCN; decorin [KO:K04660]
113414935  VCAN; versican core protein isoform X1 [KO:K06793]
113421378  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
113419560  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
113419565  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
113419566  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
113410120  THBS1; thrombospondin-1 [KO:K16857]
113413938  THBS4; thrombospondin-4 [KO:K04659]
113425462  COMP; cartilage oligomeric matrix protein [KO:K04659]
113429206  thrombospondin-3-like [KO:K04659]
113413345  THBS2; thrombospondin-2 [KO:K04659]
113418295  FBN1; fibrillin-1 [KO:K06825]
113414280  FBN2; fibrillin-2 [KO:K23342]
113427440  fibrillin-2-like [KO:K23342]
113409926  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
113410222  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
113416596  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
113416617  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
113419534  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
113419535  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
113417789  FBLN2; LOW QUALITY PROTEIN: fibulin-2 [KO:K17307]
113419709  FBLN1; fibulin-1 isoform X1 [KO:K17307]
113413221  NID1; nidogen-1 [KO:K06826]
113413760  NID2; nidogen-2 [KO:K06826]
113415656  FN1; fibronectin isoform X1 [KO:K05717]
113417262  SDC1; syndecan-1 [KO:K06257]
113428057  SDC2; syndecan-2 [KO:K16336]
113419833  SDC3; syndecan-3 [KO:K16337]
113410457  SDC4; syndecan-4 [KO:K16338]
113421268  AGRN; agrin [KO:K06254]
113417800  BGN; biglycan [KO:K08118]
113413765  desmocollin-1-like [KO:K07601]
113413825  desmocollin-2-like isoform X1 [KO:K07601]
113413827  DSG2; desmoglein-2 [KO:K07597]
113432853  PKP2; plakophilin-2 [KO:K12642]
113413531  JUP; junction plakoglobin isoform X1 [KO:K10056]
113418022  DSP; desmoplakin isoform X1 [KO:K10381]
113424492  VIM; vimentin [KO:K07606]
113410830  DES; desmin [KO:K07610]
113414809  LAMA1; laminin subunit alpha-1 [KO:K05637]
113411266  LAMA2; laminin subunit alpha-2 [KO:K05637]
113411423  ITGA1; integrin alpha-1 [KO:K06480]
113411426  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
113422604  ITGA2B; integrin alpha-IIb [KO:K06476]
113413449  ITGA3; integrin alpha-3 [KO:K06482]
113412433  ITGA4; integrin alpha-4 [KO:K06483]
113416112  ITGA5; integrin alpha-5 [KO:K06484]
113418690  ITGA6; integrin alpha-6 [KO:K06485]
113420736  ITGA7; integrin alpha-7 [KO:K06583]
113421139  ITGA8; integrin alpha-8 [KO:K06584]
113419916  ITGA9; integrin alpha-9 [KO:K06585]
113424664  ITGA10; integrin alpha-10 [KO:K06586]
113425680  ITGA11; integrin alpha-11 [KO:K06587]
113412421  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
113415014  ITGB1; integrin beta-1 [KO:K05719]
113422071  ITGB3; integrin beta-3 [KO:K06493]
113412075  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
113410750  ITGB5; integrin beta-5 [KO:K06588]
113416505  ITGB6; integrin beta-6 [KO:K06589]
113416559  integrin beta-6-like isoform X1 [KO:K06589]
113418883  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113421581  TLN2; talin-2 [KO:K06271]
113423536  TLN1; talin-1 isoform X1 [KO:K06271]
113416359  VCL; vinculin [KO:K05700]
113426665  ACTN3; alpha-actinin-3 [KO:K21073]
113413285  ACTN2; alpha-actinin-2 [KO:K21073]
113417391  ACTG1; actin, cytoplasmic 2 [KO:K05692]
113429080  actin, cytoplasmic 1 [KO:K05692]
113431096  actin, clone 302-like [KO:K05692]
113423411  actin, gamma-enteric smooth muscle-like [KO:K12315]
113415784  DAG1; dystroglycan [KO:K06265]
113413443  SGCA; alpha-sarcoglycan [KO:K12565]
113417336  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
113417931  SGCB; beta-sarcoglycan [KO:K12566]
113421655  SGCD; delta-sarcoglycan [KO:K12563]
113416877  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
113411824  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
113412217  SSPN; sarcospan [KO:K22194]
113429579  sarcospan-like [KO:K22194]
113420468  DMD; LOW QUALITY PROTEIN: dystrophin [KO:K10366]
113422858  SNTA1; alpha-1-syntrophin [KO:K24063]
113426973  SNTB1; beta-1-syntrophin [KO:K24064]
113423424  SNTB2; beta-2-syntrophin [KO:K24064]
113413836  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
113424341  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
113421170  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
113417182  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
113410115  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
113416742  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
113421401  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
113427881  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
113416393  ANK3; ankyrin-3 [KO:K09259]
113427487  spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
113425544  SPTBN4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
113409994  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
113418048  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
113426675  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
113410203  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
113420813  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
113412202  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
113409780  MYH15; myosin-15 [KO:K24220]
113412133  myosin-1B-like isoform X1 [KO:K24220]
113412134  myosin-1B-like isoform X1 [KO:K24220]
113412136  myosin-3-like [KO:K24220]
113412137  myosin-1B-like isoform X1 [KO:K24220]
113422853  MYH7B; myosin-7B [KO:K24220]
113422248  myosin-7 [KO:K17751]
113422280  LOW QUALITY PROTEIN: myosin-6-like [KO:K17751]
113421794  myosin-10-like isoform X1 [KO:K10352]
113418218  MYH10; myosin-10 isoform X1 [KO:K10352]
113422407  MYH11; myosin-11 isoform X1 [KO:K10352]
113432768  MYH9; myosin-9 isoform X1 [KO:K10352]
113415661  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
113420027  MYL4; myosin light chain 4 [KO:K12750]
113429306  myosin light chain 3-like [KO:K12750]
113424905  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113415528  MYL5; myosin light chain 5 [KO:K12753]
113414478  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
113421339  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
113426695  myosin regulatory light chain 2, skeletal muscle isoform-like isoform X1 [KO:K12758]
113421724  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
113432822  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
113413379  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
113414343  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
113420778  MYBPH; myosin-binding protein H [KO:K24494]
113413315  ACTA1; actin, alpha skeletal muscle [KO:K10354]
113410105  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
113422534  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
113420771  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
113418522  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
113427138  TNNC2; troponin C, skeletal muscle [KO:K12042]
113412539  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
113412543  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
113418613  TNNI3; troponin I, cardiac muscle [KO:K12044]
113420790  TNNT2; troponin T, cardiac muscle [KO:K12045]
113421617  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
113423537  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
113429591  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
113414166  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
113412441  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
113424912  MYOT; myotilin isoform X1 [KO:K19875]
113420015  TCAP; telethonin [KO:K19879]
113411817  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
113420227  LOW QUALITY PROTEIN: nebulin-like [KO:K18267]
113420261  nebulin-like [KO:K18267]
113416404  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
113411762  MYOZ2; myozenin-2 [KO:K26050]
113430751  myozenin-3-like [KO:K26050]
113425397  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
113420996  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
113411847  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
113425673  F-actin-capping protein subunit alpha-1-like [KO:K10364]
113417000  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
113413003  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
113430029  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
113419509  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
113416541  xin actin-binding repeat-containing protein 2-like [KO:K27381]
113416485  xin actin-binding repeat-containing protein 2-like [KO:K27381]
113413848  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
113415405  MYPN; myopalladin [KO:K22028]
113415316  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
113415814  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
113416384  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
113424301  TMOD4; tropomodulin-4 [KO:K10370]
113415500  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
113418306  tropomodulin-3-like isoform X1 [KO:K10370]
113418323  tropomodulin-2-like [KO:K10370]
113424473  ZYX; zyxin isoform X1 [KO:K06273]
113423778  FHL1; four and a half LIM domains protein 1 [KO:K14365]
113411616  FHL2; four and a half LIM domains protein 2 [KO:K14380]
113416087  FHL3; four and a half LIM domains protein 3 [KO:K24414]
113419747  LMOD3; leiomodin-3 [KO:K22030]
113420770  LMOD1; leiomodin-1 isoform X1 [KO:K22030]
113413046  LMOD2; leiomodin-2 [KO:K22030]
113414066  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
113412142  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
113425895  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
113420230  formin-like protein 2 [KO:K23957]
113420262  formin-like protein 2 [KO:K23957]
113422084  FMNL1; formin-like protein 1 [KO:K23957]
113422724  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
113421162  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
113413707  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
113422325  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
113416730  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
113415891  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
113413219  FMN2; formin-2 [KO:K02184]
113414818  MYOM1; myomesin-1 isoform X1 [KO:K24495]
113410535  MYOM2; myomesin-2 [KO:K24495]
113420661  MYOM3; myomesin-3 [KO:K24495]
113424518  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
113426363  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
113428001  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
113428004  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
113428008  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
113427997  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
113414621  TRIM54; LOW QUALITY PROTEIN: tripartite motif-containing protein 54 [KO:K10653]
113426483  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
113429274  tripartite motif-containing protein 55-like [KO:K10654]
113417576  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
113410323  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
113416962  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
113418816  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
113418949  AMP deaminase 2-like [KO:K01490] [EC:3.5.4.6]
113422192  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
113414257  CAPN3; calpain-3 [KO:K08573] [EC:3.4.22.54]
113425138  PLEC; plectin [KO:K10388]
113420410  SYNE1; nesprin-1 isoform X1 [KO:K19326]
113413685  SYNE2; nesprin-2 [KO:K19346]
113423623  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
113432722  SUN2; SUN domain-containing protein 2 [KO:K19347]
113419087  TMEM43; transmembrane protein 43 [KO:K27488]
113417684  EMD; emerin isoform X1 [KO:K12569]
113421674  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
113426263  LMNB2; lamin-B2 [KO:K07611]
113416127  LMNB1; lamin-B1 [KO:K07611]
113418329  lamin-L(III)-like [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
nss04512  ECM-receptor interaction
nss04814  Motor proteins
KO pathway
ko04820   
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